Perfluorocarbons-Based 19F Magnetic Resonance Imaging in Biomedicine

Simultaneous Assessment of Cardiac Inflammation and Extracellular Matrix Remodeling After Myocardial Infarction

(2019) Isabel T. Ramos et al.   Circulation-Cardiovascular Imaging

Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement

(2019) Henryk M. Faas et al.   Contrast Media & Molecular Imaging

Multicore Liquid Perfluorocarbon-Loaded Multimodal Nanoparticles for Stable Ultrasound and 19 F MRI Applied to In Vivo Cell Tracking

(2019) Olga Koshkina et al.   ADVANCED FUNCTIONAL MATERIALS

Fluorinated Glycopolymers as Reduction-responsive 19F MRI Agents for Targeted Imaging of Cancer

(2019) Changkui Fu et al.   BIOMACROMOLECULES

19F MRI Nanoprobes for the Turn-On Detection of Phospholipase A2 with a Low Background

(2019) Chang Guo et al.   ANALYTICAL CHEMISTRY

Integrating Fluorinated Polymer and Manganese‐Layered Double Hydroxide Nanoparticles as pH‐activated 19 F MRI Agents for Specific and Sensitive Detection of Breast Cancer

(2019) Cheng Zhang et al.   Small

Furin‐Controlled Fe 3 O 4 Nanoparticle Aggregation and 19 F Signal “Turn‐On” for Precise MR Imaging of Tumors

(2019) Zhanling Ding et al.   ADVANCED FUNCTIONAL MATERIALS

An iterative sparse deconvolution method for simultaneous multicolor 19 F‐MRI of multiple contrast agents

(2019) Jasper Schoormans et al.   MAGNETIC RESONANCE IN MEDICINE

Fluorine Meets Amine: Reducing Microenvironment-Induced Amino-Activatable Nanoprobes for 19F-Magnetic Resonance Imaging of Biothiols

(2018) Pingsheng Huang et al.   ACS Applied Materials & Interfaces

In Vivo Tracking and 1H/19F Magnetic Resonance Imaging of Biodegradable Polyhydroxyalkanoate/Polycaprolactone Blend Scaffolds Seeded with Labeled Cardiac Stem Cells

(2018) Christakis Constantinides et al.   ACS Applied Materials & Interfaces

Highly Sensitive Detection of Caspase-3/7 Activity in Living Mice Using Enzyme-Responsive 19F MRI Nanoprobes

(2018) Kazuki Akazawa et al.   BIOCONJUGATE CHEMISTRY

Folate receptor-targeted 19 F MR molecular imaging and proliferation evaluation of lung cancer

(2018) Xiuan Xu et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Targeted delivery of monoclonal antibody conjugated docetaxel loaded PLGA nanoparticles into EGFR overexpressed lung tumour cells

(2018) Jitendrakumar Patel et al.   JOURNAL OF MICROENCAPSULATION

Imaging macrophage distribution and density in mammary tumors and lung metastases using fluorine-19 MRI cell tracking

(2018) Ashley V. Makela et al.   MAGNETIC RESONANCE IN MEDICINE

Fast, quantitative, murine cardiac 19F MRI/MRS of PFCE-labeled progenitor stem cells and macrophages at 9.4T

(2018) Christakis Constantinides et al.   PLoS One

19F-perfluorocarbon-labeled human peripheral blood mononuclear cells can be detected in vivo using clinical MRI parameters in a therapeutic cell setting

(2018) Corby Fink et al.   Scientific Reports

Local Intratracheal Delivery of Perfluorocarbon Nanoparticles to Lung Cancer Demonstrated with Magnetic Resonance Multimodal Imaging

(2018) Lina Wu et al.   Theranostics

Rapid quantification of inflammation in tissue samples using perfluorocarbon emulsion and fluorine-19 nuclear magnetic resonance

(2018) Eric T. Ahrens et al.   BIOTECHNIQUES

A pH-responsive nanoprobe for turn-on 19F-magnetic resonance imaging

(2018) Chang Guo et al.   CHEMICAL COMMUNICATIONS

Endothelial cell mineralocorticoid receptors oppose VEGF-induced gene expression and angiogenesis

(2018) Achim Lother et al.   JOURNAL OF ENDOCRINOLOGY

19F MRI in orthotopic cancer model via intratracheal administration of ανβ3-targeted perfluorocarbon nanoparticles

(2018) Xiuan Xu et al.   Nanomedicine

Improved cellular uptake of perfluorocarbon nanoparticles for in vivo murine cardiac 19F MRS/MRI and temporal tracking of progenitor cells

(2018) Christakis Constantinides et al.   Nanomedicine-Nanotechnology Biology and Medicine

Hypoxia-Responsive 19F MRI Probes with Improved Redox Properties and Biocompatibility

(2017) Da Xie et al.   INORGANIC CHEMISTRY

Folate receptor-targeted ultrasonic PFOB nanoparticles: Synthesis, characterization and application in tumor-targeted imaging

(2017) Keshi Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Advantages and Limitations of Salmon-Gal/Tetrazolium Salt Histochemistry for the Detection of LacZ Reporter Gene Activity in Murine Epithelial Tissue

(2017) Claudia Merkwitz et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Chemical shift encoding (CSE) for sensitive fluorine-19 MRI of perfluorocarbons with complex spectra

(2017) Ruud B. van Heeswijk et al.   MAGNETIC RESONANCE IN MEDICINE

Ultrasound and magnetic resonance molecular imaging of atherosclerotic neovasculature with perfluorocarbon magnetic nanocapsules targeted against vascular endothelial growth factor receptor 2 in rats

(2017) Hua Chen et al.   Molecular Medicine Reports

19F CEST imaging probes for metal ion detection

(2017) Qiaoli Peng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ultrasound molecular imaging with cRGD-PLGA-PFOB nanoparticles for liver fibrosis staging in a rat model

(2017) Jiqing Xuan et al.   Oncotarget

Tracking Perfluorocarbon Nanoemulsion Delivery by 19F MRI for Precise High Intensity Focused Ultrasound Tumor Ablation

(2017) Soo Hyun Shin et al.   Theranostics

Quantifying tumor associated macrophages in breast cancer: a comparison of iron and fluorine-based MRI cell tracking

(2017) Ashley V. Makela et al.   Scientific Reports

Temporal accumulation and localization of isoflurane in the C57BL/6 mouse and assessment of its potential contamination in 19 F MRI with perfluoro-crown-ether-labeled cardiac progenitor cells at 9.4 Tesla

(2016) Christakis Constantinides et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Application of dual 19 F and iron cellular MRI agents to track the infiltration of immune cells to the site of a rejected stem cell transplant

(2016) Jeffrey M. Gaudet et al.   MAGNETIC RESONANCE IN MEDICINE

Characterization of perfluorocarbon relaxation times and their influence on the optimization of fluorine-19 MRI at 3 tesla

(2016) Roberto Colotti et al.   MAGNETIC RESONANCE IN MEDICINE

Theranostic tumor targeted nanoparticles combining drug delivery with dual near infrared and 19 F magnetic resonance imaging modalities

(2016) Hieu Vu-Quang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Paramagnetic fluorinated nanoemulsions for sensitive cellular fluorine-19 magnetic resonance imaging

(2016) Alexander A. Kislukhin et al.   NATURE MATERIALS

Lymph Node Micrometastases and In-Transit Metastases from Melanoma: In Vivo Detection with Multispectral Optoacoustic Imaging in a Mouse Model

(2016) Volker Neuschmelting et al.   RADIOLOGY

Preparation and Characterization of Novel Perfluorooctyl Bromide Nanoparticle as Ultrasound Contrast Agent via Layer-by-Layer Self-Assembly for Folate-Receptor-Mediated Tumor Imaging

(2016) Yue Hu et al.   Biomed Research International

19F-MRI for monitoring human NK cellsin vivo

(2016) Myriam N. Bouchlaka et al.   OncoImmunology

In-Vivo Detection and Tracking of T Cells in Various Organs in a Melanoma Tumor Model by 19F-Fluorine MRS/MRI

(2016) Christine Gonzales et al.   PLoS One

Intracellular Self-Assembly and Disassembly of 19F Nanoparticles Confer Respective “Off” and “On” 19F NMR/MRI Signals for Legumain Activity Detection in Zebrafish

(2015) Yue Yuan et al.   ACS Nano

Targeted tumor theranostics using folate-conjugated and camptothecin-loaded acoustic nanodroplets in a mouse xenograft model

(2015) Wei-Tsung Chen et al.   BIOMATERIALS

Noninvasive Imaging of Early Venous Thrombosis by 19F Magnetic Resonance Imaging With Targeted Perfluorocarbon Nanoemulsions

(2015) S. Temme et al.   CIRCULATION

Antigen-specific T cell therapies for cancer: Figure 1.

(2015) Teresa Manzo et al.   HUMAN MOLECULAR GENETICS

Polymeric micelles and nanoemulsions as tumor-targeted drug carriers: Insight through intravital imaging

(2015) Natalya Rapoport et al.   JOURNAL OF CONTROLLED RELEASE

Synergy between surface and core entrapped metals in a mixed manganese–gadolinium nanocolloid affords safer MR imaging of sparse biomarkers

(2015) Kezheng Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging

(2015) Elizabeth Huynh et al.   Nature Nanotechnology

Eight-channel transceiver RF coil array tailored for1H/19F MR of the human knee and fluorinated drugs at 7.0 T

(2015) Yiyi Ji et al.   NMR IN BIOMEDICINE

Fluorine MR Imaging of Inflammation in Atherosclerotic Plaque in Vivo

(2015) Ruud B. van Heeswijk et al.   RADIOLOGY

Recent Advances in 19 Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions

(2015) Anne H. Schmieder et al.   Engineering

Tracking the Fate of Stem Cell Implants with Fluorine-19 MRI

(2015) Jeffrey M. Gaudet et al.   PLoS One

In Vivo Fate Imaging of Intracerebral Stem Cell Grafts in Mouse Brain

(2015) Annette Tennstaedt et al.   PLoS One

Mapping In Vivo Tumor Oxygenation within Viable Tumor by 19F-MRI and Multispectral Analysis

(2015) Yunzhou Shi et al.   NEOPLASIA

Controlled Intracellular Self-Assembly and Disassembly of 19F Nanoparticles for MR Imaging of Caspase 3/7 in Zebrafish

(2014) Yue Yuan et al.   ACS Nano

Activatable19F MRI Nanoparticle Probes for the Detection of Reducing Environments

(2014) Tatsuya Nakamura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cisplatin–alginate conjugate liposomes for targeted delivery to EGFR-positive ovarian cancer cells

(2014) Yunfei Wang et al.   BIOMATERIALS

19F applications in drug development and imaging – a review

(2014) Dorota Bartusik et al.   BIOMEDICINE & PHARMACOTHERAPY

19F Magnetic Resonance Imaging (MRI): From Design of Materials to Clinical Applications

(2014) Ilaria Tirotta et al.   CHEMICAL REVIEWS

Relaxometric studies of gadolinium-functionalized perfluorocarbon nanoparticles for MR imaging

(2014) Anke de Vries et al.   Contrast Media & Molecular Imaging

In vivo MR detection of fluorine-labeled human MSC using the bSSFP sequence

(2014) Emeline Ribot et al.   International Journal of Nanomedicine

19F spin–lattice relaxation of perfluoropolyethers: Dependence on temperature and magnetic field strength (7.0–14.1T)

(2014) Deepak K. Kadayakkara et al.   JOURNAL OF MAGNETIC RESONANCE

Clinical cell therapy imaging using a perfluorocarbon tracer and fluorine-19 MRI

(2014) Eric T. Ahrens et al.   MAGNETIC RESONANCE IN MEDICINE

Balanced UTE-SSFP for19F MR imaging of complex spectra

(2014) Matthew J. Goette et al.   MAGNETIC RESONANCE IN MEDICINE

Hyperpolarized and Inert Gas MRI: The Future

(2014) Marcus J. Couch et al.   MOLECULAR IMAGING AND BIOLOGY

Double-tuned Radiofrequency Coil for 19F and 1H Imaging

(2014) Yosuke OTAKE et al.   Magnetic Resonance in Medical Sciences

Facile Synthesis of Magnetite/Perfluorocarbon Co-Loaded Organic/Inorganic Hybrid Vesicles for Dual-Modality Ultrasound/Magnetic Resonance Imaging and Imaging-Guided High-Intensity Focused Ultrasound Ablation

(2013) Dechao Niu et al.   ADVANCED MATERIALS

Perfluorocarbon Nanoparticles for Physiological and Molecular Imaging and Therapy

(2013) Junjie Chen et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Multi-Chromatic pH-Activatable19F-MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical-Shift Barcodes

(2013) Xiaonan Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterization of early neovascular response to acute lung ischemia using simultaneous 19F/1H MR molecular imaging

(2013) Anne H. Schmieder et al.   ANGIOGENESIS

A multi-modality platform to image stem cell graft survival in the naïve and stroke-damaged mouse brain

(2013) Philipp Boehm-Sturm et al.   BIOMATERIALS

pH-Triggered Au-fluorescent mesoporous silica nanoparticles for19F MR/fluorescent multimodal cancer cellular imaging

(2013) Shizhen Chen et al.   CHEMICAL COMMUNICATIONS

Perfluoropropane Gas as a Magnetic Resonance Lung Imaging Contrast Agent in Humans

(2013) Ahmed F. Halaweish et al.   CHEST

Monitoring of Monocyte Recruitment in Reperfused Myocardial Infarction With Intramyocardial Hemorrhage and Microvascular Obstruction by Combined Fluorine 19 and Proton Cardiac Magnetic Resonance Imaging

(2013) Yu-Xiang Ye et al.   CIRCULATION

Selective In Vivo Visualization of Immune-Cell Infiltration in a Mouse Model of Autoimmune Myocarditis by Fluorine-19 Cardiac Magnetic Resonance

(2013) Ruud B. van Heeswijk et al.   Circulation-Cardiovascular Imaging

RGD decoration of PEGylated polyester nanocapsules of perfluorooctyl bromide for tumor imaging: Influence of pre or post-functionalization on capsule morphology

(2013) Odile Diou et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Optimization of rapid acquisition with relaxation enhancement (RARE) pulse sequence parameters for19F-MRI studies

(2013) Alfonso Mastropietro et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Assessing intrarenal nonperfusion and vascular leakage in acute kidney injury with multinuclear1H/19F MRI and perfluorocarbon nanoparticles

(2013) Lingzhi Hu et al.   MAGNETIC RESONANCE IN MEDICINE

Bimodal Perfluorocarbon Nanoemulsions for Nasopharyngeal Carcinoma Targeting

(2013) Pan Kee Bae et al.   MOLECULAR IMAGING AND BIOLOGY

In vivoMRI cell tracking using perfluorocarbon probes and fluorine-19 detection

(2013) Eric T. Ahrens et al.   NMR IN BIOMEDICINE

Probing different perfluorocarbons forin vivoinflammation imaging by19F MRI: image reconstruction, biological half-lives and sensitivity

(2013) Christoph Jacoby et al.   NMR IN BIOMEDICINE

pH-responsive star polymer nanoparticles: potential 19F MRI contrast agents for tumour-selective imaging

(2013) Kewei Wang et al.   Polymer Chemistry

Molecular MR Imaging of Neovascular Progression in the Vx2 Tumor with αvβ3-Targeted Paramagnetic Nanoparticles

(2013) Anne H. Schmieder et al.   RADIOLOGY

Pulmonary Ultrashort Echo Time19F MR Imaging with Inhaled Fluorinated Gas Mixtures in Healthy Volunteers: Feasibility

(2013) Marcus J. Couch et al.   RADIOLOGY

A novel probe for the non-invasive detection of tumor-associated inflammation

(2013) Anthony Balducci et al.   OncoImmunology

19F molecular MR imaging for detection of brain tumor angiogenesis: in vivo validation using targeted PFOB nanoparticles

(2012) Céline Giraudeau et al.   ANGIOGENESIS

Suppression of inflammation in a mouse model of rheumatoid arthritis using targeted lipase-labile fumagillin prodrug nanoparticles

(2012) Hui-fang Zhou et al.   BIOMATERIALS

Rapid quantification of oxygen tension in blood flow with a fluorine nanoparticle reporter and a novel blood flow-enhanced-saturation-recovery sequence

(2012) Lingzhi Hu et al.   MAGNETIC RESONANCE IN MEDICINE

Fluorine-19 Magnetic Resonance Angiography of the Mouse

(2012) Ruud B. van Heeswijk et al.   PLoS One

Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis

(2012) U. Flogel et al.   Science Translational Medicine

19F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells

(2011) T. Kevin Hitchens et al.   MAGNETIC RESONANCE IN MEDICINE

Simultaneous dual-nuclei imaging for motion corrected detection and quantification of19F imaging agents

(2011) Jochen Keupp et al.   MAGNETIC RESONANCE IN MEDICINE

Quantitative tissue oxygen measurement in multiple organs using 19F MRI in a rat model

(2011) Siyuan Liu et al.   MAGNETIC RESONANCE IN MEDICINE

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Quantifying the Evolution of Vascular Barrier Disruption in Advanced Atherosclerosis with Semipermeant Nanoparticle Contrast Agents

(2011) Huiying Zhang et al.   PLoS One

In Vivo Tracking of Human Neural Stem Cells with 19F Magnetic Resonance Imaging

(2011) Philipp Boehm-Sturm et al.   PLoS One

Theragnostics for tumor and plaque angiogenesis with perfluorocarbon nanoemulsions

(2010) G. M. Lanza et al.   ANGIOGENESIS

Customizable, multi-functional fluorocarbon nanoparticles for quantitative in vivo imaging using 19F MRI and optical imaging

