Review
Oncology
Anna K. Casasent, Mathilde M. Almekinders, Charlotta Mulder, Proteeti Bhattacharjee, Deborah Collyar, Alastair M. Thompson, Jos Jonkers, Esther H. Lips, Jacco van Rheenen, E. Shelley Hwang, Serena Nik-Zainal, Nicholas E. Navin, Jelle Wesseling
Summary: This article reviews the basic knowledge of ductal carcinoma in situ (DCIS) and explores the fundamental biology of DCIS, including the impact of genomic events in neoplastic cells and the surrounding microenvironment on the progression of DCIS to invasive breast cancer. Additionally, it discusses the information needed to prevent overtreatment of indolent DCIS lesions and ensure adequate treatment for high-risk patients.
NATURE REVIEWS CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zengjie Wu, Qing Lin, Haibo Wang, Guanqun Wang, Guangming Fu, Tiantian Bian
Summary: The study developed a radiomics nomogram based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to accurately differentiate between ductal carcinoma in situ with microinvasion (DCISM) and pure ductal carcinoma in situ (DCIS) breast cancer. The radiomics signature and nomogram model showed better performance in calibration and validation compared to the clinical factor model, indicating good potential for clinical utility.
ACADEMIC RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Leslie R. Lamb, Geunwon Kim, Tawakalitu O. Oseni, Manisha Bahl
Summary: The study found that the upgrade rate of noncalcified ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) at surgery is 21.8%. Upgrade risk is associated with older patient age and family history of breast cancer in a first-degree relative.
ACADEMIC RADIOLOGY
(2021)
Article
Pathology
Maartje van Seijen, Katarzyna Jozwiak, Sarah E. Pinder, Allison Hall, Savitri Krishnamurthy, Jeremy Sj Thomas, Laura C. Collins, Jonathan Bijron, Joost Bart, Danielle Cohen, Wen Ng, Ihssane Bouybayoune, Hilary Stobart, Jan Hudecek, Michael Schaapveld, Alastair Thompson, Esther H. Lips, Jelle Wesseling
Summary: The study evaluated the interobserver agreement in grading DCIS among pathologists from the Netherlands, the UK, and the USA, finding a moderate association. When adjusted for national guidelines, the association did not change, but pathologists using the UK guidelines showed significantly higher association. Immunohistochemistry analysis suggested a correlation between ER positivity/HER2 negativity and non-high grade DCIS.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Shelby Lynn Hophan, Olena Odnokoz, Huiping Liu, Yuan Luo, Seema Khan, William Gradishar, Zhuan Zhou, Sunil Badve, Mylin A. Torres, Yong Wan
Summary: Ductal carcinoma in situ (DCIS) is a noninvasive breast cancer, but the molecular mechanisms behind its progression to invasive ductal carcinoma (IDC) and the complexity of each lesion are still unclear. Understanding the molecular features that lead to DCIS progression and finding new strategies to identify molecular mechanisms are crucial for more targeted therapy.
Article
Oncology
Sayuka Nakayama, Hiroko Masuda, Sakiko Miura, Takashi Kuwayama, Rikako Hashimoto, Kanae Taruno, Terumasa Sawada, Sadako Akashi-Tanaka, Seigo Nakamura
Summary: This study evaluated the frequency of IDC upgrades in patients diagnosed with DCIS before surgery and found a certain number of mixed IDC. Careful follow-up is recommended for non-surgical treatment.
Article
Oncology
Yufei Zeng, Weiqi Gao, Xiaosong Chen, Kunwei Shen
Summary: Patients with invasive ductal carcinoma (IDC) accompanied by ductal carcinoma in situ (DCIS) have a lower 21-gene recurrence score (RS) possibly due to lower expression of proliferation and invasion genes. The proportion and grade of DCIS independently influence the 21-gene RS in IDC/DCIS patients. Further evaluation is needed to determine the impact of the DCIS component in IDC on prognosis due to the relatively short follow-up period and low recurrence rate.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
S. W. Vrede, A. M. C. Hulsman, C. Reijnen, K. Van de Vijver, E. Colas, G. Mancebo, C. P. Moiola, A. Gil-Moreno, J. Huvila, M. Koskas, V Weinberger, L. Minar, E. Jandakova, M. Santacana, X. Matias-Guiu, F. Amant, M. P. L. M. Snijders, H. V. N. Kusters-Vandevelde, J. Bulten, J. M. A. Pijnenborg
Summary: The study evaluated the relationship between the amount of preoperative endometrial tissue surface and the degree of concordance with final low- and high-grade endometrial cancer. The findings suggest that higher preoperative endometrial tissue surface does not increase the concordance between pre- and postoperative low- and high-grade diagnosis in EC.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Oncology
Thaer Khoury
Summary: This article discusses the issue of overtreatment in breast diseases and the importance of active surveillance trials. It also examines the differentiation between low-risk ductal carcinoma in situ (DCIS) and atypical ductal hyperplasia (ADH), as well as the grading of DCIS. Evaluating these issues can help determine the necessity of treatment and reduce the risk of overtreatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Minping Hong, Sijia Fan, Zhexuan Yu, Chen Gao, Zhen Fang, Liang Du, Shiwei Wang, Xiaobo Chen, Maosheng Xu, Changyu Zhou
Summary: This study aimed to establish an MRI-based radiomics nomogram for predicting the upstaging of ductal carcinoma in situ (DCIS) and assisting with risk stratification.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rachel Miceli, Yiming Gao, Kun Qian, Samantha L. Heller
Summary: This study investigates whether kinetic features of clinically available ultrafast MRI (UF-MRI) can predict upgrade of biopsy-proven ductal carcinoma in situ (DCIS) to invasive cancer at surgery. The study found a significant association between shorter time to enhancement (TTE) on preoperative UF-MRI, larger lesion size on dynamic contrast-enhanced MRI (DCE-MRI) and mammography, and the upgrade of DCIS to invasive cancer. These findings have implications for surgical planning.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Review
Oncology
Umar Wazir, Neill Patani, Nahed Balalaa, Kefah Mokbel
Summary: Traditionally, the presence of ductal carcinoma in situ (DCIS) with invasive breast cancer meant that the patient may require complete removal of the breast in order to completely remove the disease. Recently there has been some evidence to the contrary. In this article, we have reviewed the current published literature to determine the rate at which DCIS was eradicated by chemotherapy and endocrine therapies administered prior to surgery, which we determined to be 40.5% and 15% respectively.
Article
Surgery
Candice A. M. Sauder, Hira Abidi, Richard J. Bold
Summary: Ductal carcinoma in situ is a diverse disease with variable progression to invasive carcinoma. Current treatment recommendations do not consider this variability. De-escalation approach, involving the use of molecular assays and exploring alternative therapies, is being studied to differentiate treatment based on future progression and recurrence risk. Shared decision-making is crucial in the management of ductal carcinoma in situ.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhou Huang, Xue Chen, Nan Jiang, Su Hu, Chunhong Hu
Summary: A nomogram combining clinicopathologic, conventional MRI features, and DCE-MRI radiomics signatures can be useful in predicting DCISMI from preoperative DCIS cases. Logistic regression was used to construct multiple models and evaluate their performance using ROC curve analysis, with the mixed model showing the highest AUC in the validation cohort.
BMC MEDICAL IMAGING
(2023)
Article
Biology
Satoi Nagasawa, Yuta Kuze, Ichiro Maeda, Yasuyuki Kojima, Ai Motoyoshi, Tatsuya Onishi, Tsuguo Iwatani, Takamichi Yokoe, Junki Koike, Motohiro Chosokabe, Manabu Kubota, Hibiki Seino, Ayako Suzuki, Masahide Seki, Katsuya Tsuchihara, Eisuke Inoue, Koichiro Tsugawa, Tomohiko Ohta, Yutaka Suzuki
Summary: The study conducted a multi-omic analysis of ductal carcinoma in situ (DCIS) and identified age, gene amplification, and gene mutation as possible indicators of relapse. The results revealed heterogeneous cell populations in DCIS, providing predictive markers for classifying and optimizing treatment.
COMMUNICATIONS BIOLOGY
(2021)
Editorial Material
Biochemical Research Methods
Rainer A. Leitgeb, David Sampson, Regine Choe, Christine Hendon, Kevin Eliceiri, James Tunnell
Summary: The guest editors introduce a feature issue containing papers based on research presented at the OSA Biophotonics Congress, held from April 20-23, 2020, in a first all virtual, web conference format undertaken by OSA. This is done under the terms of the OSA Open Access Publishing Agreement.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Chemistry, Analytical
Jenu V. Chacko, Han Nim Lee, Wenxin Wu, Marisa S. Otegui, Kevin W. Eliceiri
Summary: Fluorescence properties of molecules are utilized to study the structural and functional nature of biological processes, with correlative imaging techniques combining physical properties and biochemical states to probe molecules at a cellular level. By generating hyperdimensional contrast through combining multiple fluorescence properties, better contrast between different molecules can be achieved to study cellular heterogeneity effectively.
Article
Biochemistry & Molecular Biology
Qiuchen Guo, Duanchen Sun, Alexander S. Barrett, Sonali Jindal, Nathan D. Pennock, Matthew W. Conklin, Zheng Xia, Elizabeth Mitchell, Ravikant Samatham, Naomi Mirza, Steven Jacques, Sheila Weinmann, Virginia F. Borges, Kirk C. Hansen, Pepper J. Schedin
Summary: Mammographically-detected breast density has an impact on breast cancer risk and progression, and the presence of fibrillar collagen plays a crucial role in breast density. This study investigated the physiological factors influencing collagen production in the breast. Through the analysis of gene expression in female rats, the study revealed a triphasic pattern of collagen gene regulation and reproductive state-dependent composition. The findings were confirmed in human breast tissue from premenopausal women. The study also found a correlation between the collagen gene signature and poor progression-free survival in breast cancer patients. These findings contribute to a better understanding of normal breast function, the etiology of breast density, and breast cancer risk and outcomes.
Article
Virology
Edward L. Evans, Ginger M. Pocock, Gabriel Einsdorf, Ryan T. Behrens, Ellen T. A. Dobson, Marcel Wiedenmann, Christian Birkhold, Paul Ahlquist, Kevin W. Eliceiri, Nathan M. Sherer
Summary: This article introduces an automated imaging strategy, HIV RGB, for studying single-cell RNA regulation of HIV-1. Different fluorescently tagged viral RNA and protein species are recorded using multicolor long-term time-lapse video microscopy, and image processing is performed using an open-source workflow called NR-SAT based on ImageJ plugins. This method can be adapted to study various dynamic viral or cellular processes.
Letter
Biochemical Research Methods
Curtis T. Rueden, Mark C. Hiner, Edward L. Evans, Michael A. Pinkert, Alice M. Lucas, Anne E. Carpenter, Beth A. Cimini, Kevin W. Eliceiri
Article
Biology
Elizabeth M. Haynes, Korri H. Burnett, Jiaye He, Marcel W. Jean-Pierre, Martin Jarzyna, Kevin W. Eliceiri, Jan Huisken, Mary C. Halloran
Summary: This study reveals that KLC4, a subunit of the motor protein kinesin-1, plays a crucial role in regulating axon branching and arborization pattern of sensory neurons during development. KLC4 is required for stabilization of nascent axon branches, proper microtubule dynamics, and endosomal transport. Additionally, KLC4 is involved in establishing molecular differences between central and peripheral axons, and is implicated in stress response circuits.
Article
Oncology
Elizabeth S. S. Burnside, Sarina Schrager, Lori DuBenske, Jon Keevil, Terry Little, Amy Trentham-Dietz, Betsy Rolland, Dhavan Shah, Oguzhan Alagoz
Summary: This study successfully developed a shared decision-making tool for breast cancer screening using interdisciplinary team science methods and quality improvement principles. Two iterative cycles of plan-do-study-act were conducted to develop and improve the tool, and patient and physician feedback and data supported its implementation. This study demonstrates the importance of team science and quality improvement in improving breast cancer screening.
JCO ONCOLOGY PRACTICE
(2023)
Article
Chemistry, Multidisciplinary
Samir Rosas, Keegan A. Schoeller, Edward Chang, Hongyan Mei, Mikhail A. Kats, Kevin W. Eliceiri, Xinyu Zhao, Filiz Yesilkoy
Summary: Label-free and nondestructive mid-infrared vibrational hyperspectral imaging is an important tissue analysis tool that provides spatially resolved biochemical information. This study introduces an advanced mid-infrared spectrochemical tissue imaging modality using metasurfaces to capture quantitative molecular maps of large-area murine brain tissue sections. The results demonstrate that plasmonic metasurfaces enhance chemical contrast in infrared images and enable the detection of ultrathin tissue regions. This imaging method has the potential to have a broad impact on translational research and clinical histopathology.
ADVANCED MATERIALS
(2023)
Article
Oncology
Allison R. Dahlke, Noelle K. LoConte, Angela Flickinger, Sara Richie, Jenna Klink, Amy Trentham-Dietz, Rebecca Shirley, Kristin Litzelman
Summary: The purpose of this project was to establish partnerships between researchers at the University of Wisconsin Carbone Cancer Center (UWCCC) and community educators in the Division of Extension. The project aimed to create bidirectional relationships, educate researchers on community outreach, and facilitate collaborative projects. Surveys and focus groups were conducted to assess the needs and evaluations showed the success and acceptability of the project activities.
CANCER CAUSES & CONTROL
(2023)
Article
Biology
Han Nim Lee, Jenu Varghese Chacko, Ariadna Gonzalez Solis, Kuo-En Chen, Jessica A. S. Barros, Santiago Signorelli, A. Harvey Millar, Richard David Vierstra, Kevin W. Eliceiri, Marisa S. Otegui, Yoselin Benitez-Alfonso
Summary: This study reveals a new function of NBR1 in the degradation of damaged chloroplasts through microautophagy, where NBR1 associates with photodamaged chloroplasts independently of ATG7 and delivers them to vacuoles for degradation.
Editorial Material
Biochemical Research Methods
Beth A. Cimini, Kevin W. Eliceiri
Letter
Biochemical Research Methods
Gabriel J. Selzer, Curtis T. Rueden, Mark C. Hiner, Edward L. Evans, Kyle I. S. Harrington, Kevin W. Eliceiri
Editorial Material
Biochemical Research Methods
Anne E. Carpenter, Beth A. Cimini, Kevin W. Eliceiri
Article
Biochemical Research Methods
Zheyu Li, Bin Li, Kevi W. Eliceiri, Vijaykrishnan Narayanan
Summary: This paper presents a computation efficient analysis workflow for WSIs classification based on compression domain processing. By leveraging the pyramidal magnification structure of WSI files and compression domain features, the methods assign different decompression depths to the patches of WSIs, reducing unnecessary access to high zoom levels and expensive full decompression.
BIOMEDICAL OPTICS EXPRESS
(2023)