Intensified Downstream Processing of Monoclonal Antibodies Using Membrane Technology
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Title
Intensified Downstream Processing of Monoclonal Antibodies Using Membrane Technology
Authors
Keywords
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Journal
Biotechnology Journal
Volume -, Issue -, Pages 2000309
Publisher
Wiley
Online
2020-10-02
DOI
10.1002/biot.202000309
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Note: Only part of the references are listed.- Impact of depth filtration on disulfide bond reduction during downstream processing of monoclonal antibodies from CHO cell cultures
- (2019) Brian O'Mara et al. BIOTECHNOLOGY AND BIOENGINEERING
- Preparation and characterization of acid and solvent resistant polyimide ultrafiltration membrane
- (2019) Chengyu Yang et al. APPLIED SURFACE SCIENCE
- Optimization of continuous purification of recombinant patchoulol synthase from Escherichia coli with membrane adsorbers
- (2019) Chantal Brämer et al. BIOTECHNOLOGY PROGRESS
- Control of antibody high and low molecular weight species by depth filtration based cell culture harvesting
- (2019) Deqiang Yu et al. BIOTECHNOLOGY AND BIOENGINEERING
- Purification of monoclonal antibodies in a stirred cell with polyethyleneimine‐modified polyethersulfone ultrafiltration membrane
- (2019) Alexandra Wagner et al. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
- Innovative next-generation monoclonal antibody purification using activated carbon: A challenge for flow-through and column-free processes
- (2019) Takashi Ishihara et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Characterization of membrane adsorbers used for impurity removal during the continuous purification of monoclonal antibodies
- (2019) Helena Trnovec et al. JOURNAL OF CHROMATOGRAPHY A
- Impact of micro and macroporous TFF membranes on product sieving and chromatography loading for perfusion cell culture
- (2019) Nuno D. S. Pinto et al. BIOTECHNOLOGY AND BIOENGINEERING
- Comparison of Cationic Flocculants for the Clarification of CHO-derived Monoclonal Antibodies
- (2019) Rimenys Junior Carvalho BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
- A direct comparison between membrane adsorber and packed column chromatography performance
- (2019) Cristiana Boi et al. JOURNAL OF CHROMATOGRAPHY A
- Perfusion mammalian cell culture for recombinant protein manufacturing – A critical review
- (2018) Jean-Marc Bielser et al. BIOTECHNOLOGY ADVANCES
- Single pass diafiltration integrated into a fully continuous mAb purification process
- (2018) Joanna Rucker-Pezzini et al. BIOTECHNOLOGY AND BIOENGINEERING
- Improved HCP Reduction Using a New, All-Synthetic Depth Filtration Media Within an Antibody Purification Process
- (2018) Hoang C. Nguyen et al. Biotechnology Journal
- Modeling the Downstream Processing of Monoclonal Antibodies Reveals Cost Advantages for Continuous Methods for a Broad Range of Manufacturing Scales
- (2018) Jonathan Hummel et al. Biotechnology Journal
- Larger pore size hollow fiber membranes as a solution to the product retention issue in filtration-based perfusion bioreactors
- (2018) Samantha B. Wang et al. Biotechnology Journal
- Current state of the art in continuous bioprocessing
- (2018) Mark Schofield BIOTECHNOLOGY LETTERS
- Intermolecular interactions in highly concentrated formulations of recombinant therapeutic proteins
- (2018) Youngbin Baek et al. CURRENT OPINION IN BIOTECHNOLOGY
- Continuous purification of Candida antarctica lipase B using 3-membrane adsorber periodic counter-current chromatography
- (2018) Chantal Brämer et al. ENGINEERING IN LIFE SCIENCES
- Scalability of pre-packed preparative chromatography columns with different diameters and lengths taking into account extra column effects
- (2018) Susanne Schweiger et al. JOURNAL OF CHROMATOGRAPHY A
- Rapid preparative separation of monoclonal antibody charge variants using laterally-fed membrane chromatography
- (2018) Rahul Sadavarte et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Improved HCP Reduction Using a New, All-Synthetic Depth Filtration Media Within an Antibody Purification Process
- (2018) Hoang C. Nguyen et al. Biotechnology Journal
- Modeling the Downstream Processing of Monoclonal Antibodies Reveals Cost Advantages for Continuous Methods for a Broad Range of Manufacturing Scales
- (2018) Jonathan Hummel et al. Biotechnology Journal
- Larger pore size hollow fiber membranes as a solution to the product retention issue in filtration-based perfusion bioreactors
- (2018) Samantha B. Wang et al. Biotechnology Journal
- The effects of alternating tangential flow (ATF) residence time, hydrodynamic stress and filtration flux on high-density perfusion cell culture
- (2018) Jason Walther et al. BIOTECHNOLOGY AND BIOENGINEERING
- Progression of continuous downstream processing of monoclonal antibodies: current trends and challenges
- (2018) Balaji Somasundaram et al. BIOTECHNOLOGY AND BIOENGINEERING
- Surface Modification of Cellulose Membranes To Prepare a High-Capacity Membrane Adsorber for Monoclonal Antibody Purification via Hydrophobic Charge-Induction Chromatography
- (2018) Na Ma et al. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
- Sartobind STIC® salt-tolerant membrane chromatography
- (2018) Stefan Fischer-Frühholz et al. NATURE METHODS
- Process intensification in biologics manufacturing
- (2018) J. Strube et al. CHEMICAL ENGINEERING AND PROCESSING
- Polishing approach with fully connected flow-through purification for therapeutic monoclonal antibody
- (2018) Takamitsu Ichihara et al. ENGINEERING IN LIFE SCIENCES
- DNA retention on depth filters
- (2018) Ohnmar Khanal et al. JOURNAL OF MEMBRANE SCIENCE
- Antibody separation using lectin modified poly(HEMA-EDMA) hydrogel membranes
- (2017) Esra Feyzioğlu Demir et al. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
- Shear contributions to cell culture performance and product recovery in ATF and TFF perfusion systems
- (2017) Samantha Wang et al. JOURNAL OF BIOTECHNOLOGY
- Facile preparation of salt-tolerant anion-exchange membrane adsorber using hydrophobic membrane as substrate
- (2017) Jinxin Fan et al. JOURNAL OF CHROMATOGRAPHY A
- Preparative separation of monoclonal antibody aggregates by cation-exchange laterally-fed membrane chromatography
- (2017) Pedram Madadkar et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Purification of monoclonal antibodies entirely in flow-through mode
- (2017) Tsuyoshi Yamada et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Investigation of single-pass tangential flow filtration (SPTFF) as an inline concentration step for cell culture harvest
- (2017) Abhiram Arunkumar et al. JOURNAL OF MEMBRANE SCIENCE
- Advances in recombinant antibody manufacturing
- (2016) Renate Kunert et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Characterization and comparison of ATF and TFF in stirred bioreactors for continuous mammalian cell culture processes
- (2016) Daniel J. Karst et al. BIOCHEMICAL ENGINEERING JOURNAL
- Development of adsorptive hybrid filters to enable two-step purification of biologics
- (2016) Nripen Singh et al. mAbs
- Membrane-based hydrophobic interaction chromatography
- (2016) Anh Vu et al. SEPARATION SCIENCE AND TECHNOLOGY
- Electrospun nanofiber membranes
- (2016) Xuefen Wang et al. Current Opinion in Chemical Engineering
- Clarification technologies for monoclonal antibody manufacturing processes: Current state and future perspectives
- (2015) Nripen Singh et al. BIOTECHNOLOGY AND BIOENGINEERING
- Advective hydrogel membrane chromatography for monoclonal antibody purification in bioprocessing
- (2015) Ying Hou et al. BIOTECHNOLOGY PROGRESS
- Nanofiber adsorbents for high productivity continuous downstream processing
- (2015) Oliver Hardick et al. JOURNAL OF BIOTECHNOLOGY
- End-to-end integrated fully continuous production of recombinant monoclonal antibodies
- (2015) Rahul Godawat et al. JOURNAL OF BIOTECHNOLOGY
- A new multimodal membrane adsorber for monoclonal antibody purifications
- (2015) Juan Wang et al. JOURNAL OF MEMBRANE SCIENCE
- A laterally-fed membrane chromatography module
- (2015) Pedram Madadkar et al. JOURNAL OF MEMBRANE SCIENCE
- PDADMAC flocculation of Chinese hamster ovary cells: Enabling a centrifuge-less harvest process for monoclonal antibodies
- (2015) Thomas McNerney et al. mAbs
- Effects of chemical sanitization using NaOH on the properties of polysulfone and polyethersulfone ultrafiltration membranes
- (2014) Achyuta Teella et al. BIOTECHNOLOGY PROGRESS
- Understanding and modeling alternating tangential flow filtration for perfusion cell culture
- (2014) William Kelly et al. BIOTECHNOLOGY PROGRESS
- Nonspecific interactions of chromatin with immunoglobulin G and protein A, and their impact on purification performance
- (2014) Pete Gagnon et al. JOURNAL OF CHROMATOGRAPHY A
- Recent advances in bioprocessing application of membrane chromatography
- (2013) Valerie Orr et al. BIOTECHNOLOGY ADVANCES
- Very high density of CHO cells in perfusion by ATF or TFF in WAVE bioreactor™. Part I. Effect of the cell density on the process
- (2013) Marie-Françoise Clincke et al. BIOTECHNOLOGY PROGRESS
- The effect of protein a cycle number on the performance and lifetime of an anion exchange polishing step
- (2012) Timothy Iskra et al. BIOTECHNOLOGY AND BIOENGINEERING
- A new large-scale manufacturing platform for complex biopharmaceuticals
- (2012) Jens H. Vogel et al. BIOTECHNOLOGY AND BIOENGINEERING
- Membrane Technology in Bioprocess Science
- (2012) Holger Fröhlich et al. CHEMIE INGENIEUR TECHNIK
- Effect of membrane hydrophilization on ultrafiltration performance for biomolecules separation
- (2012) H. Susanto et al. Materials Science & Engineering C-Materials for Biological Applications
- Predicting diafiltration solution compositions for final ultrafiltration/diafiltration steps of monoclonal antibodies
- (2011) Mark Teeters et al. BIOTECHNOLOGY AND BIOENGINEERING
- Single pass tangential flow filtration to debottleneck downstream processing for therapeutic antibody production
- (2011) Jemelle Dizon-Maspat et al. BIOTECHNOLOGY AND BIOENGINEERING
- Process and economic evaluation for monoclonal antibody purification using a membrane-only process
- (2011) Hemanthram Varadaraju et al. BIOTECHNOLOGY PROGRESS
- Performance of Protein-A-Based Affinity Membranes for Antibody Purification
- (2011) Lokman Uzun et al. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
- A novel primary amine-based anion exchange membrane adsorber
- (2011) Maybelle Woo et al. JOURNAL OF CHROMATOGRAPHY A
- Protein concentration with single-pass tangential flow filtration (SPTFF)
- (2011) Catherine Casey et al. JOURNAL OF MEMBRANE SCIENCE
- Simultaneous removal of leached protein-A and aggregates from monoclonal antibody using hydrophobic interaction membrane chromatography
- (2011) Seung Mi Yoo et al. JOURNAL OF MEMBRANE SCIENCE
- RECENT DEVELOPMENTS IN MEMBRANE-BASED SEPARATIONS IN BIOTECHNOLOGY PROCESSES: REVIEW
- (2011) A. S. Rathore et al. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
- Effects of solution environment on mammalian cell fermentation broth properties: Enhanced impurity removal and clarification performance
- (2010) Matthew Westoby et al. BIOTECHNOLOGY AND BIOENGINEERING
- Hydrophobic salts markedly diminish viscosity of concentrated protein solutions
- (2010) Wei Du et al. BIOTECHNOLOGY AND BIOENGINEERING
- Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment
- (2010) Yao-Ming Huang et al. BIOTECHNOLOGY PROGRESS
- Industrialization of mAb production technology: The bioprocessing industry at a crossroads
- (2010) Brian Kelley mAbs
- Development of a polishing step using a hydrophobic interaction membrane adsorber with a PER.C6®-derived recombinant antibody
- (2009) Michael Kuczewski et al. BIOTECHNOLOGY AND BIOENGINEERING
- Profiling of host cell proteins by two-dimensional difference gel electrophoresis (2D-DIGE): Implications for downstream process development
- (2009) Mi Jin et al. BIOTECHNOLOGY AND BIOENGINEERING
- Salt tolerant membrane adsorbers for robust impurity clearance
- (2009) William T. Riordan et al. BIOTECHNOLOGY PROGRESS
- Theoretical analysis of excipient concentrations during the final ultrafiltration/diafiltration step of therapeutic antibody
- (2009) Fudu Miao et al. BIOTECHNOLOGY PROGRESS
- Electrospun polyethersulfone affinity membrane: Membrane preparation and performance evaluation
- (2009) Zuwei Ma et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Performance of a New Protein A Affinity Membrane for the Primary Recovery of Antibodies
- (2008) C. Boi et al. BIOTECHNOLOGY PROGRESS
- Electrospun regenerated cellulose nanofiber affinity membrane functionalized with protein A/G for IgG purification
- (2008) Z MA et al. JOURNAL OF MEMBRANE SCIENCE
- Upstream processes in antibody production: Evaluation of critical parameters
- (2007) Era Jain et al. BIOTECHNOLOGY ADVANCES
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