The actin modulator hMENA regulates GAS 6‐ AXL axis and pro‐tumor cancer/stromal cell cooperation

Cross-talk between receptor tyrosine kinases AXL and ERBB3 regulates invadopodia formation in melanoma cells

(2019) Or-Yam Revach et al.   CANCER RESEARCH

Combinations of immuno-checkpoint inhibitors predictive biomarkers only marginally improve their individual accuracy

(2019) Matteo Pallocca et al.   Journal of Translational Medicine

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

(2019) Yu Shi et al.   NATURE

Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

(2019) Junya Peng et al.   CELL RESEARCH

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

(2018) Jianfang Liu et al.   CELL

CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

(2018) Shicheng Su et al.   CELL

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis

(2018) Francesca Di Modugno et al.   ONCOGENE

hMENA is a key regulator in endothelin-1/β-arrestin1–induced invadopodial function and metastatic process

(2018) Francesca Di Modugno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

(2018) Anne-Marie Givel et al.   Nature Communications

Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells

(2018) Matthew A. Lakins et al.   Nature Communications

FAP delineates heterogeneous and functionally divergent stromal cells in immune-excluded breast tumors

(2018) Viviana Cremasco et al.   Cancer Immunology Research

TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy

(2017) Yemsratch T. Akalu et al.   IMMUNOLOGICAL REVIEWS

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells

(2017) Sandra Tavares et al.   Nature Communications

The significance of ENAH in carcinogenesis and prognosis in gastric cancer

(2017) Dan-Dan Wang et al.   Oncotarget

Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy

(2017) Ryu Kanzaki et al.   Scientific Reports

Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth

(2017) Anisha M. Hammer et al.   NEOPLASIA

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

(2016) Christopher J. Tape et al.   CELL

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

(2016) Willy Hugo et al.   CELL

Molecular Pathways: AXL, a Membrane Receptor Mediator of Resistance to Therapy

(2016) M. Scaltriti et al.   CLINICAL CANCER RESEARCH

Pancreatic cancer microenvironment, to target or not to target?

(2016) R. M. Carr et al.   EMBO Molecular Medicine

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

(2016) Philippe Gascard et al.   GENES & DEVELOPMENT

The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

(2016) Andrew D. Rouillard et al.   Database-The Journal of Biological Databases and Curation

The pattern of hMENA isoforms is regulated by TGF-β1 in pancreatic cancer and may predict patient outcome

(2016) Roberta Melchionna et al.   OncoImmunology

Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial

(2015) Naiyer A Rizvi et al.   LANCET ONCOLOGY

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Prognostic impact of alternative splicing-derived hMENA isoforms in resected, node-negative, non-small-cell lung cancer

(2015) Emilio Bria et al.   Oncotarget

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

(2014) Ruth Scherz-Shouval et al.   CELL

Pancreatic Cancer Clinical Trials and Accrual in the United States

(2013) William A. Hoos et al.   JOURNAL OF CLINICAL ONCOLOGY

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Fibroblast Activation Protein in Remodeling Tissues

(2012) M. Jacob et al.   CURRENT MOLECULAR MEDICINE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors

(2012) F. Di Modugno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

(2011) R. Navab et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress promotes myofibroblast differentiation and tumour spreading

(2010) Aurore Toullec et al.   EMBO Molecular Medicine

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer

(2010) K Vuoriluoto et al.   ONCOGENE

The Cooperation between hMena Overexpression and HER2 Signalling in Breast Cancer

(2010) Francesca Di Modugno et al.   PLoS One

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

(2010) M. Kraman et al.   SCIENCE

Metastasis: tumor cells becoming MENAcing

(2010) Frank Gertler et al.   TRENDS IN CELL BIOLOGY

Ena/VASP: towards resolving a pointed controversy at the barbed end

(2009) J. E. Bear et al.   JOURNAL OF CELL SCIENCE

Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

(2009) C. Gjerdrum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes

(2007) M. Tjwa et al.   BLOOD