Establishing the pattern of the vertebrate limb

The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13

(2020) Maria Félix Bastida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb

(2020) Irene Delgado et al.   Science Advances

Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes

(2019) Eddie Rodríguez-Carballo et al.   BMC BIOLOGY

Positional Information ‐ a concept underpinning our understanding of developmental biology

(2019) Neil Vargesson   DEVELOPMENTAL DYNAMICS

An autoregulatory cell cycle timer integrates growth and specification in chick wing digit development

(2019) Joseph Pickering et al.   eLife

Can laboratory model systems instruct human limb regeneration?

(2019) Ben D. Cox et al.   DEVELOPMENT

Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity

(2018) Bo Gao et al.   DEVELOPMENT

Regulatory integration of Hox factor activity with T-box factors in limb development

(2018) Deepak Jain et al.   DEVELOPMENT

Reassessing the Role of Hox Genes during Vertebrate Development and Evolution

(2018) Moisés Mallo   TRENDS IN GENETICS

Genomic Knockout of Two Presumed Forelimb Tbx5 Enhancers Reveals They Are Nonessential for Limb Development

(2018) Thomas J. Cunningham et al.   Cell Reports

Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis

(2018) Bjørt K. Kragesteen et al.   NATURE GENETICS

An intrinsic cell cycle timer terminates limb bud outgrowth

(2018) Joseph Pickering et al.   eLife

Timed Collinear Activation of Hox Genes during Gastrulation Controls the Avian Forelimb Position

(2018) Chloe Moreau et al.   CURRENT BIOLOGY

Evolution of antero-posterior patterning of the limb: Insights from the chick

(2017) Matthew Towers   GENESIS

The Conserved Sonic Hedgehog Limb Enhancer Consists of Discrete Functional Elements that Regulate Precise Spatial Expression

(2017) Laura A. Lettice et al.   Cell Reports

Anatomical integration of the sacral–hindlimb unit coordinated by GDF11 underlies variation in hindlimb positioning in tetrapods

(2017) Yoshiyuki Matsubara et al.   Nature Ecology & Evolution

Inhibition of Shh signalling in the chick wing gives insights into digit patterning and evolution

(2016) Joseph Pickering et al.   DEVELOPMENT

Shhand ZRS enhancer colocalisation is specific to the zone of polarising activity

(2016) Iain Williamson et al.   DEVELOPMENT

Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity

(2016) Rita Aires et al.   DEVELOPMENTAL CELL

A role for HOX13 proteins in the regulatory switch between TADs at theHoxDlocus

(2016) Leonardo Beccari et al.   GENES & DEVELOPMENT

Evolution of Hoxa11 regulation in vertebrates is linked to the pentadactyl state

(2016) Yacine Kherdjemil et al.   NATURE

Cranial shape evolution in adaptive radiations of birds: comparative morphometrics of Darwin's finches and Hawaiian honeycreepers

(2016) Masayoshi Tokita et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Gradients, waves and timers, an overview of limb patterning models

(2016) Irene Delgado et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Gata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb Development

(2016) Shinichi Hayashi et al.   PLoS Genetics

Spatiotemporal regulation of GLI target genes in the mammalian limb bud

(2015) Jordan P. Lewandowski et al.   DEVELOPMENTAL BIOLOGY

How the embryo makes a limb: determination, polarity and identity

(2015) Cheryll Tickle   JOURNAL OF ANATOMY

Sall4-Gli3system in early limb progenitors is essential for the development of limb skeletal elements

(2015) Ryutaro Akiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An intrinsic timer specifies distal structures of the vertebrate limb

(2015) Patricia Saiz-Lopez et al.   Nature Communications

RA Acts in a Coherent Feed-Forward Mechanism with Tbx5 to Control Limb Bud Induction and Initiation

(2015) Satoko Nishimoto et al.   Cell Reports

Diffusible signals and epigenetic timing cooperate in late proximo-distal limb patterning

(2014) A. Rosello-Diez et al.   DEVELOPMENT

Formation of Proximal and Anterior Limb Skeleton Requires Early Function of Irx3 and Irx5 and Is Negatively Regulated by Shh Signaling

(2014) Danyi Li et al.   DEVELOPMENTAL CELL

Vertebrate Limb Bud Formation Is Initiated by Localized Epithelial-to-Mesenchymal Transition

(2014) J. Gros et al.   SCIENCE

Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients

(2014) J. Raspopovic et al.   SCIENCE

Sonic hedgehog-expressing cells in the developing limb measure time by an intrinsic cell cycle clock

(2014) Kavitha Chinnaiya et al.   Nature Communications

A Combination of Activation and Repression by a Colinear Hox Code Controls Forelimb-Restricted Expression of Tbx5 and Reveals Hox Protein Specificity

(2014) Satoko Nishimoto et al.   PLoS Genetics

GATA6 Is a Crucial Regulator of Shh in the Limb Bud

(2014) Elena Kozhemyakina et al.   PLoS Genetics

Sp6 and Sp8 Transcription Factors Control AER Formation and Dorsal-Ventral Patterning in Limb Development

(2014) Endika Haro et al.   PLoS Genetics

The Evolution of Lineage-Specific Regulatory Activities in the Human Embryonic Limb

(2013) Justin Cotney et al.   CELL

Switching Axial Progenitors from Producing Trunk to Tail Tissues in Vertebrate Embryos

(2013) Arnon Dias Jurberg et al.   DEVELOPMENTAL CELL

Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning

(2013) Timothy A. Sanders et al.   NATURE

Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb

(2013) B. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Switch Between Topological Domains Underlies HoxD Genes Collinearity in Mouse Limbs

(2013) G. Andrey et al.   SCIENCE

Antagonism between Retinoic Acid and Fibroblast Growth Factor Signaling during Limb Development

(2013) Thomas J. Cunningham et al.   Cell Reports

Oct4 Is Required ∼E7.5 for Proliferation in the Primitive Streak

(2013) Brian DeVeale et al.   PLoS Genetics

Hox genes regulate the onset of Tbx5 expression in the forelimb

(2012) C. Minguillon et al.   DEVELOPMENT

Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos

(2012) J. Itou et al.   DEVELOPMENT

Opposing Functions of the ETS Factor Family Define Shh Spatial Expression in Limb Buds and Underlie Polydactyly

(2012) Laura A. Lettice et al.   DEVELOPMENTAL CELL

Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb

(2012) Justin Cotney et al.   GENOME RESEARCH

Hox Genes Regulate Digit Patterning by Controlling the Wavelength of a Turing-Type Mechanism

(2012) R. Sheth et al.   SCIENCE

A regulatory network of two galectins mediates the earliest steps of avian limb skeletal morphogenesis

(2011) Ramray Bhat et al.   BMC DEVELOPMENTAL BIOLOGY

Pitx1 is necessary for normal initiation of hindlimb outgrowth through regulation of Tbx4 expression and shapes hindlimb morphologies via targeted growth control

(2011) V. Duboc et al.   DEVELOPMENT

Islet1-mediated activation of the  -catenin pathway is necessary for hindlimb initiation in mice

(2011) Y. Kawakami et al.   DEVELOPMENT

Axial Hox9 activity establishes the posterior field in the developing forelimb

(2011) B. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diffusible Signals, Not Autonomous Mechanisms, Determine the Main Proximodistal Limb Subdivision

(2011) A. Rosello-Diez et al.   SCIENCE

Initiation of Proximal-Distal Patterning in the Vertebrate Limb by Signals and Growth

(2011) K. L. Cooper et al.   SCIENCE

Insights into bird wing evolution and digit specification from polarizing region fate maps

(2011) Matthew Towers et al.   Nature Communications

WNT5A/JNK and FGF/MAPK Pathways Regulate the Cellular Events Shaping the Vertebrate Limb Bud

(2010) Jerome Gros et al.   CURRENT BIOLOGY

Oriented cell motility and division underlie early limb bud morphogenesis

(2010) L. A. Wyngaarden et al.   DEVELOPMENT

Growth differentiation factor 11 signaling controls retinoic acid activity for axial vertebral development

(2010) Young Jae Lee et al.   DEVELOPMENTAL BIOLOGY

Identification of genes downstream of the Shh signalling in the developing chick wing and syn-expressed with Hoxd13 using microarray and 3D computational analysis

(2010) Fiona Bangs et al.   MECHANISMS OF DEVELOPMENT

A random cell motility gradient downstream of FGF controls elongation of an amniote embryo

(2010) Bertrand Bénazéraf et al.   NATURE

The Role of Spatially Controlled Cell Proliferation in Limb Bud Morphogenesis

(2010) Bernd Boehm et al.   PLOS BIOLOGY

A Self-Regulatory System of Interlinked Signaling Feedback Loops Controls Mouse Limb Patterning

(2009) J.-D. Benazet et al.   SCIENCE

Hoxd13 binds in vivo and regulates the expression of genes acting in key pathways for early limb and skeletal patterning

(2008) Valentina Salsi et al.   DEVELOPMENTAL BIOLOGY

Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

(2008) Jianjian Zhu et al.   DEVELOPMENTAL CELL

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

(2008) S. A. Vokes et al.   GENES & DEVELOPMENT

Integration of growth and specification in chick wing digit-patterning

(2008) Matthew Towers et al.   NATURE

Genetic evidence that FGFs have an instructive role in limb proximal–distal patterning

(2008) Francesca V. Mariani et al.   NATURE

Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity

(2008) T. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA