Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor)

The Elusive Inhibitory Function of the Acidic N-Terminal Segment of the Prodomain of PCSK9: The Plot Thickens

(2019) Nabil G. Seidah   JOURNAL OF MOLECULAR BIOLOGY

Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain

(2019) M. Ultsch et al.   JOURNAL OF MOLECULAR BIOLOGY

Functional analysis of natural PCSK 9 mutants in modern and archaic humans

(2019) Sepideh Mikaeeli et al.   FEBS Journal

The ever-expanding saga of the proprotein convertases and their roles in body homeostasis

(2018) Nabil G. Seidah et al.   CURRENT OPINION IN LIPIDOLOGY

Posttranslational modification of proprotein convertase subtilisin/kexin type 9 is differentially regulated in response to distinct cardiometabolic treatments as revealed by targeted proteomics

(2018) Marie-Soleil Gauthier et al.   Journal of Clinical Lipidology

Malaria severity: Possible influence of the E670G PCSK9 polymorphism: A preliminary case-control study in Malian children

(2018) Charles Arama et al.   PLoS One

Structure and evolution of the Fam20 kinases

(2018) Hui Zhang et al.   Nature Communications

A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice

(2018) Rachid Essalmani et al.   BIOLOGICAL CHEMISTRY

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

(2018) Derek Klarin et al.   NATURE GENETICS

New insights of altered lipid profile in Fragile X Syndrome

(2017) Artuela Çaku et al.   PLoS One

Role of lipoproteins and proprotein convertase subtilisin/kexin type 9 in endotoxin clearance in sepsis

(2016) Keith R. Walley   Current Opinion in Critical Care

Proprotein convertase subtilisin / kexin 9 (PCSK9) inhibitors and the future of dyslipidemia therapy: an updated patent review (2011-2015)

(2016) Sandy Elbitar et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation

(2016) Delia Susan-Resiga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E670G polymorphism of PCSK9 gene of patients with coronary heart disease among Han population in Hainan and three provinces in the northeast of China

(2016) Xi-Min He et al.   Asian Pacific Journal of Tropical Medicine

FAM20A binds to and regulates FAM20C localization

(2016) Yoshio Ohyama et al.   Scientific Reports

A Single Kinase Generates the Majority of the Secreted Phosphoproteome

(2015) Vincent S. Tagliabracci et al.   CELL

Genetics of Familial Hypercholesterolemia

(2015) Ariel Brautbar et al.   Current Atherosclerosis Reports

Role of PCSK9 beyond liver involvement

(2015) Bertrand Cariou et al.   CURRENT OPINION IN LIPIDOLOGY

Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other

(2015) Chutikarn Butkinaree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice

(2015) Anna Roubtsova et al.   JOURNAL OF LIPID RESEARCH

A semi-automated mass spectrometric immunoassay coupled to selected reaction monitoring (MSIA–SRM) reveals novel relationships between circulating PCSK9 and metabolic phenotypes in patient cohorts

(2015) Marie-Soleil Gauthier et al.   METHODS

A secretory kinase complex regulates extracellular protein phosphorylation

(2015) Jixin Cui et al.   eLife

Cholesterol levels in Fragile X syndrome

(2014) Elizabeth Berry-Kravis et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

PCSK9

(2014) Nabil G. Seidah et al.   CIRCULATION RESEARCH

Annexin A2 Reduces PCSK9 Protein Levels via a Translational Mechanism and Interacts with the M1 and M2 Domains of PCSK9

(2014) Kévin Ly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation and characterization of the circulating truncated form of PCSK9

(2014) Bomie Han et al.   JOURNAL OF LIPID RESEARCH

Hereditary deletion of the entireFAM20Cgene in a patient with Raine syndrome

(2013) Farouq K. Ababneh et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Transintestinal Cholesterol Excretion Is an Active Metabolic Process Modulated by PCSK9 and Statin Involving ABCB1

(2013) Cédric Le May et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Crystal structure of the Golgi casein kinase

(2013) J. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia

(2012) Marianne Abifadel et al.   ATHEROSCLEROSIS

FAM20C Plays an Essential Role in the Formation of Murine Teeth

(2012) Xiaofang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Furin-cleaved Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Is Active and Modulates Low Density Lipoprotein Receptor and Serum Cholesterol Levels

(2012) Michael T. Lipari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secreted Kinase Phosphorylates Extracellular Proteins That Regulate Biomineralization

(2012) V. S. Tagliabracci et al.   SCIENCE

Rosuvastatin, Proprotein Convertase Subtilisin/Kexin Type 9 Concentrations, and LDL Cholesterol Response: the JUPITER Trial

(2011) Z. Awan et al.   CLINICAL CHEMISTRY

Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

(2011) Paola Lo Surdo et al.   EMBO REPORTS

Furin Is the Major Processing Enzyme of the Cardiac-specific Growth Factor Bone Morphogenetic Protein 10

(2011) Delia Susan-Resiga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In VivoEvidence That Furin from Hepatocytes Inactivates PCSK9

(2010) Rachid Essalmani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of the Prosegment and pH on the Activity of PCSK9

(2010) Suzanne Benjannet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PCSK9 gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan

(2009) Lung-An Hsu et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation

(2009) Steve Poirier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new method for measurement of total plasma PCSK9: clinical applications

(2009) Geneviève Dubuc et al.   JOURNAL OF LIPID RESEARCH

PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans

(2008) Thilina Dewpura et al.   FEBS Journal

Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

(2008) Ahmed Zaid et al.   HEPATOLOGY

Molecular basis for LDL receptor recognition by PCSK9

(2008) H. J. Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic variants in PCSK9 in the Japanese population: Rare genetic variants in PCSK9 might collectively contribute to plasma LDL cholesterol levels in the general population

(2007) Yasuko Miyake et al.   ATHEROSCLEROSIS