Mitochondrial Isolevuglandins Contribute to Vascular Oxidative Stress and Mitochondria-Targeted Scavenger of Isolevuglandins Reduces Mitochondrial Dysfunction and Hypertension

Cardiolipin, Perhydroxyl Radicals, and Lipid Peroxidation in Mitochondrial Dysfunctions and Aging

(2020) Alexander V. Panov et al.   Oxidative Medicine and Cellular Longevity

Tobacco Smoking Induces Cardiovascular Mitochondrial Oxidative Stress, Promotes Endothelial Dysfunction and Enhances Hypertension

(2019) Sergey Dikalov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Isolevuglandin scavenger attenuates pressure overload-induced cardiac oxidative stress, cardiac hypertrophy, heart failure and lung remodeling

(2019) Linlin Shang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting of reactive isolevuglandins in mitochondrial dysfunction and inflammation

(2019) Vladimir Mayorov et al.   Redox Biology

Isolevuglandins as mediators of disease and the development of dicarbonyl scavengers as pharmaceutical interventions

(2019) Sean S. Davies et al.   PHARMACOLOGY & THERAPEUTICS

Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

(2019) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice

(2018) Stefano Tarantini et al.   AGING CELL

A novel high-throughput assay for respiration in isolated brain microvessels reveals impaired mitochondrial function in the aged mice

(2018) Venkata N. Sure et al.   GeroScience

Isolevuglandins and cardiovascular disease

(2018) Sean S. Davies et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Oxidative Stress, Inflammation, and Vascular Aging in Hypertension

(2017) Tomasz J. Guzik et al.   HYPERTENSION

Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension

(2017) Robert A. Egnatchik et al.   Pulmonary Circulation

Global Disparities of Hypertension Prevalence and ControlClinical Perspective

(2016) Katherine T. Mills et al.   CIRCULATION

Mitochondrial Cyclophilin D in Vascular Oxidative Stress and HypertensionNovelty and Significance

(2016) Hana A. Itani et al.   HYPERTENSION

Novel targets for mitochondrial medicine

(2016) Wang Wang et al.   Science Translational Medicine

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

(2016) Angela V. Hafner et al.   Aging-US

Accumulation of isolevuglandin-modified protein in normal and fibrotic lung

(2016) Stacey Mont et al.   Scientific Reports

Structural mechanisms of cyclophilin D-dependent control of the mitochondrial permeability transition pore

(2015) Manuel Gutiérrez-Aguilar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Immune activation caused by vascular oxidation promotes fibrosis and hypertension

(2015) Jing Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy

(2015) Nelma Pertega-Gomes et al.   JOURNAL OF PATHOLOGY

Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum

(2015) Margarida Freitas et al.   Journal of Sexual Medicine

Oligoclonal CD8 + T Cells Play a Critical Role in the Development of Hypertension

(2014) Daniel W. Trott et al.   HYPERTENSION

Pathogenesis of Target Organ Damage in Hypertension: Role of Mitochondrial Oxidative Stress

(2014) Speranza Rubattu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DC isoketal-modified proteins activate T cells and promote hypertension

(2014) Annet Kirabo et al.   JOURNAL OF CLINICAL INVESTIGATION

Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress

(2013) Rafal R. Nazarewicz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nox2-Induced Production of Mitochondrial Superoxide in Angiotensin II-Mediated Endothelial Oxidative Stress and Hypertension

(2013) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

Cardiolipin asymmetry, oxidation and signaling

(2013) Valerian E. Kagan et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Physiologic Functions of Cyclophilin D and the Mitochondrial Permeability Transition Pore

(2013) John W. Elrod et al.   CIRCULATION JOURNAL

Sirtuin 3 (SIRT3) Protein Regulates Long-chain Acyl-CoA Dehydrogenase by Deacetylating Conserved Lysines Near the Active Site

(2013) Sivakama S. Bharathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mosaic Theory revisited: common molecular mechanisms coordinating diverse organ and cellular events in hypertension

(2013) David G. Harrison   Journal of the American Society of Hypertension

Lipids of mitochondria

(2013) Susanne E. Horvath et al.   PROGRESS IN LIPID RESEARCH

SIRT3 Reverses Aging-Associated Degeneration

(2013) Katharine Brown et al.   Cell Reports

Mitochondria in Vascular Health and Disease

(2012) Peter Dromparis et al.   Annual Review of Physiology

Acetaminophen inhibits cytochrome c redox cycling induced lipid peroxidation

(2012) Huiyong Yin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1

(2012) Iain Scott et al.   BIOCHEMICAL JOURNAL

Role of the NADPH Oxidases in the Subfornical Organ in Angiotensin II–Induced Hypertension

(2012) Heinrich E. Lob et al.   HYPERTENSION

Mitochondrial sirtuins: regulators of protein acylation and metabolism

(2012) Wenjuan He et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Combination therapy as initial treatment for newly diagnosed hypertension

(2011) James B. Byrd et al.   AMERICAN HEART JOURNAL

Phosphatidylethanolamines Modified by γ-Ketoaldehyde (γKA) Induce Endoplasmic Reticulum Stress and Endothelial Activation

(2011) Lilu Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling

(2010) Anna E. Dikalova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Reactive γ-ketoaldehydes formed via the isoprostane pathway disrupt mitochondrial respiration and calcium homeostasis

(2010) Irina G. Stavrovskaya et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of Scavengers of γ-Ketoaldehydes That Do Not Inhibit Prostaglandin Biosynthesis

(2009) Irene Zagol-Ikapitte et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Redox Signaling, Vascular Function, and Hypertension

(2008) Moo Yeol Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements

(2008) Jacek Zielonka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction

(2007) Abdulrahman K. Doughan et al.   CIRCULATION RESEARCH