Chymase as a Possible Therapeutic Target for Amelioration of Non-Alcoholic Steatohepatitis

Effects of the chymase inhibitor fulacimstat on adverse cardiac remodeling after acute myocardial infarction – Results of the CHIARA MIA 2 trial

(2020) Hans-Dirk Duengen et al.   AMERICAN HEART JOURNAL

A novel hamster nonalcoholic steatohepatitis model induced by a high-fat and high-cholesterol diet

(2018) Yuta Miyaoka et al.   EXPERIMENTAL ANIMALS

Hepatic mast cell concentration directly correlates to stage of fibrosis in NASH

(2018) Jamie Lombardo et al.   HUMAN PATHOLOGY

Chymase inhibitor prevents the development and progression of non-alcoholic steatohepatitis in rats fed a high-fat and high-cholesterol diet

(2017) Yuta Miyaoka et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Improvement of cardiovascular remodelling by chymase inhibitor

(2016) Shinji Takai et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Chymase inhibition protects diabetic rats from renal lesions

(2016) MEI ZHANG et al.   Molecular Medicine Reports

Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats

(2014) Shinji Takai et al.   JOURNAL OF HYPERTENSION

Chymase Inhibition Attenuates Lipopolysaccharide/ D-Galactosamine-Induced Acute Liver Failure in Hamsters

(2014) Yoshiro Imai et al.   PHARMACOLOGY

Neutrophil-Derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection

(2012) Tomohiro Kurihara et al.   CIRCULATION

Chymase inhibitor ameliorates hepatic steatosis and fibrosis on established non-alcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet

(2012) Shinsuke Masubuchi et al.   HEPATOLOGY RESEARCH

Multiple Mechanisms for the Action of Chymase Inhibitors

(2012) Shinji Takai et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Chymase inhibition prevents myocardial fibrosis through the attenuation of NOX4-associated oxidative stress in diabetic hamsters

(2012) Yasutaka Maeda et al.   Journal of Diabetes Investigation

Doxycycline, a matrix metalloprotease inhibitor, reduces vascular remodeling and damage after cerebral ischemia in stroke-prone spontaneously hypertensive rats

(2011) Paulo W. Pires et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Consistent Alterations of Circulating Matrix Metalloproteinases Levels in Untreated Hypertensives and in Spontaneously Hypertensive Rats: A Relevant Pharmacological Target

(2011) Vanessa Fontana et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Angiotensin II induces NF-κB, JNK and p38 MAPK activation in monocytic cells and increases matrix metalloproteinase-9 expression in a PKC- andRho kinase-dependent manner

(2011) H. Yaghooti et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Blood Glucose Level and Survival in Streptozotocin-Treated Human Chymase Transgenic Mice

(2011) Kazi Rafiq   CHINESE JOURNAL OF PHYSIOLOGY

The role of thiazolidinediones in non-alcoholic steatohepatitis – A systematic review and meta analysis

(2011) Suzanne E. Mahady et al.   JOURNAL OF HEPATOLOGY

Detection of chymase-digested C-terminally truncated apolipoprotein A-I in normal human serum

(2011) Yoko Usami et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis

(2010) Dina G. Tiniakos et al.   Annual Review of Pathology-Mechanisms of Disease

Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE−/− mice

(2010) Ilze Bot et al.   CARDIOVASCULAR RESEARCH

The fatty acid composition of plasma cholesteryl esters and estimated desaturase activities in patients with nonalcoholic fatty liver disease and the effect of long-term ezetimibe therapy on these levels

(2010) Hyohun Park et al.   CLINICA CHIMICA ACTA

The specific chymase inhibitor TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice

(2010) Hazuki Takato et al.   EXPERIMENTAL LUNG RESEARCH

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet

(2010) Keitaro Tashiro et al.   HEPATOLOGY RESEARCH

Prevalence, gender, ethnic variations, and prognosis of NASH

(2010) Etsuko Hashimoto et al.   JOURNAL OF GASTROENTEROLOGY

Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure

(2010) Chunli Yan et al.   LIVER INTERNATIONAL

Deletion of angiotensin II type I receptor reduces hepatic steatosis

(2009) Yoshitaka Nabeshima et al.   JOURNAL OF HEPATOLOGY

Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells

(2009) Eduardo L.M. Guimarães et al.   JOURNAL OF HEPATOLOGY

Chymase Inhibition Provides Pancreatic Islet Protection in Hamsters With Streptozotocin-Induced Diabetes

(2009) Shinji Takai et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Significance of Chymase-Dependent Matrix Metalloproteinase-9 Activation on Indomethacin-Induced Small Intestinal Damages in Rats

(2009) K. Kakimoto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis

(2009) Eugen Florin Georgescu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Administration of angiotensin II, but not catecholamines, induces accumulation of lipids in the rat heart

(2008) Makiko Hongo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis

(2008) Masafumi Uno et al.   HEPATOLOGY

Mechanisms of Arterial Remodeling in Hypertension

(2008) Jay D. Humphrey   HYPERTENSION

Chymase activates promatrix metalloproteinase-9 in human abdominal aortic aneurysm

(2007) Keiichi Furubayashi et al.   CLINICA CHIMICA ACTA

Significance of chymase-dependent angiotensin II formation in the progression of human liver fibrosis

(2007) Koji Komeda et al.   HEPATOLOGY RESEARCH