Review
Nutrition & Dietetics
Christina Chrysohoou, Christos Fragoulis, Ioannis Leontsinis, Ioannis Gastouniotis, Dimitra Fragouli, Maximos Georgopoulos, Emmanouil Mantzouranis, Marina Noutsou, Konstantinos P. Tsioufis
Summary: The mechanisms leading to the development of heart failure in diabetes mellitus patients are multifactorial. Assessing the risk of heart failure development in diabetic patients is valuable for identifying high-risk subgroups and defining low-risk subpopulations. Both imaging parameters and biomarkers are important tools for recognizing diabetic patients at risk of heart failure manifestation and arrhythmogenic risk, and for improving patients' outcomes utilizing drugs and non-pharmaceutical cardioprotective tools such as diet modification.
Article
Cardiac & Cardiovascular Systems
Gerasimos Filippatos, Javed Butler, Dimitrios Farmakis, Faiez Zannad, Anne Pernille Ofstad, Joao Pedro Ferreira, Jennifer B. Green, Julio Rosenstock, Sven Schnaidt, Martina Brueckmann, Stuart J. Pocock, Milton Packer, Stefan D. Anker
Summary: In patients with heart failure and preserved ejection fraction, empagliflozin significantly reduces the risk of heart failure outcomes, regardless of diabetes status at baseline.
Review
Chemistry, Multidisciplinary
Michael Lichtenauer, Peter Jirak, Vera Paar, Brigitte Sipos, Kristen Kopp, Alexander E. Berezin
Summary: Heart failure and type 2 diabetes mellitus have a synergistic effect on cardiovascular morbidity and mortality in patients with established cardiovascular disease. While conventional biomarkers show limited predictive ability in HFpEF, novel biomarkers may improve risk stratification and prediction of poor outcomes in these patients. Further research in large clinical trials is required to elucidate the role of novel biomarkers in point-of-care and routine practice for T2DM patients with HF.
APPLIED SCIENCES-BASEL
(2021)
Article
Cardiac & Cardiovascular Systems
Leen Delrue, Marc Vanderheyden, Monika Beles, Pasquale Paolisso, Giuseppe Di Gioia, Riet Dierckx, Sofie Verstreken, Marc Goethals, Ward Heggermont, Jozef Bartunek
Summary: The study found that elevated levels of serpin peptidase inhibitor, clade A member 3 (SERPINA3) are associated with increased mortality or unplanned cardiac readmission in patients with de novo or worsened heart failure. Elevated SERPINA3 levels may identify a subgroup of heart failure patients at higher mortality risk.
Article
Cardiac & Cardiovascular Systems
Leen Delrue, Marc Vanderheyden, Monika Beles, Pasquale Paolisso, Giuseppe Di Gioia, Riet Dierckx, Sofie Verstreken, Marc Goethals, Ward Heggermont, Jozef Bartunek
Summary: The study revealed that elevated levels of circulating SERPINA3 in heart failure patients may be associated with increased mortality or unplanned cardiac readmission, especially in patients with elevated levels of SERPINA3 along with other markers.
Article
Cardiac & Cardiovascular Systems
Stefano Ghio, Valentina Mercurio, Andrea Attanasio, Gaetano Asile, Carlo Gabriele Tocchetti, Stefania Paolillo
Summary: There is a strong bidirectional relationship between diabetes mellitus (DM) and heart failure (HF), with DM activating multiple molecular and pathophysiological mechanisms that can damage the heart in the long term. However, the prognostic role of DM in chronic and acute HF is still unclear, with gaps in evidence due to the heterogeneity of patient phenotypes and the necessity to better characterize individual patients and their comorbidities. This review aims to summarize the negative impact of DM on HF and analyze available data on the prognostic implications in both chronic and acute HF.
HEART FAILURE REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Shaoping Wang, Bijan J. Borah, Shujuan Cheng, Shiying Li, Ze Zheng, Xiaoyan Gu, Ming Gong, Yi Lyu, Jinghua Liu
Summary: The study found that diabetic patients had greater EF improvement after revascularization, and had higher risk of overall mortality. However, in the EF improved group, the risk was similar between diabetic and non-diabetic patients. Therefore, further research is needed to determine the indication for revascularization in patients with coronary artery disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Catarina Cidade-Rodrigues, Filipe M. Cunha, Catarina Elias, Diana Oliveira, Paulo Bettencourt, Patricia Lourenco
Summary: The study found that elevated uric acid levels predicted higher mortality in acute heart failure patients with diabetes, but not in non-diabetic patients. Uric acid may play a different role in acute heart failure depending on the presence of diabetes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Jesse D. Cochran, Yoshimitsu Yura, Mark C. Thel, Heather Doviak, Ariel H. Polizio, Yuka Arai, Yohei Arai, Keita Horitani, Eunbee Park, Nicholas W. Chavkin, Anupreet Kour, Soichi Sano, Nitin Mahajan, Megan Evans, Mahalia Huba, Nadia Martinez Naya, Hanna Sun, Young Ho Ban, Karen K. Hirschi, Stefano Toldo, Antonio Abbate, Todd E. Druley, Frederick L. Ruberg, Mathew S. Maurer, Justin A. Ezekowitz, Jason R. B. Dyck, Kenneth Walsh
Summary: The study identified an enrichment of TET2-mediated CH in patients with HFpEF, which was associated with exacerbated diastolic dysfunction. Patients with HFpEF, aged >= 70 years and CH, exhibited a worse prognosis in terms of 5-year cardiovascular-related hospitalization rate compared with those without CH.
Article
Cardiac & Cardiovascular Systems
Matthieu Wargny, Mikael Croyal, Stephanie Ragot, Elise Gand, David Jacobi, Jean-Noel Trochu, Xavier Prieur, Cedric Le May, Thomas Goronflot, Bertrand Cariou, Pierre-Jean Saulnier, Samy Hadjadj
Summary: This study investigated whether TMAO and its precursors could be potential prognostic factors for heart failure in patients with type 2 diabetes. Results showed that TMAO and its precursors were not significant prognostic factors for heart failure requiring hospitalization, but homocysteine was identified as an independent risk factor for all-cause death in these patients.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alberto Palazzuoli, Massimo Iacoviello
Summary: Type 2 diabetes mellitus is a significant risk factor for heart failure, both directly and indirectly. Its presence in heart failure patients is associated with a worse prognosis. Patients with heart failure are also more prone to developing type 2 diabetes mellitus.
HEART FAILURE REVIEWS
(2023)
Article
Multidisciplinary Sciences
Irena Patsan, Amanda Tapley, Peter Davoren, Alison Fielding, Elizabeth Holliday, Jean Ball, Andrew Davey, Mieke van Driel, Rachel Turner, Katie Mulquiney, Neil Spike, Kristen FitzGerald, Parker Magin
Summary: This study aimed to describe the temporal trends and associations of Australian general practitioner registrars' prescription and initiation of "new" second-line oral agents compared to sulphonylureas. The results showed a significant increase in the prescription and initiation of "new" medications compared to sulphonylureas over time, with less prescribing for non-English-speaking patients and regional variation.
Article
Peripheral Vascular Disease
Michael A. Francisco, Joshua F. Lee, Zachary Barrett-O'Keefe, H. Jonathan Groot, Stephen M. Ratchford, Kanokwan Bunsawat, Jeremy K. Alpenglow, John J. Ryan, Jose N. Nativi, Russell S. Richardson, D. Walter Wray
Summary: The study revealed a significant decline in lower limb microvascular function in patients with HFpEF compared to healthy controls, possibly associated with systemic inflammation and oxidative damage. However, disease-related biomarkers of inflammation and oxidative damage were not correlated with responses to passive leg movement.
Article
Cardiac & Cardiovascular Systems
Benedicte Heegaard, Tania Deis, Kasper Rossing, Mads Ersboll, Caroline Kistorp, Finn Gustafsson
Summary: This study aims to investigate the impact of diabetes on hemodynamics in heart failure patients. It found that heart failure patients with diabetes have higher filling pressures, including pulmonary capillary wedge pressure, central venous pressure, cardiac index, and mean arterial pressure. Additionally, poor glycemic control in diabetic patients is associated with higher filling pressures. Therefore, diabetic cardiomyopathy may contribute to the increased mortality in heart failure patients with diabetes, but other unknown mechanisms beyond hemodynamic factors are also likely involved.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Lukasz Wolowiec, Joanna Banach, Jacek Budzynski, Anna Wolowiec, Mariusz Kozakiewicz, Maciej Bielinski, Albert Jasniak, Agata Olejarczyk, Grzegorz Grzesk
Summary: The study aimed to assess the prognostic value of plasma catestatin concentration in patients with heart failure with reduced ejection fraction (HFrEF) in predicting unplanned hospitalization and all-cause death at a 2-year follow-up. The study included 122 hospitalized Caucasian patients in NYHA classes II to IV. Patients who died during the follow-up period had higher levels of CST, NT-proBNP, troponin T, creatinine, and glucose, and lower TAPSE, hemoglobin concentration, hematocrit, and platelet count compared to survivors. Plasma catestatin concentration was positively associated with NYHA class and blood NT-proBNP concentration. Higher plasma catestatin concentration increased the risk of all-cause death by more than five times. Plasma CST concentration is a valuable prognostic parameter in predicting death from all causes and unplanned hospitalization in patients with HFrEF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Behavioral Sciences
Tazman Davies, Daisy Coyle, Maria Shahid, Simone Pettigrew, Jason H. Y. Wu, Matti Marklund
Summary: This study examined the prevalence and impact of price promotions on purchases of packaged foods and beverages in Australia, finding that "less healthy" products were more frequently purchased on price promotion. Low socio-economic status households consumed more energy from price-promoted "less healthy" products, indicating that restricting these promotions could improve diet quality and reduce dietary inequalities.
Article
Nutrition & Dietetics
Simone Pettigrew, Leon Booth, Elizabeth Dunford, Tailane Scapin, Jacqui Webster, Jason Wu, Maoyi Tian, D. Praveen, Gary Sacks
Summary: This study assessed support for a broad range of nutrition interventions across seven countries. The results showed substantial support for interventions involving food labelling and food reformulation, while fiscal interventions had the weakest support. Factors associated with stronger support were higher self-rated health, higher educational attainment, female sex, older age, and perceptions of consuming a healthy diet.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Peripheral Vascular Disease
Kathy Trieu, Daisy H. Coyle, Emalie Rosewarne, Maria Shahid, Rain Yamamoto, Chizuru Nishida, Bruce Neal, Feng J. He, Matti Marklund, Jason H. Y. Wu
Summary: This study modeled the impact of complying with the World Health Organization's sodium benchmarks in Australia and found that adopting more stringent WHO benchmarks could more effectively prevent cardiovascular disease, chronic kidney disease, and stomach cancer, reducing deaths and new cases.
Letter
Endocrinology & Metabolism
Tae Won Yi, Michelle M. Y. Wong, Brendon L. L. Neuen, Clare Arnott, Paul Poirier, Jochen Seufert, April Slee, Wally Rapattoni, Fernando G. G. Ang, David C. C. Wheeler, Kenneth W. W. Mahaffey, Vlado Perkovic, Adeera Levin
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Vikas S. Sridhar, Brendon L. Neuen, Robert A. Fletcher, April Slee, Fernando G. Ang, Wally Rapattoni, Clare Arnott, David Z. Cherney, Vlado Perkovic, David C. Wheeler, Adeera Levin
Summary: This study analyzed a pooled population from two clinical trials and confirmed the kidney protective effect of canagliflozin in patients with type 2 diabetes and varying levels of kidney function.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
SokCin Tye, Megumi Oshima, Clare Arnott, Brendon L. Neuen, Robert A. Fletcher, Bruce Neal, Hiddo J. L. Heerspink
Summary: This study aimed to investigate the association between improvements in multiple cardiovascular risk markers and the risk of cardiovascular and kidney outcomes in patients with type 2 diabetes and high cardiovascular risk participating in the CANVAS program. The results showed that improvements in multiple risk markers were associated with a reduced risk of cardiovascular and kidney outcomes.
DIABETES OBESITY & METABOLISM
(2023)
Letter
Endocrinology & Metabolism
Michael A. A. Tsoukas, Vincent Woo, Sheldon W. W. Tobe, April Slee, Wally Rapattoni, Fernando G. G. Ang, Jochen Seufert, Brendon L. L. Neuen, Clare Arnott, Kenneth W. W. Mahaffey, David C. C. Wheeler
DIABETES OBESITY & METABOLISM
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Clare Arnott, Bruce Neal
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, Research & Experimental
Kristy K. Law, Daisy H. Coyle, Bruce Neal, Liping Huang, Eden M. Barrett, Clare Arnott, Clara K. Chow, Gian Luca Di Tanna, Thomas Lung, Dariush Mozaffarian, Seth A. Berkowitz, Jencia Wong, Ted Wu, Stephen Twigg, Amanda Gauld, David Simmons, Milan K. Piya, Freya MacMillan, Chee L. Khoo, Maoyi Tian, Kathy Trieu, Jason H. Y. Wu
Summary: This study aims to test the efficacy of a medically tailored meal program in Australia for individuals with type 2 diabetes. Participants in the intervention group will receive pre-prepared meals and nutrition education to prevent or manage chronic conditions. The primary outcome will be glycated hemoglobin levels, and the study will provide data to support the implementation of this program on a larger scale.
