Article
Surgery
Julie Liu, Jennifer Woo Baidal, Ilene Fennoy, Kristina L. Parkinson, Lori Lynch, Jeffrey L. Zitsman
Summary: Severe obesity often comes with co-morbid conditions, successful weight loss can lead to the remission of these conditions. Adolescents have lower prevalence of co-morbid conditions compared to adults, earlier weight loss may help reduce the prevalence of these conditions.
Review
Psychiatry
Clemence Bougeard, Francoise Picarel-Blanchot, Ramona Schmid, Rosanne Campbell, Jan Buitelaar
Summary: This study provides an overview of the prevalence of ASD and its comorbidities in children and adolescents in the United States and Europe. The results show an increasing prevalence of ASD over time and significant heterogeneity in the prevalence of comorbidities, highlighting the importance of personalized approaches to treatment and support. Understanding the prevalence of ASD and its comorbidities is crucial for raising awareness among stakeholders.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Immunology
Alba Llibre, Martin Dedicoat, Julie G. Burel, Caroline Demangel, Matthew K. O'Shea, Claudio Mauro
Summary: This review provides a comprehensive understanding of the immune-metabolic adaptations of macrophages to mycobacterial infections. It discusses the changes in glycolysis, oxidative metabolism, and fatty acid utilization in response to mycobacteria, as well as the impact of critical tuberculosis co-morbidities on host metabolic responses. The review also explores how immune-metabolic knowledge can be utilized for the development of new diagnostic and therapeutic strategies for mycobacterial diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Louise Bicart-See, Jean-Luc Thibault, Aurelia Poujois, France Woimant, Floriane Bouquet-Castiglione, Pierre Lozeron, Nathalie Kubis
Summary: This retrospective study analyzed 27 OT patients and found associations between movement disorders and OT, but further research is needed to classify OT (primary or pseudo).
JOURNAL OF NEUROLOGY
(2021)
Review
Cell Biology
Irene Maeve Rea, H. Denis Alexander
Summary: Covid-19 has had a significant impact on human life, with varying degrees of symptoms in different individuals. Older people and those with comorbidities such as diabetes, heart disease, and obesity are more likely to develop severe symptoms. Enhancing the immune function in older and frail individuals to prevent serious Covid-19 infection is a key consideration.
AGEING RESEARCH REVIEWS
(2022)
Article
Immunology
Maria Giufre, Maria Dorrucci, Alessandra Lo Presti, Francesca Farchi, Rita Cardines, Romina Camilli, Fernanda Pimentel de Araujo, Fabiola Mancini, Alessandra Ciervo, Maria Corongiu, Annalisa Pantosti, Marina Cerquetti, Catia Valdarchi
Summary: After the Hib vaccine became widely used, the most common cause of Haemophilus influenzae invasive disease is now non-encapsulated (NTHi), which affects mainly young and elderly individuals. This study aimed to investigate the nasopharyngeal carriage rate of H. influenzae and associated risk factors in adults with co-morbidities. The results showed that colonization with H. influenzae in adults over 50 years old with co-morbidities was occasionally observed, and the presence of acute respiratory symptoms was the only factor associated with H. influenzae colonization. All colonizing isolates were NTHi, and there was a high degree of genetic diversity among the isolates.
Article
Biochemistry & Molecular Biology
Hanfei Xu, Karen Schwander, Michael R. Brown, Wenyi Wang, R. J. Waken, Eric Boerwinkle, L. Adrienne Cupples, Lisa de las Fuentes, Diana van Heemst, Oyomoare Osazuwa-Peters, Paul S. de Vries, Ko Willems van Dijk, Yun Ju Sung, Xiaoyu Zhang, Alanna C. Morrison, D. C. Rao, Raymond Noordam, Ching-Ti Liu
Summary: Recent studies compare and evaluate four approaches to handle missing data in LRS-stratified meta-analyses, finding that the Safe Approach and Moderator Approach are slightly conservative and yield almost identical p values.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2021)
Review
Infectious Diseases
Denis Macina, Keith E. Evans
Summary: Research suggests that pertussis may be associated with certain chronic conditions or health issues, but the results are not entirely consistent. Some chronic conditions may increase the risk of contracting pertussis, while pertussis may also affect the exacerbation or onset of certain chronic conditions. Additional research is needed to confirm or refute these associations and further understand the pathophysiological mechanisms behind them.
