Review
Oncology
Nayden G. Naydenov, Susana Lechuga, Emina H. Huang, Andrei I. Ivanov
Summary: Colorectal cancer (CRC) is a deadly disease that often presents at an advanced stage, with few interventions available. Myosins, a family of actin motor proteins, play crucial roles in regulating cell proliferation, differentiation, and motility. Altered expression or mutations of myosins have been documented in CRC, but their specific roles in cancer development remain poorly understood.
Review
Medicine, Research & Experimental
Milad Moloudizargari, Fatemeh Moradkhani, Shirin Hekmatirad, Marjan Fallah, Mohammad Hossein Asghari, Russel J. Reiter
Summary: Melatonin's biological functions extend beyond regulating circadian rhythm and include potential anticancer effects. It shares common mechanisms with existing anticancer agents, targeting major intracellular pathways and regulators to mitigate tumor growth and invasiveness. Melatonin also induces epigenetic modifications and DNA damage in malignant cells, highlighting its therapeutic potential in cancer therapy.
Article
Oncology
Shengjie Tang, Shuangjiang Li, Tao Liu, Yiwei He, Haiyang Hu, Yunhe Zhu, Shoujun Tang, Haining Zhou
Summary: MicroRNAs play pivotal roles in lung cancer development and progression, serving as potential biomarkers and therapeutic targets. Research has revealed the importance of microRNAs in regulating lung cancer cell growth, spread, and metastasis.
Article
Chemistry, Physical
Binbin Chu, Xuan Qin, Qianqian Zhu, Houyu Wang, Zhen Wen, Xuhui Sun, Yao He, Shuit-Tong Lee
Summary: This study presents a novel electrotherapeutic strategy using triboelectric nanogenerators (TENG) to suppress cancer cell migration in vitro and alleviate early tumor metastasis in vivo. The TENG stimulation with an output current of 150 μA can effectively destroy the cellular cytoskeleton and inhibit cancer cell migration. In mouse models, TENG-based treatments with the current of 150 μA prevent cancer cell spreading to other body sites without apparent toxicity to normal organs and tissues.
Review
Oncology
Arpita Datta, Shuo Deng, Vennila Gopal, Kenneth Chun-Hong Yap, Clarissa Esmeralda Halim, Mun Leng Lye, Mei Shan Ong, Tuan Zea Tan, Gautam Sethi, Shing Chuan Hooi, Alan Prem Kumar, Celestial T. Yap
Summary: The cellular process of EMT is a critical mechanism in cancer metastasis, involving reorganization of the cytoskeleton composed of actin filaments, microtubules, and intermediate filaments. Understanding the physiological functions of the cytoskeleton and targeting key components for EMT regulation may offer promising approaches for cancer therapy, particularly in tackling multidrug-resistant cancer cells.
Review
Pharmacology & Pharmacy
Wojciech Koch, Anna Wawruszak, Wirginia Kukula-Koch, Magdalena Zdzieblo, Pawel Helon, Zainab M. Almarhoon, Basem Al-Omari, Daniela Calina, Javad Sharifi-Rad
Summary: Crocetin, a natural product derived from certain plants, shows promising anti-cancer properties. It inhibits tumor cell proliferation, induces apoptosis, suppresses angiogenesis, and enhances chemotherapy. Crocetin modulates multiple cellular and molecular pathways to exert its anti-cancer effects.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Maryne Dupuy, Maxime Gueguinou, Marie Potier-Cartereau, Frederic Lezot, Marion Papin, Aurelie Chantome, Francoise Redini, Christophe Vandier, Franck Verrecchia
Summary: Ion channels play a crucial role in tumor development, with aberrant expression promoting key functions like cell proliferation, resistance to apoptosis, angiogenesis, invasion, and metastasis. Potassium channels are the largest and most diverse family among all ion channels, and this review provides an overview of their role in cancer, including their nomenclature, structure, and their involvement in the control of biological functions that promote tumor development. Additionally, it also focuses on the role of two specific classes of potassium channels, SKCa and Kv1, in cancer progression.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Immunology
Ali Hazrati, Kosar Malekpour, Zahra Mirsanei, Arezou Khosrojerdi, Nasim Rahmani-Kukia, Neda Heidari, Ardeshir Abbasi, Sara Soudi
Summary: Cancer-associated mesenchymal stem/stromal cells (CA-MSCs) play a crucial role in tumor growth, immune evasion, metastasis, drug resistance, and angiogenesis by interacting with tumor and non-tumor cells in the tumor microenvironment. These cells affect the function of tumor cells and non-tumor cells through the production of cytokines, chemokines, and growth factors. Understanding these interactions is essential for targeted tumor therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Jingdian Liu, Kai Zhao, Sisi Wu, Chaoxi Li, Chao You, Junwen Wang, Kai Shu, Ting Lei
Summary: As an adaptor protein, PDCD10 is involved in regulating diverse biological processes and has a dual role in cancers, either promoting or inhibiting tumor growth depending on cell/tissue specificity and different cellular interactors.
