Article
Multidisciplinary Sciences
Emiko Desvaux, Antoine Hamon, Sandra Hubert, Cheima Boudjeniba, Bastien Chassagnol, Jack Swindle, Audrey Aussy, Laurence Laigle, Jessica Laplume, Perrine Soret, Pierre Jean-Francois, Isabelle Dupin-Roger, Mickael Guedj, Philippe Moingeon
Summary: This study utilized a computational repurposing approach to identify candidate therapeutic drugs to control progression towards severe airways inflammation during COVID-19. Analysis highlighted the potential of drugs such as dexamethasone, JAK2 inhibitors, estrogens, and inhibitors of alarmins or their receptors in preventing or slowing down the progression of severe COVID-19. The study also identified various drugs interacting with the aforementioned targets as potential treatments.
Article
Pharmacology & Pharmacy
Vatsalya Vatsalya, Fengyuan Li, Jane Frimodig, Khushboo S. Gala, Shweta Srivastava, Maiying Kong, Vijay A. Ramchandani, Wenke Feng, Xiang Zhang, Craig J. McClain
Summary: The study found that thiamine can effectively reduce the Th17 cell-mediated IL-17 proinflammatory response, targeting the cytokine storm and neurological symptoms of COVID-19, with an estimated effective and safe dose range of 79-474 mg daily.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Edouard Charles Le Carpentier, Emmanuel Canet, Damien Masson, Maelle Martin, Guillaume Deslandes, Aurelie Gaultier, Eric Dailly, Ronan Bellouard, Matthieu Gregoire
Summary: In this study, the impact of inflammation on the pharmacokinetics of midazolam in COVID-19 patients was investigated. The results suggest that inflammation could reduce the metabolism of midazolam by CYP3A. Therefore, caution should be exercised when administering drugs metabolized by CYP3A in cases of severe inflammation.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Chemistry, Medicinal
Yu Zheng, Yuke Li, Mao Li, Rujing Wang, Yuhong Jiang, Mengnan Zhao, Jun Lu, Rui Li, Xiaofang Li, Sanjun Shi
Summary: This article discusses the importance of cytokine storm in the context of the COVID-19 pandemic and the potential of using nanotechnology as a treatment approach. In response to the challenges posed by viral variants, new technologies need to be developed to neutralize or control cytokine storm.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Immunology
Jianbo Tian, Ming Zhang, Meng Jin, Fengqin Zhang, Qian Chu, Xiaoyang Wang, Can Chen, Huihui Yue, Li Zhang, Ronghui Du, Dong Zhao, Zhaofu Zeng, Yang Zhao, Kui Liu, Mengmei Wang, Ke Hu, Xiaoping Miao, Huilan Zhang
Summary: This study found that tocilizumab treatment in COVID-19 patients can lower the risk of in-hospital death and acute respiratory distress syndrome. Patients had heightened inflammation and dysregulated immune cells before treatment, but these indicators improved after tocilizumab administration.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Charles Ochieng' Olwal, Nora Nghuchuzie Nganyewo, Kesego Tapela, Alexandra Lindsey Djomkam Zune, Oloche Owoicho, Yaw Bediako, Samuel Duodu
Summary: Sepsis and COVID-19 share many pathophysiological and clinical features, both leading to consumptive thrombocytopenia, coagulopathy, multi-organ dysfunction syndrome, respiratory failure, among other complications. Therefore, lessons learned from sepsis care could potentially inform on COVID-19 management.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Shaul Lev, Tamar Gottesman, Gal Sahaf Levin, Doron Lederfein, Evgeny Berkov, Dror Diker, Aliza Zaidman, Amir Nutman, Tahel Ilan Ber, Alon Angel, Lior Kellerman, Eran Barash, Roy Navon, Olga Boico, Yael Israeli, Michal Rosenberg, Amir Gelman, Roy Kalfon, Einav Simon, Noa Avni, Mary Hainrichson, Oren Zarchin, Tanya M. Gottlieb, Kfir Oved, Eran Eden, Boaz Tadmor
Summary: This single-center cohort study found that IP-10 levels correlated with COVID-19 severity and admission to the intensive care unit, and corticosteroid therapy significantly decreased IP-10 levels. Serial IP-10 measurements may serve as an actionable aid in managing inflammation and guiding therapeutic decisions in COVID-19 patients.
Article
Medicine, Research & Experimental
Neha Dabholkar, Srividya Gorantla, Sunil Kumar Dubey, Amit Alexander, Rajeev Taliyan, Gautam Singhvi
Summary: SARS-CoV-2, the virus responsible for COVID-19, primarily affects the respiratory system and can lead to acute respiratory distress syndrome and potentially multi-organ failure. Efforts to manage COVID-19 include the use of antiviral drugs, but research into the potential use of methylene blue as a treatment has shown promise.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Microbiology
Claude Kwe Yinda, Julia R. Port, Trenton Bushmaker, Irene Offei Owusu, Jyothi N. Purushotham, Victoria A. Avanzato, Robert J. Fischer, Jonathan E. Schulz, Myndi G. Holbrook, Madison J. Hebner, Rebecca Rosenke, Tina Thomas, Andrea Marzi, Sonja M. Best, Emmie de Wit, Carl Shaia, Neeltje van Doremalen, Vincent J. Munster
Summary: The study demonstrates that humanized transgenic mice developed dose-dependent disease when inoculated with SARS-CoV-2, showing upper and lower respiratory tract infection with viral replication also in the brain. The pathological and immunological manifestations observed in these mice resemble human COVID-19, suggesting the model's usefulness in elucidating COVID-19 pathogenesis and testing countermeasures.
Editorial Material
Medicine, Research & Experimental
Hugh Rosen, Michael B. A. Oldstone
Summary: In this study, the researchers explored the association between S1P serum levels and the severity of COVID-19, proposing a new prognostic indicator.
EMBO MOLECULAR MEDICINE
(2021)
Review
Immunology
Aitor Gonzaga, Etelvina Andreu, Luis M. Hernandez-Blasco, Rut Meseguer, Karima Al-Akioui-Sanz, Barbara Soria-Juan, Jose Carlos Sanjuan-Gimenez, Cristina Ferreras, Juan R. Tejedo, Guillermo Lopez-Lluch, Rosa Goterris, Loreto Macia, Jose M. Sempere-Ortells, Abdelkrim Hmadcha, Alberto Borobia, Jose L. Vicario, Ana Bonora, Cristobal Aguilar-Gallardo, Jose L. Poveda, Cristina Arbona, Cristina Alenda, Fabian Tarin, Francisco M. Marco, Esperanza Merino, Francisco Jaime, Jose Ferreres, Juan Carlos Figueira, Carlos Canada-Illana, Sergio Querol, Manuel Guerreiro, Cristina Eguizabal, Alejandro Martin-Quiros, Angel Robles-Marhuenda, Antonio Perez-Martinez, Carlos Solano, Bernat Soria
Summary: The COVID-19 pandemic has had an unprecedented global impact, causing significant social and economic disruptions and a high number of fatalities. In some cases, the virus can cause immune abnormalities and severe respiratory illness, necessitating the development of innovative therapeutic approaches to prevent mortality in high-risk patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Philip S. Crooke, John T. Tossberg, Krislyn P. Porter, Thomas M. Aune
Summary: Decreased A-to-I editing of Alu dsRNAs is associated with increased inflammatory responses in patients with severe COVID-19 disease.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yan Yang, Zixin Cai, Jingjing Zhang
Summary: This meta-analysis investigated the association between hyperglycemia at admission and COVID-19 outcomes, and found that hyperglycemia at admission may be a strong predictor of mortality and complications in COVID-19 patients.
BIOSCIENCE REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Purva Asrani, Keshav Tiwari, Mathew Suji Eapen, Kielan Darcy McAlinden, Greg Haug, Matt D. Johansen, Philip M. Hansbro, Katie L. Flanagan, Md. Imtaiyaz Hassan, Sukhwinder Singh Sohal
Summary: COVID-19, caused by the novel coronavirus SARS-CoV-2, has led to a global pandemic, with the development and distribution of vaccines being crucial. This review article categorizes and analyzes potential drugs for COVID-19, highlighting the need for effective therapeutic interventions for those who are not vaccinated or susceptible to emerging SARS-CoV-2 variant strains.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Hongjun Chen, Leisheng Zhang, Wei Zhang, Lili Liu, Zhihua Dai, Miao Chen, Donghang Zhang
Summary: This study evaluated the effects of early blood purification therapy on severe and critical COVID-19 patients, showing that blood purification therapy significantly reduced inflammatory cytokine levels, improved related symptoms and complications, and held promise in slowing down the deterioration of the disease in the early stage.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Chemistry, Organic
Dale Kuik, J. Adam McCubbin, Geoffrey K. Tranmer
SYNTHESIS-STUTTGART
(2017)
Article
Chemistry, Organic
Jennifer Bao, Dale Kuik, Geoffrey K. Tranmer
Article
Biochemistry & Molecular Biology
Dinghua Liang, Xing Wu, Brian B. Hasinoff, David E. Herbert, Geoffrey K. Tranmer
Article
Materials Science, Multidisciplinary
A. R. Majdinasab, P. K. Manna, Y. Wroczynskyj, J. van Lierop, N. Cicek, G. K. Tranmer, Q. Yuan
MATERIALS CHEMISTRY AND PHYSICS
(2019)
Review
Chemistry, Medicinal
Nitesh Sanghai, Kashfia Shafiq, Geoffrey K. Tranmer
Summary: Global scientists are working tirelessly to find the best solution to treat COVID-19, resorting to drug repurposing methods with existing approved drugs, as there is currently no single drug approved by the FDA for treating SARS-CoV-2 that causes COVID-19.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Review
Geriatrics & Gerontology
Kashfia Shafiq, Nitesh Sanghai, Ying Guo, Jiming Kong
Summary: This review discusses the mechanisms of accelerated aging in neurodegenerative diseases, such as ALS, AD, and PD, focusing on the post-translational modifications of SOD1 by oxidative stress. The misfolded SOD1 plays a role in the pathogenesis by propagating like prions from cell to cell, and these modified conformations are detected in brain tissues of patients with these diseases. Oxidative stress-induced non-native modifications of SOD1 are considered to contribute to the global implication in accelerated or pathological aging.
Letter
Medicine, Research & Experimental
Nitesh Sanghai, Geoffrey K. Tranmer
CURRENT MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Nitesh Sanghai, Geoffrey K. Tranmer
Summary: This review presents evidence of the pivotal role of H2O2 in modulating the toxicity of SOD1 in the pathophysiology of ALS, and highlights the importance of targeting pathological concentrations of H2O2 to halt the misfolding of SOD1.
Article
Chemistry, Medicinal
Katia Messner, Billy Vuong, Geoffrey K. Tranmer
Summary: This review discusses the history of boron's early use in drugs and the use of boron functional groups in medicinal chemistry. It highlights critical developments from these functional groups and showcases the application of boron in prodrugs, softdrugs, and nanocarriers.
Review
Cell Biology
Nitesh Sanghai, Geoffrey K. Tranmer
Summary: This article discusses the common pathological mechanisms of neurodegenerative diseases (NDDs), including aging, oxidative stress, defective protein handling, and neuroinflammation. The authors applied a holistic approach to identify and present shared mechanisms among different NDDs, which is particularly relevant for diseases like AD, PD, and ALS, and could aid in the development and diagnosis of new strategies.
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
