Multilevel regulation and molecular mechanism of poly (rC)‐binding protein 1 in cancer

RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity

(2020) Ephraim A. Ansa-Addo et al.   Science Advances

Hsa_circ_0003998 promotes epithelial to mesenchymal transition of hepatocellular carcinoma by sponging miR-143-3p and PCBP1

(2020) Li-na Song et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Oroxylin A increases the sensitivity of temozolomide on glioma cells by hypoxia-inducible factor 1α/hedgehog pathway under hypoxia

(2019) Mian Wei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Specific binding of PCBP1 to heavily oxidized RNA to induce cell death

(2018) Takashi Ishii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA-Binding Protein PCBP1 Functions as a Tumor Suppressor in Prostate Cancer by Inhibiting Mitogen Activated Protein Kinase 1

(2018) Yingying Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Splicing factor poly(rC)-binding protein 1 is a novel and distinctive tumor suppressor

(2018) Jihua Guo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translation

(2018) Hongshun Shi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Function, clinical application, and strategies of Pre-mRNA splicing in cancer

(2018) Cuixia Di et al.   CELL DEATH AND DIFFERENTIATION

Poly r(C) Binding Protein 1 Regulates Posttranscriptional Expression of the Ubiquitin Ligase TRIM56 in Ovarian Cancer

(2018) Lei Zhao et al.   IUBMB LIFE

Fyn/heterogeneous nuclear ribonucleoprotein E1 signaling regulates pancreatic cancer metastasis by affecting the alternative splicing of integrin β1

(2017) Peng Jiang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression

(2017) Simon Grelet et al.   NATURE CELL BIOLOGY

PolyC-binding proteins enhance expression of the CDK2 cell cycle regulatory protein via alternative splicing

(2017) Xinjun Ji et al.   NUCLEIC ACIDS RESEARCH

Poly(C)-binding protein 1 mediates drug resistance in colorectal cancer

(2017) Jiani Guo et al.   Oncotarget

LC3/GABARAP family proteins: autophagy-(un)related functions

(2016) Marco B. E. Schaaf et al.   FASEB JOURNAL

Extracellular vesicle miR-7977 is involved in hematopoietic dysfunction of mesenchymal stromal cells via poly(rC) binding protein 1 reduction in myeloid neoplasms

(2016) Hiroto Horiguchi et al.   HAEMATOLOGICA

Poly C binding protein 1 represses autophagy through downregulation of LC3B to promote tumor cell apoptosis in starvation

(2016) Wenliang Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Post-Transcriptional Regulation of the Human Mu-Opioid Receptor (MOR) by Morphine-Induced RNA Binding Proteins hnRNP K and PCBP1

(2016) Kyu Young Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27

(2016) L. A. Link et al.   MOLECULAR CANCER RESEARCH

Direct Regulation of Alternative Splicing by SMAD3 through PCBP1 Is Essential to the Tumor-Promoting Role of TGF-β

(2016) Veenu Tripathi et al.   MOLECULAR CELL

Identification and characterization of an hnRNP E1 translational silencing motif

(2016) Andrew S. Brown et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-490 regulates lung cancer metastasis by targeting poly r(C)-binding protein 1

(2016) Jindong Li et al.   TUMOR BIOLOGY

Poly r(C) binding protein is post-transcriptionally repressed by MiR-490-3p to potentiate squamous cell carcinoma

(2016) Shan Xia et al.   TUMOR BIOLOGY

Extracellular vesicle miR-7977 is involved in hematopoietic dysfunction of mesenchymal stromal cells via poly(rC) binding protein 1 reduction in myeloid neoplasms

(2016) Hiroto Horiguchi et al.   HAEMATOLOGICA

Poly r(C) Binding Protein-1 is Central to Maintenance of Cancer Stem Cells in Prostate Cancer Cells

(2015) Qi Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Downregulated Poly-C binding protein-1 is a novel predictor associated with poor prognosis in Acute Myeloid Leukemia

(2015) Meifeng Zhou et al.   Diagnostic Pathology

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

HOTAIR Long Noncoding RNA Promotes Gastric Cancer Metastasis through Suppression of Poly r(C)-Binding Protein (PCBP) 1

(2015) Z.-Z. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Translational regulation of inhibin βA by TGFβ via the RNA-binding protein hnRNP E1 enhances the invasiveness of epithelial-to-mesenchymal transitioned cells

(2015) B V Howley et al.   ONCOGENE

A role of autophagy in PTP4A3-driven cancer progression

(2014) Yu-Han Huang et al.   Autophagy

The Poly(C)-Binding Protein-1 Regulates Expression of the Androgen Receptor

(2014) Brianna Cloke et al.   ENDOCRINOLOGY

PCBP1 is an important mediator of TGF-β-induced epithelial to mesenchymal transition in gall bladder cancer cell line GBC-SD

(2014) Hang-Yu Zhang et al.   MOLECULAR BIOLOGY REPORTS

Autophagy promotes paclitaxel resistance of cervical cancer cells: involvement of Warburg effect activated hypoxia-induced factor 1-α-mediated signaling

(2014) X Peng et al.   Cell Death & Disease

Molecular aspects of cancer cell resistance to chemotherapy

(2013) Magali Rebucci et al.   BIOCHEMICAL PHARMACOLOGY

Radiation-induced mitotic cell death and glioblastoma radioresistance: A new regulating pathway controlled by integrin-linked kinase, hypoxia-inducible factor 1alpha and survivin in U87 cells

(2013) Olivia Lanvin et al.   EUROPEAN JOURNAL OF CANCER

Poly (C)-Binding Protein 1 Regulates p63 Expression through mRNA Stability

(2013) Seong-Jun Cho et al.   PLoS One

TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells

(2012) Lionel Flamant et al.   BMC CANCER

Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: Potential role of hypoxia

(2012) Delphine Tamara Marie-Egyptienne et al.   CANCER LETTERS

Establishment of a TGFβ-Induced Post-Transcriptional EMT Gene Signature

(2012) George S. Hussey et al.   PLoS One

Abnormal Expression of the Pre-mRNA Splicing Regulators SRSF1, SRSF2, SRPK1 and SRPK2 in Non Small Cell Lung Carcinoma

(2012) Stephanie Gout et al.   PLoS One

Exposure to hypoxia following irradiation increases radioresistance in prostate cancer cells

(2012) Derek Hennessey et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Regulation of p73 activity by post-translational modifications

(2012) F Conforti et al.   Cell Death & Disease

Splicing Factor hnRNP A2/B1 Regulates Tumor Suppressor Gene Splicing and Is an Oncogenic Driver in Glioblastoma

(2011) R. Golan-Gerstl et al.   CANCER RESEARCH

Activation of the HIF Prolyl Hydroxylase by the Iron Chaperones PCBP1 and PCBP2

(2011) Anjali Nandal et al.   Cell Metabolism

Oxaliplatin: a review in the era of molecularly targeted therapy

(2011) T. Alcindor et al.   Current Oncology

Knockdown of the β1 integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis

(2011) John J. Grzesiak et al.   INTERNATIONAL JOURNAL OF CANCER

IGFBP3 and BAG1 enhance radiation-induced apoptosis in squamous esophageal cancer cells

(2010) Kei Yoshino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of differentially expressed transcripts and translatants targeted by knock-down of endogenous PCBP1

(2010) Li-Rong Huo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

PCBP1 Suppresses the Translation of Metastasis-Associated PRL-3 Phosphatase

(2010) Haihe Wang et al.   CANCER CELL

Proteomic and Functional Analyses Reveal the Potential Involvement of Endoplasmic Reticulum Stress and α-CP1 in the Anticancer Activities of Oridonin in HepG2 Cells

(2010) Hui Wang et al.   INTEGRATIVE CANCER THERAPIES

PCBP-1 regulates alternative splicing of the CD44 gene and inhibits invasion in human hepatoma cell line HepG2 cells

(2010) Tong Zhang et al.   Molecular Cancer

TGF-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI

(2010) Arindam Chaudhury et al.   NATURE CELL BIOLOGY

The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability

(2010) Ariane Scoumanne et al.   NUCLEIC ACIDS RESEARCH

p63 and p73, the Ancestors of p53

(2010) V. Dotsch et al.   Cold Spring Harbor Perspectives in Biology

Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery

(2009) Chen-Xin Dai et al.   BMC CANCER

Depletion of the Poly(C)-binding Proteins αCP1 and αCP2 from K562 Cells Leads to p53-independent Induction of Cyclin-dependent Kinase Inhibitor (CDKN1A) and G1Arrest

(2009) Shelly A. Waggoner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of transcripts and translatants targeted by overexpressed PCBP1

(2008) Li-Rong Huo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

A Cytosolic Iron Chaperone That Delivers Iron to Ferritin

(2008) H. Shi et al.   SCIENCE