Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway

Ca 2+ signalling plays a role in celastrol‐mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats

(2019) Vincent Kam Wai Wong et al.   BRITISH JOURNAL OF PHARMACOLOGY

PRAK plays a pivotal role in protecting the heart against ischemia/ reperfusion injury and myocardial infarction

(2019) Yu Tina Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Repurposing of drugs as STAT3 inhibitors for cancer therapy

(2019) Pathum S. Thilakasiri et al.   SEMINARS IN CANCER BIOLOGY

STAT3: a multifaceted oncoprotein

(2018) Aleks C. Guanizo et al.   GROWTH FACTORS

Curcumin suppresses cardiac fibroblasts activities by regulating the proliferation and cell cycle via the inhibition of the p38 MAPK/ERK signaling pathway

(2018) Guanhua Fang et al.   Molecular Medicine Reports

Emerging roles of sphingosylphosphorylcholine in modulating cardiovascular functions and diseases

(2018) Di Ge et al.   ACTA PHARMACOLOGICA SINICA

Soluble CD74 Reroutes MIF/CXCR4/AKT‐Mediated Survival of Cardiac Myofibroblasts to Necroptosis

(2018) Josefin Soppert et al.   Journal of the American Heart Association

Novel effects of sphingosylphosphorylcholine on the apoptosis of breast cancer via autophagy/AKT/p38 and JNK signaling

(2018) Di Ge et al.   JOURNAL OF CELLULAR PHYSIOLOGY

STAT3: a link between CaMKII–βIV-spectrin and maladaptive remodeling?

(2018) Mohit Hulsurkar et al.   JOURNAL OF CLINICAL INVESTIGATION

Do STAT3 inhibitors have potential in the future for cancer therapy?

(2017) Andrea L.A. Wong et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance

(2017) Marilen Federico et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structure-based identification of CaMKIIα-interacting MUPP1 PDZ domains and rational design of peptide ligands to target such interaction in human fertilization

(2016) Yi-Le Zhang et al.   AMINO ACIDS

Sodium orthovanadate suppresses palmitate-induced cardiomyocyte apoptosis by regulation of the JAK2/STAT3 signaling pathway

(2016) Jing Liu et al.   APOPTOSIS

Arsenic trioxide mediates HAPI microglia inflammatory response and subsequent neuron apoptosis through p38/JNK MAPK/STAT3 pathway

(2016) Jiamin Mao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cardiac-specific ablation of the STAT3 gene in the subacute phase of myocardial infarction exacerbated cardiac remodeling

(2015) Daichi Enomoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK

(2015) Jing Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy

(2015) Hong-Wei Yue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Bioorthogonal Chemoenzymatic Functionalization of Calmodulin for Bioconjugation Applications

(2015) Chethana Kulkarni et al.   BIOCONJUGATE CHEMISTRY

Effects of sphingosylphosphorylcholine against oxidative stress and acute lung ınjury ınduced by pulmonary contusion in rats

(2015) Burhan Aksu et al.   JOURNAL OF PEDIATRIC SURGERY

Inhibition of autophagy promoted sphingosylphosphorylcholine induced cell death in non-small cell lung cancer cells

(2014) Hongwei Yue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

(2013) Derek J. Hausenloy et al.   JOURNAL OF CLINICAL INVESTIGATION

Adult cardiac fibroblast proliferation is modulated by calcium/calmodulin-dependent protein kinase II in normal and hypertrophied hearts

(2013) Tamara P. Martin et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Extracellular calmodulin regulates growth and cAMP-mediated chemotaxis in Dictyostelium discoideum

(2012) Danton H. O’Day et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Electrical field stimulation induces cardiac fibroblast proliferation through the calcineurin–NFAT pathway

(2012) Qing-Qing Chen et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Regulation of apoptosis and autophagy by sphingosylphosphorylcholine in vascular endothelial cells

(2011) Di Ge et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1

(2011) Peramaiyan Rajendran et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Intravenous Sphingosylphosphorylcholine Protects Ischemic and Postischemic Myocardial Tissue in a Mouse Model of Myocardial Ischemia/Reperfusion Injury

(2011) Christine Herzog et al.   MEDIATORS OF INFLAMMATION

Synthesis of novel oxime-containing pyrazole derivatives and discovery of regulators for apoptosis and autophagy in A549 lung cancer cells

(2010) Liang-Wen Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of CaMKII in cardiovascular health, disease, and arrhythmia

(2010) Peter J. Mohler et al.   HEART RHYTHM

Inhibition of Calcium–Calmodulin-Dependent Kinase II Suppresses Cardiac Fibroblast Proliferation and Extracellular Matrix Secretion

(2010) Wei Zhang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

TGFBR3, a potential negative regulator of TGF-β signaling, protects cardiac fibroblasts from hypoxia-induced apoptosis

(2010) WenFeng Chu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

JAK redux: a second look at the regulation and role of JAKs in the heart

(2009) Mazen Kurdi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: Role of sphingosine-1-phosphate

(2009) Miguel A. Frias et al.   CARDIOVASCULAR RESEARCH

Dissociation of Calmodulin-Target Peptide Complexes by the Lipid Mediator Sphingosylphosphorylcholine

(2009) Erika Kovacs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosylphosphorylcholine as a novel calmodulin inhibitor

(2008) Erika Kovacs et al.   BIOCHEMICAL JOURNAL

Membrane translocation of small GTPase Rac1 and activation of STAT1 and STAT3 in pacing-induced sustained atrial fibrillation

(2008) Chia-Ti Tsai et al.   HEART RHYTHM