Article
Cell & Tissue Engineering
Yen-Ta Chen, Fei-Chi Chuang, Chih-Chao Yang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Chi-Ruei Huang, Kuan-Hui Huang, Hon-Kan Yip
Summary: The combined use of melatonin and adipose-derived mesenchymal stem cells effectively protects the testis against acute testicular torsion-induced ischemia-reperfusion injury.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Mengdong Liu, Yunshu Yang, Bin Zhao, Yuefan Yang, Jing Wang, Kuo Shen, Xuekang Yang, Dahai Hu, Guoxu Zheng, Juntao Han
Summary: The study showed that ADMSC-Exos reduced oxidative stress, inflammation, and microglial infiltration by activating the SIRT1 pathway, providing protective effects against radiation-induced brain injury.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Abhishek Sahu, Jin Jeon, Min Suk Lee, Hee Seok Yang, Giyoong Tae
Summary: Mesenchymal stem cell (MSC) based therapy shows great potential in treating diseases, but the low viability of transplanted cells in injured tissues due to high oxidative stress levels is a major obstacle. Using a ROS-scavenging nanozyme to protect MSCs from oxidative stress-mediated apoptosis can significantly improve therapeutic potential and survival in high oxidative stress conditions. Incorporating nanozymes into MSCs is a simple and efficient way to enhance MSC-based cell therapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Medicine, Research & Experimental
Yue Wang, Tao Liu, Guangming Jiao, Yingguang Lv, Chenxi Piao, Xiangyu Lu, Haiyang Ma, Hongbin Wang
Summary: The aim of this study was to investigate the therapeutic efficacy of exosomes from adipose-derived mesenchymal stem cells (ADSCs-exo) against hepatectomy combined with ischemia-reperfusion injury (IRI) and compare it with the effect of adipose-derived mesenchymal stem cells (ADSCs). The results showed that ADSCs-exo alleviated histopathological injuries and ultrastructural changes in the endoplasmic reticulum (ER), and significantly improved ALP, TP and CAT levels. The therapeutic effects of ADSCs-exo and ADSCs were similar, indicating that ADSCs-exo is a novel cell-free therapeutic approach for surgery-related liver injury.
Article
Biology
Qifang Niu, Yang Yang, Delong Li, Wenwen Guo, Chong Wang, Haoyue Xu, Zhien Feng, Zhengxue Han
Summary: This study found that exosomes derived from bone marrow mesenchymal stem cells (BMSCs-exosomes) can effectively reduce necrotic lesions, alleviate oxidative stress and inflammation, and promote new blood vessel formation in a rat model of free abdomen flap transplantation, thus reducing ischemia-reperfusion injury and improving the survival of skin flaps.
Article
Cell & Tissue Engineering
Aref Jafari, Ali Reza Khalatbary, Saeid Taghiloo, Mohamad Sedigh Mirzaie, Eisa Nazar, Mahnaz Poorhassan, Esmaeil Akbari, Mahdiyeh Asadzadeh, Amir Raoo, Davood Nasiry
Summary: This study investigated the combined effect of exosomes derived from human placental mesenchymal stem cells (hpMSCs-Exos) and hyperbaric oxygen (HBO) on spinal cord ischemia-reperfusion injury (IR) in rats. The results showed that this combined treatment improved neurological function, increased levels of antioxidative and anti-inflammatory factors, and decreased levels of oxidative and inflammatory factors, thereby providing synergistic neuroprotection in rats undergoing IR.
REGENERATIVE THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Chih-Chao Yang, Pei-Hsun Sung, John Y. Chiang, Han-Tan Chai, Chih-Hung Chen, Yi-Ching Chu, Yi-Chen Li, Hon-Kan Yip
Summary: Combined tacrolimus and melatonin therapy was more effective than either single treatment in protecting the kidney from IR injury by suppressing inflammation and oxidative stress.
Review
Cardiac & Cardiovascular Systems
Chen Chang, Ru-Ping Cai, Ying-Man Su, Qiang Wu, Qiang Su
Summary: Ischemic cardiomyopathy is treated mainly with thrombolytic drugs, percutaneous coronary intervention, and coronary artery bypass grafting. Myocardial ischemia-reperfusion injury (MIRI) is a complication of obstructive revascularization with limited therapeutic options. Mesenchymal stem cell-derived exosomes (MSC-EXOs) can alleviate MIRI and prevent limitations caused by direct MSC administration. Using MSC-EXOs instead of MSCs is a potentially beneficial cell-free treatment strategy for MIRI.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Cell & Tissue Engineering
Wei-Cheng Tseng, Pei-Ying Lee, Ming-Tsun Tsai, Fu-Pang Chang, Nien-Jung Chen, Chiang-Ting Chien, Shih-Chieh Hung, Der-Cherng Tarng
Summary: This study demonstrates that the enhancing effect of MSCs, especially HMSCs, on tissue autophagy can be applied to suppress renal tubular apoptosis and attenuate renal impairment during renal I/R injury in rats. These findings provide further mechanistic support for HMSC therapy and its investigation in clinical trials of ischemic AKI.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Tamara Merz, Oscar McCook, Cosima Brucker, Christiane Waller, Enrico Calzia, Peter Radermacher, Thomas Datzmann
Summary: The discovery of endogenous H2S with cytoprotective properties has led to efforts in developing H2S as a therapeutic agent. H2S's ability to regulate various processes makes it potentially useful in managing critical illnesses. However, current methods of delivering H2S are not feasible for clinical use. Na2S2O3, a clinically approved compound, shows promise in pre-clinical studies for managing critical illnesses. Clinical trials are investigating its potential in myocardial infarction, and it may also be relevant for pre-eclampsia and COVID-19 pneumonia.
Article
Cell Biology
Qingman Li, Lijie Zhu, Fangqing Niu, Qingmin Li, Che Wang, Honghui Yang, Chuanyu Gao
Summary: Both HDAC4 up-regulation and miR-206 down-regulation were observed in myocardial tissues and cardiomyocytes during myocardial ischemia-reperfusion injury (MIRI). By manipulating the levels of HDAC4 and miR-206, it is possible to reduce cell apoptosis, lower inflammatory cytokines and oxidative stress markers, exerting a protective effect on myocardial ischemia-reperfusion injury.
CELL DEATH DISCOVERY
(2021)
Article
Chemistry, Multidisciplinary
Sheng Li, Ke Yang, Weilong Cao, Rui Guo, Zhihao Liu, Jing Zhang, Aodi Fan, Yuting Huang, Chuanrui Ma, Lan Li, Guanwei Fan
Summary: This study investigated the therapeutic effect and mechanism of TSA-pretreated MSC-derived exosomes (TSA-MSCexo) in ameliorating myocardial ischemia-reperfusion injury in rats. The results showed that TSA-MSCexo significantly relieved myocardial injury compared to MSCexo. MiRNA microarray analysis identified miR-223-5p as a potential mediator for TSA-MSCexo's cardio-protective function by inhibiting CCR2 activation and reducing monocyte infiltration, while enhancing angiogenesis.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Endocrinology & Metabolism
Niloofar Dehdari Ebrahimi, Sara Shojaei-Zarghani, Ehsan Taherifard, Sanaz Dastghaib, Shima Parsa, Nasim Mohammadi, Fatemeh Sabet Sarvestani, Zahra Moayedfard, Nima Hosseini, Heidar Safarpour, Alireza Sadeghi, Negar Azarpira, Ali Reza Safarpour
Summary: This study evaluates the protective effects of melatonin therapy on testicular tissue damage caused by physical, heat, and ischemic factors in animal models. The results show that melatonin therapy improves histopathological characteristics of testicular tissue and enhances sperm quality and tissue markers of oxidative stress. However, there are limitations and bias risks in the included studies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaxing Kang, Yiran Song, Yuxin Luo, Jia Song, Chenyang Li, Shuangshuang Yang, Jinbo Guo, Jun Yu, Xiaolan Zhang
Summary: The study showed that exosomes derived from human umbilical cord mesenchymal stem cells (hUC-MSCs) protect against non-alcoholic steatohepatitis (NASH) through the Nrf2/NQO-1 pathway, exerting antioxidant and anti-inflammatory effects.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Immunology
Jiale Li, Qinbao Peng, Ronghua Yang, Kunsheng Li, Peng Zhu, Yufeng Zhu, Pengyu Zhou, Gabor Szabo, Shaoyi Zheng
Summary: This review discusses the use of machine perfusion and mesenchymal stem cells to improve the quality and outcomes of marginal organs in transplantation. By continuously perfusing the organs to mimic physiological conditions, evaluating pre-transplant organ function, and treating the organs with pharmacological, gene, and stem cell therapy, the quality and adaptability of the organs can be enhanced. Promising preclinical results indicate the potential clinical translation of this innovative strategy to improve the quality of marginal grafts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Mahmoud S. El-Tarabany, Ayman A. Saleh, Iman E. El-Araby, Mohammed A. El-Magd
Summary: This study identified novel SNPs in the leptin receptor gene of female Japanese quails, which were significantly associated with growth and egg production traits. Quails with the GG/GG haplotype showed lower egg production, feed intake, and growth performance, as well as altered lipid profile and sex hormone levels. However, they exhibited higher levels of LEP/LEPR and apoptosis-related genes in the hypothalamus and ovaries. The study suggests selecting quails with the AA/AA and AG/AG haplotypes to improve reproduction and growth performance.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Doaa H. Assar, Samah Abou Asa, Moshira A. El-Abasy, Zizy Elbialy, Mustafa Shukry, Amera Abd El Latif, Mona N. BinMowyna, Norah A. Althobaiti, Mohammed A. El-Magd
Summary: The study found that dietary supplementation of A. awamori can protect against OTA-induced renal and cardiac damage in rabbits. A. awamori improves rabbit's growth performance and immune response, restores altered hematological parameters, and reduces renal and cardiac injury markers. It also enhances antioxidant defense, reduces oxidative and nitrosative stress, and attenuates inflammation in a dose-dependent manner.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Faisal A. Alzahrani, Saleh A. Alkarim, Yousef M. Hawsawi, Wesam H. Abdulaal, Raed Albiheyri, Bassem Kurdi, Hassan Alguridi, Mohammed A. El-Magd
Summary: The COVID-19 pandemic has caused a global crisis with millions of deaths, and effective treatment options are still lacking. This study explores the potential antiviral activity of 25-HC, an oxysterol derivative, against SARS-CoV-2. Through molecular docking, molecular dynamics simulation, and MM/GBSA analysis, the study demonstrates the inhibitory activity and binding stability of 25-HC against viral enzymes RdRp and M-pro. These findings suggest the potential of 25-HC as a treatment and prevention option for COVID-19 complications.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Amira A. Sallam, Mona M. Ahmed, Mohammed A. El-Magd, Ahmed Magdy, Heba Ghamry, Mohammad Y. Alshahrani, Magdy F. Abou El-Fotoh
Summary: This study demonstrates that quercetin has protective effects against the immunotoxic, inflammatory, and oxidative effects caused by carbon nanotubes.
Article
Multidisciplinary Sciences
Attia Ahmed Attia, Afrah Fatthi Salama, Jayda G. Eldiasty, Sahar Abd El-Razik Mosallam, Sabry Ali El-Naggar, Mohammed Abu El-Magd, Hebatala M. Nasser, Alaa Elmetwalli
Summary: This study aimed to investigate the anti-tumor properties of amygdalin against Ehrlich ascites carcinoma (EAC) in mice and its protective properties against liver damage. The results showed that amygdalin reduced tumor burden, improved liver function parameters, and decreased oxidative stress levels in the liver. Furthermore, it was suggested that amygdalin may exert its effects through regulating the expression of antioxidant and angiogenesis-related genes.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Amira A. Sallam, Mohammed A. El-Magd, Mona M. Ahmed, Heba I. Ghamry, Mohammad Y. Alshahrani, Rabab A. Hegazy, Ahmed Magdy, Magdy F. Abou El-Fotoh
Summary: The study found that quercetin can alleviate neurotoxicity induced by multi-walled carbon nanotubes. This effect is achieved through antioxidant, anti-inflammatory, and antipyroptotic mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Amira M. Shaban, Mai Raslan, Safa H. Qahl, Khaled Elsayed, Mohamed Sayed Abdelhameed, Atif Abdulwahab A. Oyouni, Osama M. Al-Amer, Ola Hammouda, Mohammed A. El-Magd
Summary: The contradictory effects of extracellular vesicles, such as exosomes (EXOs), on diabetes and diabetic nephropathy (DN) have been observed. Some studies suggest that EXOs, including camel milk EXOs, are involved in the pathogenesis of DN, while others reveal ameliorative effects. This study evaluates the effect of camel milk and its EXOs on a rat model of DN induced by streptozotocin. The results show that treatment with camel milk and/or its EXOs ameliorated DN by reducing kidney function parameters, restoring redox balance, downregulating DN-related gene expression, and decreasing renal damage.
Article
Biochemistry & Molecular Biology
Rasha Fekry Zahran, Lina Mahmoud EL-sayed, Thomas Robert Hoye, Seif-Eldin Nasr Ayyad
Summary: The present study evaluated the potential therapeutic effects of Ottelione A (OTTE) against CCl4-induced toxicity in mice. The results showed that OTTE has good antioxidant and therapeutic properties, which can help prevent CCl4-induced hepatotoxicity in both pre-treatment and post-treatment modes.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mohammed A. El-Magd, Amina M. G. Zedan, Nahla S. Zidan, Mohamed Sakran, Omar Bahattab, Atif Abdulwahab A. Oyouni, Osama M. Al-Amer, Adel Alalawy, Amira M. Elmoslemany
Summary: Avocado seeds (AvS) were found to attenuate cyclosporine A (CsA)-induced hepatotoxicity in rats by inhibiting oxidative stress and proapoptotic endoplasmic reticulum (ER) stress.
Article
Pharmacology & Pharmacy
Alaa Elmetwalli, Shimaa Mustafa Hashish, Mervat G. G. Hassan, Mohammed Abu El-Magd, Sabry Ali El-Naggar, Amina M. M. Tolba, Afrah Fatthi Salama
Summary: To counter the resistance of cancer cells to existing treatments, it is crucial to develop new treatments that target different pathways. Many cancer treatments have severe side effects that can be debilitating or life-threatening. Developing drugs that effectively treat cancer while minimizing these risks is essential for improving the quality of life of cancer patients.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Veterinary Sciences
Amira M. Shaban, Mai Raslan, Zeina Walid Sharawi, Mohamed Sayed Abdelhameed, Ola Hammouda, Hossam M. El-Masry, Khaled N. M. Elsayed, Mohammed A. El-Magd
Summary: Camel milk exosomes (CM-EXOs) from camel milk have antimicrobial and anticancer effects, exhibiting bacteriostatic and fungistatic effects on certain bacteria and fungi, while selectively inducing apoptosis in cancer cells but not normal cells. CM-EXOs also promote the production of reactive oxygen species and reduce antioxidant status in cancer cells. Overall, CM-EXOs have significant health-promoting effects.
VETERINARY SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marwa A. Elsied, Zeina W. Sharawi, Hadba Al-Amrah, Rabab A. Hegazy, Amro E. Mohamed, Rasha M. Saleh, Sanad S. El-kholy, Foad A. Farrag, Masoud H. Fayed, Mohammed A. El-Magd
Summary: This study investigated the effects of walnut kernel oil (WKO) and defatted (WKD) extracts on the stemness and senescence of bone marrow-derived mesenchymal stem cells (BM-MSCs). The results showed that WKO and WKD extracts enhanced the stemness of BM-MSCs and reduced senescence markers. These extracts have the potential to improve the therapeutic efficacy of MSCs.
Article
Zoology
Eman M. Abdelhady, Nader Y. Mostafa, Mohammed A. El-Magd, Ghada A. Kirrella
Summary: This study compared the effect of chitosan powder and chitosan nanoparticles on the shelf life of minced meat. The results showed that chitosan nanoparticles exhibited stronger antibacterial and antioxidant properties, effectively extending the shelf life of minced meat.
PAKISTAN JOURNAL OF ZOOLOGY
(2023)
Article
Zoology
Azza M. El-Kattawy, Tarek Abou Zed, Randa Megahed, Mohammed El-Magd
Summary: This study aimed to investigate the mechanism of action of simvastatin as an anti-rheumatoid arthritis drug. The findings suggest that simvastatin can relieve pristane-induced arthritis through immunomodulation, anti-inflammatory, and antioxidant effects, and may have potential for prevention of rheumatoid arthritis.
PAKISTAN JOURNAL OF ZOOLOGY
(2023)
Article
Genetics & Heredity
Dayan Wang, Panjian Lai, Qiaochun Lu, Mohammed A. El-Magd, Xiaobing Li
Summary: The c.1431C > T mutation in the ITGB3 gene causes three different alternative splicing patterns, which do not affect mRNA levels but directly lead to protein truncation and decreased expression. This mutation could be considered a pathogenic variant of Glanzmann's thrombasthenia.
