Article
Pharmacology & Pharmacy
Kazuyuki Okamura, Miyuki Sato, Takehiro Suzuki, Keiko Nohara
Summary: This study found that exposure to arsenite induces premature senescence in hepatic stellate cells and leads to upregulation of SASP factors. The SASP factors released by senescent cells can promote hepatic carcinogenesis.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Review
Cell Biology
Xiurong Cai, Adrien Guillot, Hanyang Liu
Summary: With high morbidity and mortality, hepatocellular carcinoma (HCC) is a significant and increasing burden globally. The relapse-prone nature and drug resistance of HCC are attributed to various intracellular processes and extracellular interplay, which actively participate in tumor microenvironment remodeling. Cellular senescence, considered as a fail-safe program, plays a crucial role in the progression of chronic inflammatory liver diseases and carcinogenesis. The potential of senescence in affecting anti-cancer strategies is gaining attention in recent studies.
Article
Medicine, Research & Experimental
Yuan Zhou, Li Zhang, Yue Ma, Li Xie, Yong-Yu Yang, Cheng Jin, Hui Chen, Ying Zhou, Guang-Qi Song, Jia Ding, Jian Wu
Summary: This study found that senescent hepatic stellate cells (HSCs) play a crucial role in the development of nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Senescent HSCs secrete proteins that activate morphogenic hedgehog or oncogenic Wnt signaling pathways, promoting the malignant transformation of steatotic or dysplastic hepatocytes.
Review
Geriatrics & Gerontology
Wen-juan Wang, Xiang-mei Chen, Guang-yan Cai
Summary: Renal fibrosis plays a crucial role in chronic kidney disease, but the complex and unclear pathological process hinders effective treatment. Cellular senescence and the SASP are reported to cause renal fibrosis, and inhibiting them may be a potential strategy for prevention and treatment. Emerging interventions targeting the SASP, caloric restriction and mimetics, as well as novel regeneration therapies with stem cells, show promising therapeutic strategies.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Cell Biology
Ruchi Kumari, Parmjit Jat
Summary: Cellular senescence is a stable cell cycle arrest triggered in response to various stimuli, characterized by dynamic changes in senescent cells. It has both positive effects on tissue repair and anti-cancer mechanisms, but can also negatively impact organismal health. Multiple pathways, including p53/p21 and p16/pRB, play central roles in regulating this process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yihua Huang, Xue Yang, Yan Meng, Changchun Shao, Jianping Liao, Fengwei Li, Rong Li, Yingying Jing, Aimin Huang
Summary: The hepatic SASP plays a crucial role in hepatocarcinogenesis by promoting the activation of macrophages, which is closely related to the expression of Bcl3 in hepatocytes.
CELL AND BIOSCIENCE
(2021)
Article
Food Science & Technology
Mengfan Zhang, Turtushikh Damba, Zongmei Wu, Sandra Serna-Salas, Manon Buist-Homan, Klaas Nico Faber, Han Moshage
Summary: This study demonstrates that esculetin can induce HSC senescence and reverse the activated phenotype of HSC. The effect is dependent on PI3K-Akt-GSK3B signaling. This finding suggests that esculetin could be a potential drug for the treatment of hepatic fibrosis.
Review
Cell Biology
Jing Yang, Mengmeng Liu, Dongchun Hong, Musheng Zeng, Xing Zhang
Summary: Cellular senescence in cancer presents a dual role, acting as both a preventative measure and a promoter of tumor development. Senescent cells contribute to oncogenesis through their secretory phenotype, both inhibiting tumor growth and creating an environment conducive to tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Jinwei Xie, Yan Wang, Lingyun Lu, Lu Liu, Xijie Yu, Fuxing Pei
Summary: Cellular senescence plays a significant role in the onset and progression of osteoarthritis, but the link between cellular senescence and the disease remains unclear. Current evidence supports the involvement of senescent cells of different cell types in osteoarthritis, with a focus on the underlying mechanisms of senescence in chondrocytes.
AGEING RESEARCH REVIEWS
(2021)
Article
Cell Biology
Pramudi Wijayasiri, Stuart Astbury, Philip Kaye, Fiona Oakley, Graeme J. Alexander, Timothy J. Kendall, Aloysious D. Aravinthan
Summary: This study reveals a direct relationship between hepatocyte senescence and hepatic stellate cell activation in liver fibrosis. The activation of human HSCs by media derived from senescent HepG2 cells indicates the involvement of factors secreted by senescent hepatocytes in driving liver fibrosis.
