Article
Immunology
Hao Zhang, Zeyu Wang, Ziyu Dai, Wantao Wu, Hui Cao, Shuyu Li, Nan Zhang, Quan Cheng
Summary: In this study, the infiltration pattern of 65 immune cells was collected and evaluated to construct the Immune Cell Pair (ICP) score, which showed a robust reliability and efficacy in predicting the survival of patients with gliomas, in pan-cancer samples, and six independent cancer types. The ICP score was also correlated with the genomic alteration features in gliomas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Caiyu Guo, Fanye Zeng, Hui Liu, Jianlin Wang, Xue Huang, Judong Luo
Summary: This study established a prognostic model based on eight immune-related genes for predicting the prognosis of esophageal cancer patients.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Yue Zhao, Li Xu, Xinyu Wang, Shuai Niu, Hezhong Chen, ChunGuang Li
Summary: MicroRNAs (miRNAs) and their target genes play a crucial role in tumor progression, especially in esophageal cancer (EC). By analyzing differentially expressed miRNAs and mRNAs, a risk model involving three miRNAs was designed to predict prognosis in EC patients. The target genes of miRNAs were found to be significantly associated with immune infiltration, tumor microenvironment, cancer stemness properties, and tumor mutation burden in EC. Additionally, a pan-cancer analysis revealed that the miRNA target genes affected tumor immunity similarly across different cancers.
MOLECULAR ONCOLOGY
(2021)
Article
Immunology
Shuning Ding, Xi Sun, Li Zhu, Yafen Li, Weiguo Chen, Kunwei Shen
Summary: In this study, a four-gene signature based on immune-related genes was developed for prognostic prediction in breast cancer. The results showed that patients in the low-risk group had significantly better overall survival compared to those in the high-risk group. The immune-related prognostic signature (IRPS) was found to be an independent predictor of patient survival and when combined with clinical factors, showed good predictive performance.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Zhi Zhang, Cheng Chen, Ying Fang, Sheng Li, Xiaohua Wang, Lei Sun, Guoren Zhou, Jinjun Ye
Summary: The study aimed to explore a prognostic model for esophageal cancer based on immune-related genes. A total of 247 upregulated and 56 downregulated IRGs were identified, and a prognostic model with 9 IRGs was developed through multivariate Cox regression analysis. The model was verified as an independent predictor and showed accurate prognostic prediction.
Article
Oncology
Yue Ma, Zhuo Yang, Jing Liu, Danbo Wang
Summary: This study identified molecular targets related to T cell infiltration in cervical cancer and identified CD48 as a key molecule involved in the progression and prognosis of cervical cancer. These findings provide new insights into the development of molecular therapy and immunotherapy against cervical cancer.
Article
Biotechnology & Applied Microbiology
Xiaowei Huang, Chan Chen, Yajing Xu, Lanxiao Shen, Yi Chen, Huafang Su
Summary: The study found that the balance between infiltrating T-cell abundance (ITA) and EMT-related gene expression is crucial for the prognosis of colon cancer patients, and identified seven genes that are statistically related to the prognosis of patients with colon cancer.
Editorial Material
Biochemistry & Molecular Biology
Samuel Chuah, Valerie Chew
Summary: A study identified a 9-ARG signature predictive of survival in uveal melanoma patients, associated with various cancer hallmarks and immune-related pathways. The signature also showed connections to immune cell infiltration and potential implications for future immunotherapy.
BIOSCIENCE REPORTS
(2021)
Article
Immunology
Ke-wei Wang, Mei-dan Wang, Zi-xi Li, Ben-shun Hu, Jun-jie Wu, Zheng-dong Yuan, Xiao-long Wu, Qin-fang Yuan, Feng-lai Yuan
Summary: The study proposes a signature based on genes associated with antigen processing and presentation (APscore) to predict prognosis and response to immune checkpoint inhibitors in advanced gastric cancer. The APscore is found to be an effective predictive biomarker and prognostic biomarker, and is associated with the tumor microenvironment, molecular characteristics, and clinical features. Therefore, the APscore can guide treatment decisions for gastric cancer patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Peicheng Jiang, Feng Yang, Caifeng Zou, Tianyuan Bao, Mengmeng Wu, Dongqin Yang, Shurui Bu
Summary: A prognostic signature of ferroptosis-related genes was identified for pancreatic cancer patients, showing that lower risk scores were associated with better overall survival. The signature also exhibited relevance with immune characteristics, suggesting potential for enhancing personalized immunotherapy efficacy.
Article
Immunology
Jie Wang, Wei Xia, Yujie Huang, Haoran Li, Yuchen Tang, Ye Li, Bin Yi, Zixiang Zhang, Jian Yang, Zhifei Cao, Jian Zhou
Summary: In this study, a novel risk score model and nomogram were constructed for gastric cancer (GC), showing satisfactory predictive performance. The study also confirmed the association between vascular mimicry (VM) and immune infiltration, and identified SERPINF1 and TFPI2 as immunologic and prognostic biomarkers related to VM in GC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Lin Wang, Xueping Li, Lan Zhao, Longyang Jiang, Xinyue Song, Aoshuang Qi, Ting Chen, Mingyi Ju, Baohui Hu, Minjie Wei, Miao He, Lin Zhao
Summary: This study aimed to predict the prognosis of esophageal cancer (ESCA) patients by utilizing a novel prognostic signature based on DNA repair-related genes. The research established a five-gene prognostic model with strong correlation to patient survival and clinical value under different clinical parameters. Additionally, the study found that certain small-molecule drugs could improve patient survival.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Immunology
Qile Dai, Weimiao Wu, Amei Amei, Xiting Yan, Lingeng Lu, Zuoheng Wang
Summary: The study indicates a close association between the abundance of immune cells and survival in breast cancer patients, suggesting the potential for developing cancer immunotherapies targeting tumor-infiltrating immune cells in the future.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Yi Jiang, Zhenhao Zeng, Situ Xiong, Ming Jiang, Gaomin Huang, Chiyu Zhang, Xiaoqing Xi
Summary: The study identified two distinct immune clusters in BLCA patients, characterized by high and low ImmuneScores. CD96 and IBSP were identified as prognostic genes. ImmuneScoreH showed inactivation of innate immune cell chemotaxis, while ImmuneScoreL exhibited low tumor antigen load as a potential immune escape mechanism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Mathematical & Computational Biology
Linlin Tan, Dingzhuo Cheng, Jianbo Wen, Kefeng Huang, Qin Zhang
Summary: The study revealed the correlation between hypoxia and prognosis, as well as immune cell infiltration in patients with esophageal cancer, providing an immunological perspective for the development of personalized therapy.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Rui Su, Lei Dong, Chenying Li, Sigrid Nachtergaele, Mark Wunderlich, Ying Qing, Xiaolan Deng, Yungui Wang, Xiaocheng Weng, Chao Hu, Mengxia Yu, Jennifer Skibbe, Qing Dai, Dongling Zou, Tong Wu, Kangkang Yu, Hengyou Weng, Huilin Huang, Kyle Ferchen, Xi Qin, Bin Zhang, Jun Qi, Atsuo T. Sasaki, David R. Plas, James E. Bradner, Minjie Wei, Guido Marcucci, Xi Jiang, James C. Mulloy, Jie Jin, Chuan He, Jianjun Chen
Article
Cell & Tissue Engineering
Hengyou Weng, Huilin Huang, Huizhe Wu, Xi Qin, Boxuan Simen Zhao, Lei Dong, Hailing Shi, Jennifer Skibbe, Chao Shen, Chao Hu, Yue Sheng, Yungui Wang, Mark Wunderlich, Bin Zhang, Louis C. Dore, Rui Su, Xiaolan Deng, Kyle Ferchen, Chenying Li, Miao Sun, Zhike Lu, Xi Jiang, Guido Marcucci, James C. Mulloy, Jianhua Yang, Zhijian Qian, Minjie Wei, Chuan He, Jianjun Chen
Article
Cell Biology
Huilin Huang, Hengyou Weng, Wenju Sun, Xi Qin, Hailing Shi, Huizhe Wu, Boxuan Simen Zhao, Ana Mesquita, Chang Liu, Celvie L. Yuan, Yueh-Chiang Hu, Stefan Huettelmaier, Jennifer R. Skibbe, Rui Su, Xiaolan Deng, Lei Dong, Miao Sun, Chenying Li, Sigrid Nachtergaele, Yungui Wang, Chao Hu, Kyle Ferchen, Kenneth D. Greis, Xi Jiang, Minjie Wei, Lianghu Qu, Jun-Lin Guan, Chuan He, Jianhua Yang, Jianjun Chen
NATURE CELL BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Huizhe Wu, Wenyan Qin, Senxu Lu, Xiufang Wang, Jing Zhang, Tong Sun, Xiaoyun Hu, Yalun Li, Qiuchen Chen, Yuanhe Wang, Haishan Zhao, Haiyan Piao, Rui Zhang, Minjie Wei
Article
Oncology
Rui Su, Lei Dong, Yangchan Li, Min Gao, Li Han, Mark Wunderlich, Xiaolan Deng, Hongzhi Li, Yue Huang, Lei Gao, Chenying Li, Zhicong Zhao, Sean Robinson, Brandon Tan, Ying Qing, Xi Qin, Emily Prince, Jun Xie, Hanjun Qin, Wei Li, Chao Shen, Jie Sun, Prakash Kulkarni, Hengyou Weng, Huilin Huang, Zhenhua Chen, Bin Zhang, Xiwei Wu, Mark J. Olsen, Markus Muschen, Guido Marcucci, Ravi Salgia, Ling Li, Amir T. Fathi, Zejuan Li, James C. Mulloy, Minjie Wei, David Horne, Jianjun Chen
Review
Medicine, Research & Experimental
Xiaoyu Sun, Xuemei Lv, Yuanyuan Yan, Yanyun Zhao, Rong Ma, Miao He, Minjie Wei
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Oncology
Baohui Hu, Qian Wei, Xueping Li, Mingyi Ju, Lin Wang, Chenyi Zhou, Lianze Chen, Zinan Li, Minjie Wei, Miao He, Lin Zhao
Article
Medicine, Research & Experimental
Bo Li, Mingyan Liu, Yu Wang, Shiqiang Gong, Weifan Yao, Wenshuai Li, Hua Gao, Minjie Wei
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Biochemical Research Methods
Mingyi Ju, Jia Bi, Qian Wei, Longyang Jiang, Qiutong Guan, Ming Zhang, Xinyue Song, Ting Chen, Jingyi Fan, Xiaojuan Li, Minjie Wei, Lin Zhao
Summary: This study conducted a pan-cancer analysis of NLRP3-inflammasome-related genes across 24 human cancers, revealing the potential prognostic and therapeutic value of NLRP3 inflammasome in various cancer types. It was found that NLRP3 inflammasome may influence tumor immunity and serve as a stronger predictor for immune signatures compared to tumor mutation burden and glycolytic activity. The study also highlighted the predictive value of NLRP3 inflammasome for cancer immunotherapy response in diverse cancers.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Oncology
Ming Zhang, Yan Wang, Longyang Jiang, Xinyue Song, Ang Zheng, Hua Gao, Minjie Wei, Lin Zhao
Summary: In summary, CBR3-AS1 plays a critical role in the chemotherapy resistance of breast cancer by mediating the miR-25-3p and MEK4/JNK1 regulatory axes. The potential of CBR3-AS1 as a targetable oncogene and therapeutic biomarker of breast cancer was identified.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Senxu Lu, Li Han, Xiaoyun Hu, Tong Sun, Dongping Xu, Yalun Li, Qiuchen Chen, Weifan Yao, Miao He, Zhenning Wang, Huizhe Wu, Minjie Wei
Summary: This study identified the crosstalk between the m(6)A reader IMP2 and lncRNA ZFAS1, which promotes CRC proliferation and progression through enhanced recruitment of OLA1, ATP hydrolysis, and glycolysis. IMP2 and ZFAS1 are overexpressed in CRC and can serve as independent biomarkers for prognostic prediction. ZFAS1 is stabilized by m(6)A modification and plays a critical role in CRC development.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Qijun Li, Shiqiang Gong, Weifan Yao, Yibin Yu, Chao Liu, Renjun Wang, Hao Pan, Minjie Wei
Summary: The study focused on developing PEG-interpenetrated dual-sensitive hydrogels loaded with nano lipid carriers (NLC) for topical drug administration, with the successful preparation of ALA nano lipid carrier and thorough investigation and verification of its physicochemical properties.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Wensi Liu, Zhaojin Yu, Haichao Tang, Xiangyi Wang, Bing Zhang, Jianhang Zhao, Xinli Liu, Jingdong Zhang, Minjie Wei
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)