(2010) Mangala Srinivas et al.   BIOMATERIALS

Early Assessment of Pulmonary Inflammation by 19 F MRI In Vivo

(2010) Bernd Ebner et al.   Circulation-Cardiovascular Imaging

Nanomedicine strategies for molecular targets with MRI and optical imaging

(2010) Dipanjan Pan et al.   Future Medicinal Chemistry

Simultaneous Dual Frequency $^{1}{\rm H}$ and $^{19}{\rm F}$ Open Coil Imaging of Arthritic Rabbit Knee at 3T

(2010) Franklin D Hockett et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Variable Antibody-dependent Activation of Complement by Functionalized Phospholipid Nanoparticle Surfaces

(2010) Christine T. N. Pham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo observation of intracellular oximetry in perfluorocarbon-labeled glioma cells and chemotherapeutic response in the CNS using fluorine-19 MRI

(2010) Deepak K. K. Kadayakkara et al.   MAGNETIC RESONANCE IN MEDICINE

Noninvasive mapping of spontaneous fluctuations in tumor oxygenation using F19 MRI

(2010) J. Magat et al.   MEDICAL PHYSICS

Fluorine (19F) MRS and MRI in biomedicine

(2010) Jesús Ruiz-Cabello et al.   NMR IN BIOMEDICINE

Cavitation Properties of Block Copolymer Stabilized Phase-Shift Nanoemulsions Used as Drug Carriers

(2010) Natalya Rapoport et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Quantitative magnetic resonance fluorine imaging: today and tomorrow

(2010) Junjie Chen et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Drug packaging and delivery using perfluorocarbon nanoparticles for targeted inhibition of vascular smooth muscle cells

(2009) Zhao-xiong Zhou et al.   ACTA PHARMACOLOGICA SINICA

Perfluorocarbon Nanoemulsions for Quantitative Molecular Imaging and Targeted Therapeutics

(2009) Megan M. Kaneda et al.   ANNALS OF BIOMEDICAL ENGINEERING

Chemistry, Physical Chemistry, and Uses of Molecular Fluorocarbon−Hydrocarbon Diblocks, Triblocks, and Related CompoundsUnique “Apolar” Components for Self-Assembled Colloid and Interface Engineering

(2009) Marie Pierre Krafft et al.   CHEMICAL REVIEWS

Perfluorocarbon emulsions as a promising technology: a review of tissue and vascular gas dynamics

(2009) Bruce D. Spiess   JOURNAL OF APPLIED PHYSIOLOGY

A Temperature-Sensitive Liposomal1H CEST and19F Contrast Agent for MR Image-Guided Drug Delivery

(2009) Sander Langereis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vivo cytometry of antigen-specific t cells using19F MRI

(2009) Mangala Srinivas et al.   MAGNETIC RESONANCE IN MEDICINE

Anti-angiogenic perfluorocarbon nanoparticles for diagnosis and treatment of atherosclerosis

(2009) Shelton D. Caruthers et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Fluorine-containing nanoemulsions for MRI cell tracking

(2009) Jelena M. Janjic et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

19F- and Fluorescently Labeled Micelles as Nanoscopic Assemblies for Chemotherapeutic Delivery

(2008) Wenjun Du et al.   BIOCONJUGATE CHEMISTRY

Exploiting lipid raft transport with membrane targeted nanoparticles: A strategy for cytosolic drug delivery

(2008) Kathryn C. Partlow et al.   BIOMATERIALS

In Vivo Monitoring of Inflammation After Cardiac and Cerebral Ischemia by Fluorine Magnetic Resonance Imaging

(2008) Ulrich Flögel et al.   CIRCULATION

Minute dosages of ανβ3-targeted fumagillin nanoparticles impair Vx-2 tumor angiogenesis and development in rabbits

(2008) Patrick M. Winter et al.   FASEB JOURNAL

Detection of targeted perfluorocarbon nanoparticle binding using19F diffusion weighted MR spectroscopy

(2008) Emily A. Waters et al.   MAGNETIC RESONANCE IN MEDICINE

In vivo “hot spot” MR imaging of neural stem cells using fluorinated nanoparticles

(2008) Jesús Ruiz-Cabello et al.   MAGNETIC RESONANCE IN MEDICINE

Rapid monitoring of oxygenation by19F magnetic resonance imaging: Simultaneous comparison with fluorescence quenching

(2008) Bénédicte F. Jordan et al.   MAGNETIC RESONANCE IN MEDICINE

NK cells and cancer immunosurveillance

(2008) I Waldhauer et al.   ONCOGENE

Physical principles of quantitative nuclear magnetic resonance oximetry

(2007) Vikram et al.   Frontiers in Bioscience-Landmark