Hereditary hemochromatosis promotes colitis and colon cancer and causes bacterial dysbiosis in mice

Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer

(2020) Yangzom D. Bhutia et al.   Asian Journal of Pharmaceutical Sciences

Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2

(2020) Bojana Ristic et al.   BIOCHEMICAL JOURNAL

Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology

(2020) Rikki A. M. Brown et al.   Frontiers in Oncology

Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis

(2019) Nupur K. Das et al.   Cell Metabolism

Deficiency of Dietary Fiber in Slc5a8-Null Mice Promotes Bacterial Dysbiosis and Alters Colonic Epithelial Transcriptome towards Proinflammatory Milieu

(2019) Sathish Sivaprakasam et al.   Canadian Journal of Gastroenterology and Hepatology

Iron and Cancer

(2018) Suzy V. Torti et al.   Annual Review of Nutrition

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Role of Intestinal HIF-2α in Health and Disease

(2016) Sadeesh K. Ramakrishnan et al.   Annual Review of Physiology

Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs

(2015) Y. D. Bhutia et al.   CANCER RESEARCH

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon

(2015) Noortje Ijssennagger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Iron Homeostasis and Therapeutic Implications of Iron Chelators in Cancer

(2014) Mohsin Raza et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The composition of the gut microbiota shapes the colon mucus barrier

(2014) H. E. Jakobsson et al.   EMBO REPORTS

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Hereditary Hemochromatosis: Missed Diagnosis or Misdiagnosis?

(2013) Cynthia E. Cherfane et al.   AMERICAN JOURNAL OF MEDICINE

Intakes of heme iron and zinc and colorectal cancer incidence: a meta-analysis of prospective studies

(2013) Lei Qiao et al.   CANCER CAUSES & CONTROL

Endoscopic and Histologic Abnormalities of Gastrointestinal Tract in Patients With Hereditary Hemochromatosis

(2013) Wei-Xun Zhou et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Cancer risk inHFEC282Y homozygotes: results from the HUNT 2 study

(2013) ARNE Åsberg et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

HFE gene C282Y variant is associated with colorectal cancer in Caucasians: a meta-analysis

(2013) Weidong Chen et al.   TUMOR BIOLOGY

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Genetic modification of iron metabolism in mice affects the gut microbiota

(2012) Keren Buhnik-Rosenblau et al.   BIOMETALS

Hypoxia-Inducible Factor-2  Activation Promotes Colorectal Cancer Progression by Dysregulating Iron Homeostasis

(2012) X. Xue et al.   CANCER RESEARCH

Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing

(2012) Nicholas A Bokulich et al.   NATURE METHODS

Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies

(2012) Anna Klindworth et al.   NUCLEIC ACIDS RESEARCH

Iron Availability Increases the Pathogenic Potential of Salmonella Typhimurium and Other Enteric Pathogens at the Intestinal Epithelial Interface

(2012) Guus A. M. Kortman et al.   PLoS One

Dietary Heme Alters Microbiota and Mucosa of Mouse Colon without Functional Changes in Host-Microbe Cross-Talk

(2012) Noortje IJssennagger et al.   PLoS One

Heme Iron from Meat and Risk of Colorectal Cancer: A Meta-analysis and a Review of the Mechanisms Involved

(2011) N. M. Bastide et al.   Cancer Prevention Research

Red and Processed Meat and Colorectal Cancer Incidence: Meta-Analysis of Prospective Studies

(2011) Doris S. M. Chan et al.   PLoS One

Hereditary Hemochromatosis: Pathogenesis, Diagnosis, and Treatment

(2010) Antonello Pietrangelo   GASTROENTEROLOGY

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

Iron: An emerging factor in colorectal carcinogenesis

(2010) Anita CG Chua   WORLD JOURNAL OF GASTROENTEROLOGY

HFE C282Y homozygotes are at increased risk of breast and colorectal cancer

(2009) Nicholas J. Osborne et al.   HEPATOLOGY

New functions for an iron storage protein: The role of ferritin in immunity and autoimmunity

(2008) Stefania Recalcati et al.   JOURNAL OF AUTOIMMUNITY

Intestinal TM7 bacterial phylogenies in active inflammatory bowel disease

(2008) T. Kuehbacher et al.   JOURNAL OF MEDICAL MICROBIOLOGY