Review
Medicine, Research & Experimental
Dominik Hartl, Valeria de Luca, Anna Kostikova, Jason Laramie, Scott Kennedy, Enrico Ferrero, Richard Siegel, Martin Fink, Sohail Ahmed, John Millholland, Alexander Schuhmacher, Markus Hinder, Luca Piali, Adrian Roth
Summary: In the era of precision medicine, drug discovery and development are undergoing unprecedented opportunities and challenges. By adopting new technologies and methods, the transition from serendipity-driven to data-driven approach is achieved, promoting the development of modern Translational Precision Medicine methods.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Health Care Sciences & Services
Ruggero De Maria Marchiano, Gabriele Di Sante, Geny Piro, Carmine Carbone, Giampaolo Tortora, Luca Boldrini, Antonella Pietragalla, Gennaro Daniele, Maria Tredicine, Alfredo Cesario, Vincenzo Valentini, Daniela Gallo, Gabriele Babini, Marika D'Oria, Giovanni Scambia
Summary: The emergence of Precision Medicine has revolutionized translational research globally, emphasizing patient-centric therapeutic choices and digitizing individual health status. Real world data-based translational applications offer a promising alternative to traditional evidence-based medicine approaches.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Medicine, General & Internal
Thilo von Groote, Melanie Meersch-Dini
Summary: Sepsis and septic shock are major public health concerns, but current treatment strategies often lack precision. Biomarkers provide opportunities to improve patient care and clinical research, by predicting and evaluating these conditions. They can potentially pave the way for precision medicine in sepsis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Fangyoumin Feng, Bihan Shen, Xiaoqin Mou, Yixue Li, Hong Li
Summary: The response rate of most anti-cancer drugs is limited due to cancer heterogeneity and complex drug mechanisms. Personalized treatment using molecular biomarkers shows promise. Advances in pharmacogenomics, especially computational methods in drug response prediction, have been successful and increasingly utilized in personalized cancer medicine.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Biochemical Research Methods
Chen Yang, Xiaowen Huang, Yan Li, Junfei Chen, Yuanyuan Lv, Shixue Dai
Summary: This study retrospectively analyzed 1135 HCC patients and developed a random forest-based prediction model to estimate TP53 mutational status, as well as a robust poor prognosis-associated signature which showed superior ability to predict survival in TP53-mutant patients. In silico screening revealed three targets and two agents that might have potential therapeutic implications in high-PPS patients, presenting a comprehensive view of potential treatment strategy.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Medicine, General & Internal
Elisa Assirelli, Susanna Naldi, Veronica Brusi, Jacopo Ciaffi, Lucia Lisi, Luana Mancarella, Federica Pignatti, Lia Pulsatelli, Cesare Faldini, Francesco Ursini, Simona Neri
Summary: Research biobanks are non-profit structures that collect, manipulate, store, analyze and distribute systematically organized biological samples and data for research and development purposes. The Rheumatology BioBank (RheumaBank) in Italy collects, processes, stores, and distributes biological samples and associated data from patients with inflammatory joint diseases, aiming to promote large-scale, high-quality research studies in rheumatoid arthritis (RA), psoriatic arthritis (PsA), and other spondyloarthritides (SpA) to improve treatment personalization.
FRONTIERS IN MEDICINE
(2023)
Article
Health Care Sciences & Services
Umile Giuseppe Longo, Arianna Carnevale, Carlo Massaroni, Daniela Lo Presti, Alessandra Berton, Vincenzo Candela, Emiliano Schena, Vincenzo Denaro
Summary: The study proposes a personalized, predictive, participatory, precision, and preventive (P5) medicine model, highlighting the potential for tailoring diagnosis and therapy for patients with RC diseases by defining genetic predispositions and assessing lifestyle and environmental factors.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Health Care Sciences & Services
Samir Rachid Zaim, Colleen Kenost, Hao Helen Zhang, Yves A. Lussier
Summary: This study introduces a novel approach to develop reference standards for evaluating the accuracy of single-subject analyses in transcriptomes, proteomes, and metabolomes. By optimizing thresholding effect-size and expression-level, the study aimed to improve consensus between different analytical methods. Results demonstrated that robust reference standards can reduce bias and increase concordance among analytical methods.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Clinical Neurology
Eva Ceskova, Petr Silhan
Summary: Personalised medicine aims to provide individualized treatment for each patient, using quantifiable indicators to make decisions. Precision psychiatry is in its early stages, utilizing artificial intelligence and machine learning to gather and analyze sufficient data for diagnosis assessment and treatment planning.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Review
Oncology
Kazuma Kiyotani, Yujiro Toyoshima, Yusuke Nakamura
Summary: The significant advances in cancer genomics have allowed for precision medicine based on genomic and molecular profiling, but clinical application still faces challenges. Cancer immunotherapies, particularly targeting neoantigens derived from somatic mutations, offer potential for precise treatment based on genomic sequencing results.
CANCER BIOLOGY & MEDICINE
(2021)
Review
Medicine, General & Internal
Theodoros Karampitsakos, Brenda M. Juan-Guardela, Argyris Tzouvelekis, Jose D. Herazo-Maya
Summary: Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous and lethal chronic lung disease. Precision medicine approaches have not been effectively implemented in IPF clinical practice, despite the existence of numerous diagnostic, prognostic, and theragnostic biomarker candidates.
Editorial Material
Medicine, General & Internal
John C. Marshall, Aleksandra Leligdowicz
Summary: Infection leads to sepsis, and the development of clinical disease is triggered by the innate immune response of the host. However, the advancement of understanding in this biological response has not been matched by successful treatment development. The COVID-19 pandemic has brought about changes in this aspect, showing potential therapeutic approaches and the possibility of evaluating them. This article reviews the history of mediator-targeted therapy for sepsis and discusses the conceptual, biological, technological, and organizational challenges that need to be addressed to develop effective treatments for a leading cause of global morbidity and mortality.
Review
Health Care Sciences & Services
Vibeke Fosse, Emanuela Oldoni, Chiara Gerardi, Rita Banzi, Maddalena Fratelli, Florence Bietrix, Anton Ussi, Antonio L. Andreu, Emmet McCormack
Summary: The introduction of personalized medicine brings new challenges to disease modeling. This article evaluates the relevance, validity, and predictive value of current preclinical models used in stratified medicine approaches. Through analyzing case models in oncology and brain disorders, it is found that the currently available methods need further development and validation. There are also identified deficits in preclinical research, including relevance of experimental models, quality assessment practices, reporting, regulation, and the gap between preclinical and clinical research.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Kun Liu, Yingbo Zhang, Cesar Martin, Xiaoling Ma, Bairong Shen
Summary: Since the birth of the first IVF baby in 1978, over eight million IVF babies have been born worldwide, leading to numerous advancements in reproductive medicine. Through a comprehensive search, curation, and review of scientific papers, the progress and technologies in reproductive medicine were summarized. Both male and female reproductive medicine have made significant progress, with markers advancing from karyotype analysis to single-cell omics. However, the limited availability of comprehensive databases hinder the application of precision medicine in reproductive medicine, including risk exposure, disease markers, prevention drugs, and effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Susan P. P. Foy, Kyle Jacoby, Daniela A. A. Bota, Theresa Hunter, Zheng Pan, Eric Stawiski, Yan Ma, William Lu, Songming Peng, Clifford L. L. Wang, Benjamin Yuen, Olivier Dalmas, Katharine Heeringa, Barbara Sennino, Andy Conroy, Michael T. T. Bethune, Ines Mende, William White, Monica Kukreja, Swetha Gunturu, Emily Humphrey, Adeel Hussaini, Duo An, Adam J. J. Litterman, Boi Bryant Quach, Alphonsus H. C. Ng, Yue Lu, Chad Smith, Katie M. M. Campbell, Daniel Anaya, Lindsey Skrdlant, Eva Yi-Hsuan Huang, Ventura Mendoza, Jyoti Mathur, Luke Dengler, Bhamini Purandare, Robert Moot, Michael C. C. Yi, Roel Funke, Alison Sibley, Todd Stallings-Schmitt, David Y. Y. Oh, Bartosz Chmielowski, Mehrdad Abedi, Yuan Yuan, Jeffrey A. A. Sosman, Sylvia M. M. Lee, Adam J. J. Schoenfeld, David Baltimore, James R. R. Heath, Alex Franzusoff, Antoni Ribas, Arati V. V. Rao, Stefanie J. J. Mandl
Summary: We used CRISPR-Cas9 non-viral precision genome-editing to knockout the endogenous TCR genes and insert neoantigen-specific TCRs into T cells of cancer patients. This approach demonstrated the feasibility of isolating and cloning multiple TCRs that recognize mutational neoantigens. The gene-edited T cells showed promising results in a phase I clinical trial.
NATURE REVIEWS DRUG DISCOVERY
(2023)
Article
Psychiatry
Michelle T. Pedersen, Thea O. Andersen, Amy Clotworthy, Andreas K. Jensen, Katrine Strandberg-Larsen, Naja H. Rod, Tibor V. Varga
Summary: The COVID-19 pandemic and national lockdowns have had negative effects on mental health. Mental health was worse during strict lockdown periods and improved during reopening phases. Women, young individuals, and those with mental and/or chronic illnesses had poorer mental health compared to others. Individuals with pre-existing mental illnesses had less variability in mental health over time. The largest differences between gender and age groups were observed during the second lockdown.
Article
Endocrinology & Metabolism
Tibor V. Varga, Tianwei Xu, Mika Kivimaki, Amar J. Mehta, Reiner Rugulies, Naja H. Rod
Summary: The study found that individuals with high organizational justice had more favorable long-term cardiometabolic biomarker patterns compared to those with low organizational justice. This suggests that organizational justice may contribute to the lower risk of chronic diseases by influencing metabolic trajectories over time.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Lotte Simonsen, Jesper Lau, Thomas Kruse, Tingqing Guo, Jim McGuire, Jacob Fuglsbjerg Jeppesen, Kristoffer Niss, Per Sauerberg, Kirsten Raun, Charlotta Dornonville de la Cour
Summary: Combining GLP-1 and glucagon receptor agonism for weight loss and metabolic control has received attention, but reproducing results in humans is difficult. Pre-clinical evaluation of co-agonists showed species differences and challenges in predicting optimal receptor balance in humans. The pharmacodynamic effects of the co-agonists varied depending on species, compound exposure, and study length, complicating the identification of an optimal clinical candidate and explaining the low number of clinical successes for this dual agonism.
Article
Clinical Neurology
Thea Otte Andersen, Agnete Skovlund Dissing, Elin Rosenbek Severinsen, Andreas Kryger Jensen, Vi Thanh Pham, Tibor V. Varga, Naja Hulvej Rod
Summary: It was found that sleep behavior is a significant predictor for forecasting mental health symptoms, outperforming novel approaches using objective and subjective smartphone behavior.
Article
Multidisciplinary Sciences
Amelie Keller, Jonathan Groot, Joane Matta, Feifei Bu, Tarik El Aarbaoui, Maria Melchior, Daisy Fancourt, Marie Zins, Marcel Goldberg, Anne-Marie Nybo Andersen, Naja H. Rod, Katrine Strandberg-Larsen, Tibor V. Varga
Summary: This study investigated the impact of the COVID-19 pandemic on mental health and found a relationship between housing conditions and mental health in European countries. Living alone was associated with higher levels of loneliness and lower life satisfaction. Lack of access to outdoor facilities and household crowding were also suggestively associated with worse mental health outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Amy Clotworthy, Megan Davies, Timothy J. Cadman, Jessica Bengtsson, Thea O. Andersen, Manik Kadawathagedara, Johan L. Vinther, Tri-Long Nguyen, Tibor V. Varga
Summary: In this study, the authors estimated the time and costs associated with meeting diverse formatting requirements for manuscript submissions in biomedical publishing. They found a significant diversity in submission requirements among the analyzed journals. It was estimated that approximately 230 million USD were lost in 2021 alone due to reformatting articles, and this number could reach 2.5 billion USD between 2022 and 2030 if the current practice remains unchanged. The authors concluded that free-format submission guidelines would benefit both researchers and editors, but a minimum set of requirements is necessary to avoid structured manuscript submissions.