Review
Oncology
Carolyn J. Kravitz, Qin Yan, Don X. Nguyen
Summary: In recent years, it has been discovered that histone and DNA modifying enzymes play a role in different stages of metastasis. Epigenomic alterations can now be measured and detected in human tumors or liquid biopsies. Alterations in the epigenome may cause a loss in lineage integrity, leading to the development of malignant cell clones with a proclivity for relapse. Genetic aberrations acquired during tumor progression or therapeutic response, as well as the evolution of the stroma, can also contribute to these alterations. This review emphasizes the importance of leveraging chromatin and DNA modifying mechanisms as biomarkers and therapeutic targets for metastatic cancers.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Oncology
Alessandra Caligiuri, Stefano Gitto, Giulia Lori, Fabio Marra, Maurizio Parola, Stefania Cannito, Alessandra Gentilini
Summary: Pro-inflammatory cytokines play a key role in the development of liver cancer, with OSM playing a significant role. IL-6 type cytokines operate through the gp130 and JAK/STAT signaling pathways. Although therapeutic approaches for HCC and CCA have been implemented, there are limited treatment options. We discuss the potential of selectively inhibiting OSM-related pathways for the treatment of liver malignancies.
Review
Biochemistry & Molecular Biology
Nayden G. Naydenov, Jennifer E. Koblinski, Andrei I. Ivanov
Summary: The scaffolding protein Anillin interacts with major cytoskeletal structures and plays a key role in regulating cell division and other important activities in non-dividing cells. Its overexpression is associated with poor prognosis in solid cancers, and it is implicated in the regulation of tumor growth and metastasis through both canonical and novel functions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Cell Biology
Md Ataur Rahman, Moon Nyeo Park, Md Hasanur Rahman, Md Mamunur Rashid, Rokibul Islam, Md Jamal Uddin, Md Abdul Hannan, Bonglee Kim
Summary: p53, the key tumor suppressor protein, plays a significant role in regulating various biological processes, including energy metabolism, cell cycle, apoptosis, and more. Autophagy, a crucial cellular process, is involved in maintaining cellular homeostasis. The relationship between p53 and autophagy is complex and not completely understood, as p53 can both inhibit and activate autophagy depending on its cellular localization and mode of action. Understanding the interaction between p53 and autophagy is important for cancer treatment and management.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hsiang-Hao Chuang, Yen-Yi Zhen, Yu-Chen Tsai, Cheng-Hao Chuang, Michael Hsiao, Ming-Shyan Huang, Chih-Jen Yang
Summary: In this review, the authors summarize the mechanisms of FAK-mediated signaling networks during tumor development and the recent progress of FAK-targeted small-molecule compounds for anticancer activity from preclinical and clinical evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Jiaqi Liu, Chi Tim Leung, Luyun Liang, Yuqin Wang, Jian Chen, Keng Po Lai, William Ka Fai Tse
Summary: This review summarizes the current findings of DUBs in the most common cancers worldwide, including liver, breast, prostate, colorectal, pancreatic, and lung cancers, with regards to their roles in proliferation, metastasis, and apoptosis. The review provides an updated overview of the current findings and can serve as a quick guide for researchers in identifying target DUBs in cancer.
Review
Biochemistry & Molecular Biology
Linnea Hojer Wang, Markus Wehland, Petra M. M. Wise, Manfred Infanger, Daniela Grimm, Michael C. C. Kreissl
Summary: This manuscript investigates four tyrosine kinase inhibitors (TKIs), cabozantinib, vandetanib, pralsetinib, and selpercatinib, used for treating advanced and/or metastatic medullary thyroid cancer (MTC). The focus is on treatment-related hypertension, a well-known adverse effect (AE) of these TKIs. While TKI-induced hypertension is rarely a dose-limiting side effect, complications associated with hypertension can increase with longer patient survival without proper medication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Justina Joksiene, Jayashree Sahana, Markus Wehland, Herbert Schulz, Jose Luis Cortes-Sanchez, Judit Prat-Duran, Daniela Grimm, Ulf Simonsen
Summary: A diabetogenic state induced by spaceflight causes stress and health problems in astronauts. Microgravity is a main stressor in space that leads to hyperglycaemia. The molecular pathways and synergistic effects of microgravity and hyperglycaemia are not fully understood.
Editorial Material
Biochemistry & Molecular Biology
Marcus Krueger
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Thomas J. Corydon, Herbert Schulz, Peter Richter, Sebastian M. Strauch, Maik Boehmer, Dario A. Ricciardi, Markus Wehland, Marcus Krueger, Gilmar S. Erzinger, Michael Lebert, Manfred Infanger, Petra M. Wise, Daniela Grimm
Summary: Microgravity has a significant impact on the health of space explorers, affecting cell proliferation, differentiation, and growth. With the planning of deep space exploration and the commercialization of space travel, researchers are focusing on gene regulation in cells and organisms exposed to real and simulated microgravity. Cancer and metastasis research in particular benefit from these findings.
