Article
Chemistry, Organic
Jie Yang, Lizhi Gai, Xiaoyang Chen, Yanfei Liu, Shengmei Wu, Jiao Feng, Xinbing Sui, Hua Lu
Summary: This study synthesized dyes with stable seven-membered N,O-boron-chelated skeleton and thoroughly investigated their photophysical properties through spectroscopic tests and theoretical calculations. Single-crystal X-ray diffraction studies provided evidence of their structure. These dyes produced singlet oxygen species under laser irradiation, showing potential as photosensitizers for treating superficial tumors.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Shan Xue, Mengwei Li, Yi Han, Yulan Chen
Summary: A series of N,O-bidentated BPh2 complexes were designed and synthesized, showing inherent D-A structures, distorted molecular conformations, and loose packing in crystal structures. The compounds exhibited high solid-state fluorescence efficiency and color contrast reversible mechanochromic properties, with sensitivity and response modulated by electronic and steric effects. The study suggests that N,O-bidentated BPh2 based emitters enable the development of excellent MCL-active materials with potential applications in optical force sensors and optoelectronic devices.
Article
Multidisciplinary Sciences
Yingzheng Li, Shaoqi Zhan, Lianpeng Tong, Wenlong Li, Yilong Zhao, Ziqi Zhao, Chang Liu, Marten S. G. Ahlquist, Fusheng Li, Licheng Sun
Summary: Water oxidation is essential for generating renewable fuels through electrochemical and photoelectrochemical methods. Ruthenium complexes have proven to be efficient water-oxidation catalysts, with a new study showing a polymerization strategy that alters the O-O bond formation pathway of the catalyst.
Article
Materials Science, Biomaterials
Robert Conway-Kenny, Albert Ferrer-Ugalde, Oriol Careta, Xiaoneng Cui, Jianzhang Zhao, Carme Nogues, Rosario Nunez, Justo Cabrera-Gonzalez, Sylvia M. Draper
Summary: Four novel transition metal-carborane photosensitisers were prepared by Sonogashira cross-coupling, with RuCB displaying the most attractive photophysical properties. The monocarborane-phenanthroline complexes RuCB and IrCB were the best internalised by SKBR-3 cells, demonstrating high photoactivity and cell-killing effects. These photosensitisers have potential as dual anti-cancer agents for PDT and BNCT due to their high boron content and photoactive properties.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Organic
Hyung Yoon, Alexandra Galls, Soren D. Rozema, Scott J. Miller
Summary: Enantioselective Cu-catalyzed C-O cross coupling reactions have been developed to yield atropisomeric resorcinol-bearing quinazolinones. By using a new guanidinylated dimeric peptidic ligand, the desired products were obtained with good yields and excellent stereocontrol. The reaction was easily scalable and various product derivatizations were carried out.
Article
Chemistry, Multidisciplinary
Yool Lee, Chaeun Oh, Jin Kim, Myong-Suk Park, Woo Kyun Bae, Kyung Hyun Yoo, Seungwoo Hong
Summary: The activation of dioxygen plays a crucial role in aerobic life, with metal ions' redox versatility being essential for processes involving reactive oxygen species. Synthetic metal complexes have shown potential in activating dioxygen and generating ROS, with implications for cancer treatment and the development of potent antitumor agents.
Article
Biochemistry & Molecular Biology
Sofia Balou, Athanasios Zarkadoulas, Maria Koukouvitaki, Luciano Marchio, Eleni K. Efthimiadou, Christiana A. Mitsopoulou
Summary: The synthesis and characterization of two ruthenium (II) polypyridyl complexes were reported, wherein it was found that these complexes bind to DNA via a minor groove mode of binding and can induce apoptosis of MCF-7 cells at low concentrations. Additionally, confocal microscopy showed that one of the complexes localizes in the nucleus and is more efficient at internalizing in MCF-7 cells than in HEK-293 cells.
BIOINORGANIC CHEMISTRY AND APPLICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Richard J. Mitchell, Anitha S. Gowda, Alexander G. Olivelli, Aron J. Huckaba, Sean Parkin, Jason M. Unrine, Viral Oza, Jessica S. Blackburn, Folami Ladipo, David K. Heidary, Edith C. Glazer
Summary: Cancer cells rely on glycolysis for energy but recent studies have shown that their mitochondria still play an active role. The study synthesized and characterized ruthenium compounds with triarylphosphine-containing bipyridyl ligands which showed high depolarizing capabilities on mitochondrial membranes in cancer cells. These compounds have the potential for anticancer applications due to their potency against cancer cells and low toxicity in zebrafish embryos.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Zicong Marvin Wong, Xue Yong, Tianqi Deng, Wen Shi, Gang Wu, Ning Li, He-Kuan Luo, Shuo-Wang Yang
Summary: Metal-organic complexes with radical characteristics have attracted significant attention due to their unique properties and potential applications. This study investigates a series of neutral Ni complexes with different configurations and finds that macrocyclic complexes possess extremely strong multiradical characteristics and exhibit strong induced ring current in the presence of an external magnetic field.
JOURNAL OF PHYSICAL CHEMISTRY A
(2022)
Article
Chemistry, Physical
Nebal Alassad, Noy B. Nechmad, Ravindra S. Phatake, Ofer Reany, N. Gabriel Lemcoff
Summary: In this study, the structure, latency, and activity of twelve sulfur-chelated ruthenium precatalysts were investigated by varying their ligand shell. The results revealed that different ligand shells and activation stimuli significantly influenced the catalytic efficiency for different substrate types. In addition, light irradiation was found to promote cis/trans or trans/cis-dihalo isomerization, but did not activate otherwise inactive catalysts.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lanmei Chen, Jie Wang, Xianhong Cai, Suxiang Chen, Jingjing Zhang, Baojun Li, Weigang Chen, Xinhua Guo, Hui Luo, Jincan Chen
Summary: Novel cyclometalated Ru(II)-isoquinoline complexes were synthesized and evaluated for their cytotoxic effects on lung cancer cells, showing superior anticancer activity compared to cisplatin with low toxicity. RuIQ-5 exhibited unique mechanisms in inducing apoptosis in cancer cells and inhibiting Nrf2 overexpression, making it a promising anticancer therapeutic agent.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Nida Shahid, Rahul Kumar Singh, Navdeep Srivastava, Amrendra K. K. Singh
Summary: A series of Ru(III)-NHC complexes have been prepared through a base-free route. These air and moisture-stable complexes, which represent rare examples of paramagnetic Ru(III)-NHC complexes, were shown to be excellent metal precursors for the synthesis of new Ru(II)-NHC complexes. This work allows easy access to new Ru-NHC complexes for the study of new properties and novel applications.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Yuji Mikata, Yasuko Kuroda, Kyoko Naito, Kana Murakami, Chihiro Yamamoto, Shoko Yabe, Shizuka Yonemura, Arimasa Matsumoto, Hajime Katano
Summary: Seven new bis(mu-oxo)dimanganese complexes with Mn-2(iii,iii) or Mn-2(iii,iv) oxidation states were prepared using quinoline- and isoquinoline-based tetraamine ligands. Quinoline complexes stabilize the Mn-2(iii,iii) oxidation state, while isoquinoline ligands afford Mn-2(iii,iv) complexes. A systematic comparison of 14 complexes highlights the distinct deviation of quinoline and tripodal amine motifs in this ligand series.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Suvam Saha, Anagha Haridas, Faneesha Assanar, Charu Bansal, P. K. Sudhadevi Antharjanam, Sundargopal Ghosh
Summary: The reaction between Cp* based ruthenium and molybdenum complexes with different boranes was investigated. The result showed that the ruthenium complexes formed various dihydridoborate complexes at room temperature, while the molybdenum complexes formed agostic borate species at elevated temperatures.
DALTON TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Maria George Elias, Stephanie Mehanna, Elias Elias, Rony S. Khnayzer, Costantine F. Daher
Summary: The study demonstrates that the photoactivated chemotherapy drug [Ru(bpy)2BC]Cl2 has multi-mechanistic effects, increasing cytotoxicity by inducing ROS production and DNA damage. It mediates apoptosis by interfering with pathways related to cell apoptosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Physics, Applied
Shanhe Su, Yinghui Zhou, Guozhen Su, Jincan Chen
Summary: One consequence of the Nernst theorem is that the heat capacities of a thermodynamic system under different constraints approach zero as the temperature approaches absolute zero. This consequence reveals the temperature dependence of the heat capacity at ultra-low temperatures and deduces the general form and simplest expression of heat capacities under such conditions. This consequence also provides a new research method and is rigorously proven to be equivalent to the Nernst theorem, serving as another description of the third law of thermodynamics.
MODERN PHYSICS LETTERS B
(2023)
Article
Physics, Multidisciplinary
Jingyi Chen, Youlin Wang, Guozhen Su, Jincan Chen, Shanhe Su
Summary: The general expressions of heat and work are derived using two representations of quantum mechanics. Quantum coherence, associated with the superposition of basis vectors, is shown to be essential in thermodynamics. Coherence work generates the power in the spin precession process, while coherence heat mainly determines the heat in the spontaneous emission process. These results establish a fundamental framework for finding thermodynamic relations in quantum evolution processes.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2023)
Review
Cell Biology
Kamel Mhalhel, Mirea Sicari, Lidia Pansera, Jincan Chen, Maria Levanti, Nicolas Diotel, Sepand Rastegar, Antonino Germana, Giuseppe Montalbano
Summary: In the past century, advancements in biotechnology, biochemistry, and pharmacognosy have brought attention to flavonoids, which are polyphenolic secondary metabolites capable of modulating various biological mechanisms, including those involved in neuronal plasticity, learning, and memory. Flavonoids also impact biological processes associated with neurodegenerative diseases such as oxidative stress, neuroinflammation, and mitochondrial dysfunction. Therefore, certain flavonoids can be used as adjuvants to prevent and counteract disorders like Alzheimer's and Parkinson's diseases. Zebrafish, with its high genome homology to humans, similar brain organization and neurochemical processes, and maintained neurogenic activity in the adult brain, provides a valuable model for studying human neurodegenerative diseases and the effects of flavonoids on these disorders.
Article
Physics, Applied
Junyi Wang, Youlin Wang, Xiaohang Chen, Jincan Chen, Shanhe Su
Summary: In this study, a model of a thermophotovoltaic device that combines a near-field thermal emitter and a hot-carrier solar cell is established. The study introduces the concept of fluctuating electromagnetic near-field theory for radiative thermal transport and Landauer's formula for carrier extraction. The expressions for efficiency and power output are derived, and the impact of voltage and extraction energy of energy selective contacts on the device performance is revealed. The results demonstrate that exploiting radiation between the emitter and the cell and extracting carriers through electron tunneling effects can significantly enhance the efficiency of the proposed device.
APPLIED PHYSICS LETTERS
(2023)
Article
Engineering, Chemical
Tianyu Gao, Depeng Wang, Lichao Xia, Shanshan Zhao, Ronghua Xu, Hanmin Zhang, Fangang Meng, Zanmin Zhou, Jincan Chen, Wanli Liu
Summary: Membrane fouling is a major issue in membrane bioreactors (MBRs) that limits their stable operation. The nature of residual foulants after chemical cleaning is not well understood. In this study, fouled membranes from a large-scale MBR were analyzed to identify the key components resistant to chemical cleaning. The results showed that certain foulants, such as uronic acids, are responsible for irreversible fouling. The interaction between bio-cakes also plays a significant role in membrane fouling. Keystone taxa, such as c_WS6 and c_Deltaproteobacteria, were found to contribute to the accumulation of organic foulants. These findings provide insights for fouling control in MBRs.
Article
Physics, Applied
Shanhe Su, Zhiyuan Lin, Jincan Chen
Summary: A quantum engine powered by quantum measurement is introduced, enabling the conversion of heat into work without the need for compression and expansion of the resonance frequency within a finite-time unitary transformation. The study derives the work output, quantum heat, and efficiency, emphasizing the significance of thermal divergence in open quantum systems. The optimization of the measurement basis to enhance performance is achieved by linking thermal divergence to nonequilibrium free energy and entropy. The spin-engine architecture presents a comprehensive platform for future investigations into harnessing work from quantum measurements.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Physics, Multidisciplinary
Jianying Du, Tong Fu, Jingyi Chen, Shanhe Su, Jincan Chen
Summary: A simple device with a quantum dot embedded between two reservoirs characterized by different distribution functions allows for the reversal and amplification of heat flow in quantum systems. This phenomenon is made possible by controlling the energy levels of the quantum dot and the chemical potentials of the reservoirs. The device has practical applications as a micro/nano cooler.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2023)
Article
Environmental Sciences
Chao Fang, Ronghui Zheng, Fukun Hong, Shunyang Chen, Guangcheng Chen, Min Zhang, Fulong Gao, Jincan Chen, Jun Bo
Summary: This study investigates the contamination of meso-and microplastics (MMPs) on submerged mangrove leaves and the herbivorous snails that feed on them in four mangrove forests in Beibu Gulf, Guangxi Province, China. The results show that the abundance of MMPs on the mangrove leaves ranges from 0.01 +/- 0.00 to 0.42 +/- 0.15 items cm-2, while in the snails it ranges from 0.33 +/- 0.21 to 6.20 +/- 2.91 items individual-1. Significant positive correlations are found between the snails and leaves in terms of the abundance of total MMPs and the proportions of MMPs with the same characteristics.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Shasha Yuan, Sixian Guo, Yongtao Tan, Mengdi Li, Yi Lu, Ronghua Xu, Ahmed Tawfik, Zanmin Zhou, Jincan Chen, Wanli Liu, Fangang Meng
Summary: The ecological processes of attached biofilms and suspended biomass were studied in a sequencing batch moving bed biofilm reactor. Attached biofilms played a crucial role in nitrification and denitrification activities, while the different ecological processes were observed between attached and suspended communities in the reactor.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Ronghua Xu, Wentian Zhang, Yue Fu, Fuqiang Fan, Zanmin Zhou, Jincan Chen, Wanli Liu, Fangang Meng
Summary: This study reveals the positive role of influent species immigration (ISI) in mitigating membrane fouling in membrane bioreactors (MBRs) treating municipal wastewater. The results show that ISI can reduce the fouling rate and the sludge from the MBR-C (fed with raw municipal wastewater) has higher fouling index and biofilm formation potential than the MBR-E (fed with sterilized municipal wastewater). The presence of diverse and abundant populations responsible for floc-forming, hydrolysis/fermentation, and SMP degradation in the influent supports the increased floc size and lowered SMP concentrations in the MBR-C.
Article
Fisheries
Jun Bo, Ronghui Zheng, Yulu Jiang, Jincan Chen, Chao Fang, Christyn Bailey, Yusheng Zhang, Jae-Seong Lee, Helmut Segner
Summary: Global warming and changes in environmental conditions may impact the health of marine species. This study examined the liver transcriptome and proteome of the hybrid grouper to understand the physiological pathways affected by climate change-related stressors. The results revealed time-dependent and stressor-specific responses, with elevated temperature having a dominant effect.
Article
Biochemistry & Molecular Biology
Jincan Chen, Xinhua Guo, Dunhui Li, Hong Tang, Jie Gao, Wenzhu Yu, Xufeng Zhu, Zirong Sun, Zunnan Huang, Lanmei Chen
Summary: We designed and synthesized three new carboline-based cyclometalated iridium complexes, which exhibited high potential antitumor effects and induced cell death through mitochondrial events and activation of the caspase pathway. These novel iridium complexes also demonstrated a prominent inhibitory effect on tumor growth.
Article
Medicine, Research & Experimental
Lin Yang, Qiuling Zhao, Wenbin Liu, Ting Chen, Xiuliang Qiu, Jincan Chen, Shengqiang Huang, Ruyi Huang, Liangliang Dong
Summary: Inhibition of HPK1 enhances the efficacy of anti-PD-1 immunotherapy in non-Hodgkin's lymphoma, suggesting that HPK1 inhibitors are promising drug targets for cancer immunotherapy.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Physics, Fluids & Plasmas
Jingyi Chen, Youlin Wang, Jincan Chen, Shanhe Su
Summary: The Drazin inverse of the Liouvillian superoperator is used to determine the dynamics of a time-dependent system governed by the Markovian master equation. Under the condition of slow driving, the perturbation expansion of the density operator of the system in powers of time can be derived. A finite-time cycle model of the quantum refrigerator driven by a time-dependent external field is established, and the Lagrange multiplier method is adopted to find the optimal cooling performance. The effects of the frequency exponent determining dissipation characteristics on the optimal performance of the refrigerator are discussed systematically.
Article
Astronomy & Astrophysics
Shanhe Su, Jincan Chen
Summary: It is demonstrated that the equivalence between the Nernst theorem and the heat capacity statement of the third law of thermodynamics can be mathematically proven through a simple method.
MODERN PHYSICS LETTERS A
(2023)
