Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions

Molecular engineering strategies and methods for the expression and purification of IgG1-based bispecific bivalent antibodies

(2018) N. Dimasi et al.   METHODS

Structure of the Fc fragment of the NIST reference antibody RM8671

(2018) D. Travis Gallagher et al.   Acta Crystallographica Section F-Structural Biology Communications

Preclinical assessment of an antibody–PBD conjugate that targets BCMA on multiple myeloma and myeloma progenitor cells

(2018) Krista Kinneer et al.   LEUKEMIA

Efficient Preparation of Site-Specific Antibody–Drug Conjugates Using Cysteine Insertion

(2017) Nazzareno Dimasi et al.   MOLECULAR PHARMACEUTICS

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Modulating IgG effector function by Fc glycan engineering

(2017) Tiezheng Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics

(2016) Pamela Thompson et al.   JOURNAL OF CONTROLLED RELEASE

Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development

(2015) Paresh Agarwal et al.   BIOCONJUGATE CHEMISTRY

Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (T-DM1)

(2014) H. Uppal et al.   CLINICAL CANCER RESEARCH

Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

(2014) Vaheh Oganesyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Influence of Adnectin Binding on the Extracellular Domain of Epidermal Growth Factor Receptor

(2014) Roxana E. Iacob et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Investigating Monoclonal Antibody Aggregation Using a Combination of H/DX-MS and Other Biophysical Measurements

(2013) Roxana E. Iacob et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pepsin Immobilized on High-Strength Hybrid Particles for Continuous Flow Online Digestion at 10 000 psi

(2012) Joomi Ahn et al.   ANALYTICAL CHEMISTRY

Peptide Backbone Sampling Convergence with the Adaptive Biasing Force Algorithm

(2012) Christina E. Faller et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

(2011) Tsunehiro Mizushima et al.   GENES TO CELLS

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Database searching and accounting of multiplexed precursor and product ion spectra from the data independent analysis of simple and complex peptide mixtures

(2009) Guo-Zhong Li et al.   PROTEOMICS

The detection, correlation, and comparison of peptide precursor and product ions from data independent LC-MS with data dependant LC-MS/MS

(2009) Scott J. Geromanos et al.   PROTEOMICS

High-Speed and High-Resolution UPLC Separation at Zero Degrees Celsius

(2008) Thomas E. Wales et al.   ANALYTICAL CHEMISTRY

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY