Article
Cell Biology
Yuan Chen, Shiben Ji, Jianxin Ying, Yongchang Sun, Jun Liu, Guohong Yin
Summary: This study identifies a novel biomarker, KRT6A, for early diagnosis of bladder tumors and reveals its role in promoting bladder tumor progression. Additionally, it uncovers the regulatory axis of KRT6A/miR-31-5p in bladder tumor growth.
Article
Cell Biology
Jun Yang, Manlong Qi, Xiang Fei, Xia Wang, Kefeng Wang
Summary: The upregulated expression of hsa_circRNA_0088036 in bladder cancer is positively correlated with overall survival and clinicopathologic characteristics. Knockdown of hsa_circRNA_0088036 inhibits the growth, migration, and invasion of bladder cancer cells, acting through the miR-140-3p/FOXQ1 signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Dexiang Feng, Jiancheng Lv, Kai Li, Qiang Cao, Jie Han, Hao Yu, Yidong Cheng, Juntao Zhuang, Lingkai Cai, Haiwei Yang, Xiao Yang, Qiang Lu
Summary: Studies have shown that circZNF609, a circular RNA, is significantly upregulated in bladder cancer and is associated with poor patient survival. Overexpression of circZNF609 promotes bladder cancer cell proliferation, migration, and resistance to cisplatin chemotherapy. Mechanistically, circZNF609 acts as a sponge for miR-1200, alleviating its inhibitory effect on the target gene CDC25B. These findings suggest that circZNF609 has significant potential as a new diagnostic biomarker and therapeutic target in bladder cancer.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yongzhi Li, Benkang Shi, Fengming Dong, Xingwang Zhu, Bing Liu, Yili Liu
Summary: The study demonstrates that high expression of KCNQ1OT1 in bladder cancer promotes tumor progression by regulating the miR-218-5p/HS3ST3B1 signaling pathway.
CANCER GENE THERAPY
(2021)
Article
Cell Biology
Haiyun Xie, Mingchao Wang, Haifeng Yu, Huan Wang, Lifeng Ding, Ruyue Wang, Wenqin Luo, Zeyi Lu, Qiming Zheng, Liangliang Ren, Zhenwei Zhou, Wenjing Su, Liqun Xia, Gonghui Li
Summary: The m(7)G modification is found to be present in RNA internal positions and plays a crucial role in the proliferation and metastasis of bladder cancer. METTL1 is shown to promote the processing of miR-760 in an m(7)G-dependent manner and indirectly degrade tumor suppressor ATF3 mRNA.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Ling Zuo, Yi Zhu, Jinli Han, Hongwei Liu
Summary: This article demonstrates that circSHPRH is downregulated in bladder cancer tissues and is associated with high grade, high pathological stage, lymphatic metastasis, and poor prognosis. Silencing circSHPRH promotes proliferation, migration, and invasion of bladder cancer cells, while overexpression suppresses tumor growth. Mechanistic studies reveal that circSHPRH acts as a sponge of miR-942, targeting BARX2. Suppression of miR-942 or overexpression of BARX2 counteracts the promoting effects of circSHPRH silencing on bladder cancer cell proliferation and invasion. Additionally, circSHPRH overexpression partially eliminates the inhibitory effects of miR-942 on BARX2 expression and activates the Wnt/β-catenin signaling pathway by regulating BARX2.
