Genetic deficiency of Phactr1 promotes atherosclerosis development via facilitating M1 macrophage polarization and foam cell formation

Molecular mechanism for nobiletin to enhance ABCA1/G1 expression in mouse macrophages

(2020) Tomoe Tsuboi et al.   ATHEROSCLEROSIS

Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection

(2019) David Adlam et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Phosphatase Actin Regulator-1 (PHACTR-1) Knockdown Suppresses Cell Proliferation and Migration and Promotes Cell Apoptosis in the bEnd.3 Mouse Brain Capillary Endothelial Cell Line

(2019) Yao Jing et al.   MEDICAL SCIENCE MONITOR

Pleiotropic effects of laminar flow and statins depend on the Krüppel-like factor-induced lncRNA MANTIS

(2019) Matthias S Leisegang et al.   EUROPEAN HEART JOURNAL

Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion

(2019) Jessica M. Johnston et al.   Science Advances

Lipoprotein receptor signalling in atherosclerosis

(2019) Chieko Mineo   CARDIOVASCULAR RESEARCH

PHACTR1 splicing isoforms and eQTLs in atherosclerosis-relevant human cells

(2018) Valérie-Anne Codina-Fauteux et al.   BMC Medical Genetics

Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of AtherosclerosisNovelty and Significance

(2018) Jenneke Leentjens et al.   CIRCULATION RESEARCH

PHACTR1 regulates oxidative stress and inflammation to coronary artery endothelial cells via interaction with NF-κB/p65

(2018) Zhihui Zhang et al.   ATHEROSCLEROSIS

Role of Ox-LDL and LOX-1 in Atherogenesis

(2018) Ajoe John Kattoor et al.   CURRENT MEDICINAL CHEMISTRY

Atherosclerosis and immunity: a perspective

(2018) Fereshte Abdolmaleki et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Optical Coherence Tomography–Defined Plaque Vulnerability in Relation to Functional Stenosis Severity and Microvascular Dysfunction

(2018) Eisuke Usui et al.   JACC-Cardiovascular Interventions

Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1

(2016) Michael E. Reschen et al.   ATHEROSCLEROSIS

Low MT‐CO1 in Monocytes and Microvesicles Is Associated With Outcome in Patients With Coronary Artery Disease

(2016) Paul Holvoet et al.   Journal of the American Heart Association

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

CREB pathway links PGE2 signaling with macrophage polarization

(2015) Bing Luan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidized LDL–bound CD36 recruits an Na+/K+-ATPase–Lyn complex in macrophages that promotes atherosclerosis

(2015) Yiliang Chen et al.   Science Signaling

Oxidized LDL–bound CD36 recruits an Na+/K+-ATPase–Lyn complex in macrophages that promotes atherosclerosis

(2015) Yiliang Chen et al.   Science Signaling

Macrophage Phenotypes and Their Modulation in Atherosclerosis

(2014) Federica De Paoli et al.   CIRCULATION JOURNAL

Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection

(2014) Stéphanie Debette et al.   NATURE GENETICS

Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction

(2013) Jessica van Setten et al.   ATHEROSCLEROSIS

Myeloid Krüppel-Like Factor 4 Deficiency Augments Atherogenesis in ApoE −/− Mice—Brief Report

(2012) Nikunj Sharma et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Third universal definition of myocardial infarction

(2012) Kristian Thygesen et al.   EUROPEAN HEART JOURNAL

G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly

(2012) M. Wiezlak et al.   JOURNAL OF CELL SCIENCE

CD14++CD16+ Monocytes Independently Predict Cardiovascular Events

(2012) Kyrill S. Rogacev et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetic Heritability of Ischemic Stroke and the Contribution of Previously Reported Candidate Gene and Genomewide Associations

(2012) Steve Bevan et al.   STROKE

Structures of the Phactr1 RPEL Domain and RPEL Motif Complexes with G-Actin Reveal the Molecular Basis for Actin Binding Cooperativity

(2012) Stephane Mouilleron et al.   STRUCTURE

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

(2011) Mireille Ouimet et al.   Cell Metabolism

Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction

(2011) Christopher J. O'Donnell et al.   CIRCULATION

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE