Mechanistic Target of Rapamycin Signaling Activation Antagonizes Autophagy To Facilitate Zika Virus Replication

Autophagy Contributes to Host Immunity and Protection against Zika Virus Infection via Type I IFN Signaling

(2020) Yuyi Huang et al.   MEDIATORS OF INFLAMMATION

Guillain-Barré syndrome related to Zika virus infection: A systematic review and meta-analysis of the clinical and electrophysiological phenotype

(2020) Sonja E. Leonhard et al.   PLoS Neglected Tropical Diseases

Reduced-Beclin1-Expressing Mice Infected with Zika-R103451 and Viral-Associated Pathology during Pregnancy

(2020) Mohan Kumar Muthu Karuppan et al.   Viruses-Basel

Differential and convergent utilization of autophagy components by positive-strand RNA viruses

(2019) Emma Abernathy et al.   PLOS BIOLOGY

Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes

(2019) Chet Raj Ojha et al.   PLoS One

Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells

(2019) Shivani K. Thaker et al.   Cell Metabolism

Evasion of Innate and Intrinsic Antiviral Pathways by the Zika Virus

(2019) Taryn M. Serman et al.   Viruses-Basel

mTORC1 restricts hepatitis C virus RNA replication through ULK1-mediated suppression of miR-122 and facilitates post-replication events

(2019) Manish Kumar Johri et al.   JOURNAL OF GENERAL VIROLOGY

Discovery of a non-nucleoside RNA polymerase inhibitor for blocking Zika virus replication through in silico screening

(2018) Aryamav Pattnaik et al.   ANTIVIRAL RESEARCH

Unmasking the impact of Rictor in cancer: novel insights of mTORC2 complex

(2018) Anastasios Gkountakos et al.   CARCINOGENESIS

Inflammation-Induced, STING-Dependent Autophagy Restricts Zika Virus Infection in the Drosophila Brain

(2018) Yuan Liu et al.   Cell Host & Microbe

Induction of autophagy and interleukin 6 secretion in bystander cells: metabolic cooperation for radiation-induced rescue effect?

(2018) Eva Yi Kong et al.   JOURNAL OF RADIATION RESEARCH

Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit

(2018) Nathan Meade et al.   CELL

The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions

(2018) Po-Yuan Ke   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of selective autophagy: the p62/SQSTM1 paradigm

(2017) Trond Lamark et al.   Essays in Biochemistry

Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice

(2017) Bin Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Zika Virus Encoding Nonglycosylated Envelope Protein Is Attenuated and Defective in Neuroinvasion

(2017) Arun S. Annamalai et al.   JOURNAL OF VIROLOGY

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication

(2017) Sharon K. Kuss-Duerkop et al.   PLoS Pathogens

Zika virus disrupts molecular fingerprinting of human neurospheres

(2017) Patricia P. Garcez et al.   Scientific Reports

Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise

(2016) Jonathan J. Miner et al.   CELL

A Mouse Model of Zika Virus Pathogenesis

(2016) Helen M. Lazear et al.   Cell Host & Microbe

Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation

(2016) Hongda Li et al.   Cell Stem Cell

Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy

(2016) Qiming Liang et al.   Cell Stem Cell

Interactions between Autophagy and Inhibitory Cytokines

(2016) Tian-tian Wu et al.   International Journal of Biological Sciences

Zika Virus-Induced Microcephaly and Its Possible Molecular Mechanism

(2016) Md Imam Faizan et al.   INTERVIROLOGY

Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere

(2016) Helen M. Lazear et al.   JOURNAL OF VIROLOGY

Zika virus in semen and spermatozoa

(2016) Jean Michel Mansuy et al.   LANCET INFECTIOUS DISEASES

The Brazilian Zika virus strain causes birth defects in experimental models

(2016) Fernanda R. Cugola et al.   NATURE

The Neurobiology of Zika Virus

(2016) Hongda Li et al.   NEURON

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

Nucleotide composition of the Zika virus RNA genome and its codon usage

(2016) Formijn van Hemert et al.   Virology Journal

Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway

(2016) Valerie Le Sage et al.   Viruses-Basel

Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models

(2016) Rodrigo Delvecchio et al.   Viruses-Basel

mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2

(2016) KyeongJin Kim et al.   Nature Communications

Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears

(2016) Jonathan J. Miner et al.   Cell Reports

A Cap-to-Tail Guide to mRNA Translation Strategies in Virus-Infected Cells

(2016) Eric Jan et al.   Annual Review of Virology

Host cell mTORC1 is required for HCV RNA replication

(2015) Stefanie Stöhr et al.   GUT

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Biology of Zika Virus Infection in Human Skin Cells

(2015) Rodolphe Hamel et al.   JOURNAL OF VIROLOGY

Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014

(2014) M Besnard et al.   Eurosurveillance

West Nile Virus-Induced Activation of Mammalian Target of Rapamycin Complex 1 Supports Viral Growth and Viral Protein Expression

(2014) K. D. Shives et al.   JOURNAL OF VIROLOGY

Autophagy inhibits viral genome replication and gene expression stages in West Nile virus infection

(2014) Shintaro Kobayashi et al.   VIRUS RESEARCH

mTOR signaling and its roles in normal and abnormal brain development

(2014) Nobuyuki Takei et al.   Frontiers in Molecular Neuroscience

Single-virus tracking approach to reveal the interaction of Dengue virus with autophagy during the early stage of infection

(2013) Li-Wei Chu   JOURNAL OF BIOMEDICAL OPTICS

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Impairment of Atg5-Dependent Autophagic Flux Promotes Paraquat- and MPP+-Induced Apoptosis But Not Rotenone or 6-Hydroxydopamine Toxicity

(2013) Aracely Garcia-Garcia et al.   TOXICOLOGICAL SCIENCES

Host mTORC1 Signaling Regulates Andes Virus Replication

(2012) S. McNulty et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Upregulates Beclin1 for Induction of Autophagy and Activates mTOR Signaling

(2012) Shubham Shrivastava et al.   JOURNAL OF VIROLOGY

West Nile virus growth is independent of autophagy activation

(2012) Erica Beatman et al.   VIROLOGY

Flavivirus NS4A-induced Autophagy Protects Cells against Death and Enhances Virus Replication

(2011) Jeffrey E. McLean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis C Virus NS5A Binds to the mRNA Cap-binding Eukaryotic Translation Initiation 4F (eIF4F) Complex and Up-regulates Host Translation Initiation Machinery through eIF4E-binding Protein 1 Inactivation

(2011) Anju George et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line

(2011) Diana Scholz et al.   JOURNAL OF NEUROCHEMISTRY

The Changing Role of mTOR Kinase in the Maintenance of Protein Synthesis during Human Cytomegalovirus Infection

(2011) A. J. Clippinger et al.   JOURNAL OF VIROLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Hepatitis C Virus NS5A Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Contributing to Cell Survival by Disrupting the Interaction between FK506-binding Protein 38 (FKBP38) and mTOR

(2010) Lu Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppressor of Cytokine Signaling 3 Suppresses Hepatitis C Virus Replication in an mTOR-Dependent Manner

(2010) R. X. Shao et al.   JOURNAL OF VIROLOGY

Rapamycin-Resistant mTORC1 Kinase Activity Is Required for Herpesvirus Replication

(2010) N. J. Moorman et al.   JOURNAL OF VIROLOGY

HIV-1 Inhibits Autophagy in Bystander Macrophage/Monocytic Cells through Src-Akt and STAT3

(2010) Jennifer Van Grol et al.   PLoS One

mTOR and cancer: many loops in one pathway

(2009) Alejo Efeyan et al.   CURRENT OPINION IN CELL BIOLOGY

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

(2009) L.-A. Julien et al.   MOLECULAR AND CELLULAR BIOLOGY

The autophagy machinery is required to initiate hepatitis C virus replication

(2009) M. Dreux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Rictor and Integrin-Linked Kinase Interact and Regulate Akt Phosphorylation and Cancer Cell Survival

(2008) P. C. McDonald et al.   CANCER RESEARCH

Autophagy and antiviral immunity

(2008) Heung Kyu Lee et al.   CURRENT OPINION IN IMMUNOLOGY

The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway

(2008) Nicholas J. Buchkovich et al.   NATURE REVIEWS MICROBIOLOGY