Article
Oncology
Brian De, Rituraj Upadhyay, Kaiping Liao, Tiffany Kumala, Christopher Shi, Grace Dodoo, Joseph Abi Jaoude, Kelsey L. Corrigan, Gohar S. Manzar, Kathryn E. Marqueen, Vincent Bernard, Sunyoung S. Lee, Kanwal P. S. Raghav, Jean-Nicolas Vauthey, Ching-Wei Tzeng, Hop Tran S. Cao, Grace Lee, Jennifer Wo, Theodore S. Hong, Christopher H. Crane, Bruce D. Minsky, Grace L. Smith, Emma B. Holliday, Cullen M. Taniguchi, Albert C. Koong, Prajnan Das, Milind Javle, Ethan B. Ludmir, Eugene Koay
Summary: Tumor-related liver failure (TRLF) is the leading cause of death in patients with intrahepatic cholangiocarcinoma (ICC). The role of liver radiotherapy (L-RT) for patients with extrahepatic metastatic disease (M1) remains undefined. This study aimed to compare outcomes for M1 ICC patients treated with and without L-RT.
Article
Medicine, General & Internal
Tim Reese, Gregor Pagel, Bettina A. Bause, York von Rittberg, Kim C. Wagner, Karl J. Oldhafer
Summary: For intrahepatic cholangiocarcinoma (iCCA), complex liver resections are justified in selected patients and survival rates are comparable to conventional liver resections. Survival in iCCA is affected by resection margins and UICC stage, rather than the complexity of the case.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Prakasit Sa-Ngiamwibool, Chaiwat Aphivatanasiri, Sakkarn Sangkhamanon, Piyapharom Intarawichian, Waritta Kunprom, Malinee Thanee, Piya Prajumwongs, Watcharin Loilome, Narong Khuntikeo, Attapol Titapun, Apiwat Jareanrat, Vasin Thanasukarn, Tharatip Srisuk, Vor Luvira, Kulyada Eurboonyanun, Julaluck Promsom, Aileen Wee, Supinda Koonmee
Summary: This study aimed to improve prognostic prediction and patient stratification for iCCA by creating the KKU staging system. The incorporation of growth patterns as independent prognostic factors and modification of AJCC stages in the KKU staging system resulted in better prediction of patient survival. The KKU staging system may serve as an alternative model for iCCA staging to enhance the accuracy of survival prognostication.
Article
Oncology
Chongyu Zhao, Xiyuan Li, Li Luo, Cheng Chen, Chaobin He
Summary: This study aimed to explore the optimal positive lymph node cutoff value for predicting survival outcomes in patients with iCCA and establish a prognostic nomogram. The results showed that patients with 1-3 positive lymph nodes had significantly better overall survival compared to those with more than 4 positive lymph nodes. This study provides new evidence for more precise post-operative management of iCCA patients.
CANCER CELL INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Gonzalo Sapisochin, Tommy Ivanics, Julie Heimbach
Summary: Cholangiocarcinoma is the second-most common primary liver malignancy. Liver transplantation can be considered for intrahepatic and extrahepatic cholangiocarcinoma in select patients based on disease stage and patient characteristics.
Article
Oncology
Tiemo S. Gerber, Benjamin Goeppert, Anne Hausen, Hagen R. Witzel, Fabian Bartsch, Mario Schindeldecker, Lisa-Katharina Groeger, Dirk A. Ridder, Oscar Cahyadi, Irene Esposito, Matthias M. Gaida, Peter Schirmacher, Peter R. Galle, Hauke Lang, Wilfried Roth, Beate K. Straub
Summary: This study focuses on the differential expression and localization of cell-cell contact proteins E-cadherin and N-cadherin in primary liver cancer and liver metastases of ductal adenocarcinoma of the pancreas. The study demonstrates that N-cadherin positivity can distinguish intrahepatic cholangiocarcinoma from liver metastases of ductal adenocarcinoma of the pancreas, improving the accuracy of the diagnosis. The findings suggest that N-cadherin can be a helpful marker for differential diagnosis between these two types of cancers.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ying Xu, Feng Ye, Lu Li, Yi Yang, Jingzhong Ouyang, Yanzhao Zhou, Sicong Wang, Lizhi Xie, Jinxue Zhou, Hong Zhao, Xinming Zhao
Summary: This study aimed to establish a radiomics nomogram using multiparameter magnetic resonance imaging to differentiate intrahepatic mass-forming cholangiocarcinoma (IMCC) from colorectal cancer liver metastasis (CRLM) preoperatively. Radiomics features were extracted and selected to construct a radiomics model. The radiomics nomogram showed superior discrimination performance in both the training and external validation cohorts.
ACADEMIC RADIOLOGY
(2023)
Article
Oncology
Hisashi Kosaka, Masaki Ueno, Koji Komeda, Daisuke Hokuto, Hiroya Iida, Fumitoshi Hirokawa, Kosuke Matsui, Mitsugu Sekimoto, Masaki Kaibori
Summary: In this study, a new preoperative staging system (PRE-Stage) for patients with intrahepatic cholangiocarcinoma (ICC) was established using preoperative findings. The PRE-Stage, which includes a CRP-albumin-lymphocyte index < 3, central tumor location, and CA19-9 level > 40 U/mL, was able to predict disease-specific survival (DSS) and disease-free survival (DFS) significantly when patients were stratified into four stages. This PRE-Stage demonstrated similar accuracy in predicting the prognosis of ICC as the Liver Cancer Study Group of Japan (LCSGJ) stage based on postoperative findings.
Review
Surgery
Ali Ramouz, Sadeq Ali-Hasan-Al-Saegh, Saeed Shafiei, Sanam Fakour, Elias Khajeh, Ali Majlesara, Ali Adeliansedehi, Pascal Probst, Christoph Springfeld, De-Hua Chang, Christian Rupp, Carlos Carvalho, Mohammad Golriz, Katrin Hoffmann, Arianeb Mehrabi
Summary: Repeat liver resection is a suitable strategy for the treatment of recurrent intrahepatic cholangiocarcinoma, improving short- and long-term outcomes compared to non-surgical approaches.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Chaiwat Aphivatanasiri, Prakasit Sa-Ngiamwibool, Sakkarn Sangkhamanon, Piyapharom Intarawichian, Waritta Kunprom, Malinee Thanee, Piya Prajumwongs, Narong Khuntikeo, Attapol Titapun, Apiwat Jareanrat, Vasin Thanasukarn, Tharatip Srisuk, Vor Luvira, Kulyada Eurboonyanun, Julaluck Promsorn, Watcharin Loilome, Aileen Wee, Supinda Koonmee
Summary: This study aims to improve the classification performance of the eighth American Joint Committee on Cancer (AJCC) staging system for perihilar cholangiocarcinoma (pCCA) by proposing the Khon Kaen University (KKU) staging system developed in cholangiocarcinoma-prevalent Northeast Thailand. The results show that the new KKU staging system is able to better classify and predict the prognosis of pCCA patients, improving the accuracy of classification and survival prognosis.
FRONTIERS IN MEDICINE
(2022)
Article
Surgery
Preston Kim, Michael Littau, Talia B. Baker, Zaid Abdelsattar, Celsa Tonelli, Corinne Bunn, Sujay Kulshrestha, Fred A. Luchette, Marshall S. Baker
Summary: This study found that patients undergoing liver transplantation for intrahepatic cholangiocarcinoma demonstrate overall survival profiles similar to those undergoing surgical resection, and significantly better than patients treated with systemic therapy alone. Liver transplantation is an effective treatment modality in select patients presenting with localized intrahepatic cholangiocarcinoma.
Article
Gastroenterology & Hepatology
Xu-Feng Zhang, Feng Xue, Jin He, Sorin Alexandrescu, Hugo P. Marques, Luca Aldrighetti, Shishir K. Maithel, Carlo Pulitano, Todd W. Bauer, Feng Shen, George A. Poultsides, Oliver Soubrane, Guillaume Martel, Bas G. Koerkamp, Endo Itaru, Yi Lv, Timothy M. Pawlik
Summary: The study proposed a modified TNM staging system for intrahepatic cholangiocarcinoma, which demonstrated improved stratification of patients based on long-term survival compared to the 8th AJCC staging system. The new mTNM system showed a monotonic decrement in survival and provided better analysis of patient outcomes.
Article
Gastroenterology & Hepatology
Laurence P. Diggs, Alexander M. Fagenson, Vijay Putatunda, Kwan Nang Lau, Miral S. Grandhi, Henry A. Pitt
Summary: Hepatectomy for ICC is associated with worse postoperative outcomes compared to CRLM and HCC, with higher mortality and morbidity rates.
Article
Multidisciplinary Sciences
Gaobo Huang, Weilun Song, Yanchao Zhang, Jiawei Yu, Yi Lv, Kang Liu
Summary: This study investigated the role of liver transplantation (LT) in patients with intrahepatic cholangiocarcinoma (ICC) compared to liver resection (LR) in ICC patients and LT in hepatocellular carcinoma (HCC) patients. The results showed that the prognosis of ICC patients after LT was better than after LR, but still worse than HCC patients after LT.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Sung Hyun Kim, Dai Hoon Han, Gi Hong Choi, Jin Sub Choi, Kyung Sik Kim
Summary: For patients with intrahepatic cholangiocarcinoma (ICC), it is recommended to perform lymph node dissection (LND) including at least stations no. 12 (hepatoduodenal ligament) and 8 (common hepatic artery) for accurate staging. In lymph node-negative group, LND covering stations no. 8+12 appears to improve disease-free survival (DFS) and overall survival (OS) outcomes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Alberto Martin, Carolina Epifano, Borja Vilaplana-Marti, Ivan Hernandez, Rocio I. R. Macias, Angel Martinez-Ramirez, Ana Cerezo, Pablo Cabezas-Sainz, Maria Garranzo-Asensio, Sandra Amarilla-Quintana, Deborah Gomez-Dominguez, Eduardo Caleiras, Jordi Camps, Gonzalo Gomez-Lopez, Marta Gomez de Cedron, Ana Ramirez de Molina, Rodrigo Barderas, Laura Sanchez, Susana Velasco-Miguel, Ignacio Perez de Castro
Summary: Despite being frequently observed in cancer cells, chromosomal instability (CIN) and aneuploidy have adverse effects on cellular homeostasis. Epitranscriptomic marks catalyzed by RNA-modifying enzymes change under stress, but their association with aneuploidy is still unknown. TRMT61B, a mitochondrial RNA methyltransferase enzyme, is found to be associated with high levels of aneuploidy in cancer cells. Depletion of TRMT61B induces senescence in cells with low aneuploidy, and apoptosis in cells with high aneuploidy. These findings suggest TRMT61B as a potential biomarker for targeting highly aneuploid tumors.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Gastroenterology & Hepatology
Stephan Buch, Hamish Innes, Philipp Ludwig Lutz, Hans Dieter Nischalke, Jens U. Marquardt, Janett Fischer, Karl Heinz Weiss, Jonas Rosendahl, Astrid Marot, Marcin Krawczyk, Markus Casper, Frank Lammert, Florian Eyer, Arndt Vogel, Silke Marhenke, Johann von Felden, Rohini Sharma, Stephen Rahul Atkinson, Andrew McQuillin, Jacob Nattermann, Clemens Schafmayer, Andre Franke, Christian Strassburg, Marcella Rietschel, Heidi Altmann, Stefan Sulk, Veera Raghavan Thangapandi, Mario Brosch, Carolin Lackner, Rudolf E. Stauber, Ali Canbay, Alexander Link, Thomas Reiberger, Mattias Mandorfer, Georg Semmler, Bernhard Scheiner, Christian Datz, Stefano Romeo, Stefano Ginanni Corradini, William Lucien Irving, Joanne R. Morling, Indra Neil Guha, Eleanor Barnes, M. Azim Ansari, Jocelyn Quistrebert, Luca Valenti, Sacha A. Mueller, Marsha Yvonne Morgan, Jean-Francois Dufour, Jonel Trebicka, Thomas Berg, Pierre Deltenre, Sebastian Mueller, Jochen Hampe, Felix Stickel
Summary: This study identifies rs2242652 in TERT as a novel protective factor for HCC in patients with alcohol-related cirrhosis.
Article
Gastroenterology & Hepatology
Vincenzo Cardinale, Guido Carpino, Diletta Overi, Samira Safarikia, Wencheng Zhang, Matt Kanke, Antonio Franchitto, Daniele Costantini, Olga Riccioni, Lorenzo Nevi, Michele Chiappetta, Paolo Onori, Matteo Franchitto, Simone Bini, Yu-Han Hung, Quirino Lai, Ilaria Zizzari, Marianna Nuti, Carmine Nicoletti, Saula Checquolo, Laura Di Magno, Maria Valeria Giuli, Massimo Rossi, Praveen Sethupathy, Lola M. Reid, Domenico Alvaro, Eugenio Gaudio
Summary: Stem/progenitor cells with regenerative potential have been identified in the adult human duodenum. These cells can form organoids in vitro and differentiate into mature liver cells in vivo. The duodenal submucosal gland cells could potentially serve as a novel cell source for regenerative medicine of the liver.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Joachim Merters, Angela Lamarca
Summary: Management of biliary tract cancers (BTCs) is evolving rapidly. Chemotherapy with cisplatin and gemcitabine (with durvalumab) followed by second-line FOLFOX is the cornerstone of treatment for advanced BTC. Targeted therapies for specific genetic mutations have brought precision medicine to the forefront, and immunotherapy combined with chemotherapy has shown promising activity. The field is now exploring combination strategies to enhance therapeutic responses. This review focuses on the rationale for these combinations and summarizes current clinical trial data.
JOURNAL OF HEPATOLOGY
(2023)
Review
Cell Biology
Alessandro Gambella, Silvia Kalantari, Massimiliano Cadamuro, Marco Quaglia, Maurizio Delvecchio, Luca Fabris, Michele Pinon
Summary: The hepatocyte nuclear factor 1 beta (HNF1B) gene plays a crucial role in the development of specialized epithelia in various organs during embryogenesis. Pathogenic variants of HNF1B have been associated with a complex syndrome that mainly affects children, leading to diabetes and renal complications. However, recent studies have highlighted the importance of liver involvement, including a potential link to tumor development, expanding the understanding of HNF1B-associated disease. This review aims to provide a comprehensive analysis of the genetic, phenotypic, and clinical features of HNF1B deficiency in both pediatric and adult populations.
Article
Nutrition & Dietetics
Stephan C. Bischoff, Johann Ockenga, Ahad Eshraghian, Rocco Barazzoni, Luca Busetto, Marjo Campmans-Kuijpers, Vincenzo Cardinale, Irit Chermesh, Haluk Tarik Kani, Wafaa Khannoussi, Laurence Lacaze, Miguel Leon-Sanz, Juan M. Mendive, Michael W. Mueller, Frank Tacke, Anders Thorell, Darija Vranesic Bender, Arved Weimann, Cristina Cuerda
Summary: This practical guideline focuses on the diagnosis and treatment of obesity in patients with chronic gastrointestinal diseases, with a particular emphasis on metabolic associated liver disease. The guideline provides evidence-based advice in a condensed format, with 100 recommendations covering a multidisciplinary approach to care.
CLINICAL NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Monika Lewinska, Martin Lund Karhus, Anne-Marie Gade Ellegaard, Manuel Romero-Gomez, Rocio I. R. Macias, Jesper B. Andersen, Filip Krag Knop
Summary: Scientists developed a blood test-based method for diagnosing bile acid diarrhea (BAD), which showed superior specificity and sensitivity compared with current blood test-based diagnostics.
Article
Gastroenterology & Hepatology
Diego Calvisi, Luke Boulter, Javier Vaquero, Anna Saborowski, Luca M. Fabris, Pedro Rodrigues, Cedric E. Coulouarn, Rui Castro, Oreste Segatto, Chiara Raggi, Luc J. W. van der Laan, Guido Carpino, Benjamin Goeppert, Stephanie J. Roessler, Timothy Kendall, Matthias Evert, Ester W. Gonzalez-Sanchez, Juan Valle, Arndt Vogel, John J. Bridgewater, Mitesh J. Borad, Gregory R. Gores, Lewis Roberts, Jose J. G. B. Marin, Jesper Andersen, Domenico Alvaro, Alejandro M. Forner, Jesus Banales, Vincenzo Cardinale, Rocio I. R. Macias, Silve Vicent, Xin Chen, Chiara Braconi, Monique M. A. Verstegen, Laura Fouassier, Lewis Roberts, Alexander Scheiter, Florin M. Selaru, Katja Evert, Kirsten Utpatel, Laura Broutier, Massimiliano Cadamuro, Meritxell Huch, Robert Goldin, Sergio A. Gradilone, Yoshimasa Saito
Summary: In this Consensus Statement, experts provide recommendations on the criteria for preclinical models of cholangiocarcinoma (CCA) to increase disease understanding and develop novel therapeutic approaches.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Oncology
Ezequiel Mauro, Joana Ferrer-Fabrega, Tamara Sauri, Alexandre Soler, Amparo Cobo, Marta Burrel, Gemma Iserte, Alejandro Forner
Summary: Cholangiocarcinoma (CCA) is a highly lethal neoplasia with increasing incidence. Although surgical resection is the main treatment, it is only successful in one third of patients and has a high risk of recurrence. Other therapeutic strategies like liver transplantation, locoregional treatments, and new chemotherapy schemes based on immunotherapy or targeted therapies have potential to improve overall survival. However, more collaborative efforts and high-quality studies are needed to investigate their use and applicability.
Article
Gastroenterology & Hepatology
Ainhoa Lapitz, Mikel Azkargorta, Piotr Milkiewicz, Paula Olaizola, Ekaterina Zhuravleva, Marit M. Grimsrud, Christoph Schramm, Ander Arbelaiz, Colm J. O'Rourke, Adelaida La Casta, Malgorzata Milkiewicz, Tania Pastor, Mette Vesterhus, Raul Jimenez-Aguero, Michael T. Dill, Angela Lamarca, Juan W. Valle, Rocio I. R. Macias, Laura Izquierdo-Sanchez, Ylenia Perez Castano, Francisco Javier Caballero-Camino, Ioana Riano, Marcin Krawczyk, Cesar Ibarra, Javier Bustamante, Luiz M. Nova-Camacho, Juan M. Falcon-Perez, Felix Elortza, Maria J. Perugorria, Jesper B. Andersen, Luis Bujanda, Tom H. Karlsen, Trine Folseraas, Pedro M. Rodrigues, Jesus M. Banales
Summary: Protein biomarkers for the diagnosis and prognosis of cholangiocarcinoma (CCA) were found in serum extracellular vesicles (EVs), providing important information for individuals at high-risk, such as those with primary sclerosing cholangitis (PSC).
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Laura G. Di Pasqua, Marta Cagna, Giuseppina Palladini, Anna C. Croce, Massimiliano Cadamuro, Luca Fabris, Stefano Perlini, Luciano Adorini, Andrea Ferrigno, Mariapia Vairetti
Summary: The effects of two FXR agonists, OCA and INT-787, on hepatic levels of various proteins in a NASH model were compared. The results showed that INT-787 is superior to OCA in controlling specific cell types and clinically relevant anti-inflammatory and antifibrotic molecular mechanisms in NASH.
LIVER INTERNATIONAL
(2023)
Article
Health Care Sciences & Services
Sarah Clelland, Christina L. Nuttall, Helen E. Stott, Joseph Cope, Natalie L. Barratt, Kelly Farrell, Manyi V. Eyong, Jack P. Gleeson, Angela Lamarca, Richard A. Hubner, Juan W. Valle, Mairead G. Mcnamara
Summary: This study analyzed the case-notes of newly diagnosed patients with advanced pancreatic cancer and found that approximately two-thirds of cases had documented prognosis discussions. However, there were missed opportunities for prognosis discussions. Nurse clinicians had the highest frequency of prognosis discussion and referral to community palliative care services. Greater attention to documentation of prognosis discussions is recommended.
Article
Gastroenterology & Hepatology
David J. Pinato, Takahiro Kaneko, Antonio D'Alessio, Alejandro Forner, Petros Fessas, Beatriz Minguez, Edoardo G. Giannini, Federica Grillo, Alba Diaz, Francesco A. Mauri, Claudia A. M. Fulgenzi, Alessia Dalla Pria, Robert D. Goldin, Giulia Pieri, Pierluigi Toniutto, Claudio Avellini, Maria Corina Plaz Torres, Ayse U. Akarca, Teresa Marafioti, Sherrie Bhoori, Jose Maria Miro, Mark Bower, Norbert Brau, Vincenzo Mazzaferro
Summary: The aim of this study was to evaluate the impact of HIV infection on the functional characteristics of T cell infiltrate in hepatocellular carcinoma (HCC). Results showed that HIV infection was associated with increased immune exhaustion and higher expression of PD-L1 in tumor tissue. Therefore, prospective testing of immunotherapy in HIV-associated HCC is warranted.
Review
Oncology
Angela Lamarca, Lorena Ostios, Mairead G. Mcnamara, Carlos Garzon, Jack P. Gleeson, Julien Edeline, Ana Herrero, Richard A. Hubner, Victor Moreno, Juan W. Valle
Summary: Precision medicine has had a major impact on the management of advanced cholangiocarcinoma (CCA) patients, with molecular profiling providing new targets for treatment. However, there are still challenges such as lack of response and the development of drug resistance.
CANCER TREATMENT REVIEWS
(2023)