Article
Genetics & Heredity
Qihong Nie, Wei Wei Peng, Yuli Wang, Liting Zhong, Xuebing Zhang, Ling Zeng
Summary: This study revealed that berberine can inhibit the proliferation of colon cancer cells by regulating the β-catenin signaling pathway. The expression level of CTNNB1, the active component of berberine, was found to be higher in colon cancer patients compared to normal controls. This suggests that CTNNB1 may have potential clinical diagnostic and therapeutic value in colon cancer.
Article
Biotechnology & Applied Microbiology
Haitao Gu, Zhiquan Xu, Jianbo Zhang, Yanbing Wei, Ling Cheng, Jijian Wang
Summary: circ_0038718 is highly expressed in colon cancer and can sponge miR-195-5p in the cytoplasm, facilitating malignant progression of colon cancer cells through the miR-195-5p/Axin2 axis.
Article
Biochemistry & Molecular Biology
Young-Eun Cho, Jeong-Hee Kim, Young-Hyun Che, Yong-Jun Kim, Ji-Youn Sung, Yoon-Wha Kim, Bong-Geun Choe, Sun Lee, Jae-Hoon Park
Summary: ZKSCAN3 acts as an oncogenic transcription factor in human malignant tumors, and it has been identified as a downstream effector of the Wnt/β-catenin signaling pathway. It upregulates chromosomal instability in colon cancer cells by suppressing MAD2L2 expression. Moreover, the upregulation of ZKSCAN3 is an early event in the adenoma-carcinoma sequence during colon cancer development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Joo Mi Yi, Tae-Hong Kang, Yu Kyeong Han, Ha Young Park, Ju Hwan Yang, Jin-Han Bae, Jung-Soo Suh, Tae-Jin Kim, Joong-Gook Kim, Yan-Hong Cui, Hiromu Suzuki, Kohei Kumegawa, Sung Joo Kim, Yi Zhao, In Ja Park, Seung-Mo Hong, Joon-Yong Chung, Su-Jae Lee
Summary: This study identifies Neuralized (NEURL) as a novel tumor suppressor gene that targets oncogenic Wnt/beta-catenin signaling in human cancers. NEURL expression is epigenetically regulated and suppressed in colorectal cancer. NEURL acts as an E3 ubiquitin ligase, interacting with oncogenic beta-catenin and reducing its cytoplasmic levels, thereby disrupting the canonical Wnt/beta-catenin pathway.
Article
Cell Biology
Yanlin Cai, Yi Hu, Furong Yu, Wenjuan Tong, Shufen Wang, Shunliang Sheng, Jiayu Zhu
Summary: Globally, ovarian cancer ranks as the second most common cause of gynecologic-related cancer deaths among women, with a poor prognosis. Research has shown that downregulation of AHNAK in ovarian cancer cells can significantly inhibit cell growth and metastasis, partly by dampening the Canonical Wnt cascade. Therefore, AHNAK may serve as a biomarker and potential treatment target for ovarian cancer.
Article
Medicine, Research & Experimental
Wei Zhang, Xianhui Ruan, Yaoshuang Li, Jingtai Zhi, Linfei Hu, Xiukun Hou, Xianle Shi, Xin Wang, Jinpeng Wang, Weike Ma, Pengfei Gu, Xiangqian Zheng, Ming Gao
Summary: The study reveals that KDM1A regulates the stemness of thyroid cancer and promotes cancer progression through the Wnt/beta-catenin pathway. Inhibiting KDM1A can significantly inhibit thyroid cancer progression and enhance sensitivity to chemotherapy.
Article
Medicine, Research & Experimental
Guoqiang Yan, Shiquan Li, Meng Yue, Chenyao Li, Zhenhua Kang
Summary: The study revealed that KDM5B is abundantly expressed in colorectal cancer tissues and cells, and high KDM5B expression is associated with poor prognosis. KDM5B activates the Wnt/beta-catenin pathway by downregulating CCL14, promoting the progression of colorectal cancer.
Article
Cell & Tissue Engineering
Yuhui Xu, Jiali Hu, Qiaoying Lv, Chenyi Shi, Mengdi Qiu, Liying Xie, Wei Liu, Bingyi Yang, Weiwei Shan, Yali Cheng, Bing Zhao, Xiaojun Chen
Summary: This study aimed to investigate the potential therapeutic effects and underlying mechanisms of mesenchymal stem cells (MSCs) on well-differentiated endometrial cancer (EC). The results demonstrated that endometrium-derived MSCs (eMSCs) had the highest inhibitory effect on EC cell viability and xenograft tumor growth compared to adipose-derived MSCs (AD-MSCs) and umbilical-cord-derived MSCs (UC-MSCs). The study also revealed that eMSCs inhibited EC cell proliferation and stemness through the DKK1-Wnt/beta-catenin signaling pathway. Furthermore, the combination of eMSCs and medroxyprogesterone acetate (MPA) showed enhanced inhibition of EC growth. These findings suggest that eMSCs may be a promising therapeutic strategy for young EC patients desiring fertility preservation.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Reproductive Biology
Wenjing Hu, Min Li, Youguo Chen, Xinxian Gu
Summary: The research revealed that high expression of UBE2S in HGSOC is associated with poor prognosis. UBE2S promotes proliferation, migration, and invasion of ovarian cancer, and increases Olaparib resistance by activating the Wnt/β-catenin signaling pathway.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
Yuyang Dai, Jinsong Liu, Xuyan Li, Jianzhong Deng, Cheng Zeng, Wenbin Lu, Yongzhong Hou, Ying Sheng, Honglin Wu, Qian Liu
Summary: This research aims to investigate the regulatory network of NKD1 and miRNAs in colon cancer. The study identified let-7b-5p as a miRNA that can inhibit colon cancer cell proliferation, migration, and invasion by targeting NKD1. Further analysis revealed that NKD1 enhances colon cancer cell proliferation and migration by inhibiting APC expression.
Article
Biochemistry & Molecular Biology
Xiao-Feng Luan, Lei Wang, Xue-Feng Gai
Summary: CAMTA2 is highly expressed in colon cancer and correlated with poor survival. miR-28-5p regulates CAMTA2 expression in colon cancer. The miR-28-5p/CAMTA2 axis plays a critical role in human colon cancer development and may be a potential target for diagnosis and treatment.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Yajun Luo, Siqi Huang, Jinlai Wei, He Zhou, Wuyi Wang, Jianguo Yang, Qican Deng, Hao Wang, Zhongxue Fu
Summary: This study reveals that the high expression of LINC01606 is closely associated with poor prognosis in colon cancer. LINC01606 promotes tumor cell proliferation and invasion by regulating miR-423-5p and the Wnt/β-catenin pathway, while inhibiting ferroptosis. It is a potential therapeutic target for colon cancer.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Anatomy & Morphology
Ruofei He, Yu Chen, Chenyu Qian, YiLin Hu, Xinkun Huang, Ran Tao
Summary: This study investigated the role and mechanism of DVL in gastric cancer development, and found that DVL2 is highly expressed in gastric cancer tissues, which is significantly correlated with clinicopathological parameters and patient survival. Inhibiting DVL2 can suppress gastric cancer cell proliferation, migration, and invasion, suggesting that DVL2 may be a new therapeutic target for gastric cancer.
Article
Immunology
Jia Liu, Xiufeng Chen, Xianrong Zhou, Ruokun Yi, Zhennai Yang, Xin Zhao
Summary: The study showed that L. fermentum ZS09 could inhibit the EMT and angiogenesis pathways by suppressing the Wnt/beta-catenin signalling pathway, thus inhibiting tumor metastasis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Review
Medicine, Research & Experimental
Yutong Dong, Yueqi Chen, Lincheng Zhang, Zhansong Tian, Shiwu Dong
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Orthopedics
Xiaohua Wang, Li Fang, Shulin Wang, Yueqi Chen, Huan Ma, Hongwen Zhao, Zhao Xie
BMC MUSCULOSKELETAL DISORDERS
(2020)
Review
Cell Biology
Lincheng Zhang, Yutong Dong, Yiran Wang, Wenhui Hu, Shiwu Dong, Yueqi Chen
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Wenhui Hu, Lincheng Zhang, Yutong Dong, Zhansong Tian, Yueqi Chen, Shiwu Dong
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Article
Cell Biology
Yueqi Chen, Yiran Wang, Ruohui Tang, Jing Yang, Ce Dou, Yutong Dong, Dong Sun, Chengmin Zhang, Lincheng Zhang, Yong Tang, Qijie Dai, Fei Luo, Jianzhong Xu, Shiwu Dong
CELL DEATH & DISEASE
(2020)
Review
Genetics & Heredity
Zihan Deng, Wenhui Hu, Hongbo Ai, Yueqi Chen, Shiwu Dong
Summary: Interferons (IFNs) are cytokines that play crucial roles in regulating immunity and maintaining the balance of bone matrix by affecting the communication between osteoblasts and osteoclasts. Different types of IFNs have diverse effects on the dynamic equilibrium of the skeletal system, contributing to the overall health of bones.
