Article
Emergency Medicine
Yu Zhang, Yajuan Song, Jing Du, Wei Liu, Chen Dong, Zhaosong Huang, Zhe Zhang, Liu Yang, Tong Wang, Shaoheng Xiong, Liwei Dong, Yaotao Guo, Juanli Dang, Qiang He, Zhou Yu, Xianjie Ma
Summary: The study reveals that S100A9 enhances the proliferation and migration of skin fibroblasts, as well as the expression of COL I and TGF-beta, through the TLR-4/ERK1/2 pathway. This indicates that S100A9 plays a crucial role in skin regeneration during tissue expansion.
Article
Chemistry, Multidisciplinary
Chengrui Zhong, Yi Niu, Wenwu Liu, Yichuan Yuan, Kai Li, Yunxing Shi, Zhiyu Qiu, Keren Li, Zhu Lin, Zhenkun Huang, Dinglan Zuo, Zhiwen Yang, Yadi Liao, Yuanping Zhang, Chenwei Wang, Jiliang Qiu, Wei He, Yunfei Yuan, Binkui Li
Summary: This study identifies S100A9 as a key driver for post-TACE HCC progression by promoting mitochondrial fission and reactive oxygen species production. Higher S100A9 levels are associated with worse prognosis in HCC patients.
Article
Respiratory System
Jing Zhang, Cuifang Yuan, Enhong Li, Yiming Guo, Jie Cui, Heliang Liu, Xiaohui Hao, Lingli Guo
Summary: Elevated levels of S100A4 were found in patients with silicosis and were correlated with decreased lung function. The expression of S100A4 was also increased in the lung tissues and macrophages of silicotic mice. These findings suggest that S100A4 may play a role in the pathogenesis of silicosis.
BMC PULMONARY MEDICINE
(2022)
Article
Medicine, Research & Experimental
Chenjun Han, Qiang Liu, Yuanmin Li, Wangfu Zang, Jian Zhou
Summary: This study investigated the plasma concentration of S100A1 in patients with Acute Aortic Dissection (AAD) and its diagnostic value. The results indicated that S100A1 levels are significantly elevated in AAD patients and have potential clinical value for diagnosing the disease. Additionally, S100A1 was identified as an important risk factor for the development of AAD.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Pediatrics
Marty O. Visscher, Andrew N. Carr, Jason Winget, Thomas Huggins, Charles C. Bascom, Robert Isfort, Karen Lammers, Vivek Narendran
Summary: This study compared the skin characteristics of premature, late preterm, and full-term neonates with adults at two different time points. The results showed significant differences in protein expression in infant skin compared to adult skin. Neonatal skin had lower NMF levels than adult skin at one time point, but higher levels at another time point.
PEDIATRIC RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Verena Moosbrugger-Martinz, Corinne Leprince, Marie-Claire Mechin, Michel Simon, Stefan Blunder, Robert Gruber, Sandrine Dubrac
Summary: The discovery of loss-of-function mutations in the filaggrin gene has shed new light on the understanding of skin conditions such as ichthyosis vulgaris and atopic dermatitis. However, there is still much to learn about how filaggrin deficiency contributes to atopic dermatitis and the factors that lead to reduced filaggrin levels. This review re-evaluates the roles of filaggrin in the epidermis and atopic dermatitis, providing insights into its importance for keratinocyte alignment, maintenance of epidermal texture, and cellular abnormalities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Wenbing Hu, Zezhang Tao, Qiang Zhou, Deqing Zhao, Lei Gu, Sujin Zhu, Jun Chen
Summary: The study found that high expression of S100A8 and S100A9 may promote the expression of MMP7, MMP9, and MMP12, which are related to the invasion and metastasis of NPC cells.
TRANSLATIONAL CANCER RESEARCH
(2021)
Review
Oncology
Bi-Xia Liu, Chao-Tao Tang, Xi-Jian Dai, Ling Zeng, Fei Cheng, Youxiang Chen, Chunyan Zeng
Summary: S100P overexpression is associated with poor overall survival in patients with digestive system cancers, particularly as a prognostic indicator in non-gastrointestinal tract cancers.
FRONTIERS IN ONCOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Yiyu Chen, Tengchuan Jin, Mengsi Li, Xiao Yun, Fei Huan, Qingmei Liu, Mengjun Hu, Xiaofeng Wei, Peiyi Zheng, Guangming Liu
Summary: The crystal structure of Scy p 4 was obtained with a resolution of 1.60 angstrom by X-ray diffraction, and it revealed the presence of linear and conformational epitopes. Mutation of Asp70 and Asp18/20/70 resulted in loss of calcium-binding capacity and allergenicity. Comparative analysis showed high structural similarity of sarcoplasmic-calcium-binding protein (SCP) in crustaceans, which may contribute to cross-reactivity. The structure of Scy p 4 provides a template for epitope evaluation and localization of SCPs, aiding in the understanding of cross-reactivity among species.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Pediatrics
Tingting Zhou, Wei Liu, Xiaofang Yu, Zengcai Cao, Weijing Mu, Peimin Hou, Chuantao Ren, Aiwu Li
Summary: Aberrant development of myenteric EGCs was observed in the colon of HSCR, potentially affecting the survival of enteric neurons. Protein and mRNA expression of glial fibrillary acidic protein and S100 calcium-binding protein B showed a decreasing trend from proximal, dilated, and transitional segments to the aganglionic segment.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
Li Lin, Yabin Zhao, Zhenhua Li, Yun Li, Wei Wang, Jian Kang, Qiuyue Wang
Summary: By evaluating the expression of S100A9 and KL-6 in patients with 4 common ILDs, the study found that KL-6 can be used as a biomarker to differentiate IPF from other ILDs, while S100A9 expression is useful in indicating the progression of SAR.
Article
Cell Biology
Guorong Yan, Liang Li, Sibo Zhu, Yuhao Wu, Yeqiang Liu, Lude Zhu, Zijun Zhao, Fei Wu, Ning Jia, Caihe Liao, Long Jiang, Qingyu Zeng, Peiru Wang, Lei Shi, Zhe Zheng, Shan Fang, Guolong Zhang, Yichen Tang, Xiuli Wang
Summary: This study identified the molecular patterns of cutaneous squamous cell carcinoma (cSCC) at the single-cell level using single-cell transcriptome analysis. The results showed significant differences in gene expression and chromosomal copy number variation between cSCC cells and normal keratinocytes. The upregulation of S100A9 and FABP5 in cSCC cells was found to promote cell proliferation and migration through the NF-kappa B pathway.
CELL DEATH & DISEASE
(2022)
Article
Dermatology
Teruhiko Makino, Megumi Mizawa, Keita Takemoto, Seiji Yamamoto, Tadamichi Shimizu
Summary: This study investigated the effects of IL-4 and IL-13 and the downregulation of FLG on the expression of S100 fused-type proteins in a three-dimensional AD skin model. The results showed that the expression of FLG, FLG2, HRNR, and TCHH was decreased, while that of RPTN was increased in the AD skin model. Additionally, FLG knockdown resulted in increased expression of HRNR. These findings suggest that the expression of fused-S100 type protein family members may vary in AD and play different roles in its pathogenesis.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Chuan Zhao, Wenxin Hu, Ning Luo, Xingfu Wang, Da Lin, Zhixiong Lin
Summary: This study found that S100A9 is mainly expressed in wet keratin and some intratumoral and peritumoral cells in adamantinomatous craniopharyngioma (ACP), and its expression in wet keratin is upregulated in the high inflammation group. In addition, S100A9 is correlated with the degree of inflammation and the percentage of Ki67-positive cells. There is also a significant correlation between the area of wet keratin and the degree of inflammation in ACP. Therefore, S100A9 may be closely associated with wet keratin formation and the infiltration of inflammatory cells in ACP.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Multidisciplinary Sciences
Attila Placido Sachslehner, Leopold Eckhart
Summary: The epidermal differentiation complex (EDC) is a cluster of genes encoding components of the skin barrier in terrestrial vertebrates. In this study, it was found that caecilians have both SFTP and SEDC genes, suggesting diversification of EDC genes in amphibians. The presence of SEDC-type skin barrier genes in caecilians may have originated either in a common ancestor of tetrapods followed by loss in frogs and salamanders, or through convergent evolution in caecilians and amniotes.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Sherif A. Eldirany, Ivan B. Lomakin, Minh Ho, Christopher G. Bunick
Summary: Intermediate filaments are essential players in cellular processes, with their structural and biochemical properties playing crucial roles in filament assembly mechanisms and interactions with binding partners. Recent advances in understanding IF structure from studies on keratins, glial fibrillary acidic protein, and lamin have revealed new insights into assembly mechanisms, structural elements, and functional domains, enhancing our understanding of the connection between IF structure, pathogenic mutations, and clinical diseases in humans.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Article
Dermatology
Ayman Grada, James Q. Del Rosso, Emmy Graber, Christopher G. Bunick, Linda Stein Gold, Angela Y. Moore, Hilary Baldwin, Zaidal Obagi, Giovanni Damiani, Timothy Carrothers, Brian McNamee, Eva Hanze
Summary: The study investigated the impact of food intake on the absorption and clinical efficacy of sarecycline, a new oral narrow-spectrum third-generation tetracycline-class antibiotic approved for acne vulgaris treatment. Co-administration with high-fat food was found to decrease exposure by 21.7%, but had limited impact on clinical efficacy, allowing for weight-based dosing and flexibility in administration.
DERMATOLOGIC THERAPY
(2022)
Article
Infectious Diseases
Mahmoud A. Ghannoum, Lisa Long, Christopher G. Bunick, James Q. Del Rosso, Ahmed Gamal, Stephen K. Tyring, Thomas S. McCormick, Ayman Grada
Summary: This study evaluated the impact of sarecycline on gut microbiota and found that it had reduced antimicrobial activity compared to minocycline against a wide range of microorganisms. This suggests that sarecycline is less disruptive to gut microbiota.
Article
Infectious Diseases
Ayman Grada, Mahmoud A. Ghannoum, Christopher G. Bunick
Summary: We evaluated the clinical effectiveness of oral sarecycline against cutaneous staphylococcal infections, eyelid stye, and mucous membrane pemphigoid and found that sarecycline is a viable option for clinicians to practice improved antibiotic stewardship. Our findings demonstrate the superiority of sarecycline over broad-spectrum tetracyclines in treating staphylococcal skin infections and inflammatory skin diseases.
Article
Infectious Diseases
Madisen A. Swallow, Ryan Fan, Jeffrey M. Cohen, Christopher G. Bunick
Summary: Almost 1 billion people worldwide have acne, and oral tetracyclines are commonly prescribed for treatment. However, concerns about antibiotic resistance and side effects have arisen. Sarecycline, a narrow-spectrum tetracycline approved in 2018, shows promise in reducing resistance risk by targeting the pathogenic bacterium in acne vulgaris.
Review
Infectious Diseases
Annika Belzer, Emma Weiss, Farshid Etaee, Christopher G. Bunick, William Damsky, Caroline A. Nelson
Summary: Stenotrophomonas maltophilia is a Gram-negative bacillus that can cause skin and soft tissue infections, as well as severe bacteremia, pneumonia, and urinary tract infections. While historically prevalent in immunocompromised individuals, the incidence of S. maltophilia infections is on the rise in both immunocompromised and immunocompetent populations. It is crucial for dermatologists to be aware of this organism due to limited treatment options.
Review
Dermatology
Stefano G. Daniele, Sa Rang Kim, Ayman Grada, Angela Y. Moore, Kathleen C. Suozzi, Christopher G. Bunick
Summary: Acne vulgaris is a common skin disorder that affects not only the face but also other parts of the body. However, there is limited research specifically focusing on truncal acne, with treatment guidelines mainly derived from facial acne protocols. This article provides a clinically focused review on the epidemiology, evaluation, and available treatment options for truncal acne, aiming to highlight knowledge gaps and encourage further investigation into its management.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2022)
Letter
Dermatology
Simon F. Roy, Joseph Sarhan, Xinran Liu, Michael J. Murphy, Christopher G. Bunick, Keith A. Choate, William B. Damsky, Jennifer M. McNiff
Summary: We report two cases of cutaneous mpox virus infection with unusual clinical findings and demonstrate their histopathological, RNA in situ hybridization (ISH) and ultrastructural characteristics. Squamous syringometaplasia of the eccrine ducts was observed in two patients with polymerase chain reaction-confirmed mpox virus infection, which can aid in recognizing the disease by demonstrating viral mRNA within eccrine epithelium by ISH.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Dedee F. Murrell, Joyce M. C. Teng, Scott Guenthner, Kalyani Marathe, Steven Kempers, Kimmie Eads, Leslie Castelo-Soccio, Alan M. Mendelsohn, Jessica Raiz, Christopher G. Bunick
Summary: This analysis evaluated the efficacy and safety of a novel topical isotretinoin ointment, TMB-001, in different subtypes of congenital ichthyosis. The results showed that regardless of the subtype, TMB-001 demonstrated greater improvement in symptoms compared to vehicle.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Christopher G. Bunick, Joyce M. C. Teng, Scott Guenthner, Kalyani Marathe, Steven Kempers, Kimmie Eads, Leslie Castelo-Soccio, Alan M. Mendelsohn, Jessica Raiz, Dedee F. Murrell
Summary: This study analyzed the characteristics of participants who responded to treatment with TMB-001, a novel topical isotretinoin ointment formulation, in the CONTROL study. Baseline demographics did not affect treatment success, but higher baseline Dermatology Life Quality Index and Itch-Numeric Rating Scale scores were associated with success. Lower body surface area involvement was also linked to treatment success.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ivan B. Lomakin, Swapnil C. Devarkar, Shivali Patel, Ayman Grada, Christopher G. Bunick
Summary: Acne vulgaris is a chronic skin disease that negatively affects the physical and mental health of approximately 1 billion people worldwide. Through cryogenic electron microscopy, we discovered that sarecycline, an antibiotic against Cutibacterium acnes, can inhibit two active sites on the ribosome of this bacterium, unlike the previously detected one site on a model ribosome. The structure also revealed unique features of the ribosomal RNA and proteins in Cutibacterium acnes.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Jungsoo Chang, Michael R. Nock, Jeffrey M. Cohen, Christopher G. Bunick
Summary: A higher proportion of dermatology visits among adult females are for acne compared to adult males. Tetracycline-class antibiotics remain the most prescribed therapy for adult females of all age groups, despite potentially different pathogenesis of adult acne. Further studies comparing the effectiveness of therapies specifically for adult female acne are needed.
Review
Infectious Diseases
Faraz Yousefian, Roksana Hesari, Taylor Jensen, Sabine Obagi, Ala Rgeai, Giovanni Damiani, Christopher G. Bunick, Ayman Grada
Summary: Wound management is a significant challenge in clinical practice, and antimicrobial dressings have emerged as a promising approach to control bioburden and promote wound healing. The selection of suitable dressings depends on factors such as cost, wound type, and local microbial burden.
Article
Genetics & Heredity
Minh Ho, Brian Thompson, Jeffrey Nicholas Fisk, Daniel W. Nebert, Elspeth A. Bruford, Vasilis Vasiliou, Christopher G. Bunick
Summary: Intermediate filament (IntFil) genes provide mechanical support for plasma membranes and have undergone rapid expansions in land animal genomes, likely due to the requirements for novel proteins during the sea-to-land transition. Tissue-specific expression patterns of keratin genes were revealed using data from the GTEx project. The ClinVar database contains disease-causing variants in different domains of keratin proteins.