Article
Cell & Tissue Engineering
C. Voskamp, L. A. Anderson, W. J. L. M. Koevoet, S. Barnhoorn, P. G. Mastroberardino, G. J. V. M. van Osch, R. Narcisi
Summary: TWIST1 influences the expansion of MSCs, and its silencing-induced senescence in MSCs is characterized by a specific SASP profile and metabolic state, different from irradiation-induced senescent MSCs.
EUROPEAN CELLS & MATERIALS
(2021)
Article
Cell Biology
Yu-Ling Sun, Tao Bai, Lin Zhou, Rong-Tao Zhu, Wei-Jie Wang, Ruo-Peng Liang, Jian Li, Chi-Xian Zhang, Jian-Jun Gou
Summary: The study reveals that deficiency of SOD3 accelerates HSC activation and EMT process, thereby promoting liver fibrosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pei-Wen Wang, Tung-Yi Lin, Pei-Ming Yang, Chau-Ting Yeh, Tai-Long Pan
Summary: Hepatocellular carcinoma (HCC) development is closely associated with interactions between hepatic stellate cells (HSCs) and various hepatic cells. HSCs play a critical role in modulating extracellular remodeling, cell invasion, and macrophage polarization, thereby enhancing HCC development. This study identifies that the tumor microenvironment created by activated HSCs triggers epithelial-mesenchymal transition (EMT) and affects the tumor-associated immune microenvironment, driving hepatoma cells towards a more malignant phenotype. These findings provide new insights into the role of HSCs in hepatocarcinogenesis and suggest HSCs as a potential therapeutic target for advanced HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Vivekananda Budamagunta, Thomas C. Foster, Daohong Zhou
Summary: Immunosenescence is a complex phenomenon that leads to age-related immune dysfunction, resulting in various pathologies such as decreased ability to clear senescent and cancerous cells, increased autoimmune response, reduced ability to combat pathogens, and diminished response to vaccination. Cellular senescence and immunosenescence have not been extensively explored in terms of their relationship, yet in the context of the ongoing pandemic, immunosenescence has become a topic of great importance.
Review
Cell Biology
Runjiu Zhu, Haoyang Wan, Hong Yang, Mingrui Song, Yu Chai, Bin Yu
Summary: With the increasing proportion of older individuals in most countries, the prevalence of osteoporosis has been on the rise, leading scientists to focus on the pathogenic mechanisms of this condition. In recent years, research on cellular senescence has shed light on the role of the senescent microenvironment in osteoporosis. Senescent cells in the bone marrow secrete senescence-associated secretory phenotype (SASP) factors, which can impact both their own function and the surrounding healthy cells, exacerbating the aging process. The composition of SASP may vary depending on the cause of osteoporosis. This review summarizes the relationship between SASP factors and osteoporosis and provides new insights for the investigation of its mechanism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
H. Oka, Y. Ishida, G. Hong, P. T. T. Nguyen
EUROPEAN JOURNAL OF DENTAL EDUCATION
(2018)
Article
Oncology
Quoc Thang Pham, Naohide Oue, Yohei Sekino, Yuji Yamamoto, Yoshinori Shigematsu, Naoya Sakamoto, Kazuhiro Sentani, Naohiro Uraoka, Wataru Yasui
Article
Oncology
Yohei Sekino, Naoya Sakamoto, Keisuke Goto, Ririno Honma, Yoshinori Shigematsu, Thang Pham Quoc, Kazuhiro Sentani, Naohide Oue, Jun Teishima, Fumi Kawakami, Jose A. Karam, Kanishka Sircar, Akio Matsubara, Wataru Yasui
Article
Gastroenterology & Hepatology
Toshikazu Ohigashi, Keishi Kanno, Akiko Sugiyama, Phuong Thao Nguyen, Nobusuke Kishikawa, Yuichiro Otani, Tomoki Kobayashi, Hiroaki Matsuo, Susumu Tazuma
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2019)
Article
Oncology
Naoya Sakamoto, Yohei Sekino, Kaho Fukada, Quoc Thang Pham, Ririno Honma, Daiki Taniyama, Shoichi Ukai, Tsuyoshi Takashima, Takuya Hattori, Kazuhito Naka, Kazuaki Tanabe, Hideki Ohdan, Wataru Yasui
Article
Gastroenterology & Hepatology
Tomoki Kobayashi, Keishi Kanno, Phuong Thao Nguyen, Akiko Sugiyama, Akihiro Kawahara, Yuichiro Otani, Nobusuke Kishikawa, Masanori Ito, Susumu Tazuma
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Shoichi Ukai, Ririno Honma, Naoya Sakamoto, Yusuke Yamamoto, Quoc Thang Pham, Kenji Harada, Tsuyoshi Takashima, Daiki Taniyama, Ryuichi Asai, Kaho Fukada, Kazuhito Naka, Kazuaki Tanabe, Hideki Ohdan, Wataru Yasui
Article
Biochemistry & Molecular Biology
Yohei Sekino, Quoc Thang Pham, Kohei Kobatake, Hiroyuki Kitano, Kenichiro Ikeda, Keisuke Goto, Shogo Inoue, Tetsutaro Hayashi, Masaki Shiota, Wataru Yasui, Jun Teishima
Summary: HOXB5 plays a role in prostate cancer progression and may serve as a promising prognostic marker after prostatectomy. Its overexpression promotes cell growth and invasion in PCa cell lines, and it may be involved in the progression to neuroendocrine prostate cancer.