CURRENT GENE THERAPY
(2021)
Article
Engineering, Biomedical
Yong Tang, Keyu Luo, Jiulin Tan, Rui Zhou, Yueqi Chen, Can Chen, Zhigang Rong, Moyuan Deng, Xueke Yu, Chengmin Zhang, Qijie Dai, Wenjie Wu, Jianzhong Xu, Shiwu Dong, Fei Luo
Summary: Selective cell retention technology plays a crucial role in bone tissue engineering, and by designing appropriate scaffolds, cell adhesion, proliferation, and differentiation can be promoted to accelerate bone regeneration and angiogenesis. The newly developed scaffold holds potential for clinical applications.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Yong Tang, Keyu Luo, Yin Chen, Yueqi Chen, Rui Zhou, Can Chen, Jiulin Tan, Moyuan Deng, Qijie Dai, Xueke Yu, Jian Liu, Chengmin Zhang, Wenjie Wu, Jianzhong Xu, Shiwu Dong, Fei Luo
Summary: The phosphorylation state of PTP1B Y152 plays a central role in initiating the departure of cells from their niches during bone regeneration. A peptide called 152RM was found to promote cell migration via integrin avp3, enhance MSCs osteogenic differentiation by inhibiting ATF3, and induce type H vessels formation by activating Notch signaling. In vivo studies showed that DBM-MSN/152RM scaffolds were effective in inducing bone formation and type H vessels expansion.
BIOACTIVE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Zhiguo Ling, Chuan Yang, Jiulin Tan, Ce Dou, Yueqi Chen
Summary: MDSCs, a heterogeneous population of immature myeloid cells with immunosuppressive functions, play crucial roles in cancer-related bone metastasis and bone repair. They interact closely with stromal cells within the bone microenvironment and have promising value in the treatment of bone-related diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Engineering, Biomedical
Ce Dou, Jianmei Li, Jian He, Fei Luo, Tao Yu, Qijie Dai, Yueqi Chen, Jianzhong Xu, Xiaochao Yang, Shiwu Dong
Summary: A novel bone-targeted nanomaterial was designed for selectively eliminating mature osteoclasts while preserving beneficial preosteoclasts, showing better protective effects in treating osteoporosis with improved bone formation and vascularization. This study provides a new anabolic therapeutic strategy for bone disorders with excessive bone resorption.
BIOACTIVE MATERIALS
(2021)
Correction
Engineering, Biomedical
Yong Tang, Keyu Luo, Yin Chen, Yueqi Chen, Rui Zhou, Can Chen, Jiulin Tan, Moyuan Deng, Qijie Dai, Xueke Yu, Jian Liu, Chengmin Zhang, Wenjie Wu, Jianzhong Xu, Shiwu Dong, Fei Luo
BIOACTIVE MATERIALS
(2021)
Review
Cell Biology
Chuan Yang, Zicai Dong, Zhiguo Ling, Yueqi Chen
Summary: This review discusses the role of RNA methylation in bone metabolism and its impact on bone diseases. It summarizes advanced technologies for detecting RNA methylation and explores the potential of RNA methylation in early diagnosis and therapeutic implications for bone-related diseases. The aim of this review is to establish a theoretical basis for further research in this meaningful field.
AGEING RESEARCH REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Zicai Dong, Chuan Yang, Jiulin Tan, Ce Dou, Yueqi Chen
Summary: The skeletal system is a dynamically balanced system, and SIRT6 plays important roles in bone-related diseases such as osteoporosis, osteoarthritis, rheumatoid arthritis, and intervertebral disc degeneration. We summarize the critical roles of SIRT6 in these diseases and the relevant signaling pathways, and discuss the advances in the development of SIRT6 activators and their pharmacological profiles, providing novel treatment strategies for these skeletal diseases.
Review
Biochemistry & Molecular Biology
Bo Wang, Yutong Dong, Zhansong Tian, Yueqi Chen, Shiwu Dong
Summary: Numerous studies have shown that the skeletal system closely coordinates with the immune system, with dendritic cells and osteoclasts cooperating to mediate bone destruction and remodeling under inflammatory conditions.
Review
Rheumatology
Wenhui Hu, Yueqi Chen, Ce Dou, Shiwu Dong
Summary: This article discusses the changes in subchondral bone during OA progression and potential strategies for treating OA, including restoring abnormal remodeling and blocking blood vessels, highlighting the relationship between the subchondral bone microenvironment and OA pain.
ANNALS OF THE RHEUMATIC DISEASES
(2021)