LSD 1 inhibition induces differentiation and cell death in Merkel cell carcinoma

The nf-core framework for community-curated bioinformatics pipelines

(2020) Philip A. Ewels et al.   NATURE BIOTECHNOLOGY

Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis

(2020) Donglim Esther Park et al.   NATURE CELL BIOLOGY

Ordino: a visual cancer analysis tool for ranking and exploring genes, cell lines, and tissue samples

(2019) Marc Streit et al.   BIOINFORMATICS

Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition

(2019) Arnaud Augert et al.   Science Signaling

g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

(2019) Uku Raudvere et al.   NUCLEIC ACIDS RESEARCH

The cellular basis of mechanosensory Merkel-cell innervation during development

(2019) Blair A Jenkins et al.   eLife

Quantification of experimentally induced nucleotide conversions in high-throughput sequencing datasets

(2019) Tobias Neumann et al.   BMC BIOINFORMATICS

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Improved CUT&RUN chromatin profiling tools

(2019) Michael P Meers et al.   eLife

Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition

(2019) Alexis Harold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LSD1 Inhibition Promotes Epithelial Differentiation through Derepression of Fate-Determining Transcription Factors

(2019) Shaun Egolf et al.   Cell Reports

Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG

(2019) Jamie N. Anastas et al.   CANCER CELL

LSD1/KDM1A inhibitors in clinical trials: advances and prospects

(2019) Yuan Fang et al.   Journal of Hematology & Oncology

ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia

(2018) Tamara Maes et al.   CANCER CELL

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

(2018) Wanqiang Sheng et al.   CELL

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function

(2018) Archana Sehrawat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis

(2018) Matthias Muhar et al.   SCIENCE

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

(2018) Jay H. Kalin et al.   Nature Communications

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

(2018) Alba Maiques-Diaz et al.   Cell Reports

The biology and treatment of Merkel cell carcinoma: current understanding and research priorities

(2018) Paul W. Harms et al.   Nature Reviews Clinical Oncology

The Pfam protein families database in 2019

(2018) Sara El-Gebali et al.   NUCLEIC ACIDS RESEARCH

Neuroendocrine Key Regulator Gene Expression in Merkel Cell Carcinoma

(2018) Emil Chteinberg et al.   NEOPLASIA

Insulinoma-associated 1: A novel nuclear marker in Merkel cell carcinoma (cutaneous neuroendocrine carcinoma)

(2017) Patrick S. Rush et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains

(2017) Léa Bouché et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prediction of potent shRNAs with a sequential classification algorithm

(2017) Raphael Pelossof et al.   NATURE BIOTECHNOLOGY

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

(2017) M Ryan Corces et al.   NATURE METHODS

Thiol-linked alkylation of RNA to assess expression dynamics

(2017) Veronika A Herzog et al.   NATURE METHODS

Epigenetic plasticity and the hallmarks of cancer

(2017) William A. Flavahan et al.   SCIENCE

TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function

(2017) Emily A. Meyers et al.   Cold Spring Harbor Perspectives in Biology

Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial

(2016) Howard L Kaufman et al.   LANCET ONCOLOGY

Targeting the cancer epigenome for therapy

(2016) Peter A. Jones et al.   NATURE REVIEWS GENETICS

PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma

(2016) Paul T. Nghiem et al.   NEW ENGLAND JOURNAL OF MEDICINE

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Response rates and durability of chemotherapy among 62 patients with metastatic Merkel cell carcinoma

(2016) Jayasri G. Iyer et al.   Cancer Medicine

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC

(2015) Helai P. Mohammad et al.   CANCER CELL

The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma

(2015) Paul William Harms et al.   CANCER RESEARCH

Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermis

(2015) S. M. Ostrowski et al.   DEVELOPMENT

NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program

(2015) A. Pataskar et al.   EMBO JOURNAL

A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation

(2015) Benoit Laurent et al.   MOLECULAR CELL

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

(2015) Florian Grebien et al.   Nature Chemical Biology

Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666

(2015) Kenneth W. Duncan et al.   ACS Medicinal Chemistry Letters

Embryonic maturation of epidermal Merkel cells is controlled by a redundant transcription factor network

(2014) C. N. Perdigoto et al.   DEVELOPMENT

MS Amanda, a Universal Identification Algorithm Optimized for High Accuracy Tandem Mass Spectra

(2014) Viktoria Dorfer et al.   JOURNAL OF PROTEOME RESEARCH

Interplay between the Cancer Genome and Epigenome

(2013) Hui Shen et al.   CELL

Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells

(2013) Evan S Bardot et al.   EMBO JOURNAL

Smart-seq2 for sensitive full-length transcriptome profiling in single cells

(2013) Simone Picelli et al.   NATURE METHODS

An Optimized microRNA Backbone for Effective Single-Copy RNAi

(2013) Christof Fellmann et al.   Cell Reports

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells

(2012) William J. Harris et al.   CANCER CELL

Inhibiting Interactions of Lysine Demethylase LSD1 with Snail/Slug Blocks Cancer Cell Invasion

(2012) G. Ferrari-Amorotti et al.   CANCER RESEARCH

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

(2012) Tino Schenk et al.   NATURE MEDICINE

Control of neuronal differentiation by sumoylation of BRAF35, a subunit of the LSD1-CoREST histone demethylase complex

(2012) M. Ceballos-Chavez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Universal and Confident Phosphorylation Site Localization Using phosphoRS

(2011) Thomas Taus et al.   JOURNAL OF PROTEOME RESEARCH

LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells

(2011) Antonio Adamo et al.   NATURE CELL BIOLOGY

Specific inhibition of NF-Y subunits triggers different cell proliferation defects

(2011) Paolo Benatti et al.   NUCLEIC ACIDS RESEARCH

The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes

(2011) Gerd A. Müller et al.   NUCLEIC ACIDS RESEARCH

Merkel Cell Polyomavirus-Infected Merkel Cell Carcinoma Cells Require Expression of Viral T Antigens

(2010) R. Houben et al.   JOURNAL OF VIROLOGY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs

(2009) S. Kosugi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent developments in the MAFFT multiple sequence alignment program

(2008) K. Katoh et al.   BRIEFINGS IN BIOINFORMATICS

Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma

(2008) H. Feng et al.   SCIENCE