The SAGA chromatin-modifying complex: the sum of its parts is greater than the whole

Structure of SAGA and mechanism of TBP deposition on gene promoters

(2020) Gabor Papai et al.   NATURE

Structure of the transcription coactivator SAGA

(2020) Haibo Wang et al.   NATURE

Prp5−Spt8/Spt3 interaction mediates a reciprocal coupling between splicing and transcription

(2020) Wei Shao et al.   NUCLEIC ACIDS RESEARCH

SAGA and TFIID: Friends of TBP drifting apart

(2020) H.Th. Marc Timmers   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Dynamic modules of the coactivator SAGA in eukaryotic transcription

(2020) Youngseo Cheon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Molecular architecture of the human 17S U2 snRNP

(2020) Zhenwei Zhang et al.   NATURE

Characterization of a metazoan ADA acetyltransferase complex

(2019) Jelly H M Soffers et al.   NUCLEIC ACIDS RESEARCH

The ZZ domain as a new epigenetic reader and a degradation signal sensor

(2019) Yi Zhang et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Ataxin-7 and Non-stop coordinate SCAR protein levels, subcellular localization, and actin cytoskeleton organization

(2019) Veronica Cloud et al.   eLife

New insights into the evolutionary conservation of the sole PIKK pseudokinase Tra1/TRRAP

(2019) Alberto Elías-Villalobos et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast

(2019) Alberto Elías-Villalobos et al.   Nature Communications

Recent insights into the structure of TFIID, its assembly, and its binding to core promoter

(2019) Avinash B Patel et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mutational analysis of TAF6 revealed the essential requirement of the histone-fold domain and the HEAT repeat domain for transcriptional activation

(2018) Rashmi Dahiya et al.   FEBS Journal

Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex

(2018) Lisa M. Tuttle et al.   Cell Reports

The Pseudokinase Domain of Saccharomyces cerevisiae Tra1 Is Required for Nuclear Localization and Incorporation into the SAGA and NuA4 Complexes

(2018) Matthew D. Berg et al.   G3-Genes Genomes Genetics

Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair

(2018) Federica M. Evangelista et al.   JOURNAL OF CELL BIOLOGY

Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2

(2018) Jian Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

(2018) Ann Boija et al.   CELL

The Drosophila Dbf4 ortholog Chiffon forms a complex with Gcn5 that is necessary for histone acetylation and viability

(2018) Eliana F. Torres-Zelada et al.   JOURNAL OF CELL SCIENCE

Chaperonin CCT checkpoint function in basal transcription factor TFIID assembly

(2018) Simona V. Antonova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular structure of promoter-bound yeast TFIID

(2018) Olga Kolesnikova et al.   Nature Communications

Enzymatic modules of the SAGA chromatin-modifying complex play distinct roles in Drosophila gene expression and development

(2017) Xuanying Li et al.   GENES & DEVELOPMENT

SAGA Is a General Cofactor for RNA Polymerase II Transcription

(2017) Tiago Baptista et al.   MOLECULAR CELL

Transcription of Nearly All Yeast RNA Polymerase II-Transcribed Genes Is Dependent on Transcription Factor TFIID

(2017) Linda Warfield et al.   MOLECULAR CELL

Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA

(2017) Sari Kassem et al.   NUCLEIC ACIDS RESEARCH

Sharing the SAGA

(2017) Dominique Helmlinger et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structure of the transcription activator target Tra1 within the chromatin modifying complex SAGA

(2017) Grigory Sharov et al.   Nature Communications

Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution

(2017) Luis Miguel Díaz-Santín et al.   eLife

The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila SAGA that Functions in Gene Expression Independent of Splicing

(2016) Rachel Stegeman et al.   JOURNAL OF MOLECULAR BIOLOGY

ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth

(2016) Boyko S. Atanassov et al.   MOLECULAR CELL

Structural basis for histone H2B deubiquitination by the SAGA DUB module

(2016) M. T. Morgan et al.   SCIENCE

A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression

(2016) Benedetta Bolognesi et al.   Cell Reports

Conformational Flexibility and Subunit Arrangement of the Modular Yeast Spt-Ada-Gcn5 Acetyltransferase Complex

(2015) Dheva Setiaputra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleosome competition reveals processive acetylation by the SAGA HAT module

(2015) Alison E. Ringel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical cross-linking and mass spectrometry to determine the subunit interaction network in a recombinant human SAGA HAT subcomplex

(2015) Nha-Thi Nguyen-Huynh et al.   PROTEIN SCIENCE

MYC interacts with the human STAGA coactivator complex via multivalent contacts with the GCN5 and TRRAP subunits

(2014) Na Zhang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex

(2014) Y. Han et al.   EMBO JOURNAL

Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration

(2014) R. D. Mohan et al.   GENES & DEVELOPMENT

The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription

(2014) Jacques Bonnet et al.   GENES & DEVELOPMENT

Mapping the Deubiquitination Module within the SAGA Complex

(2014) Alexandre Durand et al.   STRUCTURE

Functional characterization and gene expression profiling of Drosophila melanogaster short dADA2b isoform-containing dSAGA complexes

(2013) Tibor Pankotai et al.   BMC GENOMICS

C-terminus of the Sgf73 subunit of SAGA and SLIK is important for retention in the larger complex and for heterochromatin boundary function

(2013) Kazuma Kamata et al.   GENES TO CELLS

The architecture of human general transcription factor TFIID core complex

(2013) Christoph Bieniossek et al.   NATURE

Separation of a functional deubiquitylating module from the SAGA complex by the proteasome regulatory particle

(2013) Sungsu Lim et al.   Nature Communications

TFIID TAF6-TAF9 Complex Formation Involves the HEAT Repeat-containing C-terminal Domain of TAF6 and Is Modulated by TAF5 Protein

(2012) Elisabeth Scheer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4

(2012) L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mRNA export and gene expression: The SAGA–TREX-2 connection

(2011) Encar García-Oliver et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation

(2011) Chuanbing Bian et al.   EMBO JOURNAL

Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex

(2011) Dominique Helmlinger et al.   EMBO JOURNAL

The Tightly Controlled Deubiquitination Activity of the Human SAGA Complex Differentially Modifies Distinct Gene Regulatory Elements

(2011) G. Lang et al.   MOLECULAR AND CELLULAR BIOLOGY

Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes

(2011) K. K. Lee et al.   Molecular Systems Biology

Structure and function of WD40 domain proteins

(2011) Chao Xu et al.   Protein & Cell

Cloning, purification, crystallization and preliminary crystallographic analysis of the tandem tudor domain of Sgf29 fromSaccharomyces cerevisiae

(2010) Jing Li et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Structural Basis for Assembly and Activation of the Heterotetrameric SAGA Histone H2B Deubiquitinase Module

(2010) Alwin Köhler et al.   CELL

Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers

(2010) Michiel Vermeulen et al.   CELL

Gcn5 regulates the dissociation of SWI/SNF from chromatin by acetylation of Swi2/Snf2

(2010) J.-H. Kim et al.   GENES & DEVELOPMENT

Domains of Tra1 Important for Activator Recruitment and Transcription Coactivator Functions of SAGA and NuA4 Complexes

(2010) B. A. Knutson et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

(2010) N. L. Samara et al.   SCIENCE

A novel histone fold domain-containing protein that replaces TAF6 in Drosophila SAGA is required for SAGA-dependent gene expression

(2009) V. M. Weake et al.   GENES & DEVELOPMENT

Structural Basis for the Interaction between Yeast Spt-Ada-Gcn5 Acetyltransferase (SAGA) Complex Components Sgf11 and Sus1

(2009) Andrew M. Ellisdon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The loss of histone H3 lysine 9 acetylation due to dSAGA-specific dAda2b mutation influences the expression of only a small subset of genes

(2009) N. Zsindely et al.   NUCLEIC ACIDS RESEARCH

Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexes

(2009) Kenneth K Lee et al.   Epigenetics & Chromatin

The STAGA Subunit ADA2b Is an Important Regulator of Human GCN5 Catalysis

(2008) A. M. Gamper et al.   MOLECULAR AND CELLULAR BIOLOGY

H2B Ubiquitylation Plays a Role in Nucleosome Dynamics during Transcription Elongation

(2008) Alastair B. Fleming et al.   MOLECULAR CELL

Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export

(2008) Alwin Köhler et al.   NATURE CELL BIOLOGY

ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding

(2008) Tamaki Suganuma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of new Spt3 and TBP mutants of Saccharomyces cerevisiae: Spt3-TBP allele-specific interactions and bypass of Spt8

(2007) L. Laprade et al.   GENETICS