CONTEMPORARY CLINICAL TRIALS
(2023)
Letter
Endocrinology & Metabolism
Abhinav Sharma, Pedro Marques, Brendon L. Neuen, Robert A. Fletcher, April Slee, Wally Rapattoni, Fernando G. Ang, Clare Arnott, Adeera Levin, Subodh Verma, Vlado Perkovic, Kenneth W. Mahaffey
DIABETES OBESITY & METABOLISM
(2023)
Article
Neurosciences
Marcia C. de Oliveira Otto, Jason H. Y. Wu, Evan L. Thacker, Heidi Tsz Mung Lai, Rozenn N. Lemaitre, Nikhil Padhye, Xiaoling Song, Irena B. King, Oscar Lopez, David S. Siscovick, Dariush Mozaffarian
Summary: The study found that circulating arachidonic acid (AA) and docosapentaenoic acid (DPA) are associated with a slower rate of cognitive decline and a lower risk of cognitive impairment, while other PUFA show no significant associations.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Green & Sustainable Science & Technology
Allison M. Gaines, Tazman Davies, Maria Shahid, Fraser Taylor, Jason HY. Wu, Michalis Hadjikakou, Simone Pettigrew, Paraskevi Seferidi, Bruce Neal
Summary: This study developed a novel approach to estimate product-specific greenhouse gas emissions (GHGe) for packaged foods and beverages in Australia. The results showed significant variations in GHGe estimates among different food categories, with meat products having the highest emissions and fruits, vegetables, nuts, and legumes having the lowest emissions. These data are important for driving industry actions and informing government policies.
JOURNAL OF CLEANER PRODUCTION
(2023)
Review
Nutrition & Dietetics
Eden M. Barrett, Ashleigh C. Hart, Saiuj Bhat, Matti Marklund, Daisy H. Coyle, Maddie Heenan, Simone Pettigrew, Jason HY. Wu
Summary: This study examined the impact of retail food environment interventions on the dietary behavior of students and staff in postsecondary education settings. The findings suggest that these interventions have a positive effect on improving dietary behaviors.
JOURNAL OF NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Frank Qian, Nathan Tintle, Paul N. Jensen, Rozenn N. Lemaitre, Fumiaki Imamura, Tobias Rudholm Feldreich, Sarah Oppeneer Nomura, Weihua Guan, Federica Laguzzi, Eunjung Kim, Jyrki K. Virtanen, Marinka Steur, Christian S. Bork, Yoichiro Hirakawa, Michelle L. O'Donoghue, Aleix Sala-Vila, Andres V. Ardisson Korat, Qi Sun, Eric B. Rimm, Bruce M. Psaty, Susan R. Heckbert, Nita G. Forouhi, Nicholas J. Wareham, Matti Marklund, Ulf Riserus, Lars Lind, Johan Arnlov, Parveen Garg, Michael Y. Tsai, James Pankow, Jeffrey R. Misialek, Bruna Gigante, Karin Leander, Julie A. Pester, Christine M. Albert, Maryam Kavousi, Arfan Ikram, Trudy Voortman, Erik B. Schmidt, Toshiharu Ninomiya, David A. Morrow, Antoni Bayes-Genis, James H. O'Keefe, Kwok Leung Ong, Jason H. Y. Wu, Dariush Mozaffarian, William S. Harris, David S. Siscovick
Summary: This study aimed to determine the associations of blood or adipose tissue levels of EPA, DPA, and DHA with incident AF. Using participant-level data from 17 prospective cohort studies, it was found that levels of omega-3 fatty acids, including EPA, DPA, DHA, and EPA+DHA, were not associated with increased risk of incident AF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Carrie Ka Wai Ho, Anna Tjhin, Eden Barrett, Daisy H. Coyle, Jason H. Y. Wu, Jimmy Chun Yu Louie
Summary: The consumption of gluten-free foods has been increasing, and it is important to understand their nutritional quality compared to non-gluten-free foods. This study examined pre-packaged foods in Hong Kong and found that non-gluten-free products had higher energy, protein, saturated fat, trans-fat, free sugar, and sodium content, and lower fiber compared to gluten-free products. Consumers should be educated on how to identify gluten-free foods as many do not declare this information on the label.
ANNALS OF NUTRITION AND METABOLISM
(2023)