Article
Endocrinology & Metabolism
Zhuoyao Mai, Manlin Liu, Ping Pan, Lin Li, Jia Huang, Xiaoli Chen, Dongzi Yang
Summary: This study found that women with PCOS aged 35 years and older had a higher cumulative live birth rate over two years of IVF/ICSI cycles compared with age- and BMI-matched controls. Factors such as the number of transferable embryos and antral follicle counts were significant predictors of cumulative live birth.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Olga Tepla, Zinovij Topurko, Simona Jirsova, Martina Moosova, Eva Fajmonova, Radek Cabela, Katerina Komrskova, Irena Kratochvilova, Jaromir Masata
Summary: The aim of this study was to evaluate the efficiency of using meiotic spindle (MS) visibility and relative position to the polar body (PB) as indicators of oocyte maturation in order to optimize intracytoplasmic sperm injection (ICSI) timing. The visualization of MS influenced the pregnancy rate (PR) for patients over 35 years, but did not affect PR for patients under 35 years. Visualization of MS appears to be a useful parameter for assessment of oocyte maturity and ICSI timing for patients older than 35.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Xue Wang, YaLing Xiao, ZhengYi Sun, JingRan Zhen, Qi Yu
Summary: There is no consensus on the timing intervals within ICSI cycles, leading to inconsistent and contradictory results. Further research is needed to determine the optimal time intervals for better laboratory and reproductive outcomes.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Lee D. Spate, Jie Yin, Lauren Sammel, Randall S. Prather, Bethany K. Redel
Summary: COVID-19 has had a significant impact on abattoirs worldwide, resulting in a critical loss of pig material for research. Commercial sources of pig oocytes are expensive and already operating at maximum capacity. This study presents an alternative source of oocytes that can produce live, healthy piglets.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Article
Reproductive Biology
Brandon A. Wyse, Noga Fuchs Weizman, Janice Montbriand, Rima Kharonsky, Ran Antes, Rina Abramov, Svetlana Madjunkova, Clifford L. Librach
Summary: Different IVF-ICSI workflows have varying effects on patients depending on their primary infertility diagnosis, highlighting the importance of tailoring the workflow to individual patients. This study emphasizes the impact of IVF laboratory procedures on embryo ploidy and the need to track these outcomes in addition to traditional IVF metrics.
JOURNAL OF OVARIAN RESEARCH
(2022)
Review
Medicine, General & Internal
Israel Maldonado Rosas, Christina Anagnostopoulou, Neha Singh, Nivita Gugnani, Keerti Singh, Dimple Desai, Mahsa Darbandi, Madhumita Manoharan, Sara Darbandi, Annapoorani Chockalingam, Sofia I. Leonardi Diaz, Sajal Gupta, Shinnosuke Kuroda, Renata Finelli, Hassan N. Sallam, Kelly A. Wirka, Florence Boitrelle, Ashok Agarwal
Summary: Oocyte retrieval, oocyte denudation, and embryo transfer are crucial steps in assisted reproduction technology (ART), and there are knowledge gaps and controversies surrounding the techniques and processes involved. The aim of this review is to provide an updated overview of these steps and techniques.
Article
Endocrinology & Metabolism
Jing Ling Ruan, Shan Shan Liang, Jia Ping Pan, Zhi Qin Chen, Xiao Ming Teng
Summary: This retrospective study found that artificial oocyte activation (AOA) with calcium ionophore ionomycin can significantly improve the reproductive outcomes of patients with previous fertilization failure and poor embryo development after intracytoplasmic sperm injection (ICSI). AOA can increase fertilization rate, embryo quality, implantation rate, clinical pregnancy rate, and live birth rate, while decreasing miscarriage rate. The study suggests that AOA is an effective and safe treatment option for some infertility patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Adrija Kumar Datta, Stuart Campbell, Nirmal Felix, Jasdev Singh Harbhajan Singh, Geeta Nargund
Summary: For women with uncompromised ovarian reserve undergoing mild stimulation IVF, optimizing live birth rate (LBR) per cycle and cumulative LBR (CLBR) is achieved with 9 oocytes or 4 embryos for fresh transfers, and 12 oocytes or 9 embryos for predicted normal responders, while safeguarding against ovarian hyperstimulation syndrome (OHSS).
