The distinct MHC‐unrestricted immunobiology of innate‐like and adaptive‐like human γδ T cell subsets—Nature's CAR‐T cells

Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells

(2020) Marc Rigau et al.   SCIENCE

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

(2020) Jérôme Le Nours et al.   SCIENCE

Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing

(2020) Mohindar M. Karunakaran et al.   IMMUNITY

γδ TCR Recognition of MR1: Adapting to Life on the Flip Side

(2020) Benjamin E. Willcox et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas

(2020) Jay Daniels et al.   Nature Communications

γ9δ2T cell diversity and the receptor interface with tumor cells

(2020) Anna Vyborova et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of a unique γδ T cell subset as a specific marker of CMV infection severity

(2020) Hannah Kaminski et al.   JOURNAL OF INFECTIOUS DISEASES

Fetal public Vγ9Vδ2 T cells expand and gain potent cytotoxic functions early after birth

(2020) Maria Papadopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth

(2020) Sarina Ravens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dynamic COVID-19 immune signature includes associations with poor prognosis

(2020) Adam G. Laing et al.   NATURE MEDICINE

Human γδ T cells recognize CD1b by two distinct mechanisms

(2020) Josephine F. Reijneveld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

γδ TCR ligands: the quest to solve a 500-million-year-old mystery

(2019) Benjamin E. Willcox et al.   NATURE IMMUNOLOGY

Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions

(2019) Maria Gutierrez-Arcelus et al.   Nature Communications

A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation

(2019) Yunyun Yang et al.   IMMUNITY

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

(2019) Toufic Mayassi et al.   CELL

γδ T Cell Update: Adaptate Orchestrators of Immune Surveillance

(2019) Adrian C. Hayday   JOURNAL OF IMMUNOLOGY

Butyrophilin-like 3 Directly Binds a Human Vγ4+ T Cell Receptor Using a Modality Distinct from Clonally-Restricted Antigen

(2019) Carrie R. Willcox et al.   IMMUNITY

An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer

(2019) Yin Wu et al.   Science Translational Medicine

The human fetal thymus generates invariant effector γδ T cells

(2019) Paola Tieppo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of TCR Vδ1+ and Vδ1−Vδ2− γδ T Cells upon Controlled Infection with Plasmodium falciparum in Tanzanian Volunteers

(2019) Tobias Rutishauser et al.   JOURNAL OF IMMUNOLOGY

Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations

(2018) Stuart Hunter et al.   JOURNAL OF HEPATOLOGY

Synthesis and Biological Evaluation of (E)-4-Hydroxy-3-methylbut-2-enyl Phosphate (HMBP) Aryloxy Triester Phosphoramidate Prodrugs as Activators of Vγ9/Vδ2 T-Cell Immune Responses

(2018) Martin S. Davey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology

(2018) Pierre Vantourout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

γδ T cell responses: How many ligands will it take till we know?

(2018) David Vermijlen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Recasting Human Vδ1 Lymphocytes in an Adaptive Role

(2018) Martin S. Davey et al.   TRENDS IN IMMUNOLOGY

The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets

(2018) Martin S. Davey et al.   Nature Communications

Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters

(2018) David A. Rhodes et al.   Frontiers in Immunology

Development and Selection of the Human Vγ9Vδ2+ T-Cell Repertoire

(2018) Carrie R. Willcox et al.   Frontiers in Immunology

Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells

(2018) Lucy C. Garner et al.   Frontiers in Immunology

Vδ2+ T Cells—Two Subsets for the Price of One

(2018) Martin S. Davey et al.   Frontiers in Immunology

The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness

(2018) Daisy Melandri et al.   NATURE IMMUNOLOGY

HCMV-Encoded NK Modulators: Lessons From in vitro and in vivo Genetic Variation

(2018) Mihil Patel et al.   Frontiers in Immunology

Sensing of cell stress by human γδ TCR-dependent recognition of annexin A2

(2017) Romain Marlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on Vγ9Vδ2 T cell activation

(2017) Siyi Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

(2017) Martin S. Davey et al.   Nature Communications

γδ T Cell-Mediated Immunity to Cytomegalovirus Infection

(2017) Camille Khairallah et al.   Frontiers in Immunology

Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers

(2016) Sobhan Roy et al.   JOURNAL OF IMMUNOLOGY

Heterogeneous yet stable Vδ2(+)T-cell profiles define distinct cytotoxic effector potentials in healthy human individuals

(2016) Paul L. Ryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor

(2016) Zsolt Sebestyen et al.   Cell Reports

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

(2015) Jamie Rossjohn et al.   Annual Review of Immunology

Chicago 2014 – 30years of γδ T cells

(2015) Marc Bonneville et al.   CELLULAR IMMUNOLOGY

Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells

(2015) Hong Wang et al.   JOURNAL OF IMMUNOLOGY

Activation of Human γδ T Cells by Cytosolic Interactions of BTN3A1 with Soluble Phosphoantigens and the Cytoskeletal Adaptor Periplakin

(2015) David A. Rhodes et al.   JOURNAL OF IMMUNOLOGY

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

γδ T Cells Confer Protection against Murine Cytomegalovirus (MCMV)

(2015) Camille Khairallah et al.   PLoS Pathogens

Control of Murine Cytomegalovirus Infection by γδ T Cells

(2015) Sabrina Sell et al.   PLoS Pathogens

Synthesis of a Phosphoantigen Prodrug that Potently Activates Vγ9Vδ2 T-Lymphocytes

(2014) Chia-Hung Christine Hsiao et al.   CHEMISTRY & BIOLOGY

Vγ9Vδ2 TCR-activation by phosphorylated antigens requires butyrophilin 3 A1 (BTN3A1) and additional genes on human chromosome 6

(2014) Felipe Riaño et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells

(2014) Andrew Sandstrom et al.   IMMUNITY

CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages

(2014) Joannah R. Fergusson et al.   Cell Reports

Gamma delta T cells recognize haptens and mount a hapten-specific response

(2014) Xun Zeng et al.   eLife

The Vγ9Vδ2 T Cell Antigen Receptor and Butyrophilin-3 A1: Models of Interaction, the Possibility of Co-Evolution, and the Case of Dendritic Epidermal T Cells

(2014) Mohindar M. Karunakaran et al.   Frontiers in Immunology

Clinical evidence implicating gamma-delta T cells in EBV control following cord blood transplantation

(2013) L Farnault et al.   BONE MARROW TRANSPLANTATION

Crystal Structure of Vδ1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human γδ T Cells

(2013) Adrienne M. Luoma et al.   IMMUNITY

Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human V 3 T Cells

(2013) B. A. Mangan et al.   JOURNAL OF IMMUNOLOGY

Proinflammatory V 2+ T Cells Populate the Human Intestinal Mucosa and Enhance IFN-  Production by Colonic    T Cells

(2013) N. E. McCarthy et al.   JOURNAL OF IMMUNOLOGY

CD1d-lipid antigen recognition by the γδ TCR

(2013) Adam P Uldrich et al.   NATURE IMMUNOLOGY

Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells

(2013) Stefano Vavassori et al.   NATURE IMMUNOLOGY

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human    T-cell subset

(2012) C. Harly et al.   BLOOD

γδ T-cell conference 2012: Close encounters for the fifth time

(2012) Bruno Silva-Santos et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

γδ T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 Response

(2012) Xun Zeng et al.   IMMUNITY

Target Specificity of an Autoreactive Pathogenic Human γδ-T Cell Receptor in Myositis

(2012) Jessica Bruder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Dendritic Epidermal    T Cell Ligands Are Rapidly and Locally Expressed by Keratinocytes following Cutaneous Wounding

(2012) H. K. Komori et al.   JOURNAL OF IMMUNOLOGY

Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor

(2012) Carrie R Willcox et al.   NATURE IMMUNOLOGY

Body-barrier surveillance by epidermal γδ TCRs

(2012) Grzegorz Chodaczek et al.   NATURE IMMUNOLOGY

Skint-1 Identifies a Common Molecular Mechanism for the Development of Interferon-γ-Secreting versus Interleukin-17-Secreting γδ T Cells

(2011) Gleb Turchinovich et al.   IMMUNITY

Skint-1 is a highly specific, unique selecting component for epidermal T cells

(2011) S. D. Barbee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human cytomegalovirus elicits fetal γδ T cell responses in utero

(2010) David Vermijlen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

V 2V 2 T Cell Receptor Recognition of Prenyl Pyrophosphates Is Dependent on All CDRs

(2010) H. Wang et al.   JOURNAL OF IMMUNOLOGY

γδ T Cells and the Lymphoid Stress-Surveillance Response

(2009) Adrian C. Hayday   IMMUNITY

A role for human skin–resident T cells in wound healing

(2009) Antoine Toulon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Long-term expansion of effector/memory V 2-    T cells is a specific blood signature of CMV infection

(2008) V. Pitard et al.   BLOOD

Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells

(2008) Lynn M Boyden et al.   NATURE GENETICS

Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis

(2008) Jessica Strid et al.   NATURE IMMUNOLOGY