Review
Oncology
L. Zhu, L. Zhao, Q. Wang, S. Zhong, X. Guo, Y. Zhu, J. Bao, K. Xu, S. Liu
Summary: miRNAs are small non-coding ribonucleic acids that play key roles in cancer development and can be encapsulated in exosomes released into the circulatory system. Circulating exosome-derived miRNAs have the potential to replace conventional biomarkers for early cancer diagnosis.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Jonas Dohmen, Alexander Semaan, Makbule Kobilay, Martin Zaleski, Vittorio Branchi, Anja Schlierf, Karina Hettwer, Steffen Uhlig, Gunther Hartmann, Jorg C. Kalff, Hanno Matthaei, Philipp Lingohr, Stefan Holdenrieder
Summary: The study compared the use of exosomal and free circulating microRNAs in colorectal adenocarcinoma, showing higher levels of microRNAs in the exosomal compartment with significant differences from the healthy control group. Combining multiple exosomal miRNAs can further enhance diagnostic sensitivity and specificity.
Review
Oncology
Md. Hafiz Uddin, Mohammed Najeeb Al-Hallak, Philip A. Philip, Ramzi M. Mohammad, Nerissa Viola, Kay-Uwe Wagner, Asfar S. Azmi
Summary: Pancreatic cancer is the fourth leading cause of cancer death in the United States, with PDAC accounting for over 90% of cases and a low survival rate. MiRNAs have been identified as sensitive biomarkers in pancreatic cancer and are found in stable forms within exosomes. Further research on exosomal miRNAs is necessary for improved diagnostic, prognostic, and therapeutic strategies.
Article
Biochemistry & Molecular Biology
Hanieh Sadeghi, Aryan Kamal, Marzieh Ahmadi, Hadi Najafi, Ali Sharifi Zarchi, Peyman Haddad, Bahareh Shayestehpour, Leila Kamkar, Masoumeh Salamati, Loabat Geranpayeh, Marzieh Lashkari, Mehdi Totonchi
Summary: This study aimed to assess the relationship between blood-based miRNAs and demographic characteristics of breast cancer patients, finding a potential multi-marker panel for early detection of breast cancer with acceptable sensitivity, specificity, and accuracy. The panel also showed promise in distinguishing benign breast diseases from breast cancer patients.
Article
Cell Biology
Michele Patricia Rode, Adny Henrique Silva, Julia Cisilotto, Daiane Rosolen, Tania Beatriz Creczynski-Pasa
Summary: This study evaluated exosomal miRNAs derived from metastatic prostate cancer cell lines LNCaP and PC-3, identifying 14 candidates for prognostic biomarkers. miR-425-5p was associated with residual tumor, pathological staging, and TP53 status in prostate cancer samples.
CELLULAR SIGNALLING
(2021)
Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Cardiac & Cardiovascular Systems
Mehrdad Samadishadlou, Reza Rahbarghazi, Zeynab Piryaei, Mahdad Esmaeili, cigir Biray Avci, Farhad Bani, Kaveh Kavousi
Summary: By integrating bioinformatics and machine learning analysis, we identified a set of miRNA biomarkers for cardiovascular diseases. The study demonstrates that miRNA signatures derived from peripheral blood mononuclear cells can serve as valuable novel biomarkers for cardiovascular diseases.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Pathology
Ghazale Faraji, Pedram Moeini, Mohammad Hasan Ranjbar
Summary: The significance of exosomal microRNAs in breast cancer diagnosis and treatment prediction is important but requires further research.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Oncology
Mohsen Karami Fath, Jalil Azami, Alireza Masoudi, Reza Mosaddeghi Heris, Elnaz Rahmani, Fatemeh Alavi, Armina Alagheband Bahrami, Zahra Payandeh, Bahman Khalesi, Masoomeh Dadkhah, Navid Pourzardosht, Vahideh Tarhriz
Summary: This review focuses on the role of exosomes in glioblastoma, highlighting their involvement in creating an immunosuppressive tumor microenvironment and their potential as therapeutic and diagnostic tools.
CANCER CELL INTERNATIONAL
(2022)
Review
Pharmacology & Pharmacy
Yulai Zeng, Shuyu Hu, Yi Luo, Kang He
Summary: Hepatocellular carcinoma (HCC) is a common cancer with unsatisfactory early diagnosis and treatment. Exosomes, containing various components, play a crucial role in the development and prognosis of HCC. Biomarkers in exosomes show potential for novel diagnostic and prognostic tools for HCC.
Article
Medical Laboratory Technology
Xinlei Zou, Ziyue Huang, Canghai Guan, Wujiang Shi, Jianjun Gao, Jiangang Wang, Yunfu Cui, Mei Wang, Yi Xu, Xiangyu Zhong
Summary: Pancreatic cancer (PC) is highly aggressive with a poor prognosis. The tumor microenvironment (TME) of PC is complex and diverse. Various cellular components in the microenvironment secrete different substances that promote tumor development. These substances can be released via exosomes, which are abundant extracellular vesicles (EVs) capable of carrying factors and enabling intercellular communication. MiRNAs are involved in regulating pathological and physiological processes and can be transported by exosomes to regulate the TME. Exosomal miRNAs hold promise as future targets for PC diagnosis and prognosis, offering potential new treatment strategies.
CLINICA CHIMICA ACTA
(2023)
Article
Genetics & Heredity
Mengfeng Liu, Xiran Yu, Jianlong Bu, Qifan Xiao, Sitong Ma, Naozhong Chen, Changfa Qu
Summary: This study found that miRNAs in salivary exosomes may serve as biomarkers for the prediction and diagnosis of lung cancer. By miRNA sequencing and qPCR validation, differentially expressed miRNAs between lung cancer and non-lung cancer groups were identified, which were associated with pathways related to cancer.
FRONTIERS IN GENETICS
(2023)
Article
Biochemical Research Methods
Xuanyi Wang, Zixuan Chai, Guizhi Pan, Youjin Hao, Bo Li, Ting Ye, Yinghong Li, Fei Long, Lixin Xia, Mingwei Liu
Summary: ExoBCD is the first well-corroborated knowledge base for exosomal studies of breast cancer, integrating a large number of annotation entries and exosomal molecules information, providing rich data on experimental biology and gene expression patterns.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Oncology
Zheng Zhao, Guiping Zhao, Shuyue Yang, Shengtao Zhu, Shutian Zhang, Peng Li
Summary: Exosomes are small single-membrane organelles containing diverse bioactive constituents, with exosomal RNAs playing a significant role in cancer development, diagnosis, and treatment, particularly in pancreatic cancer. Studies suggest that exosomal RNAs may serve as diagnostic and therapeutic biomarkers in pancreatic cancer.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Hongtao Fu, Kun Li, Shui Wang, Yuming Li
Summary: Breast cancer is the most frequent cancer in women globally. This study explored new biomarkers for breast cancer diagnosis and found that CCNB1 expression was higher in breast cancer tissues compared to normal tissues. CCNB1 was significantly related to survival time, tumor mutation burden, and other factors in breast cancer. The ACO26401.3/CCNB1-miR-139-5p axis was identified as a promising upstream pathway related to CCNB1 in breast cancer.