Article
Oncology
Daiki Taniyama, Naoya Sakamoto, Tsuyoshi Takashima, Masahiko Takeda, Quoc Thang Pham, Shoichi Ukai, Ryota Maruyama, Kenji Harada, Takashi Babasaki, Yohei Sekino, Tetsutaro Hayashi, Kazuhiro Sentani, Yves Pommier, Junko Murai, Wataru Yasui
Summary: The study established the utility of SLFN11 expression as a predictive biomarker for platinum-based chemotherapy in bladder cancer (BC) patients. SLFN11 expression correlated with overall survival in BC patients and epigenetic modifying drugs could restore sensitivity to platinum derivatives by reactivating SLFN11 expression in refractory patients.
Article
Medicine, General & Internal
Yohei Sekino, Quoc Thang Pham, Kohei Kobatake, Hiroyuki Kitano, Kenichiro Ikeda, Keisuke Goto, Tetsutaro Hayashi, Hikaru Nakahara, Kazuhiro Sentani, Naohide Oue, Wataru Yasui, Jun Teishima, Nobuyuki Hinata
Summary: The study revealed that KIFC1 expression is positive in bladder cancer, associated with poor prognosis, basal type BC, TP53 alterations, and increased sensitivity to cisplatin when knocked down. Moreover, KIFC1-positive cases were related to p53-positive cases and poor prognosis in patients treated with cisplatin-based chemotherapy. The results suggest that KIFC1 could serve as a potential biomarker and therapeutic target in bladder cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Quoc Thang Pham, Daiki Taniyama, Shintaro Akabane, Tsuyoshi Takashima, Ryota Maruyama, Yohei Sekino, Kazuhiro Sentani, Wataru Yasui, Naohide Oue
Summary: Tryptophan 2,3-dioxygenase (TDO2) is found to be associated with tumor development and its overexpression is correlated with poor prognosis in gastric cancer (GC). In this study, the researchers investigated the expression of TDO2 in GC and found that it is correlated with disease progression and clinical outcome. TDO2 expression is also associated with immune cell infiltrates and PD-L1 tumor staining. Inhibition of TDO2 expression suppresses cell proliferation, invasion, and spheroid body formation in GC. These findings suggest that TDO2 could serve as a crucial marker for prognosis prediction and targeted therapy in GC.
Article
Multidisciplinary Sciences
Hung Trong Hoang, Phuong Thao Nguyen, Nam Cong-Nhat Huynh, Tam Thi-Thanh Nguyen, Trang Thi Huyen Tu, Michael George Botelho, Lan Van Nguyen, Kaori Shima, Tomonori Sasahira
Summary: In the midst of the fourth wave of COVID-19 in Vietnam, dental schools were closed due to national lockdowns. This study analyzed the implementation of Doctor of Dental Surgery (DDS) graduation exams in 2021 compared to onsite exams in 2020 and 2022 at the Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City. The final online examination consisted of theory and practicum sessions, with similar results observed between online and onsite exams. The study identified the need for additional measures to standardize the final examination and adapt to the new normal trend in dental education.
Article
Pathology
Quoc Dat Ngo, Quoc Thang Pham, Dang Anh Thu Phan, Anh Vu Hoang, Thi Ngoc Ha Hua, Sao Trung Nguyen
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
(2019)