Article
Genetics & Heredity
Jianhua Zhu, Yan Huang, Yong Zhang, Rongfu Huang, Chunmei Huang
Summary: In this study, we found that lncRNA KCNMB2-AS1 is significantly upregulated in bladder cancer tissues and cell lines, promoting the progression of bladder cancer. Mechanistically, lncRNA KCNMB2-AS1 functions as a competitive endogenous RNA (ceRNA) by sponging miR-374a-3p and regulating the expression of S100A10, contributing to bladder cancer progression.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Yue-Wei Yin, Kai-Long Liu, Bao-Sai Lu, Wei Li, Ya-Lin Niu, Chen-Ming Zhao, Zhan Yang, Ping-Ying Guo, Jin-Chun Qi
Summary: RBM24 regulates bladder cancer progression by positively regulating Runx1t1 expression, forming a positive feedback loop that drives cancer cell proliferation. Interrupting this feedback loop may be a potential therapeutic strategy for treating bladder cancer.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Guoyan Chen, Jingjuan Shang, Minhong Li, Huijun Zhang, Hui Xu
Summary: The present study investigated the expression and function of miR-548 in gastric cancer. It was found that miR-548 was upregulated in gastric cancer and associated with lymph node metastasis and TNM stage. Patients with high miR-548 expression had a poorer survival rate. miR-548 was identified as a prognostic indicator and was found to promote the proliferation, migration, and invasion of gastric cancer. Inhibition of miR-548 might be a novel therapeutic strategy for gastric cancer.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ming Li, Jie Li, Chaoyang Ye, Weiwu Wu, Yi Cheng
Summary: In this study, the posttranscriptional regulatory effect of miR-200a-3p on STAT4 and the prognostic significance of miR-200a-3p and STAT4 were evaluated in bladder cancer. The results showed that miR-200a-3p was downregulated while STAT4 was upregulated in bladder cancer tissues and cells. Both miR-200a-3p and STAT4 were validated as independent prognostic indicators for predicting overall survival and disease-free survival in bladder cancer patients. Furthermore, miR-200a-3p was found to directly target STAT4 and suppress its protein expression, thereby inhibiting bladder cancer cell growth and inducing apoptosis. These findings suggest that the miR-200a-3p/STAT4 signaling cascade plays a crucial role in bladder cancer progression and could serve as a potential target for targeted therapies.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Wei Zhang, Jingyu Zhang, Zhi Hu, Wei Sun, Lv Xu, Hao Chu, Xiao Wang, Qiao Fu
Summary: This study elucidates the impact of long non-coding RNA ARAP1-AS1 on bladder cancer cell function. ARAP1-AS1 facilitates malignant behavior in bladder cancer cells by sponging miR-3918 and regulating KIF20A expression.
MOLECULAR BIOTECHNOLOGY
(2022)
Article
Oncology
Long He, Xiang Pan, Xialu Wang, Yuhua Cao, Peng Chen, Cheng Du, Daifa Huang
Summary: There is a mutual regulation between Rab6c and miR-218 in bladder cancer cells, where Rab6c promotes the proliferation and invasion of bladder cancer cells while miR-218 has the opposite effect.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Ji Huang, Qiu-Ming He, Qi Wu, Wei-Min Zhou, Chao Hao, Gong-Xian Wang, Xin-Hua Tu
Summary: The long non-coding RNA 00858 (LINC00858) is found to be upregulated in bladder cancer tissues and cell lines, and its knockdown inhibits proliferation, migration, and invasion of bladder cancer cells by regulating the miR-3064-5p/CTGF axis.
Article
Biochemistry & Molecular Biology
Xiaoming Yang, Xiaosong Wei, Chengzhi Yi, Yang Yang, Zhiwei Fang, Yuanheng Dai, Yufeng Guo, Dongkui Song
Summary: Bladder cancer (BC) is the most common malignant tumor in the genitourinary system. This study found that HAND2-AS1 is downregulated in BC tissues and its overexpression inhibited malignant behaviors of BC cells. Further investigation revealed that HAND2-AS1 acts as a suppressor in BC development through the modulation of miR-17-5p/KLF9 axis.
DNA AND CELL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alessandro Zucchi, Francesco Claps, Antonio Luigi Pastore, Alessandro Perotti, Andrea Biagini, Luana Sallicandro, Rosaria Gentile, Concetta Caglioti, Federico Palazzetti, Bernard Fioretti
Summary: Bladder cancer is a common urinary system tumor, especially in males. Surgery and intravesical instillations can eliminate it, but recurrences and progression are frequent. Therefore, adjuvant therapy should be considered. Resveratrol has shown potential as an adjuvant therapy for bladder cancer, with anti-proliferative effects at high concentrations and anti-angiogenic action at low concentrations. This review examines the standard therapeutic approach to bladder cancer, preclinical studies on resveratrol in bladder cancer xenotransplantation models, and discusses molecular signals, particularly the STAT3 pathway and angiogenic growth factor modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)