D‐series Resolvins activate Phospholipase D in phagocytes during inflammation and resolution

GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections

(2019) Magdalena B. Flak et al.   JOURNAL OF CLINICAL INVESTIGATION

Signaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca 2+ in cultured rat conjunctival goblet cells

(2018) Marit Lippestad et al.   EXPERIMENTAL EYE RESEARCH

Phospholipase D isoforms differentially regulate leukocyte responses to acute lung injury

(2018) Raja-Elie E. Abdulnour et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Oxidized LDL phagocytosis during foam cell formation in atherosclerotic plaques relies on a PLD2-CD36 functional interdependence

(2018) Ramya Ganesan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

(2018) Oliver Werz et al.   Nature Communications

Resolvins suppress tumor growth and enhance cancer therapy

(2017) Megan L. Sulciner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protectin D1n-3 DPAand resolvin D5n-3 DPAare effectors of intestinal protection

(2017) Thomas Gobbetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Resolvin D2 Receptor Axis in Infectious Inflammation

(2016) Nan Chiang et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32

(2016) Mattia Schmid et al.   JOURNAL OF IMMUNOLOGY

A Repertoire of MicroRNAs Regulates Cancer Cell Starvation by Targeting Phospholipase D in a Feedback Loop That Operates Maximally in Cancer Cells

(2016) Kristen Fite et al.   MOLECULAR AND CELLULAR BIOLOGY

The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases

(2016) Hor-Yue Tan et al.   Oxidative Medicine and Cellular Longevity

A Phosphatidic Acid (PA) conveyor system of continuous intracellular transport from cell membrane to nucleus maintains EGF receptor homeostasis

(2016) Karen M. Henkels et al.   Oncotarget

A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells

(2016) Taylor E. Miller et al.   Biology Open

S6K is a morphogenic protein with a mechanism involving Filamin-A phosphorylation and phosphatidic acid binding

(2015) Karen M. Henkels et al.   FASEB JOURNAL

Macrophage polarization: the link between inflammation and related diseases

(2015) Samina Bashir et al.   INFLAMMATION RESEARCH

Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion

(2015) Kristen Fite et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase D2 drives mortality in sepsis by inhibiting neutrophil extracellular trap formation and down-regulating CXCR2

(2015) Sung Kyun Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Physiological and pathophysiological roles for phospholipase D

(2015) Rochelle K. Nelson et al.   JOURNAL OF LIPID RESEARCH

Macrophages During the Fibrotic Process: M2 as Friend and Foe

(2015) Tarcio Teodoro Braga et al.   Frontiers in Immunology

Pivotal Role of Phospholipase D1 in Tumor Necrosis Factor-α–Mediated Inflammation and Scar Formation after Myocardial Ischemia and Reperfusion in Mice

(2014) Tanja Schönberger et al.   AMERICAN JOURNAL OF PATHOLOGY

Resolution of acute inflammation bridges the gap between innate and adaptive immunity

(2014) J. Newson et al.   BLOOD

Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis

(2014) Kerstin Göbel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Functional Regulation of Phospholipase D Expression in Cancer and Inflammation

(2014) Dong Woo Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase D and the Maintenance of Phosphatidic Acid Levels for Regulation of Mammalian Target of Rapamycin (mTOR)

(2014) David A. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase D in Cell Signaling: From a Myriad of Cell Functions to Cancer Growth and Metastasis

(2014) Julian Gomez-Cambronero   JOURNAL OF BIOLOGICAL CHEMISTRY

The Molecular Basis of Leukocyte Adhesion Involving Phosphatidic Acid and Phospholipase D

(2014) Francis Speranza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A river runs through it: how autophagy, senescence, and phagocytosis could be linked to phospholipase D by Wnt signaling

(2014) Julian Gomez-Cambronero et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Phospholipase D Signaling Mediates Reactive Oxygen Species-Induced Lung Endothelial Barrier Dysfunction

