RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

(2020) Tiantian Guo et al.   Molecular Neurodegeneration

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

RPS23RG1 is Required for Synaptic Integrity and Rescues Alzheimer’s Associated Cognitive Deficits

(2018) Dongdong Zhao et al.   BIOLOGICAL PSYCHIATRY

GSK3 and Tau: Two Convergence Points in Alzheimer's Disease

(2018) Felix Hernandez et al.   JOURNAL OF ALZHEIMERS DISEASE

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

(2017) Jinsoo Seo et al.   JOURNAL OF NEUROSCIENCE

Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development

(2017) Huiqian Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperphosphorylated Tau is a Cause of Neuronal Dysfunction in Tauopathy

(2017) Akihiko Takashima   JOURNAL OF ALZHEIMERS DISEASE

Hyperphosphorylation determines both the spread and the morphology of tau pathology

(2016) Wen Hu et al.   Alzheimers & Dementia

Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth

(2016) Kotaro Furusawa et al.   JOURNAL OF NEUROSCIENCE

The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death

(2016) Qiuyang Zheng et al.   MOLECULAR NEUROBIOLOGY

Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of Ubiquitination

(2015) Toshiyuki Takasugi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation by PKA and Cdk5 Mediates the Early Effects of Synapsin III in Neuronal Morphological Maturation

(2015) A. Piccini et al.   JOURNAL OF NEUROSCIENCE

Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid

(2015) Shang-Yi A. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment

(2014) Jinsoo Seo et al.   CELL

Transport and diffusion of Tau protein in neurons

(2014) Tim Scholz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice

(2014) M. V. Rao et al.   JOURNAL OF NEUROSCIENCE

Physiological and pathological phosphorylation of tau by Cdk5

(2014) Taeko Kimura et al.   Frontiers in Molecular Neuroscience

Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice

(2013) Antonio Currais et al.   AGING CELL

Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

LMTK1/AATYK1 Is a Novel Regulator of Axonal Outgrowth That Acts via Rab11 in a Cdk5-Dependent Manner

(2012) T. Takano et al.   JOURNAL OF NEUROSCIENCE

TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory

(2012) Kwok-On Lai et al.   NATURE NEUROSCIENCE

p10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicity

(2012) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition

(2011) Olivia Engmann et al.   BRAIN

Cyclin E Constrains Cdk5 Activity to Regulate Synaptic Plasticity and Memory Formation

(2011) Junko Odajima et al.   DEVELOPMENTAL CELL

Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling

(2011) Li-Ming Chen et al.   JOURNAL OF NEUROCHEMISTRY

Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders

(2011) Leslie Crews et al.   Molecular Neurodegeneration

The Involvement of Cdk5 Activator p35 in Social Isolation-Triggered Onset of Early Alzheimer’s Disease-Related Cognitive Deficit in the Transgenic Mice

(2011) Ya-Hsin Hsiao et al.   NEUROPSYCHOPHARMACOLOGY

Membrane Association Facilitates Degradation and Cleavage of the Cyclin-Dependent Kinase 5 Activators p35 and p39

(2010) Seiji Minegishi et al.   BIOCHEMISTRY

The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's  -amyloid level and tau phosphorylation

(2010) X. Huang et al.   HUMAN MOLECULAR GENETICS

Regulation and role of cyclin-dependent kinase activity in neuronal survival and death

(2010) Shin-ichi Hisanaga et al.   JOURNAL OF NEUROCHEMISTRY

A Functional Mouse Retroposed Gene Rps23r1 Reduces Alzheimer's β-Amyloid Levels and Tau Phosphorylation

(2009) Yun-wu Zhang et al.   NEURON

Relative Resistance of Cdk5-phosphorylated CRMP2 to Dephosphorylation

(2008) Adam R. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 complexes

(2008) Akiko Asada et al.   JOURNAL OF NEUROCHEMISTRY

Interplay between Cyclin-Dependent Kinase 5 and Glycogen Synthase Kinase 3  Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precursor Protein Processing

(2008) Y. Wen et al.   JOURNAL OF NEUROSCIENCE