Review
Biochemistry & Molecular Biology
Urjosee Sahana, Markus Wehland, Ulf Simonsen, Herbert Schulz, Daniela Grimm
Summary: Despite recent advances in HF therapy, CV mortality, morbidity, and HFH remain challenges. Vericiguat activates sGC to improve CV function and has shown efficacy in reducing CV death and HFH in HFrEF patients. However, it has no therapeutic effect on HFpEF. Common adverse events of vericiguat include hypotension, syncope, and anemia. Larger studies are needed to investigate the potential effect in HFpEF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Francesca Cialdai, Austin M. Brown, Cory W. Baumann, Debora Angeloni, Sarah Baatout, Alexandra Benchoua, Juergen Bereiter-Hahn, Daniele Bottai, Judith-Irina Buchheim, Marco Calvaruso, Eugenie Carnero-Diaz, Sara Castiglioni, Duccio Cavalieri, Gabriele Ceccarelli, Alexander Chouker, Gianni Ciofani, Giuseppe Coppola, Gabriella Cusella, Andrea Degl'Innocenti, Jean-Francois Desaphy, Jean-Pol Frippiat, Michael Gelinsky, Giada Genchi, Maria Grano, Daniela Grimm, Alain Guignandon, Christiane Hahn, Jason Hatton, Raul Herranz, Christine E. Hellweg, Carlo Saverio Iorio, Thodoris Karapantsios, Jack van Loon, Matteo Lulli, Jeanette Maier, Jos Malda, Emina Mamaca, Lucia Morbidelli, Angelique van Ombergen, Andreas Osterman, Aleksandr Ovsianikov, Francesco Pampaloni, Elizabeth Pavezlorie, Veronica Pereda-Campos, Cyrille Przybyla, Christopher Puhl, Petra Rettberg, Chiara Risaliti, Angela Maria Rizzo, Kate Robson-Brown, Leonardo Rossi, Giorgio Russo, Alessandra Salvetti, Daniela Santucci, Matthias Sperl, Felice Strollo, Kevin Tabury, Sara Tavella, Christiane Thielemann, Ronnie Willaert, Nathaniel J. Szewczyk, Monica Monici
Summary: This white paper presents the indications and recommendations of the SciSpacE Science Community on filling the gaps of knowledge regarding the effects of gravity alterations on animal and human systems at a cellular and tissue level. Despite previous studies, a comprehensive integrated model of the changes occurring at different system and functional levels is still lacking, making it difficult to predict the long-term consequences of human adaptation to the space environment and implement effective medical support plans.
Review
Biochemistry & Molecular Biology
Silvana Miranda, Shannon Marchal, Lina Cumps, Jenne Dierckx, Marcus Kruger, Daniela Grimm, Sarah Baatout, Kevin Tabury, Bjorn Baselet
Summary: The lunar dust problem arose from NASA's Apollo missions in 1969, as exposure to lunar dust became unavoidable. Several astronauts suffered allergy-like symptoms due to lunar dust inhalation. Research into the toxic effects of lunar dust gained significant interest and expanded to include other organ systems. With plans for future moon missions and potentially Mars missions, dust mitigation strategies are crucial for sustainable space exploration.
Meeting Abstract
Dermatology
T. Leibing, C. Manta, J. Krzistetzko, M. Adrian, C. Kirkamm, C. Sticht, S. Tonack, H. Nolte, M. Krueger, S. Offermanns, K. Schledzewski, S. Goerdt, C. Geraud
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Niklas S. Jensen, Markus Wehland, Petra M. Wise, Daniela Grimm
Summary: Hypertension is a major global health burden, with an increasing prevalence due to aging populations and sedentary lifestyles. While there is evidence of the role of vitamin D in regulating blood pressure, its direct antihypertensive effect remains unclear. However, supplementing vitamin D in combination with other antihypertensive agents may have promising results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jayashree Sahana, Jose Luis Cortes-Sanchez, Viviann Sandt, Daniela Melnik, Thomas J. Corydon, Herbert Schulz, Zexi Cai, Katja Evert, Daniela Grimm, Markus Wehland
Summary: This study cultured breast cancer cell lines MCF-7 and MDA-MB-231 under simulated microgravity conditions and investigated the gene expression pattern and cellular signaling pathways involved. The results showed that the engineered three-dimensional multicellular spheroid model can be used to study breast cancer cell behavior and evaluate the efficacy of drugs against breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jose Luis Cortes-Sanchez, Daniela Melnik, Viviann Sandt, Stefan Kahlert, Shannon Marchal, Ian R. D. Johnson, Marco Calvaruso, Christian Liemersdorf, Simon L. Wuest, Daniela Grimm, Marcus Krueger
Summary: In the preparation of space and microgravity experiments, the use of ground-based facilities for initial experiments and feasibility studies is common. One approach to simulate microgravity conditions on Earth is to use a random positioning machine (RPM) as a rotary bioreactor. Combined with a suitable low-mass model system, such as cell cultures, these devices have been shown to produce results similar to those obtained in actual space experiments under real microgravity conditions. The RPM serves as a simulator of microgravity by randomizing the impact of Earth's gravity vector especially for suspended cells, and it also simulates physiological shear forces on the adherent cell layer.
