Design and Validation of Linkers for Site-Specific Preparation of Antibody–Drug Conjugates Carrying Multiple Drug Copies Per Cysteine Conjugation Site

Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions

(2019) D. Travis Gallagher et al.   Pharmaceutics

Tuning the Diels–Alder Reaction for Bioconjugation to Maleimide Drug-Linkers

(2018) Andre H. St. Amant et al.   BIOCONJUGATE CHEMISTRY

Design, Synthesis, and in vitro Evaluation of Multivalent Drug Linkers for High-Drug-Load Antibody-Drug Conjugates

(2018) Bo Chen et al.   ChemMedChem

Efficient Preparation of Site-Specific Antibody–Drug Conjugates Using Cysteine Insertion

(2017) Nazzareno Dimasi et al.   MOLECULAR PHARMACEUTICS

Enzymatic conjugation using branched linkers for constructing homogeneous antibody–drug conjugates with high potency

(2017) Yasuaki Anami et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate

(2017) Sujiet Puthenveetil et al.   PLoS One

Orthogonal Cysteine Protection Enables Homogeneous Multi-Drug Antibody-Drug Conjugates

(2016) Matthew R. Levengood et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural Product Splicing Inhibitors: A New Class of Antibody–Drug Conjugate (ADC) Payloads

(2016) Sujiet Puthenveetil et al.   BIOCONJUGATE CHEMISTRY

Recent Advances in Site Specific Conjugations of Antibody Drug Conjugates (ADCs)

(2016) Wenlong Gao et al.   CURRENT CANCER DRUG TARGETS

Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics

(2016) Pamela Thompson et al.   JOURNAL OF CONTROLLED RELEASE

Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism

(2016) L. Nathan Tumey et al.   ACS Medicinal Chemistry Letters

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

(2015) Oleksandr Koniev et al.   CHEMICAL SOCIETY REVIEWS

Cysteine-Selective Reactions for Antibody Conjugation

(2014) Pedro M. S. D. Cal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering

(2014) Thomas H. Pillow et al.   JOURNAL OF MEDICINAL CHEMISTRY

Site-specific antibody drug conjugates for cancer therapy

(2013) Siler Panowski et al.   mAbs

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY