Article
Biotechnology & Applied Microbiology
Xin Peng, Jingyue Sun, Yao Long, Desheng Xiao, Jianhua Zhou, Yongguang Tao, Shuang Liu
Summary: Through immunohistochemistry analysis, it was found that there is over-expression of HOXC11 and LSH in patients with GAC, with patients showing low expression having longer survival times, and over-expressed cells exhibiting a more malignant phenotype.
ONCOTARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yudai Hojo, Shingo Kishi, Shiori Mori, Rina Fujiwara-Tani, Takamitsu Sasaki, Kiyomu Fujii, Yukiko Nishiguchi, Chie Nakashima, Yi Luo, Hisashi Shinohara, Hiroki Kuniyasu
Summary: The use of molecular-targeted drugs in gastric cancer treatment is increasing, but the variety of these drugs is still limited. In this study, the combination of sunitinib and pterostilbene showed significant suppression of cell proliferation and increased oxidative stress. The combination therapy also had a pronounced antitumor effect in a mouse tumor model. These findings suggest that the combined use of sunitinib and pterostilbene may be a new molecular-targeted therapy for gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Surgery
Chen-hui Ma, Huan-huan Ma, Xiao-bo Deng, Rong Yu, Ke-wei Song, Kong-kong Wei, Cai-juan Wang, Hui-xia Li, Hao Chen
Summary: The study indicates that photodynamic therapy combined with chemotherapy, targeted therapy, and immunotherapy has a good efficacy in treating poorly differentiated gastric adenocarcinoma, resolving tumor tissues and reducing tumor marker levels, particularly suitable for elderly patients.
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Fangzhou Yu, Yalan Tu, Shiwei Luo, Xuan Xiao, Wang Yao, Maolin Jiang, Xinqing Jiang, Ruimeng Yang, Youyong Yuan
Summary: An innovative dual-drug delivery system was designed in this study to achieve precise drug release ratios and generate synergistic anticancer effects.
Article
Surgery
Pooja Prasad, Ashwin Sivaharan, Maziar Navidi, Bridget H. Fergie, S. Michael Griffin, Alexander W. Phillips
Summary: This study aimed to investigate the impact of neoadjuvant chemotherapy on the prognosis of patients with gastric adenocarcinoma. The results showed that the extent of pathological downstaging in patients who received neoadjuvant chemotherapy was associated with overall survival, and a downstaging of more than 3 stages was the strongest independent predictor of overall survival. Therefore, patients downstaged due to neoadjuvant chemotherapy may have better clinical outcomes.
Review
Biology
C. R. Akshatha, Smitha Bhat, R. Sindhu, Dharini Shashank, Sarana Rose Sommano, Wanaporn Tapingkae, Ratchadawan Cheewangkoon, Shashanka K. Prasad
Summary: Gastric cancer remains a significant global health issue despite a declining incidence, often diagnosed at advanced stages with poor prognosis. Modern therapeutic options, including immune therapy and chemotherapy, have rapidly progressed, with targeted agents playing a crucial role in treatment.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Engineering, Biomedical
Wen Chen, Kun Shi, Jie Liu, Peipei Yang, Ruxia Han, Meng Pan, Liping Yuan, Chao Fang, Yongyang Yu, Zhiyong Qian
Summary: Gastric cancer is a common and deadly cancer worldwide. Surgical resection is the primary treatment method, but its effectiveness is limited for advanced cases. Intraoperative chemotherapy is an attractive option to reduce recurrence and metastasis. A study developed a dual-drug hydrogel system for intraoperative adjuvant combination chemotherapy of gastric cancer, which showed promising results in inhibiting tumor growth and improving patient outcomes.
BIOACTIVE MATERIALS
(2023)
Article
Medicine, General & Internal
Lei Deng, Adrienne Groman, Changchuan Jiang, Stuthi Perimbeti, Emmanuel Gabriel, Moshim Kukar, Sarbajit Mukherjee
Summary: The study revealed an association between preoperative chemosensitivity and postoperative survival among patients with resectable gastric adenocarcinoma. These findings may have implications for personalized postoperative therapy.
Article
Multidisciplinary Sciences
Amna Mohamed Taha, Mohammad Mabrouk Aboulwafa, Hamdallah Zedan, Omneya Mohamed Helmy
Summary: Combining sorafenib with ramucirumab or panitumumab resulted in a significant decrease in sorafenib IC50, inhibited proliferation and angiogenesis, induced apoptosis, and altered the expression of various proteins related to cell cycle and apoptosis in HepG2 cancer cells. This suggests that ramucirumab may be a useful adjunct therapy to enhance sorafenib efficacy in HCC therapy.
SCIENTIFIC REPORTS
(2022)
Article
Nanoscience & Nanotechnology
Busra Cetin Ersen, Beyza Goncu, Aydan Dag, Gokcen Birlik Demirel
Summary: In this study, targeted and multimodal therapeutic hybrid nanocarriers were fabricated for breast cancer treatments. The carrier consists of synthesized gold nanorods coated with doxorubicin conjugated glycopeptide polymer. A photosensitizer molecule was loaded into the particles for photodynamic therapy, and antisense oligonucleotides were integrated to prevent apoptotic resistance. The biocompatibility and therapeutic efficacy of these nanoparticles were evaluated on human normal skin fibroblast and breast cancer cell lines.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Tzu-Ching Chang, Hui-Ting Lee, Siao-Cian Pan, Shih-Han Cho, Chieh Cheng, Liang-Hung Ou, Chia- Lin, Chen-Sung Lin, Yau-Huei Wei
Summary: We investigated the roles of mitochondrial DNA (mtDNA) alterations and mitochondrial respiratory dysfunction in gastric adenocarcinoma (GAC) using gastric cancer cell line AGS and clinical samples. The study found that decreased mtDNA copy number and D310 mutation were associated with the development and prognosis of GAC, and mitochondrial dysfunction affected the biological characteristics of GAC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jia Wei, Xiaofeng Lu, Qin Liu, Yao Fu, Song Liu, Yang Zhao, Jiawei Zhou, Hui Chen, Meng Wang, Lin Li, Ju Yang, Fangcen Liu, Liming Zheng, Haitao Yin, Yang Yang, Chong Zhou, Ping Zeng, Xiaoyu Zhou, Naiqing Ding, Shiqing Chen, Xiaochen Zhao, Jing Yan, Xiangshan Fan, Wenxian Guan, Baorui Liu
Summary: This phase 2 trial assessed the efficacy and safety of neoadjuvant anti-PD1 treatment in combination with chemoradiotherapy for locally advanced gastric and gastroesophageal junction cancers. The results showed a pathological complete response rate of 38.2% and median disease-free survival and event-free survival of 17.0 months and 21.1 months, respectively. Grade ≥3 adverse events were experienced by 50.0% of patients during preoperative therapy.
NATURE COMMUNICATIONS
(2023)
Review
Oncology
Yuki Hirata, Ayesha Noorani, Shumei Song, Linghua Wang, Jaffer A. Ajani
Summary: Gastric adenocarcinoma remains a challenging disease to diagnose and treat, with low cure rates, especially in Western countries. This is due to the impracticality of early diagnosis, regional variations in therapeutic approaches, and the heterogeneity of gastric cancer cells and their microenvironment. Targeted interventions based on molecular subsets of gastric adenocarcinomas identified by genomic and/or multi-omics analyses show promise for improved outcomes. Future strategies involving vaccines, novel antibody technologies, and agents targeting the tumor microenvironment and immune checkpoints, supported by improved diagnostic assays, hold potential for advancements in gastric cancer management.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Chemistry, Medicinal
Xiao-Feng Zhu, Zhong-Lin Sun, Jing Ma, Bo Hu, Min-Cheng Yu, Xiu-Jie Liu, Ping Yang, Yang Xu, Dianwen Ju, Qing Mu
Summary: A study found that the combination treatment of flavonoids from Sophora alopecuroides L. with Sorafenib has a synergistic anticancer effect on hepatocellular carcinoma (HCC) cells. It enhances the inhibition of tumor growth by Sorafenib and induces cell apoptosis and cell cycle arrest. This synergistic effect is also related to the suppression of the ERK and AKT signaling pathways.
PHYTOTHERAPY RESEARCH
(2023)
Article
Medicine, General & Internal
Mei Liu, Cheng Luo, Zong-Zhou Xie, Xun Li
Summary: This study reported the treatment experience of a patient with GHA, who received the combination of pembrolizumab and bevacizumab with chemotherapy and achieved favorable survival and tolerability. The results of this study suggest that this combination therapy could be a new choice for the treatment of GHA.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Biochemical Research Methods
Tingting Zhao, Fang Cheng, Dongdong Zhan, Jin'e Li, Chunxia Zheng, Yinghui Lu, Weisong Qin, Zhihong Liu
Summary: By integrating the transcriptomics and proteomics profiles of DN patients and controls, researchers identified differentially expressed genes, constructed a regulatory network of transcription factors-target genes, and discovered new DN-specific proteins. This study provides deeper insights into the pathogenesis of DN and opens the potential avenue for finding new therapeutic interventions.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Zhiqin Deng, Huangcan Li, Shu Chen, Na Wang, Gongyuan Liu, Danjun Liu, Weihui Ou, Feijie Xu, Xiong Wang, Dangyuan Lei, Pui-Chi Lo, Yang Yang Li, Jian Lu, Mengsu Yang, Ming-Liang He, Guangyu Zhu
Summary: This study reports the use of near-infrared-activated small-molecule Pt(IV) photooxidants to directly oxidize intracellular biomolecules. These photooxidants can effectively eliminate cancer stem cells and show low toxicity in the dark. Metal-enhanced photooxidation induced by these Pt(IV) complexes leads to robust photooxidation of survival-related biomolecules, inducing oxidative stress, disrupting intracellular pH (pHi) homeostasis, and initiating nonclassical necrosis.
Article
Neurosciences
Tatyana Veremeyko, Rongcai Jiang, Mingliang He, Eugene D. Ponomarev
Summary: The complement system plays an important role in immune defense and also has important functions in the central nervous system (CNS). Recent studies have shown that complement subunits C1q, C4, and C3 have roles in synapse pruning and neurologic pathologies. C4B deficiency or low expression is related to the development of schizophrenia and autism spectrum disorders through mechanisms not related to synapse elimination. C4B has a role in the regulation of immediate early gene expression and downstream targets during CNS insults such as epileptic seizures.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Haibo Wang, Ligang Hu, Hongyan Li, Yau-Tsz Lai, Xueying Wei, Xiaohan Xu, Zhenkun Cao, Huiming Cao, Qianya Wan, Yuen-Yan Chang, Aimin Xu, Qunfang Zhou, Guibin Jiang, Ming-Liang He, Hongzhe Sun
Summary: In this study, the researchers identified the Cr(III)-proteome in cells and found that ATP synthase plays a crucial role in relieving hyperglycemia stress.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Wen Wen, Long Liao, Wei Dai, Can-Can Zheng, Xiang-Peng Tan, Yan He, Qi-Hua Zhang, Zhi-Hao Huang, Wen-You Chen, Yan-Ru Qin, Kui-Sheng Chen, Ming-Liang He, Simon Law, Maria Li Lung, Qing-Yu He, Bin Li
Summary: Through genome-wide CRISPR/Cas9 screening and gene profiling, the MEST-PURA-SRCIN1/RASAL1-ERK-snail signaling cascade was identified as an important mechanism underlying cancer metastasis in esophageal squamous cell carcinoma. Blocking the interaction between MEST and PURA could be a potential therapeutic approach for managing tumor metastasis.
Review
Pharmacology & Pharmacy
Ya-Xiu Feng, Huan Hu, Yu-Yuen Wong, Xi Yao, Ming-Liang He
Summary: Vaccination is effective in preventing infectious diseases, and microneedles are a promising tool for painless vaccine delivery, with the advantage of avoiding cold chain storage and improving accessibility for special populations.
Article
Environmental Sciences
Lin Wang, Zhi-Hao Zhou, Yun-Xia Xie, Wen-Jing Liu, Rui-Xiang Zhang, Nan Jiang, Ming-Liang He, Jian-Ge Qiu, Bing-Hua Jiang
Summary: This study revealed the mechanism of Cr(VI) in inducing carcinogenesis and angiogenesis. Chronic exposure to Cr(VI) resulted in a significant decrease in miR-199a expression levels, while overexpression of miR-199a inhibited angiogenesis and tumor growth. Additionally, Cr(VI) exposure also resulted in an increase in CXCL8 levels, while overexpression of miR-199a suppressed CXCL8 expression. These results indicate that the miR-199a/IL8 pathway plays an important role in Cr(VI)-induced carcinogenesis and angiogenesis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Xiaolong Shao, Chunyan Yao, Yiqing Ding, Haiyan Hu, Guoliang Qian, Mingliang He, Xin Deng
Summary: In Pseudomonas aeruginosa, transcription factors play a crucial role in the genetic regulation of adaptability and pathogenicity. Several techniques have been used to identify TF binding sites on the P. aeruginosa genome, and an atlas of TF binding patterns has been created. This review summarizes recent literature on TF regulatory networks involved in various processes, including quorum sensing, biofilm formation, pyocyanin synthesis, motility, secretion systems, and oxidative stress responses. Insights from the global regulatory network of transcriptional regulators could inform strategies for preventing clinical infections caused by P. aeruginosa.
Review
Biochemistry & Molecular Biology
Huan Hu, Yaxiu Feng, Ming-Liang He
Summary: Zika virus (ZIKV) infection causes neurological disorders and elicits a wide range of immune response. Type I interferons (IFNs) and its signaling cascade play a crucial role in innate immunity against ZIKV infection, but ZIKV can antagonize them. Toll-like receptors 3 (TLR3), TLR7/8 and RIG-I-like receptor 1 (RIG-1) recognize the ZIKV genome and induce the expression of Type I IFNs and interferon-stimulated genes (ISGs). ISGs exert antiviral activity at different stages of the ZIKV life cycle. The NS proteins of ZIKV directly interact with factors in the pathways to evade innate immunity, while structural proteins and antibody-binding of BDCA2 or inflammasome activation enhance ZIKV replication. In this review, recent findings about the interaction between ZIKV infection and type I IFNs pathways are summarized, and potential strategies for antiviral drug development are suggested.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Yun-Xia Xie, Zhi-Hao Zhou, Shu-Wen Liu, Ye Zhang, Wen-Jing Liu, Rui-Ke Zhang, Ming-Liang He, Jian-Ge Qiu, Lin Wang, Bing-Hua Jiang
Summary: This study showed that miR-497 is down-regulated in esophageal cancer and overexpression of miR-497 inhibits cell proliferation, tube formation, and migration. It was found that miR-497 directly binds to QKI and suppresses its expression. Overexpression of miR-497 also enhances the effect of chemotherapy and suppresses tumor growth in esophageal cancer in vivo.
Review
Biochemistry & Molecular Biology
Peiran Chen, Mandi Wu, Yaqing He, Binghua Jiang, Ming-Liang He
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has brought enormous burden with high mortality rates. Targeting the interaction between SARS-CoV-2 and host metabolism holds promise for developing therapeutic strategies. This review summarizes recent studies on the role of host metabolism during the life cycle of SARS-CoV-2, with an emphasis on glucose and lipid metabolism, and discusses microbiota and long COVID-19. Repurposed metabolism-modulating drugs for COVID-19 are also discussed, including statins, ASM inhibitors, NSAIDs, Montelukast, omega-3 fatty acids, 2-DG, and metformin.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Huangcan Li, Xiong Wang, Yiran Wang, Yichen Li, Ying Chen, Yin-Ting Wong, Jufang He, Ming-Liang He
Summary: The proteases of SARS-CoV-2 and EV71 upregulate the expression and secretion of LRPAP1, which binds with IFNAR1 to trigger receptor degradation and enhance viral infection. A peptide derived from LRPAP1 can cause IFNAR1 degradation and enhance viral infections, while an LRPAP1 inhibitor stabilizes IFNAR1 and arrests virus infections. This study reveals a novel mechanism used by viruses to evade host immunity and provides a potential strategy for developing pan-antiviral drugs.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Medicine, Research & Experimental
Yaxiu Feng, Ching Han Young, Siu Hin Lau, Ming-Liang He
Summary: Control management of SARS-CoV-2 infections is a major challenge in the 21st century. While the government responded rapidly in the early days of the outbreak and achieved encouraging results, the high infectivity, new variants, and shortcomings in transmission control measures led to an uncontrollable outbreak in 2022. Vulnerable groups such as the elderly and children experienced high hospitalization and mortality rates due to low vaccination rates. This study timely summarizes the challenges, policies, and lessons learned from the SARS-CoV-2 outbreak from 2020 to 2022, providing valuable insights for other cities facing highly infectious SARS-CoV-2 outbreaks.
Article
Biochemistry & Molecular Biology
Zhuoying Feng, Fanghang Zhou, Miaomiao Tan, Tingting Wang, Ying Chen, Wenwen Xu, Bin Li, Xin Wang, Xin Deng, Ming-Liang He
Summary: HSV-1 infection enhances the expression of m6A modification-related genes to facilitate viral replication, while inhibiting m6A modification reduces viral replication and reproduction.
Article
Biochemistry & Molecular Biology
Yichen Li, Qian Zhang, Mandi Wu, Peidong Zhang, Liang Huang, Xiaolin Ai, Zhengnan Yang, Qiuhong Shen, Yiran Wang, Ping Wang, Shengtao Zhou, Ming-Liang He
Summary: A study has found that a LncRNA associated with ovarian cancer metastasis, LncOVM, is highly correlated with poor prognosis and survival. LncOVM interacts with and stabilizes PPIP5K2, promoting the secretion of complement C5 from ovarian cancer cells, which then attracts myeloid-derived suppressor cells (MDSCs) infiltration in the tumor microenvironment (TME) to facilitate metastasis. Targeting the LncOVM-PPIP5K2-complement axis can inhibit MDSC infiltration and restore the suppression of tumorigenesis and metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
