Activation of STAT3 Regulates Reactive Astrogliosis and Neuronal Death Induced by AβO Neurotoxicity

Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer's disease

(2020) Moonseok Choi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

(2019) Nicole Reichenbach et al.   EMBO Molecular Medicine

Pro - and anti-inflammatory cytokines in the CSF of Alzheimer´s disease patients and their correlation with cognitive decline

(2019) R. Taipa et al.   NEUROBIOLOGY OF AGING

Toxic amyloid-β oligomers induced self-replication in astrocytes triggering neuronal injury

(2019) Wei Wang et al.   EBioMedicine

High molecular weight amyloid β1-42 oligomers induce neurotoxicity via plasma membrane damage

(2019) Taro Yasumoto et al.   FASEB JOURNAL

IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer’s disease

(2019) Anna Escrig et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia-Mediated Synapse Loss in Alzheimer's Disease

(2018) Lawrence Rajendran et al.   JOURNAL OF NEUROSCIENCE

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

Time-dependent effect of oligomeric amyloid-β (1–42)-induced hippocampal neurodegeneration in rat model of Alzheimer’s disease

(2018) Chennakesavan Karthick et al.   NEUROLOGICAL RESEARCH

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

(2018) Kelly Ceyzériat et al.   Acta Neuropathologica Communications

Chemokine CCL2–CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus

(2017) Dai-Shi Tian et al.   JOURNAL OF NEUROSCIENCE

Studies for Improving a Rat Model of Alzheimer’s Disease: Icv Administration of Well-Characterized β-Amyloid 1-42 Oligomers Induce Dysfunction in Spatial Memory

(2017) Ágnes Kasza et al.   MOLECULES

Alzheimer's disease as oligomeropathy

(2017) Kenjiro Ono   NEUROCHEMISTRY INTERNATIONAL

Wnt Signaling Prevents the Aβ Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons

(2017) Macarena S. Arrázola et al.   PLoS One

The role of interleukin-6 signaling in nervous tissue

(2016) Michelle Rothaug et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Hyperactivated Stat3 boosts axon regeneration in the CNS

(2016) Saloni T. Mehta et al.   EXPERIMENTAL NEUROLOGY

Balancing the immune response in the brain: IL-10 and its regulation

(2016) Diogo Lobo-Silva et al.   Journal of Neuroinflammation

Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments

(2016) Montserrat Serra-Batiste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippocampal Injections of Oligomeric Amyloid β-peptide (1–42) Induce Selective Working Memory Deficits and Long-lasting Alterations of ERK Signaling Pathway

(2016) Pierre Faucher et al.   Frontiers in Aging Neuroscience

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

(2016) Urmi Sengupta et al.   EBioMedicine

Bioanalytical chemistry of cytokines – A review

(2015) Julie A. Stenken et al.   ANALYTICA CHIMICA ACTA

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

(2015) Myles R. Minter et al.   JOURNAL OF NEUROCHEMISTRY

Ultrastructural changes to rat hippocampus in pentylenetetrazol- and kainic acid-induced status epilepticus: A study using electron microscopy

(2015) Mzia G. Zhvania et al.   MICRON

Acetylation and phosphorylation of STAT3 are involved in the responsiveness of microglia to beta amyloid

(2015) Margherita Eufemi et al.   NEUROCHEMISTRY INTERNATIONAL

Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

(2015) Marie-Victoire Guillot-Sestier et al.   NEURON

IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior

(2015) Paramita Chakrabarty et al.   NEURON

SDS-PAGE analysis of Aβ oligomers is disserving research into Alzheimer´s disease: appealing for ESI-IM-MS

(2015) Rosa Pujol-Pina et al.   Scientific Reports

Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons

(2015) Tomohiro Umeda et al.   Acta Neuropathologica Communications

Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage

(2014) Priyanka Narayan et al.   BIOCHEMISTRY

Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra

(2014) Rasajna Nadella et al.   Journal of Neuroinflammation

Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates

(2014) Leticia Forny-Germano et al.   JOURNAL OF NEUROSCIENCE

7.0T nuclear magnetic resonance evaluation of the amyloid beta (1-40) animal model of Alzheimer′s disease: comparison of cytology verification

(2014) Yu Ma et al.   Neural Regeneration Research

Early Activation of STAT3 Regulates Reactive Astrogliosis Induced by Diverse Forms of Neurotoxicity

(2014) James P. O'Callaghan et al.   PLoS One

A Novel Role of the STAT3 Pathway in Brain Inflammation-induced Human Neural Progenitor Cell Differentiation

(2013) E. Chen et al.   CURRENT MOLECULAR MEDICINE

Cocultures of GFP+-granule cells with GFP−-pyramidal cells and interneurons for the study of mossy fiber neurotransmission with paired recordings

(2013) Beatriz Osorio et al.   HIPPOCAMPUS

Progress and Developments in Tau Aggregation Inhibitors for Alzheimer Disease

(2013) Bruno Bulic et al.   JOURNAL OF MEDICINAL CHEMISTRY

Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils

(2013) Lei Gu et al.   JOURNAL OF NEUROCHEMISTRY

Sustained Interleukin-1  Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model

(2013) S. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer’s disease

(2013) B Parajuli et al.   Cell Death & Disease

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Neuronal degeneration and gliosis time-course in the mouse hippocampal formation after pilocarpine-induced status epilepticus

(2012) André Luiz do Nascimento et al.   BRAIN RESEARCH

Oligomers of beta-amyloid protein (Aβ1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain

(2012) I. Carrero et al.   EXPERIMENTAL NEUROLOGY

Neurotoxicity and Memory Deficits Induced by Soluble Low-Molecular-Weight Amyloid- 1-42 Oligomers Are Revealed In Vivo by Using a Novel Animal Model

(2012) J. Brouillette et al.   JOURNAL OF NEUROSCIENCE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

The JAK/STAT Pathway Is Involved in Synaptic Plasticity

(2012) Céline S. Nicolas et al.   NEURON

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

(2011) Jie Zhao et al.   Journal of Neuroinflammation

Brain Oligomeric β-Amyloid but Not Total Amyloid Plaque Burden Correlates With Neuronal Loss and Astrocyte Inflammatory Response in Amyloid Precursor Protein/Tau Transgenic Mice

(2011) Bibiana DaRocha-Souto et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

(2011) Xiao-dong Pan et al.   Molecular Neurodegeneration

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

(2011) C J Garwood et al.   Cell Death & Disease

Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors

(2010) Elena Alberdi et al.   CELL CALCIUM

Amyloid oligomers: formation and toxicity of Aβ oligomers

(2010) Masafumi Sakono et al.   FEBS Journal

Interferon-γ Regulates Intestinal Epithelial Homeostasis through Converging β-Catenin Signaling Pathways

(2010) Porfirio Nava et al.   IMMUNITY

Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

(2010) Izumi Maezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Functions of Signal Transducers and Activators of Transcriptions 1 and 3 as Cytokine-Inducible Proteins

(2010) HyeonJoo Cheon et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Interferon-β induces apoptosis in human SH-SY5Y neuroblastoma cells through activation of JAK-STAT signaling and down-regulation of PI3K/Akt pathway

(2010) Simona Dedoni et al.   JOURNAL OF NEUROCHEMISTRY

Tyk2/STAT3 Signaling Mediates  -Amyloid-Induced Neuronal Cell Death: Implications in Alzheimer's Disease

(2010) J. Wan et al.   JOURNAL OF NEUROSCIENCE

Soluble oligomeric forms of beta-amyloid (Aβ) peptide stimulate Aβ production via astrogliosis in the rat brain

(2009) J.L. Perez et al.   EXPERIMENTAL NEUROLOGY

Massive gliosis induced by interleukin-6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition

(2009) Paramita Chakrabarty et al.   FASEB JOURNAL

Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia

(2009) Cindy M Sondag et al.   Journal of Neuroinflammation

TTC, Fluoro-Jade B and NeuN staining confirm evolving phases of infarction induced by middle cerebral artery occlusion

(2009) Fudong Liu et al.   JOURNAL OF NEUROSCIENCE METHODS

Structure-neurotoxicity relationships of amyloid  -protein oligomers

(2009) K. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomer-specific Aβ toxicity in cell models is mediated by selective uptake

(2008) Sidhartha M. Chafekar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE