Article
Medicine, General & Internal
Lourdes Vicent, Jesus Alvarez-Garcia, Rafael Vazquez-Garcia, Jose R. Gonzalez-Juanatey, Miguel Rivera, Javier Segovia, Domingo Pascual-Figal, Ramon Bover, Fernando Worner, Francisco Fernandez-Aviles, Albert Ariza-Sole, Manuel Martinez-Selles
Summary: The aim of this study was to determine the prognostic impact of coronary artery disease (CAD) on heart failure with reduced ejection fraction (HFrEF) mortality and readmissions. A total of 583 patients with left ventricular ejection fraction <40% were included in the study, among which 266 had CAD and 137 had idiopathic dilated cardiomyopathy (DCM). The study found that one-year mortality and readmissions were similar between patients with CAD and idiopathic DCM, but patients with idiopathic DCM were more likely to receive a heart transplant.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Clara Saldarriaga, Dan Atar, Amanda Stebbins, Basil S. Lewis, Imran Zainal Abidin, Robert O. Blaustein, Javed Butler, Justin A. Ezekowitz, Adrian F. Hernandez, Carolyn S. P. Lam, Christopher M. O'Connor, Burkert Pieske, Piotr Ponikowski, Lothar Roessig, Adriaan A. Voors, Kevin J. Anstrom, Paul W. Armstrong
Summary: Coronary artery disease (CAD) is associated with higher cardiovascular events and heart failure hospitalizations in patients with Heart Failure with Reduced Ejection Fraction (HFrEF) and worsening HF. However, the treatment effect of vericiguat remains effective regardless of the presence of CAD. Patients with CAD are more likely to have other comorbidities compared to those without CAD.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Jenine E. John, Brian Claggett, Hicham Skali, Scott D. Solomon, Jonathan W. Cunningham, Kunihiro Matsushita, Suma H. Konety, Dalane W. Kitzman, Thomas H. Mosley, Donald Clark, Patricia P. Chang, Amil M. Shah
Summary: Coronary artery disease (CAD) is a significant risk factor for heart failure with preserved ejection fraction (HFpEF). The risk of developing HFpEF and heart failure with reduced ejection fraction (HFrEF) is highest within the first year after CAD develops. After one year post-CAD, the risk of developing HFrEF and HFpEF is similar. Echocardiographic measurements, particularly left ventricular diastolic function, partially account for the relationship between CAD and incident HFpEF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Yu-Wen Chen, Wei-Chieh Lee, Hsiu-Yu Fang, Cheuk-Kwan Sun, Jiunn-Jye Sheu
Summary: This study compared the outcomes of percutaneous coronary intervention (PCI) and coronary artery bypass graft surgery (CABG) for revascularization in patients with reduced ejection fraction (EF) and severe coronary artery disease (CAD). The results showed that compared to PCI, CABG was associated with a lower incidence of heart failure (HF) hospitalization but worse survival outcomes.
Article
Cardiac & Cardiovascular Systems
Katja Vu, Brian L. Claggett, Jenine E. John, Hicham Skali, Scott D. Solomon, Thomas H. Mosley, Janice E. Williams, Anna Kucharska-Newton, Tor Biering-Sorensen, Amil M. Shah
Summary: Depressive symptoms are associated with incident HFpEF in late life, independent of common comorbidities, cardiac structure and function, and prognostic biomarkers.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Timea Magdolna Szabo, Elod Erno Nagy, Adam Kirchmaier, Erhard Heidenhoffer, Hunor-Laszlo Gabor-Kelemen, Marius Frasineanu, Judit Cseke, Marta German-Sallo, Attila Frigy, Jun Sun
Summary: Vitamin D plays an important role as a prognostic biomarker in heart failure, although its therapeutic implications are still debated. This study found a close correlation between 25(OH)D and LVEF, as well as a significant positive correlation between 25(OH)D, serum uric acid, and albumin levels in HF patients. Furthermore, 25(OH)D concentration independently affected LVEF, supporting the need for establishing proper vitamin D supplementation schemes and dietary interventions in HF.
Article
Cardiac & Cardiovascular Systems
Chun-Li Wang, Yi-Hsin Chan, Victor Chien-Chia Wu, Hsin-Fu Lee, Fu-Chih Hsiao, Pao-Hsien Chu
Summary: This study found that in patients with reduced EF, global myocardial work (GMW) can provide incremental prognostic information over EF and GLS, helping to identify patients at risk for all-cause death and HF hospitalization.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Review
Cardiac & Cardiovascular Systems
Sherif F. Nagueh
Summary: HFpEF is a prevalent form of heart failure with various cardiac and non-cardiac manifestations, diagnosis of which relies on multiple measurements. Despite increasing understanding of its pathophysiology, specific treatment for HFpEF patients remains elusive.
CARDIOVASCULAR RESEARCH
(2021)
Article
Physiology
Haozhang Huang, Jin Liu, Min Lei, Zhou Yang, Kunming Bao, Qiang Li, Wenguang Lai, Bo Wang, Yibo He, Shiqun Chen, Chun-Quan Ou, Maimaitiaili Abudukerimu, Yuying Hu, Ning Tan, Jiyan Chen, Yong Liu
Summary: Among patients with coronary artery disease, those meeting the criteria for the new definition of HFimpEF tend to be younger, have fewer clinical comorbidities, and have smaller left ventricular end-diastolic diameter. These patients also demonstrated higher long-term survival rates.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Syuzanna Shahnazaryan, Sergey Pepoyan, Hamayak Sisakian
Summary: Heart failure with reduced ejection fraction (HFrEF) is a significant healthcare problem, characterized by frequent deterioration, high hospitalization rates, and mortalities. Early recognition of sub- and decompensation in HF is crucial for timely treatment and improved prognosis. Echocardiography is the gold standard for assessing ventricular function in HF patients, providing accurate and non-invasive measurements. Advanced cardiovascular ultrasound modalities offer better evaluation of hemodynamic changes and subclinical congestion in severely compromised HF patients. This review aims to summarize the advantages and limitations of available ultrasound modalities in the ambulatory monitoring of HFrEF patients.
Article
Cardiac & Cardiovascular Systems
Robert J. H. Miller, Majid Nabipoor, Erik Youngson, Gynter Kotrri, Nowell M. Fine, Jonathan G. Howlett, Ian D. Paterson, Justin Ezekowitz, Finlay A. McAlister
Summary: Among patients with HFmrEF, those with positive LVEF trajectory are less likely to experience adverse outcomes after adjusting for important confounders, including medical therapy. Categorizing HFmrEF patients based on LVEF trajectory provides meaningful clinical information and may assist clinicians with management decisions.
Article
Cardiac & Cardiovascular Systems
Yogesh N. Reddy, Barry A. Borlaug, Bernard J. Gersh
Summary: Atrial fibrillation is the most common arrhythmia in heart failure patients and can be both the cause and consequence of clinical heart failure. Some patients may benefit from maintaining sinus rhythm with catheter ablation. There is a close relationship between atrial fibrillation, left atrial myopathy, mitral regurgitation, and heart failure with preserved ejection fraction, with potential clinical benefits to catheter ablation therapy. Treatment of atrial fibrillation also requires consideration of the degree of atrial myopathy and chronicity of atrial fibrillation.
Article
Cardiac & Cardiovascular Systems
Li Shen, Pardeep Singh Jhund, Kieran Francis Docherty, Muthiah Vaduganathan, Mark Colquhoun Petrie, Akshay Suvas Desai, Lars Kober, Morten Schou, Milton Packer, Scott David Solomon, Xingwei Zhang, John Joseph Valentine McMurray
Summary: Previous guidelines for treating heart failure with reduced ejection fraction recommended initiating therapy in a chronological order based on trial history. However, this study suggests that accelerating treatment titration and optimizing treatment ordering may improve patient outcomes.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Alia S. Alhakak, Morten Sengelov, Peter G. Jorgensen, Niels E. Bruun, Cecilie Johnsen, Ulrik Abildgaard, Allan Z. Iversen, Thomas F. Hansen, John R. Teerlink, Fady I. Malik, Scott D. Solomon, Gunnar Gislason, Tor Biering-Sorensen
Summary: In patients with HFrEF, SET provides independent and incremental prognostic information regarding all-cause mortality. MPI is a significant predictor in an unadjusted model, but the association does not remain significant after multivariable adjustment. No significant associations between IVCT or IVRT and mortality were found.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Patrick M. Pilz, Jennifer E. Ward, Wei-Ting Chang, Attila Kiss, Edward Bateh, Alokkumar Jha, Sudeshna Fisch, Bruno K. Podesser, Ronglih Liao
Summary: This article outlines the strengths, limitations, and outcomes of small and large animal models of heart failure with reduced ejection fraction currently used in basic and translational research. Animal models play a critical role in understanding the molecular mechanisms of heart failure, although no model completely recapitulates the full human disease.
CIRCULATION RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Andrew Perry, Violeta V. Chacon, Joaquin Barnoya
PUBLIC HEALTH NUTRITION
(2018)
Article
Multidisciplinary Sciences
Andrew Perry, Francis Loh, Luigi Adamo, Kathleen W. Zhang, Elena Deych, Randi Foraker, Douglas L. Mann
Summary: Patients with recovered ejection fraction (HFrecEF) exhibit significant clinical heterogeneity, with distinct outcomes in terms of survival and maintenance of LVEF >= 50%. Clustering algorithms can help identify high-risk patients for recurrent heart failure, guiding treatment strategies for those with LVrecEF.
Review
Cardiac & Cardiovascular Systems
Andrew S. Perry, Song Li
Summary: The study found that early aortic valve replacement in asymptomatic patients with high-gradient severe aortic stenosis was associated with a lower mortality rate compared to watchful waiting, and there was no significant correlation between left ventricular ejection fraction and the mortality benefit of aortic valve replacement.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Marco Merlo, Marco Mase, Andrew Perry, Eluisa La Franca, Elena Deych, Laura Ajello, Diego Bellavia, Andrea Boscutti, Marco Gobbo, Giuseppe Romano, Davide Stolfo, John Gorcsan, Francesco Clemenza, Gianfranco Sinagra, Luigi Adamo
Summary: In patients with non-ischaemic dilated cardiomyopathy (NICM) and normalised left ventricular ejection fraction (LVEF), an impaired absolute global longitudinal strain (aGLS) at the time of LVEF recovery is common and associated with worse outcomes.
Article
Cardiac & Cardiovascular Systems
Andrew S. Perry, Parvathi Mudigonda, Gary S. Huang, Binish Qureshi, Richard K. Cheng, Wayne C. Levy, Song Li
Summary: This study aimed to understand the long-term outcomes of patients with heart failure with recovered ejection fraction, identify predictors of adverse events, and develop a risk stratification model. The study found that diuretic dose and B-type natriuretic peptide (BNP) were the strongest predictors of mortality and hospitalization, and a risk model incorporating functional class, BNP, and diuretic dose accurately stratified mortality risk.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew S. Perry, Elliot J. Stein, Michael Biersmith, William F. Fearon, Sammy Elmariah, Juyong B. Kim, Daniel E. Clark, Jay N. Patel, Holly Gonzales, Michael Baker, Robert N. Piana, Ravinder R. Mallugari, Samir Kapadia, Dharam J. Kumbhani, Linda Gillam, Brian Whisenant, Nishath Quader, Alan Zajarias, Frederick G. Welt, Anthony A. Bavry, Megan Coylewright, Deepak K. Gupta, Anna Vatterott, Natalie Jackson, Shi Huang, Brian R. Lindman
Summary: Elevations in circulating cardiac troponin and NT-proBNP are associated with worsening GLS in patients with severe aortic stenosis. Biomarkers of cardiac damage and stress are independently associated with mortality after transcatheter aortic valve implantation, whereas GLS is not.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew S. Perry, Song Li
Summary: This post-hoc analysis demonstrates an independent association between change in QRS duration from baseline to 3 months and long-term survival and left ventricle ejection fraction in patients with heart failure.
AMERICAN HEART JOURNAL
(2022)
Article
Endocrinology & Metabolism
Andrew S. Perry, Jeffrey S. Annis, Hiral Master, Matthew Nayor, Andrew Hughes, Aymone Kouame, Karthik Natarajan, Kayla Marginean, Venkatesh Murthy, Dan M. Roden, Paul A. Harris, Ravi Shah, Evan L. Brittain
Summary: This study used data from commercial wearable devices and electronic health records to investigate the relationship between physical activity and incident type 2 diabetes mellitus (T2DM) in a real-world population. The results showed that increased time spent in any type of physical activity was associated with a lower risk of T2DM, regardless of age, sex, BMI, or sedentary time.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Andrew S. Perry, Kahraman Tanriverdi, Antonina Risitano, Shih-Jen Hwang, Venkatesh L. Murthy, Matthew Nayor, Shilin Zhao, Daniel Levy, Ravi Shah, Jane E. Freedman
Summary: This study investigates the relationship between inflammatory proteins and weight loss/regain, finding that broad changes in inflammatory proteins are associated with weight regain after weight loss, and may identify specific pathways for modifying weight regain patterns.
Article
Cardiac & Cardiovascular Systems
Andrew S. Perry, Erin E. Dooley, Hiral Master, Nicole L. Spartano, Evan L. Brittain, Kelley Pettee Gabriel
Summary: Despite advancements in cardiovascular care, CVD remains a leading cause of death globally. Preventing CVD requires managing risk factors and detecting it early, as well as maintaining physical activity throughout life.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew S. S. Perry, Shilin Zhao, Venkatesh Murthy, Deepak K. K. Gupta, William F. F. Fearon, Juyong B. B. Kim, Samir Kapadia, Dharam J. J. Kumbhani, Linda Gillam, Brian Whisenant, Nishath Quader, Alan Zajarias, Ravinder R. R. Mallugari, Daniel E. E. Clark, Jay N. N. Patel, Holly Gonzales, Frederick G. G. Welt, Anthony A. A. Bavry, Megan Coylewright, Robert N. N. Piana, Anna Vatterott, Natalie Jackson, Robert E. E. Gerszten, Brian R. R. Lindman, Ravi Shah, Sammy Elmariah
Summary: This study demonstrates a correlation between cardiac structure and metabolism in patients with aortic stenosis, suggesting that metabolic dysfunction may be involved in the progression and mortality risk of this condition. These findings provide insights for improving the rehabilitation and survival of patients with aortic stenosis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew S. Perry, Aldo P. Maggioni, Luigi Tavazzi, Wayne C. Levy
Summary: This study aimed to investigate the association between beta-blocker therapy and survival in heart failure patients with pacemaker rhythm. The analysis of GISSI-HF trial data showed that beta-blocker therapy was significantly associated with improved survival, especially in patients with baseline pacemaker rhythm.
Article
Cell Biology
Andrew S. Perry, Shilin Zhao, Priya Gajjar, Venkatesh L. Murthy, Benoit Lehallier, Patricia Miller, Sangeeta Nair, Colin Neill, J. Jeffrey Carr, William Fearon, Samir Kapadia, Dharam Kumbhani, Linda Gillam, Joann Lindenfeld, Laurie Farrell, Megan M. Marron, Qu Tian, Anne B. Newman, Joanne Murabito, Robert E. Gerszten, Matthew Nayor, Sammy Elmariah, Brian R. Lindman, Ravi Shah
Summary: This study integrated circulating proteins and measures of frailty to characterize the proteomic architecture of frailty in a highly susceptible population. Proteomic signatures were related to clinical outcomes and systems-wide phenotypes, highlighting the importance of precision biomarkers in age-related morbidity and frailty.
Article
Cardiac & Cardiovascular Systems
Walter B. Schiffer, Andrew Perry, Elena Deych, David L. Brown, Luigi Adamo
Summary: In patients with ischaemic cardiomyopathy, delayed normalisation of LVEF is associated with reduced mortality, whereas early recovery of LVEF is not. Further studies are needed to confirm these findings.