Site‐Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Site‐Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases
Authors
Keywords
-
Journal
CHEMBIOCHEM
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2020-08-28
DOI
10.1002/cbic.202000508
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Flanking Regions Determine the Structure of the Poly-Glutamine in Huntingtin through Mechanisms Common among Glutamine-Rich Human Proteins
- (2020) Annika Urbanek et al. STRUCTURE
- Protofilament Structure and Supramolecular Polymorphism of Aggregated Mutant Huntingtin Exon 1
- (2020) Jennifer C. Boatz et al. JOURNAL OF MOLECULAR BIOLOGY
- Probing initial transient oligomerization events facilitating Huntingtin fibril nucleation at atomic resolution by relaxation-based NMR
- (2019) Samuel A. Kotler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13
- (2019) Cristina Cariulo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Random coil chemical shifts for serine, threonine and tyrosine phosphorylation over a broad pH range
- (2019) Ruth Hendus-Altenburger et al. JOURNAL OF BIOMOLECULAR NMR
- A General Strategy to Access Structural Information at Atomic Resolution in Polyglutamine Homorepeats
- (2018) Annika Urbanek et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length
- (2018) Estella A. Newcombe et al. JOURNAL OF MOLECULAR BIOLOGY
- N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting
- (2018) Sean M. Deguire et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity
- (2017) Joana Branco-Santos et al. HUMAN MOLECULAR GENETICS
- Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths
- (2017) John B. Warner et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A Solution NMR Perspective
- (2017) Maria Baias et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation
- (2017) Cristina Cariulo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core
- (2017) Hsiang-Kai Lin et al. Nature Communications
- Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models
- (2017) Manuel Daldin et al. Scientific Reports
- Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding
- (2016) Maxmore Chaibva et al. BIOPHYSICAL JOURNAL
- Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization
- (2016) Laura F. DiGiovanni et al. HUMAN MOLECULAR GENETICS
- Profiling of p5, a 24 Amino Acid Inhibitory Peptide Derived from the CDK5 Activator, p35 CDKR1 Against 70 Protein Kinases
- (2016) B.K. Binukumar et al. JOURNAL OF ALZHEIMERS DISEASE
- Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites
- (2016) Andres Binolfi et al. Nature Communications
- Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ
- (2015) Maria Blaire Bustamante et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Real-time NMR monitoring of biological activities in complex physiological environments
- (2015) Matthew J Smith et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation
- (2015) M.-T. El-Daher et al. EMBO JOURNAL
- Super-Resolution Fluorescence of Huntingtin Reveals Growth of Globular Species into Short Fibers and Coexistence of Distinct Aggregates
- (2014) Whitney C. Duim et al. ACS Chemical Biology
- Efficient Modification of Alpha-Synuclein Serine 129 by Protein Kinase CK1 Requires Phosphorylation of Tyrosine 125 as a Priming Event
- (2014) Jonas Kosten et al. ACS Chemical Neuroscience
- Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease
- (2014) Brett A. Barbaro et al. HUMAN MOLECULAR GENETICS
- Site-specific NMR mapping and time-resolved monitoring of serine and threonine phosphorylation in reconstituted kinase reactions and mammalian cell extracts
- (2013) Francois-Xavier Theillet et al. Nature Protocols
- Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin
- (2013) Nicholas Stephane Caron et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease
- (2013) K. Sathasivam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Site-Specific Mapping and Time-Resolved Monitoring of Lysine Methylation by High-Resolution NMR Spectroscopy
- (2012) François-Xavier Theillet et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice
- (2012) A. Di Pardo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Kinase inhibitors modulate huntingtin cell localization and toxicity
- (2011) Randy Singh Atwal et al. Nature Chemical Biology
- Simultaneous Detection of Protein Phosphorylation and Acetylation by High-Resolution NMR Spectroscopy
- (2010) Stamatios Liokatis et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Huntington's disease: from molecular pathogenesis to clinical treatment
- (2010) Christopher A Ross et al. LANCET NEUROLOGY
- Mutant Huntingtin N-terminal Fragments of Specific Size Mediate Aggregation and Toxicity in Neuronal Cells
- (2009) Tamara Ratovitski et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphorylation of Threonine 3
- (2009) Charity T. Aiken et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
- (2009) Leslie Michels Thompson et al. JOURNAL OF CELL BIOLOGY
- Modulation of Polyglutamine Conformations and Dimer Formation by the N-Terminus of Huntingtin
- (2009) Tim E. Williamson et al. JOURNAL OF MOLECULAR BIOLOGY
- Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice
- (2009) Xiaofeng Gu et al. NEURON
- Effects of overexpression of Huntingtin proteins on mitochondrial integrity
- (2008) Hongmin Wang et al. HUMAN MOLECULAR GENETICS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started