(2014) Peter V. Usatyuk et al.   Pulmonary Circulation

Pharmacological Inhibition of Phospholipase D Protects Mice From Occlusive Thrombus Formation and Ischemic Stroke—Brief Report

(2013) David Stegner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways

(2013) Dexi Zhou et al.   CELLULAR SIGNALLING

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents

(2013) Jesmond Dalli et al.   CHEMISTRY & BIOLOGY

Plasticity of Leukocytic Exudates in Resolving Acute Inflammation Is Regulated by MicroRNA and Proresolving Mediators

(2013) Yongsheng Li et al.   IMMUNITY

A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migration

(2013) M. Mahankali et al.   JOURNAL OF CELL SCIENCE

Phospholipase D (PLD) drives cell invasion, tumor growth and metastasis in a human breast cancer xenograph model

(2013) K M Henkels et al.   ONCOGENE

A Novel Anti-Inflammatory and Pro-Resolving Role for Resolvin D1 in Acute Cigarette Smoke-Induced Lung Inflammation

(2013) Hsi-Min Hsiao et al.   PLoS One

Resolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs

(2012) Sriram Krishnamoorthy et al.   AMERICAN JOURNAL OF PATHOLOGY

TLR2 stimulates ABCA1 expression via PKC-η and PLD2 pathway

(2012) Dae-Weon Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Identification of the Catalytic Site of Phospholipase D2 (PLD2) Newly Described Guanine Nucleotide Exchange Factor Activity

(2012) Madhu Mahankali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Key Roles for the Lipid Signaling Enzyme Phospholipase D1 in the Tumor Microenvironment During Tumor Angiogenesis and Metastasis

(2012) Q. Chen et al.   Science Signaling

Self-Limited versus Delayed Resolution of Acute Inflammation: Temporal Regulation of Pro-Resolving Mediators and MicroRNA

(2012) Gabrielle Fredman et al.   Scientific Reports

Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution

(2011) Gabrielle Fredman et al.   BIOCHEMICAL JOURNAL

The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (And a surprise discovery: PLD2 is a GEF)

(2011) Julian Gomez-Cambronero   CELLULAR SIGNALLING

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

(2011) Sungwhan F. Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvin D1 and Its Precursor Docosahexaenoic Acid Promote Resolution of Adipose Tissue Inflammation by Eliciting Macrophage Polarization toward an M2-Like Phenotype

(2011) Esther Titos et al.   JOURNAL OF IMMUNOLOGY

A Novel Phospholipase D2-Grb2-WASp Heterotrimer Regulates Leukocyte Phagocytosis in a Two-Step Mechanism

(2011) S. Kantonen et al.   MOLECULAR AND CELLULAR BIOLOGY

Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2

(2011) M. Mahankali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Concepts in Phospholipase D Signaling in Inflammation and Cancer

(2011) Julian Gomez-Cambronero   TheScientificWorldJOURNAL

MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits

(2010) Antonio Recchiuti et al.   FASEB JOURNAL

Phospholipase D2 Ablation Ameliorates Alzheimer's Disease-Linked Synaptic Dysfunction and Cognitive Deficits

(2010) T. G. Oliveira et al.   JOURNAL OF NEUROSCIENCE

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Resolvin E1 Receptor Activation Signals Phosphorylation and Phagocytosis

(2009) Taisuke Ohira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase D-mediated Activation of IQGAP1 through Rac1 Regulates Hyperoxia-induced p47phoxTranslocation and Reactive Oxygen Species Generation in Lung Endothelial Cells

(2009) Peter V. Usatyuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

μ-Opioid receptor-stimulated synthesis of reactive oxygen species is mediated via phospholipase D2

(2009) Thomas Koch et al.   JOURNAL OF NEUROCHEMISTRY

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

(2009) Matthew Spite et al.   NATURE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

The Recently Identified P2Y-Like Receptor GPR17 Is a Sensor of Brain Damage and a New Target for Brain Repair

(2008) Davide Lecca et al.   PLoS One