Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Highlighting Curcumin-Induced Crosstalk between Autophagy and Apoptosis as Supported by Its Specific Subcellular Localization

(2020) Francisco J. Sala de Oyanguren et al.   Cells

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

Cathepsin B mediated scramblase activation triggers cytotoxicity and cell cycle arrest by andrographolide to overcome cellular resistance in cisplatin resistant human hepatocellular carcinoma HepG2 cells

(2019) Kaustav Dutta Chowdhury et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin

(2019) Xuefei Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Immune checkpoint inhibitors for the treatment of MSI-H/MMR-D colorectal cancer and a perspective on resistance mechanisms

(2019) Ibrahim Halil Sahin et al.   BRITISH JOURNAL OF CANCER

Antiproliferative and apoptotic property of andrographolide against human colon cancer DLD1 cell line

(2019) Imran Khan et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Mechanistic insights into anticancer properties of oligomeric proanthocyanidins from grape seeds in colorectal cancer

(2018) Preethi Ravindranathan et al.   CARCINOGENESIS

Andrographolide sulfonate reduces mortality in Enterovirus 71 infected mice by modulating immunity

(2018) Min Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Oligomeric proanthocyanidins (OPCs) target cancer stem-like cells and suppress tumor organoid formation in colorectal cancer

(2018) Shusuke Toden et al.   Scientific Reports

The anti-cancer activity of an andrographolide analogue functions through a GSK-3β-independent Wnt/β-catenin signaling pathway in colorectal cancer cells

(2018) Somrudee Reabroi et al.   Scientific Reports

Andrographolide enhances the anti-metastatic effect of radiation in Ras-transformed cells via suppression of ERK–mediated MMP-2 activity

(2018) Chih-Chia Yu et al.   PLoS One

Oligomeric proanthocyanidins (OPCs) from grape seed extract suppress the activity of ABC transporters in overcoming chemoresistance in colorectal cancer cells

(2018) Preethi Ravindranathan et al.   CARCINOGENESIS

Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway

(2018) Yulin Peng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

When less is more

(2017) Jocelyn Kaiser   SCIENCE

Andrographolide enhanced 5-fluorouracil-induced antitumor effect in colorectal cancer via inhibition of c-MET pathway

(2017) Meng Su et al.   Drug Design Development and Therapy

Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression

(2016) Weicheng Wang et al.   BIOCHEMICAL PHARMACOLOGY

Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer

(2016) Jong-Lyel Roh et al.   CANCER LETTERS

Mismatch Repair-Deficient Cancers Are Targets for Anti-PD-1 Therapy

(2015) Sander Kelderman et al.   CANCER CELL

Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer

(2015) S. Toden et al.   Cancer Prevention Research

Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer

(2015) Shusuke Toden et al.   CARCINOGENESIS

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

(2015) Min-Young Kwon et al.   Oncotarget

Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells

(2014) Chia-Yang Lu et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of MDA-MB-231 breast cancer cell migration and invasion activity by andrographolide via suppression of nuclear factor-κB-dependent matrix metalloproteinase-9 expression

(2014) ZANJING ZHAI et al.   Molecular Medicine Reports

Tumour heterogeneity and the evolution of polyclonal drug resistance

(2014) Rebecca A. Burrell et al.   Molecular Oncology

Andrographolide Sensitizes the Cytotoxicity of Human Colorectal Carcinoma Cells Toward Cisplatin via Enhancing Apoptosis Pathways In Vitro and In Vivo

(2014) Hui-Hsuan Lin et al.   TOXICOLOGICAL SCIENCES

Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells

(2013) Che-Yi Chao et al.   CARCINOGENESIS

Calculated treatment

(2013) Natalia L. Komarova et al.   NATURE

Association of common gene variants in the WNT/β-catenin pathway with colon cancer recurrence

(2013) D Páez et al.   PHARMACOGENOMICS JOURNAL

Protective Effects of Andrographolide Analogue AL-1 on ROS-Induced RIN-mβ Cell Death by Inducing ROS Generation

(2013) Guang-Rong Yan et al.   PLoS One

Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer

(2013) Guo-Qing Bao et al.   TOXICOLOGY LETTERS

Evolutionary dynamics of cancer in response to targeted combination therapy

(2013) Ivana Bozic et al.   eLife

Andrographolide Inhibits Osteopontin Expression and Breast Tumor Growth Through Down Regulation of PI3 Kinase/Akt Signaling Pathway

(2012) S. Kumar et al.   CURRENT MOLECULAR MEDICINE

CHP1002, a novel andrographolide derivative, inhibits pro-inflammatory inducible nitric oxide synthase and cyclooxygenase-2 expressions in RAW264.7 macrophages via up-regulation of heme oxygenase-1 expression

(2012) Bo Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

(2012) Luis A. Diaz Jr et al.   NATURE

Inhibition of Tcf-4 Induces Apoptosis and Enhances Chemosensitivity of Colon Cancer Cells

(2012) Jiang Xie et al.   PLoS One

Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy

(2011) Emil Kendziorra et al.   CARCINOGENESIS

Protective Role of 14-Deoxy-11,12-didehydroandrographolide, a Noncytotoxic Analogue of Andrographolide, in Allergic Airway Inflammation

(2011) Shou-Ping Guan et al.   JOURNAL OF NATURAL PRODUCTS

Curcumin, the Golden Spice From Indian Saffron, Is a Chemosensitizer and Radiosensitizer for Tumors and Chemoprotector and Radioprotector for Normal Organs

(2010) Ajay Goel et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Andrographolide enhances 5-fluorouracil-induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells

(2008) Lu Yang et al.   CANCER LETTERS

EPIC: Phase III Trial of Cetuximab Plus Irinotecan After Fluoropyrimidine and Oxaliplatin Failure in Patients With Metastatic Colorectal Cancer

(2008) Alberto F. Sobrero et al.   JOURNAL OF CLINICAL ONCOLOGY

Multi-targeted therapy by curcumin: how spicy is it?

(2008) Ajay Goel et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL