Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance

Further considerations towards an effective and efficient oncology drug discovery DMPK strategy

(2020) Beth Williamson et al.   CURRENT DRUG METABOLISM

Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades

(2020) Michael Davies et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

In Vitro-In Vivo Extrapolation and Hepatic Clearance-Dependent Underprediction

(2019) Christine M. Bowman et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Prediction of fraction unbound in microsomal and hepatocyte incubations – a comparison of methods across industry datasets

(2019) Susanne Winiwarter et al.   MOLECULAR PHARMACEUTICS

In Vitro - In Vivo Accuracy: The CYP3A4 Anomaly

(2019) Christine M Bowman et al.   DRUG METABOLISM AND DISPOSITION

TREND ANALYSIS OF A DATABASE OF INTRAVENOUS PHARMACOKINETIC PARAMETERS IN HUMANS FOR 1352 DRUG COMPOUNDS

(2018) Franco Lombardo et al.   DRUG METABOLISM AND DISPOSITION

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

(2012) Li Di et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Practical use of the regression offset approach for the prediction ofin vivointrinsic clearance from hepatocytes

(2012) Anna-Karin Sohlenius-Sternbeck et al.   XENOBIOTICA

The Corrected Traditional Equations for Calculation of Hepatic Clearance that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water and the Corresponding Corrected PBPK Equation

(2010) Leonid M. Berezhkovskiy   JOURNAL OF PHARMACEUTICAL SCIENCES

Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction ofin vivoclearance

(2010) Joanne A. Foster et al.   XENOBIOTICA

Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development

(2009) Masato Chiba et al.   AAPS Journal

Relationship between Passive Permeability, Efflux, and Predictability of Clearance from In Vitro Metabolic Intrinsic Clearance

(2009) L. Huang et al.   DRUG METABOLISM AND DISPOSITION

Reliability of human cryopreserved hepatocytes and liver microsomes asin vitrosystems to predict metabolic clearance

(2008) R. Stringer et al.   XENOBIOTICA