Review
Virology
Kenneth Zheng, Gong Feng, Wen-Yue Liu, Giovanni Targher, Christopher D. Byrne, Ming-Hua Zheng
Summary: This narrative review provides an overview of the current literature about the extrapulmonary manifestations of COVID-19 that may affect the urinary, cardiovascular, gastrointestinal, hematological, hematopoietic, neurological, or reproductive systems. This review also describes the current understanding of the extrapulmonary complications caused by COVID-19 to improve the management and prognosis of patients with COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Pharmacology & Pharmacy
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Yaaser Q. Almulaiky, Natalia Cruz-Martins, Gaber El-Saber Batiha
Summary: SARS-CoV-2 virus enters the body through interaction with ACE2 receptors, leading to various clinical manifestations. Leukotriene inhibitors may play an important role in Covid-19 management by blocking CysLTRs or the NF-kappa B signaling pathway to alleviate symptoms.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Devika Subramanian, Aadith Vittala, Xinpu Chen, Christopher Julien, Sebastian Acosta, Craig Rusin, Carl Allen, Nicholas Rider, Zbigniew Starosolski, Ananth Annapragada, Sridevi Devaraj, Laura Franza, Rossella Cianci
Summary: The study aims to find an objective method to identify MIS-C in children infected with SARS-CoV-2. By analyzing blood samples from patients with different variants, it was found that the cytokine/chemokine panel can predict MIS-C accurately and only a few indicators are needed to achieve high precision.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
R. Castagnoli, I. Brambilla, M. De Filippo, M. Votto, D. Montagna, L. Montagna, A. Licari, G. L. Marseglia
Summary: This review provides a comprehensive overview of COVID-19 in children until July 2021, including global infection and mortality data, as well as age-specific statistics.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Chemistry, Medicinal
Fatema Hersi, Anusha Sebastian, Hamadeh Tarazi, Vunnam Srinivasulu, Ahmed Mostafa, Abdou Kamal Allayeh, Cong Zeng, Ibrahim Y. Hachim, Shan-Lu Liu, Imad A. Abu-Yousef, Amin F. Majdalawieh, Dana M. Zaher, Hany A. Omar, Taleb H. Al-Tel
Summary: The emergence of new SARS-CoV-2 variants highlights the urgent need for more effective therapeutic agents to prevent COVID-19 outbreaks. SIMR3030 has been identified as a potent inhibitor of SARS-CoV-2 PLpro, showing the ability to inhibit inflammatory markers and viral activity. This study lays the foundation for developing new drugs to tackle the COVID-19 pandemic and may pave the way for the development of novel therapeutics for future outbreaks of new SARS-CoV-2 variants or other Coronavirus species.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Immunology
Nikhil Ram-Mohan, David Kim, Elizabeth J. Zudock, Marjan M. Hashemi, Kristel C. Tjandra, Angela J. Rogers, Catherine A. Blish, Kari C. Nadeau, Jennifer A. Newberry, James Quinn, Ruth O'Hara, Euan Ashley, Hien Nguyen, Lingxia Jiang, Paul Hung, Andra L. Blomkalns, Samuel Yang
Summary: Measurement of SARS-CoV-2 RNA from the plasma of COVID-19 patients using digital polymerase chain reaction can predict disease severity, clinical deterioration, and extrapulmonary complications. It may guide patient triage and management effectively.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Immunology
Rustom Antia, M. Elizabeth Halloran
Summary: The article discusses the basic concepts underlying the transition from an epidemic to an endemic state, as well as the implications of this transition for COVID-19.
Article
Immunology
Martijn Zoodsma, Aline H. de Nooijer, Inge Grondman, Manoj Kumar Gupta, Agnes Bonifacius, Valerie A. C. M. Koeken, Emma Kooistra, Gizem Kilic, Ozlem Bulut, Nina Goedecke, Nico Janssen, Matthijs Kox, Jorge Dominguez-Andres, Adriaan J. van Gammeren, Anton A. M. Ermens, Andre J. A. M. van der Ven, Peter Pickkers, Rainer Blasczyk, Georg M. N. Behrens, Frank L. van de Veerdonk, Leo A. B. Joosten, Cheng-Jian Xu, Britta Eiz-Vesper, Mihai G. Netea, Yang Li
Summary: This study utilized the Olink platform to perform targeted proteomics and investigated protein concentrations in different groups of individuals, including hospitalized COVID-19 patients, post-COVID-19 individuals, and healthy individuals. The results showed that SARS-CoV-2 infection causes acute inflammation and has a lasting impact on the circulating proteome. Furthermore, the circulating proteome can differentiate between different disease severities and is associated with the time after infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Marcia C. Castro, Sun Kim, Lorena Barberia, Ana Freitas Ribeiro, Susie Gurzenda, Karina Braga Ribeiro, Erin Abbott, Jeffrey Blossom, Beatriz Rache, Burton H. Singer
Summary: The study found that COVID-19 in Brazil is spreading rapidly across municipalities with distinct spatial and temporal patterns of clustering, trajectories, and speed. Analysis shows that inadequate policy measures have led to high transmission and mortality burdens. The current surge in cases and deaths, along with the circulation of concerning variants, highlights the need for government to strengthen prevention and control measures.
Review
Immunology
Ellen McKenna, Richard Wubben, Johana M. Isaza-Correa, Ashanty M. Melo, Aisling Ui Mhaonaigh, Niall Conlon, James S. O'Donnell, Cliona Ni Cheallaigh, Tim Hurley, Nigel J. Stevenson, Mark A. Little, Eleanor J. Molloy
Summary: This article discusses the immunological characteristics of severe COVID-19 patients, the antiviral and pathological roles of neutrophils in SARS-CoV-2 infection, the contribution of neutrophils to complications of COVID-19, and potential therapeutic strategies targeting neutrophil-mediated inflammatory responses in COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Public, Environmental & Occupational Health
Sazada Siddiqui, Heba Waheeb Saeed Alhamdi, Huda Ahmed Alghamdi
Summary: COVID-19 is highly contagious and has caused major disruptions around the world. Prevention is crucial through measures such as self-isolation and vaccination.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
William R. Morgenlander, Stephanie N. Henson, Daniel R. Monaco, Athena Chen, Kirsten Littlefield, Evan M. Bloch, Eric Fujimura, Ingo Ruczinski, Andrew R. Crowley, Harini Natarajan, Savannah E. Butler, Joshua A. Weiner, Mamie Z. Li, Tania S. Bonny, Sarah E. Benner, Ashwin Balagopal, David Sullivan, Shmuel Shoham, Thomas C. Quinn, Susan H. Eshleman, Arturo Casadevall, Andrew D. Redd, Oliver Laeyendecker, Margaret E. Ackerman, Andrew Pekosz, Stephen J. Elledge, Matthew Robinson, Aaron A. R. Tobian, H. Benjamin Larman
Summary: This study found strong correlation between the functionality of COVID-19 convalescent plasma and polyclonal antibody targeting of specific peptides in the SARS-CoV-2 spike protein. Antibody responses to specific coronaviruses correlated with the development of highly neutralizing antibodies against CoV-2. Plasma donations reactive to the CoV-2 spike receptor binding domain had higher neutralizing titers.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Infectious Diseases
D. F. Bavaro, L. Diella, C. Fabrizio, R. Sulpasso, I. F. Bottalico, A. Calamo, C. R. Santoro, G. Brindicci, G. Bruno, A. Mastroianni, G. B. Buccoliero, S. Carbonara, S. Lo Caputo, T. Santantonio, L. Monno, G. Angarano, A. Saracino
Summary: A retrospective study of COVID-19 patients over 65 years old found that elderly patients with high CFS scores often presented with extrapulmonary symptoms at admission, even in the absence of lung involvement. These findings suggest a correlation between high CFS scores and disease progression, predicting a higher risk of mortality.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Mariana A. Vasconcelos, Ana Carmen Q. Mendonca, Enrico A. Colosimo, Noureddin Nourbakhsh, Hercilio Martelli-Junior, Ludmila R. Silva, Maria Christina L. Oliveira, Clara C. Pinhati, Robert H. Mak, Ana Cristina Simoes e Silva, Eduardo A. Oliveira
Summary: This study aimed to characterize the clinical outcomes and risk factors for COVID-19-related death in hospitalized pediatric patients with kidney diseases (KD). The results showed that pediatric patients with KD had a higher risk of death compared with non-KD patients. The higher risk was associated with low oxygen saturation at admission, living in socioeconomically disadvantaged regions, and presence of other pre-existing comorbidities.
PEDIATRIC NEPHROLOGY
(2023)
Article
Pharmacology & Pharmacy
Raphael Figuiredo Dias, Mateus da Costa Monteiro, Renata Aguiar Menezes Silva, Mirella Monique Lana Diniz, Ana Cristina Simaes Silva
Summary: This case report presents a rare pediatric case of probable tacrolimus-induced Bartter-like syndrome in a renal transplanted boy. It highlights the importance of considering losing-salt tubulopathies, such as Bartter syndrome, in transplanted patients who develop dehydration and hydroelectrolytic disorders after starting nephrotoxic immunosuppressive drugs like tacrolimus.
CURRENT DRUG SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Beatriz Castello Branco, Bruno Wilnes, Pedro Alves Soares Vaz de Castro, Caio Ribeiro Vieira Leal, Ana Cristina Silva
Summary: The posterior urethral valve (PUV) is a rare but significant cause of congenital obstruction of the lower urinary tract in pediatrics, leading to chronic kidney disease (CKD). New diagnostic strategies, including biomarkers, are essential for better prognosis assessment in PUV patients.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Eduarda Almeida Wakabayashi, Alexandre Negrao Pantaleao, Renata Araujo Avendanha, Felipe Baptista Brunheroto, Ana Cristina Silva
Summary: The present review summarizes and updates the scientific literature on congenital solitary functioning kidney (SFK), discussing its pathophysiology, diagnosis, complications, prognosis, role of novel urinary biomarkers, treatment, and follow-up. The natural history of congenital SFK is still unresolved, and there is limited research on novel urinary biomarkers in this population.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Joao Pedro Thimotheo Batista, Lucas Alexandre Santos Marzano, Renata Aguiar Menezes Silva, Karla Emilia de Sa Rodrigues, Ana Cristina Simoes e Silva
Summary: Obese individuals have higher rates of cancer incidence and mortality, and the worse outcomes of chemotherapy in these individuals are due to various factors. This article discusses the physiological and pharmacokinetic alterations caused by obesity and reviews the controversies surrounding dosing adjustment strategies in both adults and children.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Sara Tavares Araujo, Clara Tavares Araujo, Rafael Silva e Castro, Lara Machado de Oliveira Brugger, Nathalia Gualberto Souza e Silva, Debora Marques de Miranda, Ana Cristina Simoes e Silva
Summary: This review examines neurologic manifestations in COVID-19 and investigates neuroimaging markers for early diagnosis and prognosis. Magnetic resonance imaging (MRI) is the most commonly used method for observing neurologic injuries. The manifestations may result from direct viral infection or indirect mechanisms. However, further population studies are needed to evaluate neurologic manifestations in individuals with different severities of COVID-19.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Pediatrics
Raquel Medeiros de Souza, Bernardo Henrique Mendes Correa, Paulo Henrique Moreira Melo, Pedro Antunes Pousa, Tamires Sara Campos de Mendonca, Lucas Gustavo Castelar Rodrigues, Ana Cristina Simoes e Silva
Summary: Eculizumab treatment in pediatric patients with aHUS shows significant efficacy in improving renal and hematological parameters with low mortality rate. However, the limited number of studies and methodological heterogeneity necessitate further research to establish long-term efficacy and safety.
PEDIATRIC NEPHROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alessandra Aguiar dos Anjos, Isadora Tucci de Paiva, Giovanna Leticia Simoes Lima, Roberta da Silva Filha, Brunna Pinto E. Froes, Sergio Veloso Brant Pinheiro, Ana Cristina Simoes E. Silva
Summary: This review summarizes the evidence on the pathophysiological role and therapeutic potential of the Renin-Angiotensin System (RAS) molecules for the control of proteinuria and delaying the onset of chronic kidney disease (CKD) in patients with Idiopathic Nephrotic Syndrome (INS). Studies using rodent models showed that ACE2 activators and receptor Mas agonists can reduce proteinuria and improve kidney tissue damage. Limited data with pediatric patients also suggest that decreased urinary ACE2 levels correlate with proteinuria and higher concentrations of inflammatory cytokines in children with INS. The molecules of the alternative RAS axis have potential pharmacological targets for the treatment of kidney diseases including INS.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Article
Oncology
Maria Christina L. Oliveira, Ana Cristina Simoes e Silva, Enrico A. A. Colosimo, Marcia K. K. Campos, Hercilio Martelli-Junior, Ludmila R. R. Silva, Clara C. C. Pinhati, Robert H. H. Mak, Eduardo A. A. Oliveira
Summary: This study aimed to evaluate the risk factors for COVID-19-related death in hospitalized children with hematological disorders. The analysis included pediatric patients with COVID-19 registered in a Brazilian nationwide surveillance database. The study found that children with malignant hematological diseases had a higher risk of death compared to those without these disorders, and factors such as age, gender, oxygen saturation, and abdominal pain were also associated with death risk.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2023)
Article
Pediatrics
Eduardo A. Oliveira, Maria Christina L. Oliveira, Enrico A. Colosimo, Ana Cristina Simoes e Silva, Robert H. Mak, Mariana A. Vasconcelos, Ludmila R. Silva, Daniella B. Martelli, Clara C. Pinhati, Hercilio Martelli-Junior
Summary: The objective of this study was to estimate the vaccine effectiveness against hospitalization and severe illness in adolescents due to infection with SARS-CoV-2 variants. The study found that the vaccine effectiveness against COVID-19 hospitalization dropped to 59% during the omicron-predominant period. These findings suggest that the current two-dose vaccine regimen may be insufficient for the protection against SARS-CoV-2 variants.
JOURNAL OF PEDIATRICS
(2023)
Review
Pediatrics
Anna Luiza Braga Albuquerque, Rafael dos Santos Borges, Ana Flavia Conegundes, Erika Emmylaine dos Santos, Frederico Moreira Man Fu, Clara Tavares Araujo, Pedro Alves Soares Vaz de Castro, Ana Cristina Simoes e Silva
Summary: Fanconi-Debre-de Toni syndrome is a disease that affects the function of the proximal convoluted tubule in the kidney. It can be inherited or secondary to systemic disorders. In children, it is often associated with energy supply disorders, and early diagnosis and treatment can improve prognosis and quality of life.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Urology & Nephrology
Fernanda Nunes Coelho Siqueira Pinto, Jose de Bessa Junior, Jose Murillo Bastos Netto, Glaucia Cristina Medeiros Dias, Monica Maria de Almeida Vasconcelos, Eleonora Moreira Lima, Tailly de Souza Almeida, Ana Cristina Simoes e Silva, Flavia Cristina de Carvalho Mrad
Summary: The objective of this study was to translate, cross-culturally adapt, and validate the Vancouver Symptom Score (VSS) for bladder and bowel dysfunction (BBD) in Brazilian children and adolescents. The translated VSS was found to be a reliable and valid tool for identifying symptoms of BBD in Brazilian children and adolescents aged five to 16 years.
INTERNATIONAL BRAZ J UROL
(2023)
Article
Pediatrics
Raissa T. Boato, Marcos B. Aguiar, Robert H. Mak, Enrico A. Colosimo, Ana Cristina Simoes e Silva, Eduardo A. Oliveira
Summary: This case-control study found that consanguinity, positive family history, and maternal hypertension were associated with congenital anomalies of the kidney and urinary tract (CAKUT). However, these risk factors were rare in the study cohort and most cases were sporadic forms.
JOURNAL OF PEDIATRIC UROLOGY
(2023)
Review
Medical Informatics
Bruna Achtschin Fernandes, Bernardo Alves, Ana Carolina Matosinhos, Barbara Linhares Silva, Raphael Dias, Ursula Gramiscelli Hasparyk, Julia Damasio, Fernando Macedo Bastos, Ana Cristina Silva
Summary: This narrative review summarizes the use and role of telemedicine in maternal fetal medicine (MFM), emphasizing the importance of its implementation and global promotion.
HEALTH AND TECHNOLOGY
(2023)
Review
Biology
Joao Pedro Thimotheo Batista, Andre Oliveira Vilela de Faria, Thomas Felipe Silva Ribeiro, Ana Cristina Simoes e Silva
Summary: Diabetic cardiomyopathy is characterized by myocardial dysfunction in type 2 diabetes patients without traditional cardiovascular risk factors or overt clinical atherosclerosis and valvular disease. The activation of the renin-angiotensin system (RAS), oxidative stress, lipotoxicity, maladaptive immune responses, imbalanced mitochondrial dynamics, impaired myocyte autophagy, increased myocyte apoptosis, and fibrosis all contribute to the development of diabetic cardiomyopathy. Research has shown that the RAS plays a crucial role in this condition, with over-activation of the classical RAS axis leading to increased oxidative stress, fibrosis, and cardiac remodeling, while angiotensin-(1-7) has a protective effect. ACE inhibitors and angiotensin receptor blockers have been shown to improve heart functioning and reduce the occurrence of diabetic cardiomyopathy.