INFECTIOUS DISEASES AND THERAPY
(2021)
Article
Medicine, General & Internal
Anna Rulkiewicz, Iwona Pilchowska, Wojciech Lisik, Piotr Pruszczyk, Justyna Domienik-Karlowicz
Summary: Smoking is a leading cause of preventable mortality and affects both the health and economic situation within societies. This study analyzed the smoking status among professionally active adults in Poland from 2016 to 2020 and found a strong relationship between smoking and cardiovascular co-morbidities.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Matthew J. Fastiggi, Jin-ah Sim, I-Chan Huang
Summary: The study evaluated the impact of co-morbidities on financial hardship in adult cancer survivors and found that financial worry was more pronounced among survivors from low-income families, while survivors of working age were more likely to face out-of-pocket burden. Health insurance and a usual source of care did not alleviate the impact of co-morbidities on financial hardship.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Multidisciplinary Sciences
Maria Jose Aburto, Dayna Romero, Leandro F. M. Rezende, Zila M. Sanchez, Cristian Cofre Bolados, Juan Guzman-Habinger, Mario Rios, Monica Suarez-Reyes, Adilson Marques, Clemens Drenowatz, Carlos Cristi-Montero, Gerson Ferrari
Summary: The prevalence of lifestyle risk factors for non-communicable diseases is high among Chilean residents, with overweight/obesity and alcohol consumption being the most common. Men, individuals with secondary education, and those with lower household incomes are more likely to have multiple risk factors, while older adults and residents in rural areas have lower odds of having three or more risk factors. Efforts to address these risk factors may need to focus on the co-occurrence of multiple factors and consider population stratification.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Paulus Anam Ong, Febby Rosa Annisafitrie, Novita Purnamasari, Chandra Calista, Noveline Sagita, Yulia Sofiatin, Yustiani Dikot
Summary: Research on dementia prevalence and related risk factors in Jatinangor, Indonesia is limited. This study found a high prevalence rate of dementia, with different risk factors identified among different age groups. The identified modifiable risk factors could be targeted for intervention and public health policy design.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Steenland Kyle, Tan Youran, Wingo Thomas, Shi Liuhua, Xiao Siyao, Wharton Whitney
Summary: This study reveals that Black individuals have a higher incidence of Alzheimer's disease (AD) compared to White individuals. The presence of more co-morbidities is strongly associated with an increased risk of AD. Furthermore, hypertension has a greater impact on AD risk among Black individuals.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Adrian Matysek, Aneta Studnicka, Wade Menpes Smith, Michal Hutny, Pawel Gajewski, Krzysztof J. J. Filipiak, Jorming Goh, Guang Yang
Summary: Since the outbreak of COVID-19, there have been individual differences in the course of the disease, influenced by various factors. By using machine learning to analyze the clinical characteristics of affected populations, we can assess the significance and create a tool to evaluate individual risk of SARS-CoV-2 infection.
FRONTIERS IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Vanessa E. Murphy
Summary: Asthma is the most common chronic disease in pregnancy, and it requires regular assessment of symptoms, self-management education, and appropriate medication use. Pregnant women with asthma often have comorbidities such as obesity, gestational diabetes, hypertension, rhinitis, depression, and anxiety. Further research is needed to understand the relationship between asthma in pregnancy and poor neurodevelopmental outcomes like autism.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Review
Clinical Neurology
Weijia Li, Jiyoung Seo, Damianos G. Kokkinidis, Leonidas Palaiodimos, Sanjana Nagraj, Eleni Korompoki, Haralambos Milionis, Wolfram Doehner, Gregory Y. H. Lip, George Ntaios
Summary: The use of oral anticoagulation therapy in patients with heart failure and sinus rhythm can reduce the occurrence of stroke, but it also increases the risk of major bleeding. Rivaroxaban has a better effect in preventing stroke, but it is also associated with a higher risk of bleeding. There were no significant differences between the use of oral anticoagulants and the control group in terms of myocardial infarction, all-cause mortality, and hospitalization for heart failure.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Cardiac & Cardiovascular Systems
Stefan D. Anker, Muhammad Shahzeb Khan, Javed Butler, Anne Pernille Ofstad, Barbara Peil, Egon Pfarr, Wolfram Doehner, Naveed Sattar, Andrew J. S. Coats, Gerasimos Filippatos, Joao Pedro Ferreira, Faiez Zannad, Stuart Pocock, Milton Packer
Summary: In this study, the relationship between baseline BMI, weight loss, and the effects of empagliflozin on heart failure patients with reduced ejection fraction (HFrEF) were analyzed. The study found that the benefits of empagliflozin were consistent across all BMI categories, and weight loss was associated with increased risk of all-cause mortality regardless of treatment group.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Roberto F. E. Pedretti, Dominique Hansen, Marco Ambrosetti, Maria Back, Thomas Berger, Mariana Cordeiro Ferreira, Veronique Cornelissen, Constantinos H. Davos, Wolfram Doehner, Carmen de Pablo Y. Zarzosa, Ines Frederix, Andrea Greco, Donata Kurpas, Matthias Michal, Elena Osto, Susanne Pedersen, Rita Esmeralda Salvador, Maria Simonenko, Patrizia Steca, David R. Thompson, Matthias Wilhelm, Ana Abreu
Summary: Optimal patient adherence to treatment is crucial for successful secondary prevention of cardiovascular disease (CVD). However, unsatisfactory adherence rates have been consistently observed for CVD risk factors and treatment. This consensus document provides a modern reappraisal of adherence to optimal treatment and offers simple, practical, and feasible suggestions to achieve this goal in the clinical setting, focusing on evidence-based concepts.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Andrew Sindone, Wolfram Doehner, Josep Comin-Colet
Summary: Intravenous iron-carbohydrate complex supplementation has a positive effect on heart failure patients, reducing hospitalization rates and improving functional and exercise capacity.
Article
Cardiac & Cardiovascular Systems
Peter Carson, John R. Teerlink, Michel Komajda, Inder Anand, Stefan D. Anker, Javed Butler, Wolfram Doehner, Joao Pedro Ferreira, Gerasimos Filippatos, Markus Haass, Alan Miller, Steen Pehrson, Stuart J. Pocock, Sven Schnaidt, Janet M. Schnee, Faiez Zannad, Milton Packer
Summary: There is limited published information on outcome adjudication in heart failure (HF). In this study, the authors compared investigator reports (IRs) to a Clinical Events Committee (CEC) and found that IRs can be an alternative to CEC with similar accuracy and faster event accumulation. They also suggest broadening the definition of hospitalization for heart failure (HHF) to include for or with worsening disease.
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Julia Hoffmann, Sabine Hanss, Monika Kraus, Jens Schaller, Christian Schaefer, Dana Stahl, Stefan D. Anker, Gabriele Anton, Thomas Bahls, Stefan Blankenberg, Arne Blumentritt, Leif-Hendrik Boldt, Steffen Cordes, Steffen Desch, Wolfram Doehner, Marcus Doerr, Frank Edelmann, Ingo Eitel, Matthias Endres, Stefan Engelhardt, Jeanette Erdmann, Katharina Eulenburg, Volkmar Falk, Stephan B. Felix, Derk Frank, Thomas Franke, Norbert Frey, Tim Friede, Lars Geidel, Lisa Germans, Ulrich Grabmaier, Martin Halle, Joerg Hausleiter, Vera Jakobi, Ahmad-Fawad Jebran, Alexander Jobs, Stefan Kaeaeb, Mahir Karakas, Hugo A. Katus, Alexandra Klatt, Christoph Knosalla, Joachim Krebser, Ulf Landmesser, Mahsa Lee, Kristin Lehnert, Stephanie Lesser, Katrin Leyh, Roberto Lorbeer, Stephanie Mach-Kolb, Benjamin Meder, Eike Nagel, Christian H. Nolte, Abdul S. Parwani, Astrid Petersmann, Miriam Puls, Henriette Rau, Maximilian Reiser, Otto Rienhoff, Tabea Scharfe, Mario Schattschneider, Heiko Scheel, Renate B. Schnabel, Andreas Schuster, Boris Schmitt, Tim Seidler, Moritz Seiffert, Barbara-Elisabeth Staehli, Adriane Stas, Thomas J. Stocker, Lukas von Stuelpnagel, Holger Thiele, Rolf Wachter, Reza Wakili, Tanja Weis, Kerstin Weitmann, Heinz-Erich Wichmann, Philipp Wild, Tanja Zeller, Wolfgang Hoffmann, Elisabeth Maria Zeisberg, Wolfram-Hubertus Zimmermann, Dagmar Krefting, Titus Kuehne, Annette Peters, Gerd Hasenfuss, Steffen Massberg, Thomas Sommer, Stefanie Dimmeler, Thomas Eschenhagen, Matthias Nauck
Summary: The German Centre for Cardiovascular Research (DZHK) aims to conduct early and guideline-relevant studies to develop new therapies and diagnostics for people with cardiovascular disease. The DZHK designed a research platform to standardize data and sample collections across all studies and ensure compliance with legal regulations and FAIR principles. The platform includes web-based and central units for data management, as well as a Public Open Data strategy to enable interdisciplinary use of data and samples.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mareike S. Poetsch, Sandra Palus, Sophie Van Linthout, Stephan von Haehling, Wolfram Doehner, Andrew J. S. Coats, Stefan D. Anker, Jochen Springer
Summary: This study compared the effects of different doses of ACM-001 and other cardiac drugs on cardiac mass and function in tumor-induced cachexia rats. The results showed that 3 mg/kg/day ACM-001 reduced weight loss and attenuated lean mass wasting, while improving cardiac function.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Goran Loncar, Tania Garfias-Veitl, Miroslava Valentova, Mirela Vatic, Mitja Lainscak, Danilo Obradovic, Thomas Bernd Dschietzig, Wolfram Doehner, Ewa A. Jankowska, Stefan D. Anker, Stephan von Haehling
Summary: The aim of this study was to assess hip bone mineral density (BMD) in men with heart failure (HF). Dual energy X-ray absorptiometry was used to measure BMD in 141 male patients with HF. Patients with lower BMD were older, more likely to have sarcopenia, and had lower peak oxygen consumption compared to patients with higher BMD. Serum osteocalcin remained independently related to lower BMD in multivariate logistic regression analysis. Hip BMD and serum osteoprotegerin were independent predictors of impaired survival.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Letter
Respiratory System
Cindy M. M. de Jong, Chantal Visser, Remy H. H. Bemelmans, Wim G. Boersma, Bram van den Borst, J. Louise I. Burggraaf, Suzanne C. Cannegieter, Arina J. ten Cate-Hoek, F. Nanne Croles, Harald J. Faber, Laura M. Faber, Merel E. Hellemons, Lisa M. Hessels, Menno Huisman, Pieter W. Kamphuisen, Stephanie C. E. Koster, Lucia J. M. Kroft, Ivo van der Lee, Jenneke Leentjens, Karina Meijer, Maarten K. Ninaber, Brigitte M. Sondermeijer, Susanne Stads, Anton Vonk Noordegraaf, Kristien Winckers, Marieke J. H. A. Kruip, Frederikus A. Klok
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Azadeh Shafieesabet, Nadja Jauert, Oliver Hartmann, Birte Arlt, Michael Joebges, Wolfram Doehner
Summary: The aim of this study was to investigate the prognostic value of bioactive adrenomedullin (bio-ADM) on outcomes after rehabilitation in stroke patients. The results showed that plasma bio-ADM levels were associated with 6-month all-cause mortality and composite outcomes. Elevated bio-ADM concentrations (> 70 pg/ml) were associated with higher rates of all-cause mortality and composite outcomes. Therefore, bio-ADM may be a suitable novel biomarker to assess the outcomes of patients in rehabilitation after acute stroke.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Simon Hellwig, Thomas Krause, Jan F. Scheitz, Juliane Herm, Ulrike Grittner, Nadja Jauert, Jochen B. Fiebach, Mario Kasner, Wolfram Doehner, Matthias Endres, Rolf Wachter, Thomas Elgeti, Christian H. Nolte, Karl Georg Haeusler
Summary: This study compared the rate of pathological findings in patients with acute ischemic stroke (AIS) between enhanced diagnostic workup and routine diagnostic care. The results showed that enhanced diagnostic workup yielded a higher rate of pathological findings and reduced the proportion of patients with cryptogenic stroke.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Christoph Gertler, Nadja Jauert, Patrick Freyhardt, Miroslava Valentova, Sven Christopher Aland, Thula Cannon Walter-Rittel, Christina Unterberg-Buchwald, Marius Placzek, Virginia Ding-Reinelt, Tarek Bekfani, Wolfram Doehner, Gerd Hasenfuss, Bernd Hamm, Anja Sandek
Summary: This study analyzed the changes in iron signal and exercise capacity in chronic heart failure patients before and after intravenous iron therapy. The findings showed that patients with iron deficiency had lower iron content in the spleen, liver, and heart. After intravenous iron therapy, the iron content in the left ventricle, spleen, and liver increased. Improvement in exercise capacity was associated with an increase in hemoglobin levels after intravenous iron therapy.
Review
Cardiac & Cardiovascular Systems
Gregory Y. H. Lip, Radoslaw Lenarczyk, Daniele Pastori, George Ntaios, Wolfram Doehner, Renate B. Schnabel
Summary: After an ischemic stroke, patients often experience cardiovascular complications known as stroke-heart syndrome. Managing these cardiovascular issues is crucial for life expectancy and quality of life, and requires a multidisciplinary approach involving healthcare professionals. Integrated care is key to improving outcomes for patients with stroke-heart syndrome, involving appropriate antithrombotic therapy, assessment of poststroke impairments, and management of cardiovascular risk factors and comorbidities.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Wolfram Doehner, Jelena Celutkiene, Mehmet Birhan Yilmaz, Andrew J. S. Coats
Summary: Heart failure (HF) can lead to cerebral injury, such as stroke, cognitive decline, dementia, and depressive disorders. The interaction between the heart and the central nervous system (CNS) is significant, with impaired cerebral functions contributing to myocardial injury and worsening of HF symptoms. However, this comorbidity is often overlooked in both diagnosis and treatment of HF. This article discusses the pathophysiological aspects of heart-CNS interactions in HF, including stroke, cognitive function, depressive disorder, and neurovegetative control.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Patrick Despang, Martin Schikora, Wolfram Doehner
Summary: Cardiovascular disease is a major cause of death globally, with high blood pressure and elevated LDL cholesterol being major modifiable risk factors. The polypill, a combination of different drugs in one tablet, has been shown to significantly improve patients' prognosis by reducing cardiovascular events. While previous trials have focused on risk factor control, recent trials have shown prognostic improvement in primary prevention and the SECURE trial has shown a reduction in cardiovascular events in secondary prevention.