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Review
Biology
Woon Shu Yuan, Muhammad Azrai Abu, Mohd Faizal Ahmad, Marjanu Hikmah Elias, Abdul Kadir Abdul Karim
Summary: Despite the inconsistent findings and lack of rigorous trials, our review found that DHEA supplementation can have beneficial effects on ovarian cumulus cells in improving oocyte quality for women of advanced age or with poor ovarian responders. However, there is no significant difference in stimulation and pregnancy outcomes between the DHEA supplementation group and the control group.
Review
Cell Biology
Bongkoch Turathum, Er-Meng Gao, Ri-Cheng Chian
Summary: Cumulus cells play a vital role in supporting oocyte growth, maturation, and developmental competence. Their function is essential for oocyte meiotic maturation, ovulation, fertilization, and early embryo development. Understanding the role of cumulus cells is crucial for predicting oocyte quality, embryonic development competence, and pregnancy outcomes in reproductive medicine and infertility treatment.
Review
Obstetrics & Gynecology
James M. Kemper, Yanhe Liu, Masoud Afnan, Ben W. J. Mol, Dean E. Morbeck
Summary: There is a lack of evidence on embryos derived from oocytes without two pronuclei (2PN) or 'normal fertilization'. A significant difference exists between the development potential of oocytes with abnormal pronuclei and those with 2PN. Most recent studies focus on outcomes of blastocysts derived from non-2PN oocytes, suggesting that they have lower blastocyst rates and slightly reduced implantation potential compared to 2PN oocytes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Reproductive Biology
Tzung-En Tsai, Pei-Hsuan Lin, Pei-Fen Lian, Chia-Jung Li, Salvatore Giovanni Vitale, Mislav Mikus, Wan-Ping Su, Hsiao-Wen Tsai, Kuan-Hao Tsui, Li-Te Lin
Summary: AOA may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles, especially in women aged >= 40 years old.
JOURNAL OF OVARIAN RESEARCH
(2022)
Review
Cell Biology
Batara Sirait, Budi Wiweko, Ahmad Aulia Jusuf, Dein Iftitah, R. Muharam
Summary: This study examines several biomarkers in the cumulus-oocyte complex for their predictive significance in evaluating oocyte developmental competence and IVF outcomes. While these biomarkers show potential for predicting oocyte competency, challenges limit their practical application in IVF as prognostic tools.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Health Care Sciences & Services
Ioana Zaha, Petronela Naghi, Liana Stefan, Cosmina Bunescu, Mihaela Radu, Mariana Eugenia Muresan, Mircea Sandor, Liliana Sachelarie, Anca Huniadi
Summary: The microfluidic sperm selection method was found to improve the outcomes of in vitro fertilization (IVF) procedures. This method, which selects spermatozoa with the lowest DNA fragmentation rate, resulted in higher blastocyst rates and clinical pregnancy rates. It has the potential to be widely used in intracytoplasmic sperm injection (ICSI) and improve the workflow of standard IVF, reducing intervention by laboratory personnel and providing more consistent incubation conditions.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Endocrinology & Metabolism
Rui Jia, Yuanyuan Liu, Rulan Jiang, Xuli Zhu, Liang Zhou, Peipei Chen, Mingya Cao, Zhiming Zhao
Summary: This study aimed to determine the optimal number of oocytes retrieved for patients with PCOS undergoing IVF to achieve the best CLBR and live birth after fresh embryo transfer. The study found that the number of oocytes retrieved was an independent protective factor for CLBR, with a higher CLBR observed when the number of oocytes retrieved was 15 or more. Patients with 7-16 oocytes retrieved had a greater chance of live birth after fresh embryo transfer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Rita Luz, Joana Barros, Ana Aguiar, Catia Rodrigues, Ana Paula Soares, Joaquim Nunes, Sandra Sousa, Carlos Calhaz-Jorge
ACTA MEDICA PORTUGUESA
(2016)
Article
Obstetrics & Gynecology
Ch. De Geyter, C. Calhaz-Jorge, M. S. Kupka, C. Wyns, E. Mocanu, T. Motrenko, G. Scaravelli, J. Smeenk, S. Vidakovic, V. Goossens
HUMAN REPRODUCTION
(2018)
Article
Medicine, General & Internal
Sara Vargas, Maria Pulido Valente, Margarida Mendes de Almeida, Joaquim Neves, Carlos Calhaz-Jorge
ACTA MEDICA PORTUGUESA
(2019)
Article
Obstetrics & Gynecology
Catarina Reis-de-Carvalho, Jose Monteiro, Carlos Calhaz-Jorge
Summary: This study in a Portuguese tertiary hospital found that over 19 years, only 0.72% of endometrial specimens from infertile women were positive for tuberculosis. Despite Portugal having a high prevalence of tuberculosis, genital TB does not seem to significantly impact the etiology of female infertility in the country.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
C. Wyns, Ch De Geyter, C. Calhaz-Jorge, M. S. Kupka, T. Motrenko, J. Smeenk, C. Bergh, A. Tandler-Schneider, I. A. Rugescu, S. Vidakovic, V Goossens
Summary: The 21st ESHRE report on ART, IUI, and FP interventions in Europe shows a continuous increase in treatment numbers, a slight decrease in multiple delivery rates, higher pregnancy rates and multiple delivery rates after frozen embryo replacement compared to fresh cycles, as well as stable outcomes for IUI cycles. Efforts should be made to optimize data collection and reporting to improve quality control and transparency in the field of reproductive medicine.
HUMAN REPRODUCTION OPEN
(2021)
Article
Obstetrics & Gynecology
Catarina Reis-de-Carvalho, Carolina Vaz-de-Macedo, Santiago Ortiz, Anabela Colaco, Carlos Calhaz-Jorge
Summary: This case report highlights a rare occurrence of malignant mesonephric tumors in the female genital tract, specifically in the cervix. The patient had a successful treatment outcome with no recurrence after a five-year follow-up, demonstrating a favorable prognosis if managed according to guidelines for cervical adenocarcinomas. It is important to consider mesonephric adenocarcinoma as a differential diagnosis for cervical cancers despite its rarity.
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2021)
Article
Obstetrics & Gynecology
C. Wyns, C. Bergh, C. Calhaz-Jorge, Ch De Geyter, M. S. Kupka, T. Motrenko, I Rugescu, J. Smeenk, A. Tandler-Schneider, S. Vidakovic, V Goossens
HUMAN REPRODUCTION OPEN
(2020)
Article
Obstetrics & Gynecology
C. De Geyter, C. Calhaz-Jorge, M. S. Kupka, C. Wyns, E. Mocanu, T. Motrenko, G. Scaravelli, J. Smeenk, S. Vidakovic, V. Goossens
HUMAN REPRODUCTION OPEN
(2020)
Article
Obstetrics & Gynecology
Ch De Geyter, C. Wyns, C. Calhaz-Jorge, J. de Mouzon, A. P. Ferraretti, M. Kupka, A. Nyboe Andersen, K. G. Nygren, V Goossens
HUMAN REPRODUCTION
(2020)
Article
Obstetrics & Gynecology
A. P. Ferraretti, K. Nygren, A. Nyboe Andersen, J. de Mouzon, M. Kupka, C. Calhaz-Jorge, C. Wyns, L. Gianaroli, V Goossens
HUMAN REPRODUCTION OPEN
(2017)
Article
Obstetrics & Gynecology
Ana Catarina Ferreira Policiano, Joao Pedro Mendes Lopes, Sonia Alexandra Martins Barata, Anabela Mendes Colaco, Carlos Calhaz-Jorge
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2016)
Article
Obstetrics & Gynecology
C. Calhaz-Jorge, C. h De Geyter, M. S. Kupka, C. Wyns, E. Mocanu, T. Motrenko, G. Scaravelli, J. Smeenk, S. Vidakovic, V. Goossens
HUMAN REPRODUCTION OPEN
(2020)
Article
Endocrinology & Metabolism
Joana Simoes-Pereira, Joaquim Nunes, Ana Aguiar, Sandra Sousa, Catia Rodrigues, Joaquim Sampaio Matias, Carlos Calhaz-Jorge