期刊
FASEB JOURNAL
卷 34, 期 12, 页码 15647-15658出版社
WILEY
DOI: 10.1096/fj.202000911R
关键词
cancer therapy; gene expression; mechanisms; PCBP1; tumor suppressor
资金
- National Key R&D project of the Chinese Ministry of Science and Technology [2018YFE0205100]
- Key Program of the National Natural Science Foundation of China [U1632270]
- National Natural Science Foundation of China [11675234]
- Natural Science Foundation of Gansu Province, China [17JR5RA310]
Poly (rC)-binding protein 1 (PCBP1), an RNA- or DNA-binding protein with a relative molecular weight of 38 kDa, which is characterized by downregulation in many cancer types. Numerous cases have indicated that PCBP1 could be considered as a tumor suppressor to inhibit tumorigenesis, development, and metastasis. In the current review, we described the multilevel regulatory roles of PCBP1, including gene transcription, alternative splicing, and translation of many cancer-related genes. Additionally, we also provided a brief overview about the inhibitory effect of PCBP1 on most common tumors. More importantly, we summarized the current research status about PCBP1 in hypoxic microenvironment, autophagy, apoptosis, and chemotherapy of cancer cells, aiming to clarify the molecular mechanisms of PCBP1 in cancer. Taken together, in-depth study of PCBP1 in cancer may provide new ideas for cancer therapy.
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