Quality control of 40S ribosome head assembly ensures scanning competence

eIF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide

(2020) Fujun Zhou et al.   RNA

Conformational proofreading of distant 40S ribosomal subunit maturation events by a long-range communication mechanism

(2019) Valentin Mitterer et al.   Nature Communications

Novel oncogene 5MP1 reprograms c-Myc translation initiation to drive malignant phenotypes in colorectal cancer

(2019) Kuniaki Sato et al.   EBioMedicine

Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery

(2019) Martin Saurer et al.   SCIENCE

Transient Protein-RNA Interactions Guide Nascent Ribosomal RNA Folding

(2019) Olivier Duss et al.   CELL

Structure of a eukaryotic cytoplasmic pre‐40S ribosomal subunit

(2018) Alain Scaiola et al.   EMBO JOURNAL

Altered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia

(2018) Gabriel Bretones et al.   BLOOD

Visualizing late states of human 40S ribosomal subunit maturation

(2018) Michael Ameismeier et al.   NATURE

Ribosome biogenesis factor Ltv1 chaperones the assembly of the small subunit head

(2018) Jason C. Collins et al.   JOURNAL OF CELL BIOLOGY

The ATPase Fap7 Tests the Ability to Carry Out Translocation-like Conformational Changes and Releases Dim1 during 40S Ribosome Maturation

(2017) Homa Ghalei et al.   MOLECULAR CELL

Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide

(2017) Leiming Tang et al.   NUCLEIC ACIDS RESEARCH

Ribosomopathy-like properties of murine and human cancers

(2017) Sucheta Kulkarni et al.   PLoS One

Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons

(2017) Jinsheng Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation

(2017) Alan G. Hinnebusch   TRENDS IN BIOCHEMICAL SCIENCES

Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5

(2017) Eiji Obayashi et al.   Cell Reports

eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast

(2017) Pilar Martin-Marcos et al.   eLife

Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae

(2017) André Heuer et al.   eLife

Sequential domain assembly of ribosomal protein S3 drives 40S subunit maturation

(2016) Valentin Mitterer et al.   Nature Communications

Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases

(2016) Urszula M. McCaughan et al.   Nature Communications

Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations

(2015) V. Ljungstrom et al.   BLOOD

Hrr25/CK1δ-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth

(2015) Homa Ghalei et al.   JOURNAL OF CELL BIOLOGY

Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex

(2015) Jose L. Llácer et al.   MOLECULAR CELL

Structural Changes Enable Start Codon Recognition by the Eukaryotic Translation Initiation Complex

(2014) Tanweer Hussain et al.   CELL

Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes

(2014) Sébastien Ferreira-Cerca et al.   NUCLEIC ACIDS RESEARCH

Final Pre-40S Maturation Depends on the Functional Integrity of the 60S Subunit Ribosomal Protein L3

(2014) Juan J. García-Gómez et al.   PLoS Genetics

A Translation-Like Cycle Is a Quality Control Checkpoint for Maturing 40S Ribosome Subunits

(2012) Bethany S. Strunk et al.   CELL

Proofreading of pre-40S ribosome maturation by a translation initiation factor and 60S subunits

(2012) Simon Lebaron et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S ribosomal subunit

(2012) Sébastien Ferreira-Cerca et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein-Protein Interactions within Late Pre-40S Ribosomes

(2011) Melody G. Campbell et al.   PLoS One

Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNAiMet binding to the ribosome

(2010) A. K. Saini et al.   GENES & DEVELOPMENT

Yeast 18 S rRNA Is Directly Involved in the Ribosomal Response to Stringent AUG Selection during Translation Initiation

(2010) Naoki Nemoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

rRNA Maturation in Yeast Cells Depleted of Large Ribosomal Subunit Proteins

(2009) Gisela Pöll et al.   PLoS One

Navigating the ribosome's metastable energy landscape

(2009) James B. Munro et al.   TRENDS IN BIOCHEMICAL SCIENCES

Concurrent nucleation of 16S folding and induced fit in 30S ribosome assembly

(2008) Tadepalli Adilakshmi et al.   NATURE