Article
Oncology
Meng-Nan Yang, Rong Huang, Tao Zheng, Yu Dong, Wen-Juan Wang, Ya-Jie Xu, Vrati Mehra, Guang-Di Zhou, Xin Liu, Hua He, Fang Fang, Fei Li, Jian-Gao Fan, Jun Zhang, Fengxiu Ouyang, Laurent Briollais, Jiong Li, Zhong-Cheng Luo, Shanghai Birth Cohort
Summary: This study found that fetal overgrowth may be associated with a large number of altered placental gene methylations. The placental genes VSX1 and CDH13 were found to be hypermethylated in cases of fetal overgrowth. Methylation of the placental ADIPOQ gene was correlated with adiponectin levels in cord blood, suggesting the contribution of placenta-originated adiponectin to fetal adiponectin.
CLINICAL EPIGENETICS
(2022)
Article
Environmental Sciences
Xin Wang, Carrie A. Karvonen-Gutierrez, Bhramar Mukherjee, William H. Herman, Sung Kyun Park
Summary: The study found that urinary molybdenum was positively associated with adipokine levels, while cadmium, cesium, and lead were negatively associated with adipokine levels.
ENVIRONMENTAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Kajetan Kielbowski, Estera Bakinowska, Piotr Ostrowski, Bartlomiej Pala, Ewa Gromowska, Klaudia Gurazda, Pawel Dec, Andrzej Modrzejewski, Andrzej Pawlik
Summary: Psoriasis is a chronic skin condition mediated by the immune system, characterized by inflammation and excessive skin cell growth. Dendritic cells, T lymphocytes, and keratinocytes play key roles in the development of psoriasis, while the IL-23/IL-17 pathway contributes to disease progression. Adipokines secreted by adipose tissue, such as adiponectin, leptin, visfatin, and resistin, have immunomodulatory effects and may influence the progression or suppression of psoriasis. Understanding the relationship between psoriasis and adipokines could lead to new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Kathrine Stenberg, Guy W. Novotny, Thomas A. Lutz, Thomas Mandrup-Poulsen, Charlotte Reinhard Bjornvad
Summary: Indoor-confined cats are prone to obesity due to sedentary lifestyle and excessive energy intake. This study investigated the changes in gene expression related to obesity in cats and found that adiponectin expression was negatively associated with obesity in adipose tissue. In muscle, the expression of peroxisome proliferative activated receptor-gamma 2 and plasminogen activator inhibitor-1 was increased in obese cats compared to normal-weight cats. No significant changes in the expression of inflammatory cytokines were observed. This suggests that feline obesity and insulin resistance may not be solely caused by tissue-derived inflammation, but by multiple factors that require further investigation.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Yisi Shan, Yeting Chen, Haiping Gu, Yadong Wang, Yaming Sun
Summary: Epilepsy is a neurological disorder characterized by impaired glucose metabolism and changes in neuronal excitability. Leptin and adiponectin, as important regulators of glucose metabolism, have been found to be strongly associated with epilepsy. Their role in epilepsy involves various aspects such as inflammation, oxidative damage, and neuronal apoptosis. This paper aims to summarize the signaling pathways and regulation of glucose metabolism related to leptin and adiponectin in epilepsy. It also discusses the dual effects of leptin and the relationship between antiepileptic drugs and the levels of these two adipokines. Understanding their specific involvement in the pathogenesis of epilepsy has practical significance for the personalized treatment of epilepsy according to individual metabolic characteristics.
NEUROCHEMICAL RESEARCH
(2023)
Article
Immunology
Liberato Giardullo, Addolorata Corrado, Nicola Maruotti, Daniela Cici, Natalia Mansueto, Francesco Paolo Cantatore
Summary: Adipokines have diverse effects on the pathogenesis and clinical manifestations of rheumatological diseases. Different adipokines can either promote or inhibit the development and clinical course of these diseases. Further research is needed to fully understand the role of adipokines in rheumatological diseases.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Oliver C. Watkins, Preben Selvam, Reshma Appukuttan Pillai, Victoria K. B. Cracknell-Hazra, Hannah E. J. Yong, Neha Sharma, Amaury Cazenave-Gassiot, Anne K. Bendt, Keith M. Godfrey, Rohan M. Lewis, Markus R. Wenk, Shiao-Yng Chan
Summary: Maternal BMI and glycemia were found to increase the production of different placental DHA lipids, indicating an impact on different metabolic pathways. The glucose-induced elevation in placental DHA metabolism was moderated with higher maternal BMI. The associations between various DHA lipids and birthweight centile suggest that BMI and glycemia may promote fetal growth through changes in placental DHA metabolism.
MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Andreea Roxana Florian, Gheorghe Cruciat, Raluca Maria Pop, Adelina Staicu, Muresan Daniel, Stamatian Florin
Summary: This study revealed that elevated levels of leptin (L) in the early stages of pregnancy are strongly associated with the development of gestational diabetes mellitus (GDM). Meanwhile, adiponectin (AN) and CMPF levels showed no significant correlation with GDM.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Geriatrics & Gerontology
Junghee Ha, Seyul Kwak, Keun You Kim, Hyunjeong Kim, So Yeon Cho, Minae Kim, Jun-Young Lee, Eosu Kim
Summary: Obesity may influence the relationship between adipokines and cognitive function, with leptin resistance playing a role in this association. In older adults with metabolic stress, leptin-to-adiponectin ratio (LAR) may be a better indicator of Alzheimer's disease risk.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Nutrition & Dietetics
Peng Xu, Shuai Dong, Linlin Wu, Yule Bai, Xueqing Bi, Yaping Li, Chang Shu
Summary: Gestational diabetes mellitus (GDM) is a significant metabolic complication of pregnancy that affects the future health of both the mother and the newborn. The pathogenesis of GDM is not fully understood, but it is clear that placental secretion of insulin-like growth factors, adipokines, tumor necrosis factor-alpha, cytokines, and insulin resistance play a key role. Additionally, DNA methylation of related molecules and pathway-related genes influence gene expression and contribute to the pathogenesis of GDM.
Article
Environmental Sciences
Seulbi Lee, Carrie Karvonen-Gutierrez, Bhramar Mukherjee, William H. H. Herman, Sung Kyun Park
Summary: Adipokines, which are secreted by adipose tissue, may be involved in obesity-related metabolic diseases. The impact of environmental phenols and parabens on racial disparities in metabolic disease burden is not well established and requires further investigation.
ENVIRONMENTAL POLLUTION
(2022)
Review
Medicine, General & Internal
Wenhao Lu, Wenjie Feng, Jieyu Lai, Dongliang Yuan, Wenfeng Xiao, Yusheng Li
Summary: Sarcopenia is an age-related disease characterized by decreases in muscle mass, strength, and function, and an increase in body fat content, particularly visceral fat. Adipose tissue secretes adipokines, which have regulatory effects on muscle. For example, high levels of leptin decrease muscle function, while adiponectin inhibits muscle atrophy-related genes to prevent muscle mass loss. This article discusses the effects of adipokines such as leptin, adiponectin, resistin, mucin, and lipocalin-2 on muscle and their importance in understanding sarcopenia development.
CHINESE MEDICAL JOURNAL
(2023)
Article
Orthopedics
Yi Qiao, Xiangyun Yao, Yu Zhao, Yuhao Kang, Caiqi Xu, Jinzhong Zhao, Song Zhao
Summary: This study found a potential role for adipokines in the pathogenesis of frozen shoulder and demonstrated a correlation between adipokine expression and patients' pain and stiffness.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Environmental Sciences
Maya A. Deyssenroth, Maria Jose Rosa, Melissa N. Eliot, Karl T. Kelsey, Itai Kloog, Joel D. Schwartz, Gregory A. Wellenius, Shouneng Peng, Ke Hao, Carmen J. Marsit, Jia Chen
Summary: This study identified a sensitive window during which maternal exposure to PM2.5 was significantly associated with reduced infant birthweight. Specific placental genes related to amino acid transport and cellular respiration may impact infant birthweight and maternal PM2.5 exposure levels. These findings suggest that maternal PM2.5 exposure may alter placental programming of fetal growth, leading to potential downstream health effects.
ENVIRONMENTAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Min Liu, Fei Mo, Xiaohan Song, Yun He, Yan Yuan, Jiaoyan Yan, Ye Yang, Jian Huang, Shu Zhang
Summary: The study utilized comprehensive bioinformatics analysis and experimental validation to identify hsa-miR-21-5p as significantly up-regulated in breast cancer tissues, cells, and exosomes. Further investigations confirmed the diagnostic value of plasma exosomal hsa-miR-21-5p in distinguishing healthy individuals from breast cancer patients, with a sensitivity of 86.7% and specificity of 93.3%.
Article
Pediatrics
Lauren A. Eaves, Adam E. Enggasser, Marie Camerota, Semsa Gogcu, William A. Gower, Hadley Hartwell, Wesley M. Jackson, Elizabeth Jensen, Robert M. Joseph, Carmen J. Marsit, Kyle Roell, Hudson P. Santos, Jeffrey S. Shenberger, Lisa Smeester, Diana Yanni, Karl C. K. Kuban, T. Michael O'Shea, Rebecca C. Fry
Summary: This study investigated the relationship between CpG methylation in the placenta and neonatal blood and neonatal inflammation in extremely preterm infants. The study found that placental CpG methylation was strongly associated with sustained systemic inflammation (ISSI), while neonatal blood CpG methylation was associated with day-one inflammation (DOI).
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Jesse M. Tehrani, Elizabeth Kennedy, Pei Wen Tung, Amber Burt, Karen Hermetz, Tracy Punshon, Brian P. Jackson, Ke Hao, Jia Chen, Margaret R. Karagas, Devin C. Koestler, Barry Lester, Carmen J. Marsit
Summary: The study found that prenatal exposure to cadmium may affect the expression of placental microRNAs, which target genes involved in nervous system development and are associated with abnormal neurobehavioral outcomes in newborns.
PEDIATRIC RESEARCH
(2023)
Article
Water Resources
Hannah E. Laue, Yuka Moroishi, Brian P. Jackson, Thomas J. Palys, Emily R. Baker, Susan A. Korrick, Juliette C. Madan, Margaret R. Karagas
Summary: Arsenic is associated with social behaviors, and the infant gut microbiome may modify this association.
EXPOSURE AND HEALTH
(2023)
Article
Pediatrics
Elizabeth M. Kennedy, Karen Hermetz, Amber Burt, Dong Pei, Devin C. Koestler, Ke Hao, Jia Chen, Diane Gilbert-Diamond, Usha Ramakrishnan, Margaret R. Karagas, Carmen J. Marsit
Summary: Placental microRNAs are associated with early childhood growth trajectory and play a role in regulating placental cellular dynamics, impacting infant growth beyond birth.
PEDIATRIC RESEARCH
(2023)
Article
Oncology
Meghan E. Muse, Connolly D. Carroll, Lucas A. Salas, Margaret R. Karagas, Brock C. Christensen
Summary: DNA methylation is cell-type-specific and altered DNA methylation is established to occur early in breast carcinogenesis. This study presents a novel method for estimating the cellular composition of breast tissue and milk and assessing cell-type-independent alterations to DNA methylation associated with breast cancer risk factors. The study identified age-associated hypermethylated CpGs in both breast tissue and breast milk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Alexander H. Fischer, Jason Y. Y. Wong, Dalsu Baris, Stella Koutros, Margaret R. Karagas, Molly Schwenn, Alison Johnson, Juan Alguacil, Debra T. Silverman, Nathaniel Rothman
Summary: This study conducted an independent case-control study in northern New England to replicate previous findings in Spain. The study found that acidic urine pH is associated with increased bladder cancer risk, especially in smokers.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Genetics & Heredity
Shelby Bell-Glenn, Lucas A. Salas, Annette M. Molinaro, Rondi A. Butler, Brock C. Christensen, Karl T. Kelsey, John K. Wiencke, Devin C. Koestler
Summary: DNA methylation (DNAm)-based cell mixture deconvolution (CMD) is important in epigenome-wide association studies, but the detection limits and uncertainty quantification of DNAm-based CMD have not been determined. This study describes analytical frameworks for determining the detection limits and quantifying the uncertainty of DNAm-based CMD, which may improve the rigor, reproducibility, and replicability of epigenome-wide association studies involving CMD.
Article
Multidisciplinary Sciences
Gianluca Ursini, Pasquale Di Carlo, Sreya Mukherjee, Qiang Chen, Shizhong Han, Jiyoung Kim, Maya Deyssenroth, Carmen J. Marsit, Jia Chen, Ke Hao, Giovanna Punzi, Daniel R. Weinberger
Summary: Our previous research indicates that genomic risk for schizophrenia is influenced by early life complications and sex-biased neurodevelopmental trajectories. In this study, we identify specific genes and potential mechanisms in the placenta that may mediate these outcomes. Through analysis of healthy term placentae and fetal brain, we highlight 139 placenta and schizophrenia-specific risk genes, many of which are sex-biased, and suggest a connection with nutrient-sensing capabilities of placenta and trophoblast invasiveness. These findings also implicate the Coronavirus-pathogenesis pathway and its association with SARS-CoV-2-positive pregnancies.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Emily Nissen, Alexander Reiner, Simin Liu, Robert B. Wallace, Annette M. Molinaro, Lucas A. Salas, Brock C. Christensen, John K. Wiencke, Devin C. Koestler, Karl T. Kelsey
Summary: In the past decade, DNAm-based deconvolution methods have been developed to estimate the proportions of leukocytes in peripheral blood using cell-specific DNAm markers. This study provides reference ranges for immune populations in a group of post-menopausal American women.
CLINICAL EPIGENETICS
(2023)
Article
Neurosciences
Ze Zhang, John K. Wiencke, Karl T. Kelsey, Devin C. Koestler, Annette M. Molinaro, Steven C. Pike, Prasoona Karra, Brock C. Christensen, Lucas A. Salas
Summary: Studying the composition of brain cells and their association with neurological conditions is important for understanding brain-related pathophysiology and neuroscience. A DNA methylation-based deconvolution method can be used to identify different types of brain cells. Our study demonstrates the potential utility of this method in normal and diseased brain tissues, including Alzheimer's disease, autism, Huntington's disease, epilepsy, and schizophrenia. This method can accelerate the understanding of cellular composition and cell-type-specific epigenetic states in normal and diseased brain tissues.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Oncology
Ji-Qing Chen, Lucas A. Salas, John K. Wiencke, Devin C. Koestler, Annette M. Molinaro, Angeline S. Andrew, John D. Seigne, Margaret R. Karagas, Karl T. Kelsey, Brock C. Christensen
Summary: This study found associations between specific immune cell subtypes, age acceleration, and bladder cancer outcomes. These findings provide important prognostic information for the management of bladder cancer recurrence and survival.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Naisi Zhao, Flavia Teles, Jiayun Lu, Devin C. Koestler, James Beck, Eric Boerwinkle, Jan Bressler, Karl T. Kelsey, Elizabeth A. Platz, Dominique S. Michaud
Summary: This study investigated individual susceptibility to periodontitis by conducting an epigenome-wide association study using peripheral blood. The results showed that epigenetic variations in ZPF57 and HOXA4 were significantly associated with periodontitis.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bo Zhang, Jianghua He, Jinxiang Hu, Prabhakar Chalise, Devin C. Koestler
Summary: Component-wise Sparse Mixture Regression (CSMR) is a promising regression-based clustering method for detecting heterogeneous relationships. However, it can yield inconsistent results in high-dimensional data due to limitations in feature selection. We explored different regularized regression methods within the CSMR framework and found that substituting Adaptive-Lasso improved the clustering accuracy and internal consistency, even in high-dimensional scenarios.
STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY
(2023)
Article
Cell Biology
Dominique S. Michaud, Mei Chung, Naisi Zhao, Devin C. Koestler, Jiayun Lu, Elizabeth A. Platz, Karl T. Kelsey
Summary: This study investigated the association between three different biological age acceleration measures and risk of lung cancer, and found no significant association between them.
Article
Public, Environmental & Occupational Health
Michael Mortillo, Carmen J. Marsit
Summary: The purpose of this review is to summarize recent literature on the effects of early-life environmental exposures on placental DNA methylation, identify how variation in placental methylation is regulated in an exposure-specific manner, and encourage further research in this area. Multiple studies have found associations between prenatal environmental exposures and placental methylation at both gene-specific and epigenome-wide levels. Different exposures lead to unique patterns of methylation, and cross-exposure assessments have identified certain genes that consistently show differential placental methylation. Studies focusing on exposures such as air pollution, maternal smoking, environmental contaminants, and trace metals are more abundant, while studies on socioeconomic adversity and circadian disruption are scarce but show significant effects. Understanding the impacts of early-life environmental exposures on placental methylation is crucial for establishing the link between the maternal environment, epigenetic variation, and long-term health. Future studies should incorporate repeated measures of exposure throughout pregnancy to determine critical windows of heavy placental methylation effects. Methylation-based scores and sequencing technology could provide insights into epigenetic gestational age and identify more genomic regions affected by methylation. Studies on the impact of other exposures such as pesticides, alcohol, and other chemicals are also necessary.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2023)