Letter
Endocrinology & Metabolism
Tibor V. Varga
DIABETES & METABOLISM
(2023)
Article
Clinical Neurology
Aina Gabarrell-Pascuet, Tibor V. Varga, Maria Victoria Moneta, Jose Luis Ayuso-Mateos, Elvira Lara, Beatriz Olaya, Josep Maria Haro, Joan Domenech-Abella
Summary: The study conducted on a representative sample of Spanish adults aimed to assess the association between age groups and the risk of major depressive disorder (MDD) before and during the COVID-19 pandemic. The study found an increase in MDD risk among younger adults during the pandemic and identified loneliness, low resilience, and worsened economic circumstances as potential mediating factors. The findings suggest that addressing loneliness, improving resilience, and providing financial support can help reduce the impact of the pandemic on depressive symptoms among young adults.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Letter
Endocrinology & Metabolism
Tibor V. Varga
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Clinical Neurology
Aina Gabarrell-Pascuet, Joan Domenech-Abella, Naja H. Rod, Tibor V. Varga
Summary: This study used model-based clustering to identify six latent subgroups of individuals with moderate to severe depression. The study found differential associations between socioeconomic factors, somatic diseases, prescription medication use, and these subgroups of depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Thea Otte Andersen, Christoffer Sejling, Andreas Kryger Jensen, Henning Johannes Drews, Beate Ritz, Tibor V. Varga, Naja Hulvej Rod
Summary: This study investigated the complex relationship between nighttime smartphone use, sleep, and mental health among adult populations in Denmark.
Article
Medicine, General & Internal
Naja Hulvej Rod, Thea Otte Andersen, Elin Rosenbek Severinsen, Christoffer Sejling, Agnete Dissing, Vi Thanh Pham, Mette Nygaard, Lise Kristine Hojsgaard Schmidt, Henning Johannes Drews, Tibor Varga, Nina La Cour Freiesleben, Henriette Svarre Nielsen, Andreas Kryger Jensen
Summary: The SmartSleep Study aims to assess the impact of night-time smartphone use on sleep patterns and health. Through a combination of large-scale data collection and clinical examination, the study provides detailed investigations into the physiological dysregulation and long-term health consequences associated with night-time smartphone use and sleep impairment. The study includes 30,673 participants with information on smartphone use, sleep, and health.
Editorial Material
Public, Environmental & Occupational Health
Dan W. Meyrowitsch, Andreas K. Jensen, Jane B. Sorensen, Tibor V. Varga
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Pediatrics
Tibor V. Varga, Asa Andersson, Katarina Lauruschkus, asa B. Tornberg
Summary: The purpose of this study was to investigate the acute and long-term changes in hormonal and inflammatory biomarkers in nonambulant children with cerebral palsy in response to dynamic standing exercise. Blood samples were collected before and after exercise, and hormone and inflammatory metabolites were measured. The results showed that dynamic standing exercise can improve the hormone and inflammatory levels in children with cerebral palsy.
PEDIATRIC EXERCISE SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Tibor V. Varga
Summary: Prognostic risk prediction models for cardiovascular disease often overlook socioeconomic factors, leading to inequities in risk prediction. This article recommends the explicit inclusion of individual-level socioeconomic determinants in these models to promote health equity. Further research and analysis are needed to determine if prognostic risk prediction models can achieve health equity.