Acute versus Chronic Exposures to Inhaled Particulate Matter and Neurocognitive Dysfunction: Pathways to Alzheimer’s Disease or a Related Dementia

Long-term exposure to ambient air pollution, APOE-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan

(2020) Erin R. Kulick et al.   ENVIRONMENT INTERNATIONAL

Air pollution is associated with depressive symptoms in elderly women with cognitive impairment

(2020) Hicran Altuğ et al.   ENVIRONMENT INTERNATIONAL

Toxicity of urban air pollution particulate matter in developing and adult mouse brain: Comparison of total and filter-eluted nanoparticles

(2020) Amin Haghani et al.   ENVIRONMENT INTERNATIONAL

Impact of urban environmental exposures on cognitive performance and brain structure of healthy individuals at risk for Alzheimer’s dementia

(2020) Marta Crous-Bou et al.   ENVIRONMENT INTERNATIONAL

Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression

(2020) Katarzyna A. Dudek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predisposition to Alzheimer’s and Age-Related Brain Pathologies by PM2.5 Exposure: Perspective on the Roles of Oxidative Stress and TRPM2 Channel

(2020) Lu Wang et al.   Frontiers in Physiology

Alzheimer disease starts in childhood in polluted Metropolitan Mexico City. A major health crisis in progress

(2020) Lilian Calderón-Garcidueñas et al.   ENVIRONMENTAL RESEARCH

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

Long-term exposure to air pollution and trajectories of cognitive decline among older adults

(2020) Erin R. Kulick et al.   NEUROLOGY

Cell type-specific gene expression patterns associated with posttraumatic stress disorder in World Trade Center responders

(2019) Pei-Fen Kuan et al.   Translational Psychiatry

Dynamic blood brain barrier regulation in mild head trauma

(2019) Eoin O'Keeffe et al.   JOURNAL OF NEUROTRAUMA

Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts

(2019) Mafalda Cacciottolo et al.   FREE RADICAL BIOLOGY AND MEDICINE

The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

(2018) David S. Knopman et al.   Alzheimers & Dementia

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Blood-Brain Barrier Dysfunction in Ischemic Stroke: Targeting Tight Junctions and Transporters for Vascular Protection

(2018) Wazir Abdullahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

PM2.5 impairs neurobehavior by oxidative stress and myelin sheaths injury of brain in the rat

(2018) Qun Zhang et al.   ENVIRONMENTAL POLLUTION

Cardiometabolic profiles of adolescents and young adults exposed to the World Trade Center Disaster

(2018) Leonardo Trasande et al.   ENVIRONMENTAL RESEARCH

Alzheimer's disease and alpha-synuclein pathology in the olfactory bulbs of infants, children, teens and adults ≤ 40 years in Metropolitan Mexico City. APOE4 carriers at higher risk of suicide accelerate their olfactory bulb pathology

(2018) Lilian Calderón-Garcidueñas et al.   ENVIRONMENTAL RESEARCH

Enhanced exposure assessment and genome-wide DNA methylation in World Trade Center disaster responders

(2018) Pei-Fen Kuan et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Development of a cerebrovascular MRI biomarker for cognitive aging

(2018) Prashanthi Vemuri et al.   ANNALS OF NEUROLOGY

Neuroinflammation, Hyperphosphorylated Tau, Diffuse Amyloid Plaques, and Down-Regulation of the Cellular Prion Protein in Air Pollution Exposed Children and Young Adults

(2018) Lilian Calderón-Garcidueñas et al.   JOURNAL OF ALZHEIMERS DISEASE

Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum

(2018) Robin Babadjouni et al.   PLoS One

Fine particulate matter induces mitochondrial dysfunction and oxidative stress in human SH-SY5Y cells

(2018) Ying Wang et al.   CHEMOSPHERE

Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke

(2018) Changjun Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The role of the blood-brain barrier in hypertension

(2017) Anthony Setiadi et al.   EXPERIMENTAL PHYSIOLOGY

Combustion-Derived Nanoparticles in Key Brain Target Cells and Organelles in Young Urbanites: Culprit Hidden in Plain Sight in Alzheimer’s Disease Development

(2017) Angélica González-Maciel et al.   JOURNAL OF ALZHEIMERS DISEASE

Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging

(2017) Anne Maass et al.   JOURNAL OF NEUROSCIENCE

Elevated C-reactive protein and posttraumatic stress pathology among survivors of the 9/11 World Trade Center attacks

(2017) Rebecca L. Rosen et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

(2017) Helena Xicoy et al.   Molecular Neurodegeneration

Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons

(2017) Nicholas C. Woodward et al.   NEUROBIOLOGY OF AGING

Neurotoxicity of traffic-related air pollution

(2017) Lucio G. Costa et al.   NEUROTOXICOLOGY

The polluted brain

(2017) Emily Underwood   SCIENCE

Alzheimer’s disease and cigarette smoke components: effects of nicotine, PAHs, and Cd(II), Cr(III), Pb(II), Pb(IV) ions on amyloid-β peptide aggregation

(2017) Cecilia Wallin et al.   Scientific Reports

Gene expression associated with PTSD in World Trade Center responders: An RNA sequencing study

(2017) Pei-Fen Kuan et al.   Translational Psychiatry

An epigenome-wide DNA methylation study of PTSD and depression in World Trade Center responders

(2017) P-F Kuan et al.   Translational Psychiatry

Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models

(2017) M Cacciottolo et al.   Translational Psychiatry

Diesel exhaust: current knowledge of adverse effects and underlying cellular mechanisms

(2016) Sandro Steiner et al.   ARCHIVES OF TOXICOLOGY

NO 2 inhalation causes tauopathy by disturbing the insulin signaling pathway

(2016) Wei Yan et al.   CHEMOSPHERE

Nanoscale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain

(2016) Hank Cheng et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Neurodevelopmental Deceleration by Urban Fine Particles from Different Emission Sources: A Longitudinal Observational Study

(2016) Xavier Basagaña et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Long-Term Air Pollution and Traffic Noise Exposures and Mild Cognitive Impairment in Older Adults: A Cross-Sectional Analysis of the Heinz Nixdorf Recall Study

(2016) Lilian Tzivian et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Prefrontal white matter pathology in air pollution exposed Mexico City young urbanites and their potential impact on neurovascular unit dysfunction and the development of Alzheimer's disease

(2016) Lilian Calderón-Garcidueñas et al.   ENVIRONMENTAL RESEARCH

Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFα in vitro

(2016) Hank Cheng et al.   Journal of Neuroinflammation

Exposure to air pollution as a potential contributor to cognitive function, cognitive decline, brain imaging, and dementia: A systematic review of epidemiologic research

(2016) Melinda C. Power et al.   NEUROTOXICOLOGY

Neurodegenerative and neurological disorders by small inhaled particles

(2016) Harm J. Heusinkveld et al.   NEUROTOXICOLOGY

Biomarkers of Exposure to Polycyclic Aromatic Hydrocarbons and Cognitive Function among Elderly in the United States (National Health and Nutrition Examination Survey: 2001-2002)

(2016) Elizabeth A. Best et al.   PLoS One

Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain

(2016) Toby B. Cole et al.   TOXICOLOGY

Nitrogen dioxide pollution exposure is associated with olfactory dysfunction in older U.S. adults

(2016) Dara R. Adams et al.   International Forum of Allergy & Rhinology

NO2 inhalation promotes Alzheimer’s disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication

(2016) Wei Yan et al.   Scientific Reports

Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study

(2015) Jiu-Chiuan Chen et al.   ANNALS OF NEUROLOGY

Acute nitrogen dioxide (NO2) exposure enhances airway inflammation via modulating Th1/Th2 differentiation and activating JAK-STAT pathway

(2015) Xiaotong Ji et al.   CHEMOSPHERE

Traffic-Related Air Pollution and Dementia Incidence in Northern Sweden: A Longitudinal Study

(2015) Anna Oudin et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Acute nitrogen dioxide inhalation induces mitochondrial dysfunction in rat brain

(2015) Wei Yan et al.   ENVIRONMENTAL RESEARCH

Association of air pollution with cognitive functions and its modification by APOE gene variants in elderly women

(2015) Tamara Schikowski et al.   ENVIRONMENTAL RESEARCH

Blood–brain barrier dysfunction following traumatic brain injury

(2015) Himakarnika Alluri et al.   METABOLIC BRAIN DISEASE

Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later Childhood

(2015) Bradley S. Peterson et al.   JAMA Psychiatry

A Pilot Study to Assess Effects of Long-Term Inhalation of Airborne Particulate Matter on Early Alzheimer-Like Changes in the Mouse Brain

(2015) Dhaval P. Bhatt et al.   PLoS One

Prenatal exposure to polycyclic aromatic hydrocarbons and cognitive dysfunction in children

(2014) Wiesław A. Jedrychowski et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Traffic-related Air Pollution in Relation to Cognitive Function in Older Adults

(2014) Cathryn Tonne et al.   EPIDEMIOLOGY

Air Pollution During Pregnancy and Childhood Cognitive and Psychomotor Development

(2014) Mònica Guxens et al.   EPIDEMIOLOGY

Fine Particulate Matter Air Pollution and Cognitive Function Among U.S. Older Adults

(2014) Jennifer A. Ailshire et al.   JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES

Increased Risk of Dementia in Patients Exposed to Nitrogen Dioxide and Carbon Monoxide: A Population-Based Retrospective Cohort Study

(2014) Kuang-Hsi Chang et al.   PLoS One

Early-Life Exposure to Polycyclic Aromatic Hydrocarbons and ADHD Behavior Problems

(2014) Frederica P. Perera et al.   PLoS One

Diesel Exhaust Exposure and the Risk of Lung Cancer—A Review of the Epidemiological Evidence

(2014) Yi Sun et al.   International Journal of Environmental Research and Public Health

Nitrogen dioxide (NO2) pollution as a potential risk factor for developing vascular dementia and its synaptic mechanisms

(2013) Hongyan Li et al.   CHEMOSPHERE

Components of air pollution and cognitive function in middle-aged and older adults in Los Angeles

(2013) Nicole M. Gatto et al.   NEUROTOXICOLOGY

Recent Advances in Particulate Matter and Nanoparticle Toxicology: A Review of theIn VivoandIn VitroStudies

(2013) Abderrahim Nemmar et al.   Biomed Research International

Neurobehavioral effects of exposure to traffic-related air pollution and transportation noise in primary schoolchildren

(2012) Elise van Kempen et al.   ENVIRONMENTAL RESEARCH

Residential Proximity to Nearest Major Roadway and Cognitive Function in Community-Dwelling Seniors: Results from the MOBILIZE Boston Study

(2012) Gregory A. Wellenius et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Novel object recognition ability in female mice following exposure to nanoparticle-rich diesel exhaust

(2012) Tin-Tin Win-Shwe et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Glutamatergic Neurons in Rodent Models Respond to Nanoscale Particulate Urban Air Pollutants in Vivo and in Vitro

(2011) Todd E. Morgan et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Diesel Exhaust Activates and Primes Microglia: Air Pollution, Neuroinflammation, and Regulation of Dopaminergic Neurotoxicity

(2011) Shannon Levesque et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Cells, biomarkers, and post-traumatic stress disorder: evidence for peripheral involvement in a central disease

(2011) James A. Andrews et al.   JOURNAL OF NEUROCHEMISTRY

Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology

(2011) L K Fonken et al.   MOLECULAR PSYCHIATRY

Nanoparticle-rich diesel exhaust affects hippocampal-dependent spatial learning and NMDA receptor subunit expression in female mice

(2011) Tin-Tin Win-Shwe et al.   Nanotoxicology

Heart disease among adults exposed to the September 11, 2001 World Trade Center disaster: Results from the World Trade Center Health Registry

(2011) Hannah T. Jordan et al.   PREVENTIVE MEDICINE

Blood–Brain Barrier Pathophysiology in Traumatic Brain Injury

(2011) Adam Chodobski et al.   Translational Stroke Research

Oxidative stress, endothelial dysfunction and inflammatory response in rat heart to NO2 inhalation exposure

(2010) Hongyan Li et al.   CHEMOSPHERE

Pre and post-natal exposure to ambient level of air pollution impairs memory of rats: the role of oxidative stress

(2010) Ana C.T. Zanchi et al.   INHALATION TOXICOLOGY

Association of Traffic-Related Air Pollution with Children’s Neurobehavioral Functions in Quanzhou, China

(2009) Shunqin Wang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly

(2009) Ulrich Ranft et al.   ENVIRONMENTAL RESEARCH

Prenatal Airborne Polycyclic Aromatic Hydrocarbon Exposure and Child IQ at Age 5 Years

(2009) F. P. Perera et al.   PEDIATRICS

Current Understanding of Ultrafine Particulate Matter Emitted from Mobile Sources

(2009) Christian Seigneur   JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION

Reducing post-traumatic anxiety by immunization

(2008) Gil M. Lewitus et al.   BRAIN BEHAVIOR AND IMMUNITY

Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid β-42 and α-Synuclein in Children and Young Adults

(2008) Lilian Calderón-Garcidueñas et al.   TOXICOLOGIC PATHOLOGY