Apoptosis signal-regulating kinase 1 (ASK1) as a therapeutic target for neurological diseases

Apoptosis Signal Regulating Kinase 1 Deletion Mitigates the α-Synuclein Pre-formed Fibril Propagation Model in Mice

(2019) Jie Zhang et al.   NEUROBIOLOGY OF AGING

Multiple sclerosis - a review

(2018) R. Dobson et al.   EUROPEAN JOURNAL OF NEUROLOGY

Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases

(2017) Kathleen M. Schoch et al.   NEURON

Valproic acid and ASK1 deficiency ameliorate optic neuritis and neurodegeneration in an animal model of multiple sclerosis

(2017) Yuriko Azuchi et al.   NEUROSCIENCE LETTERS

The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis

(2015) Takao Fujisawa et al.   HUMAN MOLECULAR GENETICS

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Apoptosis signal-regulating kinase 1 modulates the phenotype of α-synuclein transgenic mice

(2015) Kang-Woo Lee et al.   NEUROBIOLOGY OF AGING

Charting the human proteome: Understanding disease using a tissue-based atlas

(2015) M. Uhlen et al.   SCIENCE

Parkinson’s disease: animal models and dopaminergic cell vulnerability

(2014) Javier Blesa et al.   Frontiers in Neuroanatomy

Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

(2012) John M. Kyriakis et al.   PHYSIOLOGICAL REVIEWS

Apoptosis Signal-Regulating Kinase 1 Mediates MPTP Toxicity and Regulates Glial Activation

(2012) Kang-Woo Lee et al.   PLoS One

Peroxiredoxin-2 Protects against 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration via Attenuation of the Apoptosis Signal-Regulating Kinase (ASK1) Signaling Cascade

(2011) X. Hu et al.   JOURNAL OF NEUROSCIENCE

Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway

(2010) Xiaoli Guo et al.   EMBO Molecular Medicine

Apoptosis Signal-Regulating Kinase 1 Regulates Colitis and Colitis-Associated Tumorigenesis by the Innate Immune Responses

(2009) Yoku Hayakawa et al.   GASTROENTEROLOGY

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

(2008) H. Nishitoh et al.   GENES & DEVELOPMENT