Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension

Selonsertib for Patients with Bridging Fibrosis or Compensated Cirrhosis Due to NASH: Results from Randomized Ph III STELLAR Trials

(2020) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects

(2020) Cara H. Nelson et al.   CLINICAL PHARMACOKINETICS

Apoptosis signal-regulating kinase 1 activation by Nox1-derived oxidants is required for TNFα receptor endocytosis

(2019) Hyehun Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The cardiomyocyte “redox rheostat”: Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death

(2019) Daniel N. Meijles et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effects of Selonsertib in Patients with Diabetic Kidney Disease

(2019) Glenn M. Chertow et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension

(2018) Grant R. Budas et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Programmed necrosis in cardiomyocytes: mitochondria, death receptors and beyond

(2018) Junxia Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of irradiation and bone marrow transplantation on angiotensin II-induced aortic inflammation in ApoE knockout mice

(2018) Jyoti Patel et al.   ATHEROSCLEROSIS

ASK1 contributes to fibrosis and dysfunction in models of kidney disease

(2018) John T. Liles et al.   JOURNAL OF CLINICAL INVESTIGATION

The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial

(2017) Rohit Loomba et al.   HEPATOLOGY

Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure

(2017) Marion Lanier et al.   ACS Medicinal Chemistry Letters

Heart failure with preserved ejection fraction in hypertension

(2016) Loon Yee Louis Teo et al.   CURRENT OPINION IN CARDIOLOGY

Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-α/ASK1/JNK pathway

(2015) Qing-Qing Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts

(2015) Stephen J. Fuller et al.   CARDIOVASCULAR RESEARCH

Nox and Inflammation in the Vascular Adventitia

(2015) Daniel N. Meijles et al.   HYPERTENSION

Targeting myocardial remodelling to develop novel therapies for heart failure

(2014) Guido Tarone et al.   EUROPEAN JOURNAL OF HEART FAILURE

The Requirement of CD8+ T Cells To Initiate and Augment Acute Cardiac Inflammatory Response to High Blood Pressure

(2014) F. Ma et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Apoptosis Signal–Regulating Kinase 1 Reduces Myocardial Ischemia–Reperfusion Injury in the Mouse

(2013) Stefano Toldo et al.   Journal of the American Heart Association

Novel mechanism of angiotensin II-induced cardiac injury in hypertensive rats: the critical role of ASK1 and VEGF

(2011) Hisato Nako et al.   HYPERTENSION RESEARCH

Activation of ASK1, downstream MAPKK and MAPK isoforms during cardiac ischaemia

(2010) Stephen J. Harding et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitogen-Activated Protein Kinase Signaling in the Heart: Angels Versus Demons in a Heart-Breaking Tale

(2010) Beth A. Rose et al.   PHYSIOLOGICAL REVIEWS

ERK1/2 Signaling Dominates Over RhoA Signaling in Regulating Early Changes in RNA Expression Induced by Endothelin-1 in Neonatal Rat Cardiomyocytes

(2010) Andrew K. Marshall et al.   PLoS One

The roles of ASK family proteins in stress responses and diseases

(2009) Kazuki Hattori et al.   Cell Communication and Signaling

ASK1 Regulates Cardiomyocyte Death but Not Hypertrophy in Transgenic Mice

(2009) Qinghang Liu et al.   CIRCULATION RESEARCH