Review
Cell Biology
David A. Lewis, Tony Ly
Summary: CD8(+) T cells are crucial in immunity and immuno-oncology, as they undergo complex cellular growth, cell cycle entry, and differentiation to produce antigen-specific cytotoxic T lymphocytes. Some activated T cells will differentiate into memory T cells which are essential in adaptive immunity. This review explores the control of cell cycle entry in CD8(+) T cells and the interaction between these mechanisms and pathways regulating immunological phenotypes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Raquel Garcia-Ferreras, Jesus Osuna-Perez, Guillermo Ramirez-Santiago, Almudena Mendez-Perez, Andres M. Acosta-Moreno, Lara Del Campo, Maria J. Gomez-Sanchez, Marta Iborra, Beatriz Herrero-Fernandez, Jose M. Gonzalez-Granado, Francisco Sanchez-Madrid, Yolanda R. Carrasco, Patricia Boya, Nuria Martinez-Martin, Esteban Veiga
Summary: Research shows that B cells capture bacteria from infected dendritic cells through trans-phagocytosis, and this process activates CD8(+) T cells to regulate bacterial infections. Additionally, it is demonstrated that B cells that have captured bacteria expressing tumor antigens may be utilized as novel cellular immunotherapies against cancer.
Article
Immunology
Emil Lagumdzic, Clara Pernold, Marta Viano, Simone Olgiati, Michael W. Schmitt, Kerstin H. Mair, Armin Saalmueller
Summary: Pigs have the potential to be a valuable research model for studying human diseases, pharmacology, and transplantation. This study aimed to better understand the porcine immune system by analyzing the transcriptomes of different subsets of porcine CD8(+) T cells. The results showed distinct gene expression patterns in different subsets, providing valuable information for further research on porcine immune cell subsets.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Qin Xie, Jian Ding, Yi Chen
Summary: CD8(+) T lymphocytes play a crucial role in host antitumor immunity, but tumor-driven microenvironments can inhibit their activation and cytotoxicity. Stromal cells exert immunosuppressive effects in the tumor microenvironment.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Immunology
Eleonora Gallerani, Davide Proietto, Beatrice Dallan, Marco Campagnaro, Salvatore Pacifico, Valentina Albanese, Erika Marzola, Peggy Marconi, Antonella Caputo, Victor Appay, Riccardo Gavioli, Francesco Nicoli
Summary: Research indicates that older individuals have defective primary SARS-CoV-2-specific CD8(+) T-cell responses, with lower magnitude and quality compared to younger adults, as well as recognizing a lower number of epitopes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Laura Llao-Cid, Philipp M. Roessner, Vicente Chapaprieta, Selcen Oeztuerk, Tobias Roider, Marie Bordas, Ana Izcue, Dolors Colomer, Sascha Dietrich, Stephan Stilgenbauer, Bola Hanna, Jose Ignacio Martin-Subero, Martina Seiffert
Summary: The EOMES SNP is associated with increased risk for CLL due to its negative impact on CD8(+) T-cell-mediated immune control of the disease. EOMES is essential for the expansion and maintenance of CD8(+) T cells, and thus involved in adaptive immune control of CLL.
Article
Oncology
Pedro Velica, Pedro P. Cunha, Nikola Vojnovic, Iosifina Petrina Foskolou, David Bargiela, Milos Gojkovic, Helene Rundqvist, Randall S. Johnson
Summary: By ectopically expressing the HIF transcription factor in CD8(+) T cells, this study demonstrated an enhanced antitumor efficacy against tumor targets. A specific mutation in HIF2 alpha showed the most effective antitumor T cell response, suggesting a potential strategy to increase therapeutic efficacy of CD8(+) T cells.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Biology
Kazuki Sasaki, Mouhamad Al Moussawy, Khodor Abou-Daya, Camila Macedo, Amira Hosni-Ahmed, Silvia Liu, Mariam Juya, Alan F. Zahorchak, Diana M. Metes, Angus W. Thomson, Fadi G. Lakkis, Hossam A. Abdelsamed
Summary: Activated memory T cells can influence the phenotype and transcription of surrounding naive T cells, which may have implications for immune responses following vaccination, infection, or transplantation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Mladen Jergovic, Christopher P. Coplen, Jennifer L. Uhrlaub, David G. Besselsen, Shu Cheng, Megan J. Smithey, Janko Nikolich-Zugich
Summary: Infections can lead to the expansion of a subpopulation of long-lived, Ly6C(+) CD8(+) Tn cells with accelerated effector function, depending on the action of IFN-I. This highlights the significant role of infection-driven IFN-I in regulating Tn homeostasis and function, with potential implications for immunotherapy.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Ramdane Igalouzene, Hector Hernandez-Vargas, Nicolas Benech, Alexandre Guyennon, David Bauche, Celia Barrachina, Emeric Dubois, Julien C. Marie, Saidi M'Homa Soudja
Summary: SMAD4 plays an important role in preventing inflammatory bowel disease (IBD) by controlling the activation of CD8(+) T cells. This study reveals the mechanism by which SMAD4 regulates the expression of TGF-beta target genes to prevent pathogenic responses in the gut. In addition, SMAD4 deficiency enhances the retention of CD8(+) T cells in the intestinal epithelium and their response to other factors, resulting in chronic microbiota-driven CD8(+) T cell activation.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Young-Jun Ju, Sung-Woo Lee, Yoon-Chul Kye, Gil-Woo Lee, Hee-Ok Kim, Cheol-Heui Yun, Jae-Ho Cho
Summary: The response to self-ligands within the naïve CD8(+) T cell pool is heterogeneous, leading to subsets of cells with varying expression levels of Ly6C and CD5, and different responses to viral infection through type I interferon signaling. This diversity is controlled by self-reactivity, which influences the functional properties and gene expression profiles of CD8(+) T cell subsets, ultimately affecting antigen-specific immune responses.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Youhui Si, Yihan Wang, Qiaomu Tian, Qiang Wang, Jared M. Pollard, Pramod K. Srivastava, Aaron P. Esser-Kahn, Joel H. Collier, Anne I. Sperling, Anita S. Chong
Summary: The current study provides evidence that intranasal administration of peptide antigens primes naive CD8+ T cells in the lung independently before priming in the draining mediastinal lymph node. The transcriptional responses of lung cDC1 and cDC2 to intranasal nanofiber immunization were found to be distinct, but both subsets acquire shared transcriptional responses upon migration into the lymph node, revealing a stepwise activation process of cDC1 and cDC2 towards their ability to cross-prime effector and functional memory CD8+ T cell responses.
Article
Immunology
Tarun Tyagi, Kanika Jain, Timur O. Yarovinsky, Michael Chiorazzi, Jing Du, Cecilia Castro, Jules Griffin, Asawari Korde, Kathleen A. Martin, Shervin S. Takyar, Richard A. Flavell, Abhijit A. Patel, John Hwa
Summary: This study reveals the immunosuppressive role of platelets in tumor growth and identifies the platelet protein TLT-1 as a key player in suppressing CD8 T cells. Anti-TLT-1 antibody shows potential as a therapeutic option to rescue T cell function and reduce tumor size. Clinically, higher TLT-1 levels are associated with reduced survival in non-small cell lung cancer patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Guojun Zhang, Mingkai Xu, Xiaoqing Zhang, Ling Ma, Huiwen Zhang
Summary: SAM-1 can activate T cells and induce apoptosis in human tumor cells by regulating dendritic cell signaling pathways and cytokine production, mediated through TRAIL.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Oncology
Masanobu Shiga, Jun Miyazaki, Kozaburo Tanuma, Yoshiyuki Nagumo, Takayuki Yoshino, Shuya Kandori, Hiromitsu Negoro, Takahiro Kojima, Ryota Tanaka, Naoko Okiyama, Yasuhiro Fujisawa, Miyuki Watanabe, Sho Yamasaki, Hideyasu Kiyohara, Makoto Watanabe, Taka-aki Sato, Hideaki Tahara, Hiroyuki Nishiyama, Ikuya Yano
Summary: The study found that cationic liposome TDM (Lip-TDM) exhibited superior anti-tumor effects compared to BCG in mouse models of bladder cancer, colon cancer, and melanoma, without causing weight loss or granuloma formation. The anti-tumor effect of Lip-TDM depends on CD8(+) T cells and macrophage-inducible C-type lectin (Mincle).
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)