Article
Oncology
Bo Liao, Shuangquan Chen, Yugen Li, Zhaohui Yang, Ying Yang, Xianzhong Deng, Sha Ke
Summary: BLACAT1 is significantly up-regulated in prostate cancer tissues, modulating the proliferative and metastatic abilities of prostate cancer cells and potentially regulating the expression of DVL3 by sponging miR-29a-3p.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Oncology
Haiyan Pan, Yuanlin Ding, Yugang Jiang, Xingjie Wang, Jiawei Rao, Xingshan Zhang, Haibing Yu, Qinghua Hou, Tao Li
Summary: LIFR-AS1, as a competing endogenous RNA, plays a crucial role in the pathogenesis of gastric tumors by regulating the expression of COL1A2 through sponging miR-29a-3p. Knocking down LIFR-AS1 inhibits proliferation, invasion, and migration of gastric tumor cells, suggesting that it may serve as a potential target for gastric tumor diagnosis and treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Feng Qu, Bin Zhu, Yi-Lin Hu, Qin-Sheng Mao, Ying Feng
Summary: This study identified significant upregulation of HOXA-AS3 in GC cells and tissues, correlated with tumor characteristics. Knocking down HOXA-AS3 disrupted GC cell functions and tumor metastasis. Mechanistically, HOXA-AS3 sequestered miR-29a-3p, regulating NF-kappa B signaling in GC.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Dandan Li, Mengjie Xu, Zidi Wang, Pan Huang, Congcong Huang, Zhen Chen, Gaijuan Tang, Xingji Zhu, Mengyu Cai, Shanshan Qin
Summary: The abnormal expression of NR2F1-AS1 in gastric cancer is related to its correlation with NR2F1 expression, as well as their response to epithelial-to-mesenchymal transition signaling. NR2F1-AS1 modulates the miR-29a-3p/VAMP7 axis and plays a crucial role in the progression of gastric cancer.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Wen-Yan Mo, Shi-Qiong Cao
Summary: MiR-29a-3p plays a crucial role in cancer, especially colorectal cancer. This article summarizes its expression pattern, clinical applicability, and molecular mechanisms, and explores its potential as a biomarker and therapeutic target.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Environmental Sciences
Heng Zhang, Xinmei Li, Mengmeng Jia, Jing Ji, Zhaoxu Wu, Xian Chen, Dianke Yu, Yuxin Zheng, Yanjie Zhao
Summary: This study constructed a ceRNA regulatory network in COE-induced lung squamous cell carcinoma using RNA sequencing and database analysis.The findings suggest that H19 functions as a ceRNA to increase COL1A1 expression by sponging miR-29a-3p, thereby promoting COE-induced cell malignant transformation.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Ning Bu, Yanrong Gao, Yuhang Zhao, Haibo Xia, Xuemin Shi, Yang Deng, Shurui Wang, Yibo Li, Jialing Lv, Qizhan Liu, Suhua Wang
Summary: This study reveals that H19 is involved in lung inflammation and fibrosis induced by Nd2O3 via miR-29a-3p, providing insights into the mechanisms of Nd2O3-induced lung injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Oncology
Zhichao Jin, Baoxinzi Liu, Bofan Lin, Ran Yang, Cunen Wu, Weiwei Xue, Xi Zou, Jun Qian
Summary: The long non-coding RNA RP9 pseudogene (RP9P) promotes colorectal cancer progression by regulating the miR-133a-3p/FOXQ1 axis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Lin Zhou, Jian Li, Yaping Tang, Mei Yang
Summary: The study revealed that exosomal LINC00659 derived from CAFs promotes CRC cell proliferation, invasion, and migration through the miR-342-3p/ANXA2 pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Ye Huang, Liang Wang, Di Liu
Summary: Colorectal cancer is a common malignancy with limited therapeutic options, leading to delayed treatment and increased risk of tumor recurrence. Long noncoding RNAs play important roles in the development and progression of colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Heping Zhang, Jingfang Wang, Taoyuan Yu, Jingmin Wang, Jun Lu, Zongyang Yu
Summary: This study demonstrates that silencing long non-coding RNA cancer susceptibility candidate 9 can significantly inhibit the proliferation and invasion of CRC cells. miR-542-3p and integrin-linked kinase play a negative regulatory role in this process.
Article
Biochemistry & Molecular Biology
Chih-Hsin Hsu, I-Fan Liu, Hsuan-Fu Kuo, Chia-Yang Li, Wei-Shiung Lian, Chia-Yuan Chang, Yung-Hsiang Chen, Wei-Lun Liu, Chi-Yu Lu, Yu-Ru Liu, Tzu-Chieh Lin, Tsung-Ying Lee, Chi-Yuan Huang, Chong-Chao Hsieh, Po-Len Liu
Summary: miR-29a-3p exerts a direct anti-fibrotic effect on PAH-induced cardiac fibrosis by targeting THBS2 expression, with circulating levels of both miR-29a-3p and THBS2 correlating with PAH diagnosis and showing independent prognostic value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Qing Chen, Lin Zhou, De Ma, Juan Hou, Yuxin Lin, Jie Wu, Min Tao
Summary: In this study, GAS6-AS1 was found to be highly expressed in colorectal cancer and associated with poor prognosis. GAS6-AS1 upregulated TRIM14 expression by competitively binding to miR-370-3p and miR-1296-5p, and interacted with FUS to stabilize TRIM14 mRNA. GAS6-AS1 promoted proliferation, migration, invasion, and epithelial-mesenchymal transition in colorectal cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hai-rong Zhang, Shi-yong Wu, Zhong-xue Fu
Summary: The study demonstrated that lncRNA-cCSC1 promotes cell proliferation in colorectal cancer by interacting with miR-124-3p and upregulating the expression of CD44.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Yunpeng Bai, Xiankun Liu, Qingliang Chen, Tongyun Chen, Nan Jiang, Zhigang Guo
Summary: The study demonstrated that Myricetin (Myr) preconditioning can prevent ox-LDL-induced injury in HUVECs by regulating GAS5 and miR-29a-3p, showcasing its anti-oxidant and anti-EndMT properties. Myr may have a therapeutic potential for atherosclerosis through inactivating the TLR4/NF-kappa B signaling pathway in ox-LDL-treated HUVECs.
SCIENTIFIC REPORTS
(2021)